Plasma pro-inflammatory cytokines, IgM-uria and cardiovascular events in patients with chest pain: A comparative study

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 75, Issue 8, 2015, Pages 638-645

  Tofik, Rafid ^a,b   Swärd, Per ^c   Ekelund, Ulf ^a   Struglics, André ^c   Torffvit, Ole ^b   Rippe, Bengt ^b   Bakoush, Omran ^b,d  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Department of Nephrology   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

acute coronary syndrome; albuminuria; cardiovascular mortality; cytokines; IgM uria

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; CREATININE; CYTOKINE; GAMMA INTERFERON; HIGH SENSITIVITY C REACTIVE PROTEIN; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; TROPONIN T; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ACUTE CORONARY SYNDROME; ACUTE HEART FAILURE; ACUTE HEART INFARCTION; ADULT; AGED; ALBUMINURIA; ARTICLE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; COMPARATIVE STUDY; DYSLIPIDEMIA; EMERGENCY WARD; FEMALE; FOLLOW UP; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; THORAX PAIN; UNSTABLE ANGINA PECTORIS; BLOOD; CHEST PAIN; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEINURIA; RECEIVER OPERATING CHARACTERISTIC; URINE;

ACUTE CORONARY SYNDROME; AGED; BIOMARKERS; CHEST PAIN; CYTOKINES; FEMALE; HUMANS; IMMUNOGLOBULIN M; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTEINURIA; ROC CURVE;

EID: 84943139398     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365513.2015.1057218     Document Type: Article

References (39)

