-
1
-
-
77958584113
-
Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
-
Ghoreschi, K., Laurence, A., Yang, X. P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L. et al., Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature 2010. 467: 967-971.
-
(2010)
Nature
, vol.467
, pp. 967-971
-
-
Ghoreschi, K.1
Laurence, A.2
Yang, X.P.3
Tato, C.M.4
McGeachy, M.J.5
Konkel, J.E.6
Ramos, H.L.7
-
2
-
-
46949104323
-
IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
-
Kroenke, M. A., Carlson, T. J., Andjelkovic, A. V. and Segal, B. M., IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 2008. 205: 1535-1541.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1535-1541
-
-
Kroenke, M.A.1
Carlson, T.J.2
Andjelkovic, A.V.3
Segal, B.M.4
-
3
-
-
0029788704
-
IL-12 unmasks latent autoimmune disease in resistant mice
-
Segal, B. M. and Shevach, E. M., IL-12 unmasks latent autoimmune disease in resistant mice. J. Exp. Med. 1996. 184: 771-775.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 771-775
-
-
Segal, B.M.1
Shevach, E.M.2
-
4
-
-
60749107176
-
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
-
McGeachy, M. J., Chen, Y., Tato, C. M., Laurence, A., Joyce-Shaikh, B., Blumenschein, W. M., McClanahan, T. K. et al., The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat. Immunol. 2009. 10: 314-324.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 314-324
-
-
McGeachy, M.J.1
Chen, Y.2
Tato, C.M.3
Laurence, A.4
Joyce-Shaikh, B.5
Blumenschein, W.M.6
McClanahan, T.K.7
-
5
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003. 421: 744-748.
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
Lucian, L.7
-
6
-
-
61749093508
-
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
-
Haak, S., Croxford, A. L., Kreymborg, K., Heppner, F. L., Pouly, S., Becher, B. and Waisman, A., IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 2009. 119: 61-69.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 61-69
-
-
Haak, S.1
Croxford, A.L.2
Kreymborg, K.3
Heppner, F.L.4
Pouly, S.5
Becher, B.6
Waisman, A.7
-
7
-
-
79956152607
-
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
-
El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G. X. et al., The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol. 2011. 12: 568-575.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 568-575
-
-
El-Behi, M.1
Ciric, B.2
Dai, H.3
Yan, Y.4
Cullimore, M.5
Safavi, F.6
Zhang, G.X.7
-
8
-
-
79956116032
-
RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
-
Codarri, L., Gyulveszi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T. et al., RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 2011. 12: 560-567.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 560-567
-
-
Codarri, L.1
Gyulveszi, G.2
Tosevski, V.3
Hesske, L.4
Fontana, A.5
Magnenat, L.6
Suter, T.7
-
9
-
-
84903783415
-
IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells
-
Noster, R., Riedel, R., Mashreghi, M. F., Radbruch, H., Harms, L., Haftmann, C., Chang, H. D. et al., IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Sci. Transl. Med. 2014. 6: 241ra280.
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 241ra280
-
-
Noster, R.1
Riedel, R.2
Mashreghi, M.F.3
Radbruch, H.4
Harms, L.5
Haftmann, C.6
Chang, H.D.7
-
10
-
-
0027292039
-
T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes
-
Voskuhl, R. R., Martin, R., Bergman, C., Dalal, M., Ruddle, N. H. and McFarland, H. F., T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes. Autoimmunity 1993. 15: 137-143.
-
(1993)
Autoimmunity
, vol.15
, pp. 137-143
-
-
Voskuhl, R.R.1
Martin, R.2
Bergman, C.3
Dalal, M.4
Ruddle, N.H.5
McFarland, H.F.6
-
11
-
-
0038243261
-
Experimental autoimmune encephalomyelitis: cytokines, effector T cells, and antigen-presenting cells in a prototypical Th1-mediated autoimmune disease
-
Segal, B. M., Experimental autoimmune encephalomyelitis: cytokines, effector T cells, and antigen-presenting cells in a prototypical Th1-mediated autoimmune disease. Curr. Allergy Asthma Rep. 2003. 3: 86-93.
-
(2003)
Curr. Allergy Asthma Rep.
, vol.3
, pp. 86-93
-
-
Segal, B.M.1
-
12
-
-
0037114150
-
IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
-
Gran, B., Zhang, G. X., Yu, S., Li, J., Chen, X. H., Ventura, E. S., Kamoun, M. et al., IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 2002. 169: 7104-7110.
-
(2002)
J. Immunol.
, vol.169
, pp. 7104-7110
-
-
Gran, B.1
Zhang, G.X.2
Yu, S.3
Li, J.4
Chen, X.H.5
Ventura, E.S.6
Kamoun, M.7
-
13
-
-
0030587910
-
IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
-
Willenborg, D. O., Fordham, S., Bernard, C. C., Cowden, W. B. and Ramshaw, I. A., IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 1996. 157: 3223-3227.
-
(1996)
J. Immunol.
, vol.157
, pp. 3223-3227
-
-
Willenborg, D.O.1
Fordham, S.2
Bernard, C.C.3
Cowden, W.B.4
Ramshaw, I.A.5
-
14
-
-
0037442020
-
Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system
-
Zhang, G. X., Gran, B., Yu, S., Li, J., Siglienti, I., Chen, X., Kamoun, M. et al., Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J. Immunol. 2003. 170: 2153-2160.
