Ethics of mitochondrial gene replacement: From bench to bedside

BMJ

Volumn 342, Issue 7788, 2011, Pages 87-89

  Bredenoord, Annelien ^a   Braude, Peter ^b,c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA TRANSFER; FERTILIZATION; GENE MUTATION; GENE REPLACEMENT THERAPY; GENE TRANSFER; GENETIC RISK; HUMAN; INFERTILITY THERAPY; INFORMED CONSENT; MEDICAL ETHICS; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL GENE; NONHUMAN; OOCYTE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; SPERM; ZYGOTE;

EID: 78651395112     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.c6021     Document Type: Review

References (24)

1. Hawes SM, Sapienza C, Latham KE. Ooplasmic donation in humans: the potential for epigenic modifications. Hum Reprod 2002;17:850-2.
2. Pennings G, de Wert G, Shenfield F, Cohen J, Tarlatzis B, Devroey P. ESHRE task force on ethics and law 13: the welfare of the child in medically assisted reproduction. Hum Reprod 2007;22:2585-8.
3. President's Council on Bioethics. Reproduction and responsibility. The regulation of new biotechnologies. 2004. http://bioethics.georgetown.edu/pcbe/ reports/reproductionandresponsibility/.
4. Medical Research Council. Assisted reproduction: a safe, sound future. MRC, 2004.
5. Tachibana M, Sparman M, Sritanaudomchai H, Ma H, Clepper L, Woodward J, et al. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature 2009;461:367-72.
6. Craven L, Tuppen HA, Greggains GD, Harbottle SJ, Murphy JL, Cree L, et al. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature 2010;465:82-5.
7. Bredenoord AL, Pennings G, de Wert G. Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues. Hum Reprod Update 2008;14:669-78.
8. Dresser R. First-in-human trial participants: not a vulnerable population, but vulnerable nonetheless. J Law Med Ethics 2009;37:38-50.
9. Kimmelman J. Gene transfer and the ethics of first-in-human research. Cambridge University Press, 2010.
10. Taylor RW, Turnbull DM. Mitochondrial DNA mutations in human disease. Nat Rev Genet 2005;6:389-402.
11. Bredenoord AL, Dondorp W, Pennings G, De Die-Smulders CE, de Wert G. PGD to reduce reproductive risk: the case of mitochondrial DNA disorders. Hum Reprod 2008;23:2392-401.
12. Bredenoord A, Dondorp W, Pennings G, de Die-Smulders C, Smeets B, de Wert G. Preimplantation genetic diagnosis for mitochondrial DNA disorders: ethical guidance for clinical practice. Eur J Hum Genet 2009;17:1550-9.
13. Poulton J, Bredenoord AL. 174th ENMC international workshop: applying pre-implantation genetic diagnosis to mtDNA diseases: implications of scientific advances. Neuromuscul Disord 2010;20:559-63.
14. Poulton J, Kennedy S, Oakeshott P, Wells D. Preventing transmission of maternally inherited mitochondrial DNA diseases. BMJ 2009;338:b94.
15. Bredenoord AL, Dondorp W, Pennings G, de Wert G. Avoiding transgenerational health risks of mitochondrial DNA disorders: a morally acceptable reason for sex selection? Hum Reprod 2010;25:1354-60.
16. Dresser R. Designing babies: human research issues. IRB 2004;26:1-8.
17. Malek J. Understanding risks and benefits in research on reproductive genetic technologies. J Med Philos 2007;32:339-58.
18. New sources of sex cells [editorial]. Nature 2008;452:913.
19. Van der Worp HB, Howels DW, Sena ES, Porritt MJ, Rewell S, O'Collins V, et al. Can animal models of disease reliably inform human studies? PLoS Med 2010;7:1-8.
20. Pennings G, de Wert G. Evolving ethics in medically assisted reproduction. Hum Reprod Update 2003;9:397-404.
21. Sugarman J. Policy forum: human genetics. Ethical considerations in leaping from bench to bedside. Science 1999;285:2071-2.
22. Barritt JA, Brenner CA, Malter HE, Cohen J. Rebuttal: interooplasmic transfers in humans. Reprod Biomed Online 2001;3:47-8.
23. Parens E, Juengst E. Inadvertently crossing the germ line. Science 2001;292:397.
24. Kimmelman J. The ethics of human gene transfer. Nat Rev Genet 2008;9:239-44.