1. Roe P, Wolfe M, Joffe M, Rosas SE. Inflammation, coronary artery calcification and cardiovascular events in incident renal transplant recipients. Atherosclerosis 2010;212:589-94.
2. Taylor AJ, Bobik A, Richards M, Kaye D, Raines G, Gould P, Jennings G. Myocardial endothelin-1 release and indices of inflammation during angioplasty for acute myocardial infarction and stable coronary artery disease. American Heart J 2004;148:e10.
3. Liu Y, Davidson BP, Yue Q, Belcik T, Xie A, Inaba Y, McCarty OJ, Tormoen GW, Zhao Y, Ruggeri ZM, Kaufmann BA, Lindner JR. Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging 2013;6:74-82.
4. Liu CS, Pi-Sunyer FX, Li CI, Davidson LE, Li TC, Chen W, Lin CC, Huang CY, Lin WY. Albuminuria is strongly associated with arterial stiffness, especially in diabetic or hypertensive subjects-a population-based study (Taichung Community Health Study, TCHS). Atherosclerosis 2010; 211:315-21.
5. Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-74.
6. Barlic J, Murphy PM. Chemokine regulation of atherosclerosis. J Leukoc Biol 2007;82:226-36.
7. Wan W, Murphy PM. Regulation of atherogenesis by chemokines and chemokine receptors. Arch Immunol Ther Exp (Warsz) 2013;61:1-14.
8. Kaptoge S, Di Angelantonio E, Pennells L, Wood AM, White IR, Gao P, Walker M, Thompson A, Sarwar N, Caslake M, Butterworth AS, Amouyel P, Assmann G, Bak-ker SJ, Barr EL, Barrett-Connor E, Benjamin EJ, Bjorke-lund C, Brenner H, Brunner E, Clarke R, Cooper JA, Cremer P, Cushman M, Dagenais GR, D'Agostino RB, Sr., Dankner R, Davey-Smith G, Deeg D, Dekker JM, Engstrom G, Folsom AR, Fowkes FG, Gallacher J, Gaziano JM, Giampaoli S, Gillum RF, Hofman A, Howard BV, Ingelsson E, Iso H, Jorgensen T, Kiechl S, Kitamura A, Kiyohara Y, Koenig W, Kromhout D, Kuller LH, Lawlor DA, Meade TW, Nissinen A, Nordestgaard BG, Onat A, Panagiotakos DB, Psaty BM, Rodriguez B, Rosengren A, Salomaa V, Kauhanen J, Salonen JT, Shaffer JA, Shea S, Ford I, Ste- houwer CD, Strandberg TE, Tipping RW, Tosetto A, Was-sertheil-Smoller S, Wennberg P, Westendorp RG, Whincup PH, Wilhelmsen L, Woodward M, Lowe GD, Wareham NJ, Khaw KT, Sattar N, Packard CJ, Gudnason V, Ridker PM, Pepys MB, Thompson SG, Danesh J . C-reactive protein, fibrinogen, and cardiovascular disease prediction . N Engl J Med 2012;367:1310-20.
9. Lehrke M, Millington S, Lefterova M, Cumaranatunge R, Szapary P, Wilensky R, Rader D, Lazar M, Reilly M. CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. J Am Coll Cardiol 2007;49:442.
10. Brunetti ND, Munno I, Pellegrino PL, Ruggero V, Correale M, De Gennaro L, Cuculo A, Campanale EG, Di Biase M. Inflammatory cytokines imbalance in the very early phase of acute coronary syndrome: correlations with angio-graphic findings and in-hospital events. Inflammation 2011; 34:58-66.
11. Fox CS, Matsushita K, Woodward M, Bilo HJ, Chalmers J, Heerspink HJ, Lee BJ, Perkins RM, Rossing P, Sairenchi T, Tonelli M, Vassalotti JA, Yamagishi K, Coresh J, de Jong PE, Wen CP, Nelson RG, Chronic Kidney Disease Prognosis C. Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis. Lancet 2012;380: 1662-73.
12. Tofik R, Aziz R, Reda A, Rippe B, Bakoush O. The value of IgG-uria in predicting renal failure in idiopathic glomerular diseases. A long-term follow-up study. Scand J Clin Lab Invest 2011;71:123-8.
13. Toyama T, Furuichi K, Ninomiya T, Shimizu M, Hara A, Iwata Y, Kaneko S, Wada T. The impacts of albu-minuria and low eGFR on the risk of cardiovascular death, all-cause mortality, and renal events in diabetic patients: meta-analysis. PloS one 2013;8:e71810.
14. de Zeeuw D, Parving HH, Henning RH. Microalbuminuria as an early marker for cardiovascular disease. J Am Soc Nephrol 2006;17:2100-5.
15. Brantsma AH, Bakker SJ, de Zeeuw D, de Jong PE, Gansevoort RT. Urinary albumin excretion as a predictor of the development of hypertension in the general population. J Am Soc Nephrol 2006;17:331-5.
16. Brantsma AH, Bakker SJ, Hillege HL, de Zeeuw D, de Jong PE, Gansevoort RT. Urinary albumin excretion and its relation with C-reactive protein and the metabolic syndrome in the prediction of type 2 diabetes. Diabetes Care 2005;28:2525-30.
17. Bakoush O, Segelmark M, Torffvit O, Ohlsson S, Tencer J. Urine IgM excretion predicts outcome in ANCA-associated renal vasculitis . Nephrol Dial Transplant 2006;21:1263-9.
