-
1
-
-
77951647863
-
Fetal microchimerism: the cellular and immunological legacy of pregnancy
-
Lissauer, D. M., Piper, K. P., Moss, P. A. and Kilby, M. D., Fetal microchimerism: the cellular and immunological legacy of pregnancy. Expert Rev. Mol. Med. 2009. 11: e33.
-
(2009)
Expert Rev. Mol. Med.
, vol.11
, pp. e33
-
-
Lissauer, D.M.1
Piper, K.P.2
Moss, P.A.3
Kilby, M.D.4
-
2
-
-
0028845691
-
T cell awareness of paternal alloantigens during pregnancy
-
Tafuri, A., Alferink, J., Moller, P., Hammerling, G. J. and Arnold, B., T cell awareness of paternal alloantigens during pregnancy. Science 1995. 270: 630-633.
-
(1995)
Science
, vol.270
, pp. 630-633
-
-
Tafuri, A.1
Alferink, J.2
Moller, P.3
Hammerling, G.J.4
Arnold, B.5
-
3
-
-
84863613543
-
Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity
-
Lissauer, D., Piper, K., Goodyear, O., Kilby, M. D. and Moss, P. A., Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity. J. Immunol. 2012. 189: 1072-1080.
-
(2012)
J. Immunol.
, vol.189
, pp. 1072-1080
-
-
Lissauer, D.1
Piper, K.2
Goodyear, O.3
Kilby, M.D.4
Moss, P.A.5
-
4
-
-
33845742001
-
Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus
-
Piper, K. P., McLarnon, A., Arrazi, J., Horlock, C., Ainsworth, J., Kilby, M. D., Martin, W. L. et al., Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus. Biol. Reprod. 2007. 76: 96-101.
-
(2007)
Biol. Reprod.
, vol.76
, pp. 96-101
-
-
Piper, K.P.1
McLarnon, A.2
Arrazi, J.3
Horlock, C.4
Ainsworth, J.5
Kilby, M.D.6
Martin, W.L.7
-
5
-
-
81055143766
-
Cytomegalovirus sero positivity dramatically alters the maternal CD8+ T cell repertoire and leads to the accumulation of highly differentiated memory cells during human pregnancy
-
Lissauer, D., Choudhary, M., Pachnio, A., Goodyear, O., Moss, P. A. and Kilby, M. D., Cytomegalovirus sero positivity dramatically alters the maternal CD8+ T cell repertoire and leads to the accumulation of highly differentiated memory cells during human pregnancy. Hum. Reprod. 2011. 26: 3355-3365.
-
(2011)
Hum. Reprod.
, vol.26
, pp. 3355-3365
-
-
Lissauer, D.1
Choudhary, M.2
Pachnio, A.3
Goodyear, O.4
Moss, P.A.5
Kilby, M.D.6
-
6
-
-
84866991345
-
Pregnancy imprints regulatory memory that sustains anergy to fetal antigen
-
Rowe, J. H., Ertelt, J. M., Xin, L. and Way, S. S., Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature 2012. 490: 102-106.
-
(2012)
Nature
, vol.490
, pp. 102-106
-
-
Rowe, J.H.1
Ertelt, J.M.2
Xin, L.3
Way, S.S.4
-
7
-
-
84861973985
-
Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface
-
Nancy, P., Tagliani, E., Tay, C. S., Asp, P., Levy, D. E. and Erlebacher, A., Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science 2012. 336: 1317-1321.
-
(2012)
Science
, vol.336
, pp. 1317-1321
-
-
Nancy, P.1
Tagliani, E.2
Tay, C.S.3
Asp, P.4
Levy, D.E.5
Erlebacher, A.6
-
8
-
-
77952093707
-
Major histocompatibility complex (MHC)-mediated immune regulation of decidual leukocytes at the fetal-maternal interface
-
Tilburgs, T., Scherjon, S. A. and Claas, F. H., Major histocompatibility complex (MHC)-mediated immune regulation of decidual leukocytes at the fetal-maternal interface. J. Reprod. Immunol. 2010. 85: 58-62.