-
(2003)
J. Immunol.
, vol.170
, pp. 2153-2160
-
-
Zhang, G.X.1
Gran, B.2
Yu, S.3
Li, J.4
Siglienti, I.5
Chen, X.6
Kamoun, M.7
-
15
-
-
56149125346
-
Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis
-
O'Connor, R. A., Prendergast, C. T., Sabatos, C. A., Lau, C. W., Leech, M. D., Wraith, D. C. and Anderton, S. M., Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J. Immunol. 2008. 181: 3750-3754.
-
(2008)
J. Immunol.
, vol.181
, pp. 3750-3754
-
-
O'Connor, R.A.1
Prendergast, C.T.2
Sabatos, C.A.3
Lau, C.W.4
Leech, M.D.5
Wraith, D.C.6
Anderton, S.M.7
-
16
-
-
58149251898
-
Late developmental plasticity in the T helper 17 lineage
-
Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O. and Weaver, C. T., Late developmental plasticity in the T helper 17 lineage. Immunity 2009. 30: 92-107.
-
(2009)
Immunity
, vol.30
, pp. 92-107
-
-
Lee, Y.K.1
Turner, H.2
Maynard, C.L.3
Oliver, J.R.4
Chen, D.5
Elson, C.O.6
Weaver, C.T.7
-
17
-
-
78649603873
-
Genetic proof for the transient nature of the Th17 phenotype
-
Kurschus, F., Croxford, A., Heinen, A., Wortge, S., Ielo, D. and Waisman, A., Genetic proof for the transient nature of the Th17 phenotype. Eur. J. Immunol. 2010. 40: 3336-3346.
-
(2010)
Eur. J. Immunol.
, vol.40
, pp. 3336-3346
-
-
Kurschus, F.1
Croxford, A.2
Heinen, A.3
Wortge, S.4
Ielo, D.5
Waisman, A.6
-
18
-
-
33846906914
-
IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis
-
Thakker, P., Leach, M. W., Kuang, W., Benoit, S. E., Leonard, J. P. and Marusic, S., IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 2007. 178: 2589-2598.
-
(2007)
J. Immunol.
, vol.178
, pp. 2589-2598
-
-
Thakker, P.1
Leach, M.W.2
Kuang, W.3
Benoit, S.E.4
Leonard, J.P.5
Marusic, S.6
-
19
-
-
84876808514
-
Cutting edge: the pathogenicity of IFN-gamma-producing Th17 cells is independent of T-bet
-
Duhen, R., Glatigny, S., Arbelaez, C. A., Blair, T. C., Oukka, M. and Bettelli, E., Cutting edge: the pathogenicity of IFN-gamma-producing Th17 cells is independent of T-bet. J. Immunol. 2013. 190: 4478-4482.
-
(2013)
J. Immunol.
, vol.190
, pp. 4478-4482
-
-
Duhen, R.1
Glatigny, S.2
Arbelaez, C.A.3
Blair, T.C.4
Oukka, M.5
Bettelli, E.6
-
20
-
-
84888027756
-
Highly polarized Th17 cells induce EAE via a T-bet independent mechanism
-
Grifka-Walk, H. M., Lalor, S. J. and Segal, B. M., Highly polarized Th17 cells induce EAE via a T-bet independent mechanism. Eur. J. Immunol. 2013. 43: 2824-2831.
-
(2013)
Eur. J. Immunol.
, vol.43
, pp. 2824-2831
-
-
Grifka-Walk, H.M.1
Lalor, S.J.2
Segal, B.M.3
-
21
-
-
84888016708
-
T-bet is essential for Th1-mediated, but not Th17-mediated, CNS autoimmune disease
-
O'Connor, R. A., Cambrook, H., Huettner, K. and Anderton, S. M., T-bet is essential for Th1-mediated, but not Th17-mediated, CNS autoimmune disease. Eur. J. Immunol. 2013. 43: 2818-2823.
-
(2013)
Eur. J. Immunol.
, vol.43
, pp. 2818-2823
-
-
O'Connor, R.A.1
Cambrook, H.2
Huettner, K.3
Anderton, S.M.4
-
22
-
-
0026719596
-
Interferon-gamma potentiates antibody-mediated demyelination in vivo
-
Vass, K., Heininger, K., Schafer, B., Linington, C. and Lassmann, H., Interferon-gamma potentiates antibody-mediated demyelination in vivo. Ann. Neurol. 1992. 32: 198-206.
-
(1992)
Ann. Neurol.
, vol.32
, pp. 198-206
-
-
Vass, K.1
Heininger, K.2
Schafer, B.3
Linington, C.4
Lassmann, H.5
-
23
-
-
0023221133
-
Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system
-
Panitch, H. S., Hirsch, R. L., Schindler, J. and Johnson, K. P., Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system. Neurology 1987. 37: 1097-1102.
-
(1987)
Neurology
, vol.37
, pp. 1097-1102
-
-
Panitch, H.S.1
Hirsch, R.L.2
Schindler, J.3
Johnson, K.P.4
-
24
-
-
77950534540
-
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
-
Axtell, R. C., deJong, B. A., Boniface, K., van der Voort, L. F., Bhat, R., DeSarno, P., Naves, R. et al., T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat. Med. 2010. 16: 406-412.
-
(2010)
Nat. Med.
, vol.16
, pp. 406-412
-
-
Axtell, R.C.1
de Jong, B.A.2
Boniface, K.3
van der Voort, L.F.4
Bhat, R.5
De Sarno, P.6
Naves, R.7
-
25
-
-
0032536447
-
An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
-
Segal, B. M., Dwyer, B. K. and Shevach, E. M., An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 1998. 187: 537-546.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 537-546
-
-
Segal, B.M.1
Dwyer, B.K.2
Shevach, E.M.3
|