Urine IgM-excretion as a prognostic marker for progression of type 2 diabetic nephropathy

Diabetes Research and Clinical Practice

Volumn 95, Issue 1, 2012, Pages 139-144

  Tofik, Rafid ^a   Torffvit, Ole ^a   Rippe, Bengt ^a   Bakoush, Omran ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Albuminuria; Cardiovascular mortality; End stage renal disease; Proteinuria; Urine IgM

Indexed keywords

ALBUMIN; IMMUNOGLOBULIN M;

ADULT; AGED; ALBUMINURIA; ARTICLE; CARDIOVASCULAR RISK; COHORT ANALYSIS; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MARKER; DISEASE SEVERITY; FEMALE; FOLLOW UP; HEART DEATH; HUMAN; IMMUNOGLOBULIN M DEFICIENCY; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; URINARY EXCRETION; URINE LEVEL;

ADULT; AGED; AGED, 80 AND OVER; ALBUMINURIA; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOGLOBULIN M; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES;

EID: 84355166542     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2011.10.008     Document Type: Article

References (33)

1. Poulsen M.K., Henriksen J.E., Vach W., Dahl J., Moller J.E., Johansen A., et al. Identification of asymptomatic type 2 diabetes mellitus patients with a low, intermediate and high risk of ischaemic heart disease: is there an algorithm?. Diabetologia 2010, 53(4):659-667.
2. Finne P., Reunanen A., Stenman S., Groop P.H., Gronhagen-Riska C. Incidence of end-stage renal disease in patients with type 1 diabetes. JAMA 2005, 294(14):1782-1787.
3. Borch-Johnsen K., Kreiner S. Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus. Br Med J (Clin Res Ed) 1987, 294(6588):1651-1654.
4. Eijkelkamp W.B., Zhang Z., Remuzzi G., Parving H.H., Cooper M.E., Keane W.F., et al. Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: post hoc analysis from the reduction of endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial. J Am Soc Nephrol 2007, 18(5):1540-1546.
5. Rossing K., Christensen P.K., Hovind P., Tarnow L., Rossing P., Parving H.H. Progression of nephropathy in type 2 diabetic patients. Kidney Int 2004, 66(4):1596-1605.
6. Yuyun M.F., Dinneen S.F., Edwards O.M., Wood E., Wareham N.J. Absolute level and rate of change of albuminuria over 1 year independently predict mortality and cardiovascular events in patients with diabetic nephropathy. Diabet Med 2003, 20(4):277-282.
7. Spoelstra-de Man A.M., Brouwer C.B., Stehouwer C.D., Smulders Y.M. Rapid progression of albumin excretion is an independent predictor of cardiovascular mortality in patients with type 2 diabetes and microalbuminuria. Diabetes Care 2001, 24(12):2097-2101.
8. Solbu M.D., Kronborg J., Jenssen T.G., Njolstad I., Lochen M.L., Mathiesen E.B., et al. Albuminuria, metabolic syndrome and the risk of mortality and cardiovascular events. Atherosclerosis 2009, 204(2):503-508.
9. Deckert T., Feldt-Rasmussen B., Borch-Johnsen K., Jensen T., Kofoed-Enevoldsen A. Albuminuria reflects widespread vascular damage. The Steno hypothesis. Diabetologia 1989, 32(4):219-226.
10. Luetscher J.A., Kraemer F.B., Wilson D.M., Schwartz H.C., Bryer-Ash M. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. N Engl J Med 1985, 312(22):1412-1417.
11. Chiu Y.W., Adler S.G., Budoff M.J., Takasu J., Ashai J., Mehrotra R. Coronary artery calcification and mortality in diabetic patients with proteinuria. Kidney Int 2010, 77(12):1107-1114.
12. Fioretto P., Caramori M.L., Mauer M. The kidney in diabetes: dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007. Diabetologia 2008, 51(8):1347-1355.
13. Osterby R., Gall M.A., Schmitz A., Nielsen F.S., Nyberg G., Parving H.H. Glomerular structure and function in proteinuric type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993, 36(10):1064-1070.
14. Gambara V., Mecca G., Remuzzi G., Bertani T. Heterogeneous nature of renal lesions in type II diabetes. J Am Soc Nephrol 1993, 3(8):1458-1466.