-
(2010)
J. Reprod. Immunol.
, vol.85
, pp. 58-62
-
-
Tilburgs, T.1
Scherjon, S.A.2
Claas, F.H.3
-
9
-
-
77953924059
-
Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy
-
Saito, S., Nakashima, A., Shima, T. and Ito, M., Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am. J. Reprod. Immunol. 2010. 63: 601-610.
-
(2010)
Am. J. Reprod. Immunol.
, vol.63
, pp. 601-610
-
-
Saito, S.1
Nakashima, A.2
Shima, T.3
Ito, M.4
-
10
-
-
0029036806
-
Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones
-
Piccinni, M. P., Giudizi, M. G., Biagiotti, R., Beloni, L., Giannarini, L., Sampognaro, S., Parronchi, P. et al., Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J. Immunol. 1995. 155: 128-133.
-
(1995)
J. Immunol.
, vol.155
, pp. 128-133
-
-
Piccinni, M.P.1
Giudizi, M.G.2
Biagiotti, R.3
Beloni, L.4
Giannarini, L.5
Sampognaro, S.6
Parronchi, P.7
-
11
-
-
15844395561
-
Modulation of cytokine production by dydrogesterone in lymphocytes from women with recurrent miscarriage
-
Raghupathy, R., Al Mutawa, E., Makhseed, M., Azizieh, F. and Szekeres-Bartho, J., Modulation of cytokine production by dydrogesterone in lymphocytes from women with recurrent miscarriage. BJOG 2005. 112: 1096-1101.
-
(2005)
BJOG
, vol.112
, pp. 1096-1101
-
-
Raghupathy, R.1
Al Mutawa, E.2
Makhseed, M.3
Azizieh, F.4
Szekeres-Bartho, J.5
-
12
-
-
77950627677
-
Progesterone levels in cesarean and normal delivered term placentas
-
Feinshtein, V., Ben-Zvi, Z., Sheiner, E., Amash, A., Sheizaf, B. and Holcberg, G., Progesterone levels in cesarean and normal delivered term placentas. Arch. Gynecol. Obstet. 2010. 281: 387-392.
-
(2010)
Arch. Gynecol. Obstet.
, vol.281
, pp. 387-392
-
-
Feinshtein, V.1
Ben-Zvi, Z.2
Sheiner, E.3
Amash, A.4
Sheizaf, B.5
Holcberg, G.6
-
13
-
-
84891648483
-
Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth
-
Dodd, J. M., Jones, L., Flenady, V., Cincotta, R. and Crowther, C. A., Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth. Cochrane Database Syst. Rev. 2013. 7: CD004947.
-
(2013)
Cochrane Database Syst. Rev.
, vol.7
, pp. CD004947
-
-
Dodd, J.M.1
Jones, L.2
Flenady, V.3
Cincotta, R.4
Crowther, C.A.5
-
14
-
-
79955446240
-
Does first trimester progesterone prophylaxis increase the live birth rate in women with unexplained recurrent miscarriages? Brit. Med. J
-
Coomarasamy, A., Truchanowicz, E. G. and Rai, R., Does first trimester progesterone prophylaxis increase the live birth rate in women with unexplained recurrent miscarriages? Brit. Med. J. 2011. 342: d1914.
-
(2011)
, vol.342
, pp. d1914
-
-
Coomarasamy, A.1
Truchanowicz, E.G.2
Rai, R.3
-
16
-
-
34547863907
-
Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress
-
Arck, P., Hansen, P. J., Mulac Jericevic, B., Piccinni, M. P. and Szekeres-Bartho, J., Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress. Am. J. Reprod. Immunol. 2007. 58: 268-279.
-
(2007)
Am. J. Reprod. Immunol.
, vol.58
, pp. 268-279
-
-
Arck, P.1
Hansen, P.J.2
Mulac Jericevic, B.3
Piccinni, M.P.4
Szekeres-Bartho, J.5
-
17
-
-
84874547148
-
The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses
-
Hughes, G. C., Clark, E. A. and Wong, A. H., The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses. J. Leukoc. Biol. 2013. 93: 369-375.
-
(2013)
J. Leukoc. Biol.
, vol.93
, pp. 369-375
-
-
Hughes, G.C.1
Clark, E.A.2
Wong, A.H.3
-
18
-
-
84867216518
-
Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability
-
Lee, J. H., Lydon, J. P. and Kim, C. H., Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability. Eur. J. Immunol. 2012. 42: 2683-2696.
