Low levels of Vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study

Annals of Medicine

Volumn 47, Issue 6, 2015, Pages 474-481

  Meems, Laura M G ^a   De Borst, Martin H ^a   Postma, Dirkje S ^a   Vonk, Judith M ^a   Kremer, Hubertus P H ^a   Schuttelaar, Marie Louise A ^a   Rosmalen, Judith G M ^a   Weersma, Rinse K ^a   Wolffenbuttel, Bruce H R ^a   Scholtens, Salome ^a   Stolk, Ronald P ^a   Kema, Ido P ^a   Navis, Gerjan ^a   Khan, Mohsin A F ^a   Van Der Harst, Pim ^a   De Boer, Rudolf A ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

25 hydroxyvitamin D; Co morbidity; LifeLines Cohort Study; morbidity; multimorbidity; Vitamin D; Vitamin D defi ciency

Indexed keywords

VITAMIN D; CALCIFEDIOL;

ADULT; AGE; AGED; ARTICLE; COMORBIDITY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL; BLOOD; COHORT ANALYSIS; LIQUID CHROMATOGRAPHY; NETHERLANDS; PREVALENCE; PROCEDURES; RISK FACTOR; TANDEM MASS SPECTROMETRY; VITAMIN D DEFICIENCY;

ADULT; AGED; CALCIFEDIOL; CHROMATOGRAPHY, LIQUID; COHORT STUDIES; COMORBIDITY; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; PREVALENCE; RISK FACTORS; TANDEM MASS SPECTROMETRY; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84942984453     PISSN: 07853890     EISSN: 13652060     Source Type: Journal    
DOI: 10.3109/07853890.2015.1073347     Document Type: Article

References (37)

