Proteinuria selectivity index based upon α2-macroglobulin or IgM is superior to the IgG based index in differentiating glomerular diseases: Technical note

Kidney International

Volumn 54, Issue 6, 1998, Pages 2098-2105

  Tencer, Jan ^a   Torffvjt, Ole ^b   Thysell, Hans ^b   Rippe, Bengt ^b   Grubb, Anders ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

Albuminuria; Clearance; Glomerular disease; Immunoglobulin G; Immunoglobulin M; Permeability

Indexed keywords

ALPHA 2 MACROGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ARTICLE; DIABETIC NEPHROPATHY; DIFFERENTIAL DIAGNOSIS; FEMALE; GLOMERULOPATHY; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY CLEARANCE; KIDNEY NECROSIS; MAJOR CLINICAL STUDY; MALE; MEMBRANOUS GLOMERULONEPHRITIS; MINIMAL CHANGE GLOMERULONEPHRITIS; NEPHROSCLEROSIS; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEINURIA; URINARY EXCRETION;

EID: 0031786808     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00205.x     Document Type: Article

References (36)

1. CAMERON J, WHITE R: Selectivity of proteinuria in children with nephrotic syndrome. Lancet i:463-465, 1965
2. WEBER MH: Urinary protein analysis. J Chromatogr 429:315-344, 1988
3. TISHKOV I, RAZBOYNIKOV S, TSCHOUKANOV C, SHIPKOVA P: Biochemical methods for the assessment of the selectivity of proteinuria. Int Urol Nephrol 10:245-249, 1978
4. CARLSON JA, HARRINGTON JT: Laboratory evaluation of renal function, in Diseases of the Kidney, edited by SCHRIER RW, GOTTSCHALK CW, Boston, Little, Brown and Company, 1993, pp 361-405
5. DEEN WM, BRIDGES CR, BRENNER BM, MYERS BD: Heteroporous model of glomerular size selectivity: Application to normal and nephrotic humans. Am J Physiol 249:374-389, 1985
6. MYERS BD: Pathophysiology of proteinuria in immune glomerular injury. Am J Nephrol 10:19-23, 1990
7. TENCER J, FRICK I-M, ÖQVIST B, ALM P, RIPPE B: Size-selectivity of the glomerular barrier to high molecular weight proteins. The upper size limitations of the shunt pathways. Kidney Int 53:709-715, 1998
8. MYERS BD, GUASCH A: Selectivity of the glomerular filtration barrier in healthy and nephrotic humans. Am J Nephrol 13:311-317, 1993
9. SCHUREK H-J: Mechanisms of glomerular proteinuria and hematuria. Kidney Int 46(Suppl 47):S12-S16, 1994
10. IKEGAYA N, NAGASE M, HONDA N, KUMAGAI H, HISHIDA A: Correlation between histologic features and glomerular permeability in membranous nephropathy and immunoglobulin A nephropathy. J Lab Clin Med 123:94-101, 1994
11. TENCER J, THYSELL H, GRUBB A: Stability of albumin, protein HC, immunoglobulin G, κ- and λ-chain immunoreactivity, orosomucoid and α1-antitrypsin in urine stored at various conditions. Scand J Clin Lab Invest 54:199-206, 1994
12. TENCER J, THYSELL H, ANDERSSON K, GRUBB A: Long-term stability of albumin, protein HC, immunoglobulin G, κ- and λ-chain-immunoreactivity, orosomucoid and a1-antitrypsin in urine stored at - 20°C. Scand J Urol Nephrol 31:67-71, 1997
13. PRICE CP, WHICHER J: Light-scattering immunoassay of specific proteins: A review. Ann Clin Biochem 20:1-14, 1983
14. SVENDSEN PJ, BLIRUP-JENSEN S: Determination of Human Plasma Proteins by Turbidimetry and Nephelometry. Copenhagen, Dako, 1991
15. TENCER J, THYSELL H, GRUBB A: Analysis of proteinuria: Reference limits for urine excretion of albumin, protein HC, immunoglobulin G, κ- and λ- immunoreactivity, orosornucoid and α1-antitrypsin. Scand J Clin Lab Invest 56:691-700, 1996
16. MANCINI G, CARNONARA AO, HEREMANS JF: Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2:235-254, 1965