-
(2012)
Eur. J. Immunol.
, vol.42
, pp. 2683-2696
-
-
Lee, J.H.1
Lydon, J.P.2
Kim, C.H.3
-
19
-
-
84895522621
-
Non-genomic rapid responses via progesterone in human peripheral T cells are not indirectly mimicked by sphingosine 1-phosphate
-
Chen, J. J., Lin, D. J., Liu, M. S. and Chien, E. J., Non-genomic rapid responses via progesterone in human peripheral T cells are not indirectly mimicked by sphingosine 1-phosphate. Steroids 2014. 81: 9-12.
-
(2014)
Steroids
, vol.81
, pp. 9-12
-
-
Chen, J.J.1
Lin, D.J.2
Liu, M.S.3
Chien, E.J.4
-
20
-
-
0025160037
-
Progesterone suppression of pregnancy lymphocytes is not mediated by glucocorticoid effect
-
Szekeres-Bartho, J., Philibert, D. and Chaouat, G., Progesterone suppression of pregnancy lymphocytes is not mediated by glucocorticoid effect. Am. J. Reprod. Immunol. 1990. 23: 42-43.
-
(1990)
Am. J. Reprod. Immunol.
, vol.23
, pp. 42-43
-
-
Szekeres-Bartho, J.1
Philibert, D.2
Chaouat, G.3
-
21
-
-
38849164402
-
Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone
-
Dosiou, C., Hamilton, A. E., Pang, Y., Overgaard, M. T., Tulac, S., Dong, J., Thomas, P. et al., Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone. J. Endocrinol. 2008. 196: 67-77.
-
(2008)
J. Endocrinol.
, vol.196
, pp. 67-77
-
-
Dosiou, C.1
Hamilton, A.E.2
Pang, Y.3
Overgaard, M.T.4
Tulac, S.5
Dong, J.6
Thomas, P.7
-
22
-
-
0027491672
-
Synthesis of T helper 2-type cytokines at the maternal-fetal interface
-
Lin, H., Mosmann, T. R., Guilbert, L., Tuntipopipat, S. and Wegmann, T. G., Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J. Immunol. 1993. 151: 4562-4573.
-
(1993)
J. Immunol.
, vol.151
, pp. 4562-4573
-
-
Lin, H.1
Mosmann, T.R.2
Guilbert, L.3
Tuntipopipat, S.4
Wegmann, T.G.5
-
23
-
-
84891719951
-
Profile of maternal CD4 T-cell effector function during normal pregnancy and in women with a history of recurrent miscarriage
-
Lissauer, D., Goodyear, O., Khanum, R., Moss, P. A. and Kilby, M. D., Profile of maternal CD4 T-cell effector function during normal pregnancy and in women with a history of recurrent miscarriage. Clin. Sci. 2014. 126: 347-354.
-
(2014)
Clin. Sci.
, vol.126
, pp. 347-354
-
-
Lissauer, D.1
Goodyear, O.2
Khanum, R.3
Moss, P.A.4
Kilby, M.D.5
-
24
-
-
84863638571
-
The Th1:th2 dichotomy of pregnancy and preterm labour
-
Sykes, L., MacIntyre, D. A., Yap, X. J., Teoh, T. G. and Bennett, P. R., The Th1:th2 dichotomy of pregnancy and preterm labour. Mediators Inflamm. 2012. 2012: 967629.
-
(2012)
Mediators Inflamm.
, vol.2012
, pp. 967629
-
-
Sykes, L.1
MacIntyre, D.A.2
Yap, X.J.3
Teoh, T.G.4
Bennett, P.R.5
-
25
-
-
0034008633
-
Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion
-
Raghupathy, R., Makhseed, M., Azizieh, F., Omu, A., Gupta, M. and Farhat, R., Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum. Reprod. 2000. 15: 713-718.
-
(2000)
Hum. Reprod.