1. de Groot V, Beckerman H, Lankhorst GJ, Bouter LM. How to measure comorbidity. A critical review of available methods. J Clin Epidemiol. 2003; 56: 221-9.
2. Agborsangaya CB, Ngwakongnwi E, Lahtinen M, Cooke T, Johnson JA. Multimorbidity prevalence in the general population: the role of obesity in chronic disease clustering. BMC Public Health. 2013; 13: 1161.
3. Diederichs C, Berger K, Bartels DB. The measurement of multiple chronic diseases-a systematic review on existing multimorbidity indices. J Gerontol A Biol Sci Med Sci. 2011; 66: 301-11.
4. Sorensen HT. Multimorbidity and cancer outcomes: A for more research. Clin Epidemiol. 2013; 5(Suppl 1): 1-2.
5. Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2014; 111: 23-45.
6. Hossein-nezhad A, Holick MF. Vitamin D for health: A global perspective. Mayo Clin Proc. 2013; 88: 720-55.
7. Pan A, Lucas M, Sun Q, van Dam RM, Franco OH, Manson JE, et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med. 2010; 170: 1884-91.
8. Holick MF. Vitamin D defi ciency. N Engl J Med. 2 007; 3 57: 2 66-8 1.
9. Giovannucci E. Epidemiology of vitamin D and colorectal cancer. Anticancer Agents Med Chem. 2013; 13: 11-19.
10. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies. Int J Surg. 2014; 12: 1495-9.
11. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M. I. N. I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998; 59(Suppl 20): 22-33; quiz 34-57.
12. Stolk RP, Rosmalen JG, Postma DS, de Boer RA, Navis G, Slaets JP, et al. Universal risk factors for multifactorial diseases: LifeLines: A three-generation population-based study. Eur J Epidemiol. 2008; 23: 67-74.
13. K DIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. 2012. Available at: http://www. kdigo. org/clinical-practice-guidelines/pdf/CKD/KDIGO-2012-CKD GL. pdf (accessed April 2015).
14. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005; 16: 713-16.
15. World Health Organization. International Classifi cation of Diseases. 2010. Available at: http://apps. who. int/classifi cations/icd10/browse/ 2010/en (accessed April 2015).
16. S achs M C, S hoben A, L evin G P, R obinson-Cohen C, H oofnagle A N, Swords-Jenny N, et al. Estimating mean annual 25-hydroxyvitamin D concentrations from single measurements: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2013; 97: 1243-51.
17. Guessous I, McClellan W, Kleinbaum D, Vaccarino V, Zoller O, Th eler JM, et al. Comparisons of serum vitamin d levels, status, and determinants in populations with and without chronic kidney disease not requiring renal dialysis: A 24-hour urine collection populationbased study. J Ren Nutr. 2014; 24: 303-12.
18. Annweiler C, Schott AM, Rolland Y, Beauchet O. Vitamin D defi ciency is associated with orthostatic hypotension in oldest-old women. J Intern Med. 2014; 276: 285-95.
19. Schottker B, Jorde R, Peasey A, Th orand B, Jansen EH, Groot L, et al. Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States. BMJ. 2014; 348: g3656.
20. Gonzalez-Rodriguez LG, Estaire P, Penas-Ruiz C, Ortega RM; UCM Research Group VALORNUT (920030). Vitamin D intake and dietary sources in a representative sample of Spanish adults. J Hum Nutr Diet. 2013; 26(Suppl 1): 64-72.
21. W ang Y, Z hu J, D eLuca H F. W here is the vitamin D receptor? A rch Biochem Biophys. 2012; 523: 123-33.
22. Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study. Lancet. 2012; 380: 37-43.
23. Gijsen R, Hoeymans N, Schellevis FG, Ruwaard D, Satariano WA, van den Bos GA. Causes and consequences of comorbidity: A review. J Clin Epidemiol. 2001; 54: 661-74.
24. Wolff JL, Starfi eld B, A nderson G. P revalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002; 162: 2269-76.
25. Schoen C, Osborn R. 2010 Commonwealth Fund International health policy survey. Available at: www. commonwealthfund. org/surveys/2010/ Nov/2010-international-survey. Aspx (accessed April 2015).
26. Divo MJ, Martinez CH, Mannino DM. Ageing and the epidemiology of multimorbidity. Eur Respir J. 2014; 44: 1055-68.
27. Peterlik M. Vitamin D insuffi ciency and chronic diseases: hype and reality. Food Funct. 2012; 3: 784-94.
28. Ghaly S, Lawrance I. The role of vitamin D in gastrointestinal infl ammation. Expert Rev Gastroenterol Hepatol. 2014; 8: 909-23.
29. Meems LM, van der Harst P, van Gilst WH, de Boer RA. Vitamin D biology in heart failure: molecular mechanisms and systematic review. Curr Drug Targets. 2011; 12: 29-41.
30. Mandia D, Ferraro OE, Nosari G, Montomoli C, Zardini E, Bergamaschi R. Environmental factors and multiple sclerosis severity: A descriptive study. Int J Environ Res Public Health. 2014; 11: 6417-32.
31. Zhang LL, Gong J, Liu CT. Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis. Genet Mol Res. 2014; 13: 7607-16.
32. Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: A systematic review. Lancet Diabetes Endocrinol. 2014; 2: 76-89.
33. Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, et al. Eff ect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D defi ciency: the VITdAL-ICU randomized clinical trial. JAMA. 2014; 312: 1520-30.
34. Cauley JA, Chlebowski RT, Wactawski-Wende J, Robbins JA, Rodabough RJ, Chen Z, et al. Calcium plus vitamin D supplementation and health outcomes fi ve years aft er active intervention ended: the Women ' s Health Initiative. J Womens Health (Larchmt). 2013; 22: 915-29.
35. Manson JE, Bassuk SS, Lee IM, Cook NR, Albert MA, Gordon D, et al. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials. 2012; 33: 159-71.
36. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40: 373-83.
37. Boeckxstaens P, Vaes B, Van Pottelbergh G, De Sutter A, Legrand D, Adriaensen W, et al. Multimorbidity measures were poor predictors of adverse events in patients aged / 80 years: A prospective cohort study. J Clin Epidemiol. 2015; 68: 220-7.