15. Moriya T., Ohno S., Hirasawa Y., Tanaka K., Fujita Y. Detailed glomerular ultrastructure in Japanese type 2 diabetic patients by the quick-freezing and deep-etching method. Diabetes Res Clin Pract 2008, 80(3):424-431.
16. Bakoush O., Tencer J., Tapia J., Rippe B., Torffvit O. Higher urinary IgM excretion in type 2 diabetic nephropathy compared to type 1 diabetic nephropathy. Kidney Int 2002, 61(1):203-208.
17. Moriya T., Tanaka K., Hosaka T., Hirasawa Y., Fujita Y. Renal structure as an indicator for development of albuminuria in normo- and microalbuminuric type 2 diabetic patients. Diabetes Res Clin Pract 2008, 82(3):298-304.
18. Moriya T., Moriya R., Yajima Y., Steffes M.W., Mauer M. Urinary albumin as an indicator of diabetic nephropathy lesions in Japanese type 2 diabetic patients. Nephron 2002, 91(2):292-299.
19. Myers B.D., Winetz J.A., Chui F., Michaels A.S. Mechanisms of proteinuria in diabetic nephropathy: a study of glomerular barrier function. Kidney Int 1982, 21(4):633-641.
20. Parving H.H., Nielsen F.S., Bang L.E., Smidt U.M., Svendsen T.L., Chen J.W., et al. Macro-microangiopathy and endothelial dysfunction in NIDDM patients with and without diabetic nephropathy. Diabetologia 1996, 39(12):1590-1597.
21. Kramer H.J., Nguyen Q.D., Curhan G., Hsu C.Y. Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus. JAMA 2003, 289(24):3273-3277.
22. Tofik R., Torffvit O., Rippe B., Bakoush O. Increased urine IgM excretion predicts cardiovascular events in patients with type 1 diabetes nephropathy. BMC Med 2009, 7:39.
23. Tencer J., Thysell H., Andersson K., Grubb A. Long-term stability of albumin, protein HC, immunoglobulin G, kappa- and lambda-chain-immunoreactivity, orosomucoid and alpha 1-antitrypsin in urine stored at -20 degrees C. Scand J Urol Nephrol 1997, 31(1):67-71.
24. Tencer J., Torffvit O., Thysell H., Rippe B., Grubb A. Proteinuria selectivity index based upon alpha 2-macroglobulin or IgM is superior to the IgG based index in differentiating glomerular diseases. Technical note. Kidney Int 1998, 54(6):2098-2105.
25. Hammar N., Alfredsson L., Rosen M., Spetz C.L., Kahan T., Ysberg A.S. A national record linkage to study acute myocardial infarction incidence and case fatality in Sweden. Int J Epidemiol 2001, 30(Suppl. 1):S30-S34.
26. Ohlsson S., Bakoush O., Tencer J., Torffvit O., Segelmark M. Monocyte chemoattractant protein 1 is a prognostic marker in ANCA-associated small vessel vasculitis. Mediat Inflamm 2009, 2009:584916.
27. Tencer J., Frick I.M., Oquist B.W., Alm P., Rippe B. Size-selectivity of the glomerular barrier to high molecular weight proteins: upper size limitations of shunt pathways. Kidney Int 1998, 53(3):709-715.
28. Bjork J., Back S.E., Sterner G., Carlson J., Lindstrom V., Bakoush O., et al. Prediction of relative glomerular filtration rate in adults: new improved equations based on Swedish Caucasians and standardized plasma-creatinine assays. Scand J Clin Lab Invest 2007, 67(7):678-695.
29. Bakoush O., Segelmark M., Torffvit O., Ohlsson S., Tencer J. Urine IgM excretion predicts outcome in ANCA-associated renal vasculitis. Nephrol Dial Transplant 2006, 21(5):1263-1269.
30. Bakoush O., Tencer J., Torffvit O., Tenstad O., Skogvall I., Rippe B. Increased glomerular albumin permeability in old spontaneously hypertensive rats. Nephrol Dial Transplant 2004, 19(7):1724-1731.
31. Rippe C., Rippe A., Torffvit O., Rippe B. Size and charge selectivity of the glomerular filter in early experimental diabetes in rats. Am J Physiol Renal Physiol 2007, 293(5):F1533-F1538.
32. Cachofeiro V., Goicochea M., de Vinuesa S.G., Oubina P., Lahera V., Luno J. Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney Int Suppl 2008, (111):S4-S9.
33. Isomaa B., Almgren P., Tuomi T., Forsen B., Lahti K., Nissen M., et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001, 24(4):683-689.