, vol.15
, pp. 713-718
-
-
Raghupathy, R.1
Makhseed, M.2
Azizieh, F.3
Omu, A.4
Gupta, M.5
Farhat, R.6
-
26
-
-
34249678457
-
T(H)1 cells control themselves by producing interleukin-10
-
O'Garra, A. and Vieira, P., T(H)1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 2007. 7: 425-428.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 425-428
-
-
O'Garra, A.1
Vieira, P.2
-
27
-
-
84881481536
-
IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium
-
Nguyen, T., Robinson, N., Allison, S. E., Coombes, B. K., Sad, S. and Krishnan, L., IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium. Placenta 2013. 34: 765-774.
-
(2013)
Placenta
, vol.34
, pp. 765-774
-
-
Nguyen, T.1
Robinson, N.2
Allison, S.E.3
Coombes, B.K.4
Sad, S.5
Krishnan, L.6
-
28
-
-
77649184739
-
The regulation of IL-10 production by immune cells
-
Saraiva, M. and O'Garra, A., The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 2010. 10: 170-181.
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 170-181
-
-
Saraiva, M.1
O'Garra, A.2
-
29
-
-
0029017478
-
IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau
-
Chaouat, G., Assal Meliani, A., Martal, J., Raghupathy, R., Elliott, J. F., Mosmann, T. and Wegmann, T. G., IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. J. Immunol. 1995. 154: 4261-4268.
-
(1995)
J. Immunol.
, vol.154
, pp. 4261-4268
-
-
Chaouat, G.1
Assal Meliani, A.2
Martal, J.3
Raghupathy, R.4
Elliott, J.F.5
Mosmann, T.6
Wegmann, T.G.7
-
30
-
-
0347985360
-
Effect of interleukin-10 null mutation on maternal immune response and reproductive outcome in mice
-
White, C. A., Johansson, M., Roberts, C. T., Ramsay, A. J. and Robertson, S. A., Effect of interleukin-10 null mutation on maternal immune response and reproductive outcome in mice. Biol. Reprod. 2004. 70: 123-131.
-
(2004)
Biol. Reprod.
, vol.70
, pp. 123-131
-
-
White, C.A.1
Johansson, M.2
Roberts, C.T.3
Ramsay, A.J.4
Robertson, S.A.5
-
31
-
-
27644469044
-
Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function
-
Jarvis, L. B., Matyszak, M. K., Duggleby, R. C., Goodall, J. C., Hall, F. C. and Gaston, J. S., Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function. Eur. J. Immunol. 2005. 35: 2896-2908.
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 2896-2908
-
-
Jarvis, L.B.1
Matyszak, M.K.2
Duggleby, R.C.3
Goodall, J.C.4
Hall, F.C.5
Gaston, J.S.6
-
32
-
-
67651214218
-
Regulatory IL4+CD8+ T cells in patients with ankylosing spondylitis and healthy controls
-
Zhang, L., Jarvis, L. B., Baek, H. J. and Gaston, J. S., Regulatory IL4+CD8+ T cells in patients with ankylosing spondylitis and healthy controls. Ann. Rheum. Dis. 2009. 68: 1345-1351.
-
(2009)
Ann. Rheum. Dis.
, vol.68
, pp. 1345-1351
-
-
Zhang, L.1
Jarvis, L.B.2
Baek, H.J.3
Gaston, J.S.4
-
33
-
-
84922011944
-
Oral dydrogesterone treatment during early pregnancy to prevent recurrent pregnancy loss and its role in modulation of cytokine production: a double-blind, randomized, parallel, placebo-controlled trial
-
Kumar, A., Begum, N., Prasad, S., Aggarwal, S. and Sharma, S., Oral dydrogesterone treatment during early pregnancy to prevent recurrent pregnancy loss and its role in modulation of cytokine production: a double-blind, randomized, parallel, placebo-controlled trial. Fertil. Steril. 2014. 102: 1357-1363.
-
(2014)
Fertil. Steril.
, vol.102
, pp. 1357-1363
-
-
Kumar, A.1
Begum, N.2
Prasad, S.3
Aggarwal, S.4
Sharma, S.5
-
34
-
-
41149096579
-
T-cell quality in memory and protection: implications for vaccine design
-
Seder, R. A., Darrah, P. A. and Roederer, M., T-cell quality in memory and protection: implications for vaccine design. Nat. Rev. Immunol. 2008. 8: 247-258.