17. JOACHIM GR, CAMERON JS, SCHWARTZ M, BECKER EL: Selectivity of protein excretion in patient with the nephrotic syndrome. J Clin Invest 43:2332-2346, 1964
18. SHAW AB, RISDON P, LEWIS-JACKSON JD: Protein creatinine index and Albustix in assessment of proteinuria. Br Med J 287:929-932, 1983
19. MACLEAN PR, ROBSON JS: A simple method for determing selectivity of proteinuria. Lancet i:539-542, 1967
20. GHIGGERI GM, CANDIANO G, GINERVI F, GUSMANO R, CIARDI MR, PERFUMO F, DELFINO G, CUNIBERTI C, QUEIROLO C: Renal selectivity properties towards endogenous albumin in minimal change nephropathy. Kidney Int 32:69-77, 1987
21. BLAU EB, HAAS JE: Glomerular sialic acid and proteinuria in human renal disease. Lab Invest 38:477-481, 1973
22. HIRAOKA M, TAKEDA N, TSUKAHARA H, KIMURA K, TAKAGI K, HAYASHI S, KATO E, OHTA K, SUDO M: Favorable course of steroid responsive nephrotic children with mild initial attack. Kidney Int 47:1392-1393, 1995
23. OKADA K, KAWAKAMI K, YANO I, FUNAI M, KAGAMI S, KURODA Y, OITE T: Ultrastructural alterations of glomerular anionic sites in IgA nephropathy. Clin Nephrol 31:96-102, 1989
24. WOO KT, LAU YK, GRACE SL, LEE SS, WEI SS, LIM CH: Pattern of proteinuria in IgA nephritis by SDS-PAGE: Clinical significance. Clin Nephrol 36:6-11, 1991
25. WOO KT, LAU YK, WONG KS, LEE GS, CHIN YM, CHIANG GS, LIM CH: Isoelectric focusing and selectivity index in IgA nephrotic syndrome. Nephron 67:408-413, 1994
26. SCANDLING JD, MYERS BD: Glomerular size-selectivity and microalbuminuria in early diabetic glomerular disease. Kidney Int 41: 840-846, 1992
27. VAN DEN BORN J, VAN KRAATS AA, BAKKER MA, ASSMANN KJ, VAN DEN HEUVEL LP, VEERKAMP JH, BERDEN JH: Selective proteinuria in diabetic nephropathy in the rat is associated with a relative decrease in glomerular basement membrane heparan sulphate. Diabetologia 38:161-172, 1995
28. Morano S, D'Erme M, Sensi M, De Rossi M, Medici F, Galliccia F, Andreani D, Di Mario U: Characteristics of proteinuria in experminetal diabetes mellitus. Biochem Med Metab Biol 53:92-97, 1994
29. GALL MA, ROSSING P, KOFOED-ENEVOLDSEN A, NIELSEN FS, PARVING HH: Glomerular size- and charge selectivity in type 2 (non-insulin-dependent) diabetic patients with diabetic nephropathy. Diabetologia 37:195-201, 1994
30. LAURENT J, PHILIPPON C, LAGRUE G, LAURENT G, WEIL B, ROSTOKER G: Proteinuria selectivity index-Prognostic value in lipoid nephrosis and related diseases. Nephron 65:185-189, 1993
31. ABDURRAHMAN MB, EL SHEIKH OK, ELIDRISSY AT, AL KAHTANI WM, LAMBOURNE A: Proteinuria selectivity index in Saudi children with nephrotic syndrome. Ann Clin Biochem 26:492-495, 1989
32. SOOTHILL JF, HENDRICKSE RG: Some immunological studies of the nephrotic syndrome of Nigerian children. Lancet ii:629-632, 1967
33. GLASSOCK RJ, COHEN AH, ADLER SG: Primary glomerular diseases, in The Kidney (vol 2), edited by BRENNER BM, Philadelphia, W.B. Saunders Company, 1995, pp 1397-1400
34. PAPPENHEIMER JR, RENKIN EM, BORRERO LM: Filtration, diffusion and molecular sieving through peripheral capillary membranes. A contribution to the pore theory of capillary permeability. Am J Physiol 167:13-46, 1951
35. REMUZZI A, BATTAGLIA C, ROSSI L, ZOJA C, REMUZZI G: Glomerular size selectivity in nephrotic rats exposed to diets with different protein content. Am J Physiol 253:F318-F327, 1987
36. MYERS BD, OKARMA TB, FRIEMAN S, BRIDGES C, ROSS J, ASSEFF S, DEEN WM: Mechanisms of proteinuria in human glomerulonephritis. J Clin Invest 70:732-746, 1982