18. Tofik R, Torffvit O, Rippe B, Bakoush O. Increased urine IgM excretion predicts cardiovascular events in patients with type 1 diabetes nephropathy. BMC Med 2009;7:39.
19. Tofik R, Torffvit O, Rippe B, Bakoush O. Urine IgM-excretion as a prognostic marker for progression of type 2 diabetic nephropathy. Diabetes Res Clin Pract 2012;95:139-4.
20. Tofik R, Ekelund U, Torffvit O, Sward P, Rippe B, Bakoush O. Increased urinary IgM excretion in patients with chest pain due to coronary artery disease. BMC Cardiovasc Disord 2013;13:72.
21. Tencer J, Thysell H, Grubb A. Analysis of proteinuria: reference limits for urine excretion of albumin, protein HC, immunoglobulin G, kappa- and lambda-immunoreactivity, orosomucoid and alpha 1-antitrypsin. Scand J Clin Lab Invest 1996;56:691-700.
22. Bakoush O, Torffvit O, Rippe B, Tencer J. High proteinuria selectivity index based upon IgM is a strong predictor of poor renal survival in glomerular diseases. Nephrol Dial Transplant 2001;16:1357-63.
23. Tofik R, Ohlsson S, Bakoush O. Urinary concentration of monocyte chemoattractant protein-1 in idiopathic glomeru-lonephritis: a long-term follow-up study. PloS one 2014;9:e87857.
24. Ohlsson S, Bakoush O, Tencer J, Torffvit O, Segelmark M. Monocyte chemoattractant protein 1 is a prognostic marker in ANCA-associated small vessel vasculitis. Mediators Inflamm 2009;2009:584916.
25. Tencer J, Torffvit O, Thysell H, Rippe B, Grubb A. Proteinuria selectivity index based upon alpha 2-macroglobulin or IgM is superior to the IgG based index in differentiating glomerular diseases. Technical note. Kidney Int 1998;54: 2098-105.
26. Sward P, Frobell R, Englund M, Roos H, Struglics A. Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis)-a cross-sectional analysis. Osteoarthritis Cartilage 2012;20:1302-8.
27. Ridker PM, Rifai N, Pfeffer M, Sacks F, Lepage S, Braun- wald E. Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation 2000;101:2149-53.
28. Al-Aqeedi RF, Abdullatef WK, Dabdoob W, Bener A, Albinali HA, Gehani A. The prevalence of metabolic syndrome components, individually and in combination, in male patients admitted with acute coronary syndrome, without previous diagnosis of diabetes mellitus. Libyan J Med 2013;8:20185.
29. Poldervaart JM, Reitsma JB, Koffijberg H, Backus BE, Six AJ, Doevendans PA, Hoes AW. The impact of the HEART risk score in the early assessment of patients with acute chest pain: design of a stepped wedge, cluster randomised trial. BMC Cardiovasc Disord 2013;13:77.
30. Chan D, Ng LL. Biomarkers in acute myocardial infarction. BMC Med 2010;8:34.
31. Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev 2006; 86:515-81.
32. Schottker B, Herder C, Rothenbacher D, Roden M, Kolb H, Muller H, Brenner H. Proinflammatory cytokines, adiponectin, and increased risk of primary cardiovascular events in diabetic patients with or without renal dysfunction: results from the ESTHER study. Diabetes Care 2013; 36:1703-11.
33. Sward P, Rippe B. Acute and sustained actions of hypergly-caemia on endothelial and glomerular barrier permeability. Acta Physiol (Oxf) 2012;204:294-307.
34. Axelsson J, Rippe A, Sverrisson K, Rippe B. Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability. Am J Physiol Renal Physiol 2013;305:F237-43.
35. Greka A, Mundel P. Calcium regulates podocyte actin dynamics. Semin Nephrol 2012;32:319-26.
36. Bakoush O, Tencer J, Torffvit O, Tenstad O, Skogvall I, Rippe B. Increased glomerular albumin permeability in old spontaneously hypertensive rats. Nephrol Dial Transplant 2004;19:1724-31.
37. Axelsson J, Rippe A, Oberg CM, Rippe B. Rapid, dynamic changes in glomerular permeability to macromolecules during systemic angiotensin II (ANG II) infusion in rats. Am J Physiol Renal Physiol 2012;303:F790-9.
38. Axelsson J, Rippe A, Rippe B. Acute hyperglycemia induces rapid, reversible increases in glomerular permeability in nondiabetic rats. Am J Physiol Renal Physiol 2010; 298:F1306-12.
39. Duran M, Kalay N, Ardic I, Yarlioglues M, Kayaalti F, Yilmaz Y, Akpek M, Kaya MG, Topsakal R. Microalbumin-uria is not associated with endothelial dysfunction and coronary atherosclerosis in patients with acute coronary syndromes. Ren Fail 2010;32:659-65.