Amotivation in schizophrenia: Integrated assessment with behavioral, clinical, and imaging measures

Schizophrenia Bulletin

Volumn 40, Issue 6, 2014, Pages 1328-1337

  Wolf, Daniel H ^a   Satterthwaite, Theodore D ^a   Kantrowitz, Jacob J ^a   Katchmar, Natalie ^a   Vandekar, Lillie ^a   Elliott, Mark A ^b   Ruparel, Kosha ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

fMRI; motivation; negative symptoms; progressive ratio; ventral striatum

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL ASSESSMENT INTERVIEW FOR NEGATIVE SYMPTOM; CLINICAL ASSESSMENT TOOL; COMPUTERIZED PROGRESSIVE RATIO TASK; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; MONEY; MOTIVATION; NEGATIVE SYNDROME; PERFORMANCE; REWARD; SCHIZOPHRENIA; APATHY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; VENTRAL STRIATUM; YOUNG ADULT;

ADULT; APATHY; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOTIVATION; REWARD; SCHIZOPHRENIA; VENTRAL STRIATUM; YOUNG ADULT;

EID: 84913601683     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbu026     Document Type: Article

References (66)

1. Kirkpatrick B, Fenton WS, Carpenter WT Jr, Marder S.R. The NIMH-MATRICS consensus statement on negative symptoms. Schizophr Bull. 2006;32:214-219.
2. Hanson E, Healey K, Wolf D, Kohler C. Assessment of pharmacotherapy for negative symptoms of schizophrenia. Curr Psychiatry Rep. 2010;12:563-571.
3. Wolf DH. Anhedonia in schizophrenia. Curr Psychiatry Rep. 2006;8:322-328.
4. Gard DE, Fisher M, Garrett C, Genevsky A, Vinogradov S. Motivation and its relationship to neurocognition, social cognition, and functional outcome in schizophrenia. Schizophr Res. 2009;115:74-81.
5. Foussias G, Remington G. Negative symptoms in schizophrenia: avolition and Occam's razor. Schizophr Bull. 2010;36:359-369.
6. Barch DM, Dowd EC. Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions. Schizophr Bull. 2010;36:919-934.
7. Salamone JD, Correa M, Nunes EJ, Randall PA, Pardo M. The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond. J Exp Anal Behav. 2012;97:125-146.
8. Croxson PL, Walton ME, O'Reilly JX, Behrens TE, Rushworth MF. Effort-based cost-benefit valuation and the human brain. J Neurosci. 2009;29:4531-4541.
9. McClure SM, York MK, Montague PR. The neural substrates of reward processing in humans: the modern role of FMRI. Neuroscientist. 2004;10:260-268.
10. Juckel G, Schlagenhauf F, Koslowski M, et al. Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage. 2006;29:409-416.
11. Wolf DH, Turetsky BI, Loughead J, et al. Auditory Oddball fMRI in Schizophrenia: Association of Negative Symptoms with Regional Hypoactivation to Novel Distractors. Brain Imaging Behav. 2008;2:132-145.
12. Waltz JA, Schweitzer JB, Gold JM, et al. Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers. Neuropsychopharmacology. 2009;34:1567-1577.
13. Waltz JA, Schweitzer JB, Ross TJ, et al. Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia. Neuropsychopharmacology. 2010;35:2427-2439.
14. Dowd EC, Barch DM. Pavlovian reward prediction and receipt in schizophrenia: relationship to anhedonia. PLoS One. 2012;7:e35622.
15. Simon JJ, Biller A, Walther S, et al. Neural correlates of reward processing in schizophrenia-relationship to apathy and depression. Schizophr Res. 2010;118:154-161.
16. Juckel G, Schlagenhauf F, Koslowski M, et al. Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics. Psychopharmacology (Berl). 2006;187:222-228.
17. Schlagenhauf F, Juckel G, Koslowski M, et al. Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine. Psychopharmacology (Berl). 2008;196:673-684.
18. Dowd EC, Barch DM. Anhedonia and emotional experience in schizophrenia: neural and behavioral indicators. Biol Psychiatry. 2010;67:902-911.
19. Kring AM, Gur RE, Blanchard JJ, Horan WP, Reise SP. The Clinical Assessment Interview for Negative Symptoms (CAINS): final development and validation. Am J Psychiatry. 2013;170:165-172.