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 247-258
-
-
Seder, R.A.1
Darrah, P.A.2
Roederer, M.3
-
35
-
-
34547773111
-
Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells
-
Kannanganat, S., Ibegbu, C., Chennareddi, L., Robinson, H. L. and Amara, R. R., Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells. J. Virol. 2007. 81: 8468-8476.
-
(2007)
J. Virol.
, vol.81
, pp. 8468-8476
-
-
Kannanganat, S.1
Ibegbu, C.2
Chennareddi, L.3
Robinson, H.L.4
Amara, R.R.5
-
36
-
-
34250303350
-
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
-
Darrah, P. A., Patel, D. T., DeLuca, P. M., Lindsay, R. W., Davey, D. F., Flynn, B. J., Hoff, S. T. et al., Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat. Med. 2007. 13: 843-850.
-
(2007)
Nat. Med.
, vol.13
, pp. 843-850
-
-
Darrah, P.A.1
Patel, D.T.2
De Luca, P.M.3
Lindsay, R.W.4
Davey, D.F.5
Flynn, B.J.6
Hoff, S.T.7
-
37
-
-
33646686040
-
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
-
Betts, M. R., Nason, M. C., West, S. M., De Rosa, S. C., Migueles, S. A., Abraham, J., Lederman, M. M. et al., HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 2006. 107: 4781-4789.
-
(2006)
Blood
, vol.107
, pp. 4781-4789
-
-
Betts, M.R.1
Nason, M.C.2
West, S.M.3
De Rosa, S.C.4
Migueles, S.A.5
Abraham, J.6
Lederman, M.M.7
-
38
-
-
65549115862
-
Plasticity of CD4+ T cell lineage differentiation
-
Zhou, L., Chong, M. M. and Littman, D. R., Plasticity of CD4+ T cell lineage differentiation. Immunity 2009. 30: 646-655.
-
(2009)
Immunity
, vol.30
, pp. 646-655
-
-
Zhou, L.1
Chong, M.M.2
Littman, D.R.3
-
39
-
-
0032476689
-
A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes
-
Ehring, G. R., Kerschbaum, H. H., Eder, C., Neben, A. L., Fanger, C. M., Khoury, R. M., Negulescu, P. A. et al., A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. J. Exp. Med. 1998. 188: 1593-1602.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1593-1602
-
-
Ehring, G.R.1
Kerschbaum, H.H.2
Eder, C.3
Neben, A.L.4
Fanger, C.M.5
Khoury, R.M.6
Negulescu, P.A.7
-
40
-
-
34147220723
-
The non-genomic effects on Na+/H+-exchange 1 by progesterone and 20alpha-hydroxyprogesterone in human T cells
-
Chien, E. J., Liao, C. F., Chang, C. P., Pu, H. F., Lu, L. M., Shie, M. C., Hsieh, D. J. et al., The non-genomic effects on Na+/H+-exchange 1 by progesterone and 20alpha-hydroxyprogesterone in human T cells. J. Cell. Physiol. 2007. 211: 544-550.
-
(2007)
J. Cell. Physiol.
, vol.211
, pp. 544-550
-
-
Chien, E.J.1
Liao, C.F.2
Chang, C.P.3
Pu, H.F.4
Lu, L.M.5
Shie, M.C.6
Hsieh, D.J.7
-
41
-
-
84863981781
-
The non-genomic rapid acidification in peripheral T cells by progesterone depends on intracellular calcium increase and not on Na+/H+-exchange inhibition
-
Lai, J. N., Wang, O. Y., Lin, V. H., Liao, C. F., Tarng, D. C. and Chien, E. J., The non-genomic rapid acidification in peripheral T cells by progesterone depends on intracellular calcium increase and not on Na+/H+-exchange inhibition. Steroids 2012. 77: 1017-1024.
-
(2012)
Steroids
, vol.77
, pp. 1017-1024
-
-
Lai, J.N.1
Wang, O.Y.2
Lin, V.H.3
Liao, C.F.4
Tarng, D.C.5
Chien, E.J.6
-
42
-
-
4744361075
-
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference values
-
Kratz, A., Ferraro, M., Sluss, P. M. and Lewandrowski, K. B., Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference values. N. Engl. J. Med. 2004. 351: 1548-1563.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 1548-1563
-
-
Kratz, A.1
Ferraro, M.2
Sluss, P.M.3
Lewandrowski, K.B.4
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