Effort-based decision-making paradigms for clinical trials in schizophrenia: Part 1 - Psychometric characteristics of 5 paradigms

Schizophrenia Bulletin

Volumn 41, Issue 5, 2015, Pages 1045-1054

  Reddy, L Felice ^a,b   Horan, William P ^a,b   Barch, Deanna M ^c   Buchanan, Robert W ^d   Dunayevich, Eduardo ^e   Gold, James M ^d   Lyons, Naomi ^a   Marder, Stephen R ^a,b   Treadway, Michael T ^f   Wynn, Jonathan K ^a,b   Young, Jared W ^g,h   Green, Michael F ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e AMGEN INC   (United States)

^f EMORY UNIVERSITY   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Effort; Motivation; Psychometric; Schizophrenia

Indexed keywords

ARTICLE; CLINICAL DECISION MAKING; CLINICAL TRIAL (TOPIC); COGNITION; HUMAN; MOTIVATION; NEGATIVE SYNDROME; PERCEPTION; PRIORITY JOURNAL; PSYCHOMETRY; SCHIZOPHRENIA; TEST RETEST RELIABILITY; ADULT; DECISION MAKING; DEVICES; FEMALE; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; REPRODUCIBILITY; REWARD; STANDARDS;

ADULT; CLINICAL TRIALS AS TOPIC; DECISION MAKING; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTIVATION; NEUROPSYCHOLOGICAL TESTS; PSYCHOMETRICS; PSYCHOMOTOR PERFORMANCE; REPRODUCIBILITY OF RESULTS; REWARD; SCHIZOPHRENIA;

EID: 84943196020     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbv089     Document Type: Article

References (32)

1. Markou A, Salamone JD, Bussey TJ, et al. Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia. Neurosci Biobehav Rev. 2013;37:2149-2165.
2. Salamone JD, Correa M, Farrar A, Mingote SM. Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology (Berl). 2007;191:461-482.
3. Salamone JD, Correa M, Farrar AM, Nunes EJ, Collins LE. Role of dopamine-adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation. Future Neurol. 2010;5:377-392.
4. Solomon RL. The influence of work on behavior. Psychol Bull. 1948;45:1-40.
5. Fervaha G, Graff-Guerrero A, Zakzanis KK, Foussias G, Agid O, Remington G. Incentive motivation deficits in schizophrenia reflect effort computation impairments during costbenefit decision-making. J Psychiatr Res. 2013;47:1590-1596.
6. Gold JM, Strauss GP, Waltz JA, Robinson BM, Brown JK, Frank MJ. Negative symptoms of schizophrenia are associated with abnormal effort-cost computations. Biol Psychiatry. 2013;74:130-136.
7. Barch DM, Treadway MT, Schoen N. Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment. J Abnorm Psychol. 2014;123:387-397.
8. Treadway MT, Peterman JS, Zald DH, Park S. Impaired effort allocation in patients with schizophrenia. Schizophr Res 2014;5:00701-00704.
9. Hartmann MN, Hager OM, Reimann AV, et al. Apathy but not diminished expression in schizophrenia is associated with discounting of monetary rewards by physical effort. Schizophr Bull. 2015;41:503-512.
10. Docx L, de la Asuncion J, Sabbe B, et al. Effort discounting and its association with negative symptoms in schizophrenia. Cogn Neuropsychiatry. 2015;20:172-185.
11. Wolf DH, Satterthwaite TD, Kantrowitz JJ, et al. Amotivation in schizophrenia: integrated assessment with behavioral, clinical, and imaging measures. Schizophr Bull 2014;40:1328-1337.
12. Gold JM, Kool W, Botvinick MM, Hubzin L, August S, Waltz JA. Cognitive effort avoidance and detection in people with schizophrenia. Cogn Affect Behav Neurosci. 2015;15:145-154.
13. Green MF, Horan WP, Barch DM, Gold JM. Effort-based decision making: A novel approach for assessing motivation in schizophrenia [published online ahead of print June 18, 2015]. Schizophr Bull. doi: 10.1093/schbul/sbv071.
14. Carter CS, Barch DM, Buchanan RW, et al. Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative. Biol Psychiatry. 2008;64:4-10.
15. Green MF, Nuechterlein KH, Gold JM, et al. Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry. 2004;56:301-307.
16. Horan WP, Reddy LF, Barch DM, et al. Effort-based decision making paradigms for clinical trials in schizophrenia: Part 2 - External validity and correlates. Schizophr Bull.
17. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders - Patient Edition. New York, NY: Biometrics Research Department, New York State Psychiatric Institute; 1997.
18. Kool W, McGuire JT, Rosen ZB, Botvinick MM. Decision making and the avoidance of cognitive demand. J Exp Psychol Gen. 2010;139:665-682.
19. McGuire JT, Botvinick MM. Prefrontal cortex, cognitive control, and the registration of decision costs. Proc Natl Acad of Sci U S A. 2010;107:7922-7926.
20. Cocker PJ, Hosking JG, Benoit J, Winstanley CA. Sensitivity to cognitive effort mediates psychostimulant effects on a novel rodent cost/benefit decision-making task. Neuropsychopharmacology. 2012;37:1825-1837.
21. Robbins TW. The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl). 2002;163:362-380.
22. Hairston WD, Maldjian JA. An adaptive staircase procedure for the E-Prime programming environment. Comput Methods Programs Biomed. 2009;93:104-108.
23. Cléry-Melin ML, Schmidt L, Lafargue G, Baup N, Fossati P, Pessiglione M. Why don't you try harder? An investigation of effort production in major depression. PLoS One. 2011;6:e23178.
24. Kurniawan IT, Seymour B, Talmi D, Yoshida W, Chater N, Dolan RJ. Choosing to make an effort: the role of striatum in signaling physical effort of a chosen action. J Neurophysiol. 2010;104:313-321.
25. Treadway MT, Bossaller NA, Shelton RC, Zald DH. Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia. J Abnorm Psychol. 2012;121:553-558.
26. Kay SR, Opler LA, Lindenmayer JP. The Positive and Negative Syndrome Scale (PANSS): rationale and standardization. Br J Psychiatry. 1989;155(suppl 7):59-65.
27. Horan WP, Kring AM, Gur RE, Reise SP, Blanchard JJ. Development and psychometric validation of the Clinical Assessment Interview for Negative Symptoms (CAINS). Schizophr Res. 2011;132:140-145.
28. Axelrod BN, Goldman RS, Alphs LD. Validation of the 16-item Negative Symptom Assessment. J Psychiatr Res. 1993;27:253-258.
29. Marder SR, Davis JM, Chouinard G. The effects of risperidone on the five dimensions of schizophrenia derived by factor analyses: Combined results of the North American trials. J Clin Psychiatry. 1997;58:538-546.
30. Nuechterlein KH, Green MF. MATRICS Consensus Cogntive Battery. Los Angeles, CA: MATRICS Assessment, Inc.; 2006.
31. Bratti IM, Kane JM, Marder SR. Chronic restlessness with antipsychotics. Am J Psychiatry. 2007;164:1648-1654.
32. Young JW, Markou A. Translational rodent paradigms to investigate neuromechanisms underlying behaviors relevant to amotivation and altered reward processing in schizophrenia. Schizophr Bull.