20. Der-Avakian A, Markou A. The neurobiology of anhedonia and other reward-related deficits. Trends Neurosci. 2012;35:68-77.
21. Mathalon DH, Ford JM. Neurobiology of schizophrenia: search for the elusive correlation with symptoms. Front Hum Neurosci. 2012;6:136.
22. Fulmer SM, Frijters JC. A review of self-report and alternative approaches in the measurement of student motivation. Educ Psychol Rev. 2009;21:219-246.
23. Trémeau F, Nolan KA, Malaspina D, Javitt DC. Behavioral validation of avolition in schizophrenia. Schizophr Res. 2012;138:255-261.
24. O'Tuathaigh CM, Kirby BP, Moran PM, Waddington JL. Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia. Schizophr Bull. 2010;36:271-288.
25. Treadway MT, Zald DH. Reconsidering anhedonia in depression: lessons from translational neuroscience. Neurosci Biobehav Rev. 2011;35:537-555.
26. Gold JM, Strauss GP, Waltz JA, Robinson BM, Brown JK, Frank MJ. Negative symptoms of schizophrenia are associated with abnormal effort-cost computations. Biol Psychiatry. 2013;74:130-136.
27. Fervaha G, Graff-Guerrero A, Zakzanis KK, Foussias G, Agid O, Remington G. Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making. J Psychiatr Res. 2013;47:1590-1596.
28. Cohen AS, Minor KS. Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies. Schizophr Bull. 2010;36:143-150.
29. Carter CS, Barch DM, Gur R, Gur R, Pinkham A, Ochsner K. CNTRICS final task selection: social cognitive and affective neuroscience-based measures. Schizophr Bull. 2009;35:153-162.
30. Gardner EL. What we have learned about addiction from animal models of drug self-administration. Am J Addict. 2000;9:285-313.
31. Hodos W. Progressive ratio as a measure of reward strength. Science. 1961;134:943-944.
32. Schmadel S, Schwabe K, Koch M. Effects of neonatal excitotoxic lesions of the entorhinal cortex on cognitive functions in the adult rat. Neuroscience. 2004;128:365-374.
33. Schneider M, Koch M. Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats. Neuropsychopharmacology. 2003;28:1760-1769.
34. Simpson EH, Kellendonk C, Ward RD, et al. Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia. Biol Psychiatry. 2011;69:928-935.
35. Tidey JW, Higgins ST, Bickel WK, Steingard S. Effects of response requirement and the availability of an alternative reinforcer on cigarette smoking by schizophrenics. Psychopharmacology (Berl). 1999;145:52-60.
36. Tidey JW, O'Neill SC, Higgins ST. Effects of abstinence on cigarette smoking among outpatients with schizophrenia. Exp Clin Psychopharmacol. 1999;7:347-353.
37. Horan WP, Kring AM, Gur RE, Reise SP, Blanchard JJ. Development and psychometric validation of the Clinical Assessment Interview for Negative Symptoms (CAINS). Schizophr Res. 2011;132:140-145.
38. Delgado MR, Nystrom LE, Fissell C, Noll DC, Fiez JA. Tracking the hemodynamic responses to reward and punishment in the striatum. J Neurophysiol. 2000;84:3072-3077.
39. Hariri AR, Brown SM, Williamson DE, Flory JD, de Wit H, Manuck SB. Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. J Neurosci. 2006;26:13213-13217.
40. Knutson B, Taylor J, Kaufman M, Peterson R, Glover G. Distributed neural representation of expected value. J Neurosci. 2005;25:4806-4812.
41. Stoops WW. Reinforcing effects of stimulants in humans: sensitivity of progressive-ratio schedules. Exp Clin Psychopharmacol. 2008;16:503-512.
42. Kegeles LS, Abi-Dargham A, Frankle WG, et al. Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Arch Gen Psychiatry. 2010;67:231-239.
43. Wolf DH, Gerraty R, Satterthwaite TD, et al. Striatal intrinsic reinforcement signals during recognition memory: relationship to response bias and dysregulation in schizophrenia. Front Behav Neurosci. 2011;5:81.
44. Schlagenhauf F, Sterzer P, Schmack K, et al. Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions. Biol Psychiatry. 2009;65:1032-1039.
45. Nielsen MO, Rostrup E, Wulff S, et al. Alterations of the brain reward system in antipsychotic naïve schizophrenia patients. Biol Psychiatry. 2012;71:898-905.
46. Kirsch P, Ronshausen S, Mier D, Gallhofer B. The influence of antipsychotic treatment on brain reward system reactivity in schizophrenia patients. Pharmacopsychiatry. 2007;40:196-198.
47. Koch K, Schachtzabel C, Wagner G, et al. Altered activation in association with reward-related trial-and-error learning in patients with schizophrenia. Neuroimage. 2010;50:223-232.
48. Gradin VB, Kumar P, Waiter G, et al. Expected value and prediction error abnormalities in depression and schizophrenia. Brain. 2011;134:1751-1764.
49. Abler B, Greenhouse I, Ongur D, Walter H, Heckers S. Abnormal reward system activation in mania. Neuropsychopharmacology. 2008;33:2217-2227.
50. Walter H, Kammerer H, Frasch K, Spitzer M, Abler B. Altered reward functions in patients on atypical antipsychotic medication in line with the revised dopamine hypothesis of schizophrenia. Psychopharmacology (Berl). 2009;206:121-132.
51. Nielsen MO, Rostrup E, Wulff S, et al. Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia. Arch Gen Psychiatry. 2012;69:1195-1204.
52. Weil RS, Furl N, Ruff CC, et al. Rewarding feedback after correct visual discriminations has both general and specific influences on visual cortex. J Neurophysiol. 2010;104:1746-1757.
53. Ballard IC, Murty VP, Carter RM, MacInnes JJ, Huettel SA, Adcock RA. Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior. J Neurosci. 2011;31:10340-10346.
54. Willner P, Benton D, Brown E, et al. "Depression" increases "craving" for sweet rewards in animal and human models of depression and craving. Psychopharmacology (Berl). 1998;136:272-283.
55. Insel T, Cuthbert B, Garvey M, et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010;167:748-751.
56. Artaloytia JF, Arango C, Lahti A, et al. Negative signs and symptoms secondary to antipsychotics: a double-blind, randomized trial of a single dose of placebo, haloperidol, and risperidone in healthy volunteers. Am J Psychiatry. 2006;163:488-493.
57. Randall PA, Pardo M, Nunes EJ, et al. Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences. PLoS One. 2012;7:e47934.
58. Murray GK, Corlett PR, Clark L, et al. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Mol Psychiatry. 2008;13:239, 267-239, 276.
59. Morris RW, Vercammen A, Lenroot R, et al. Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia. Mol Psychiatry. 2012;17:235, 280-235, 289.
60. Gold JM, Waltz JA, Matveeva TM, et al. Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidence. Arch Gen Psychiatry. 2012;69:129-138.
61. Ward RD, Simpson EH, Richards VL, et al. Dissociation of hedonic reaction to reward and incentive motivation in an animal model of the negative symptoms of schizophrenia. Neuropsychopharmacology. 2012;37:1699-1707.
62. Weickert TW, Goldberg TE, Callicott JH, et al. Neural correlates of probabilistic category learning in patients with schizophrenia. J Neurosci. 2009;29:1244-1254.
63. Avery R, Startup M, Calabria K. The role of effort, cognitive expectancy appraisals and coping style in the maintenance of the negative symptoms of schizophrenia. Psychiatry Res. 2009;167:36-46.
64. Grant PM, Beck AT. Defeatist beliefs as a mediator of cognitive impairment, negative symptoms, and functioning in schizophrenia. Schizophr Bull. 2009;35:798-806.
65. Kurniawan IT, Seymour B, Talmi D, Yoshida W, Chater N, Dolan RJ. Choosing to make an effort: the role of striatum in signaling physical effort of a chosen action. J Neurophysiol. 2010;104:313-321.
66. Vul E, Harris C, Winkielman P, Pashler H. Puzzlingly high correlations in fMRI studies of emotion, personality, and social cognition. Perspect Psychol Sci. 2009;4:247-290.