Inflammation impairs social cognitive processing: A randomized controlled trial of endotoxin

Brain, Behavior, and Immunity

Volumn 48, Issue , 2015, Pages 132-138

  Moieni, Mona ^a   Irwin, Michael R ^b   Jevtic, Ivana ^a   Breen, Elizabeth C ^b   Eisenberger, Naomi I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cytokines; Endotoxin; Inflammation; Mind in the eyes; Social cognition; Theory of mind

Indexed keywords

ENDOTOXIN; INTERLEUKIN 6; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; ENDOTOXIN, ESCHERICHIA COLI;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; BODY MASS; CLINICAL FEATURE; CONTROLLED STUDY; DYSPNEA; FATIGUE; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; LOW DRUG DOSE; MALE; MENTAL TASK; MYALGIA; NAUSEA; NERVOUS SYSTEM INFLAMMATION; NEUROIMMUNOLOGY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SHIVERING; SOCIAL COGNITION; TASK PERFORMANCE; THEORY OF MIND; VALIDATION PROCESS; ADOLESCENT; BLOOD; COGNITION; DRUG EFFECTS; EMOTION; INFLAMMATION; NEUROPSYCHOLOGICAL TEST; PERCEPTION; PHYSIOLOGY; PSYCHOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; COGNITION; CYTOKINES; EMOTIONS; ENDOTOXINS; FEMALE; HUMANS; INFLAMMATION; MALE; NEUROPSYCHOLOGICAL TESTS; SOCIAL PERCEPTION; THEORY OF MIND; YOUNG ADULT;

EID: 84942982399     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.03.002     Document Type: Article

References (48)

1. Andreasen, A., Krabbe, K., Krogh-Madsen, R., Taudorf, S., Pedersen, B., Moller, K., 2008. Human endotoxemia as a model of systemic inflammation. Curr. Med. Chem. 15 (17), 1697-1705.
2. Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., Van de Water, J., 2011a. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav. Immun. 25 (1), 40-45.
3. Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I.N., Van de Water, J., 2011b. Altered T cell responses in children with autism. Brain Behav. Immun. 25 (5), 840-849.
4. Baker, F., Denniston, M., Zabora, J., Polland, A., Dudley, W.N., 2002. A POMS short form for cancer patients: psychometric and structural evaluation. Psycho-Oncology 11 (4), 273-281.
5. Baron-Cohen, S., Leslie, A.M., Frith, U., 1985. Does the autistic child have a "theory of mind"? Cognition 21 (1), 37-46.
6. Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., Plumb, I., 2001. The "Reading the Mind in the Eyes" test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism. J. Child Psychol. Psychiatry 42 (2), 241-251.
7. Beck, A.T., Steer, R.A., Carbin, M.G., 1988. Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clin. Psychol. Rev. 8 (1), 77-100.
8. Breen, E., Perez, C., Olmstead, R., Eisenberger, N., Irwin, M., 2014. 135. Comparison of multiplex immunoassays and ELISAs for the determination of circulating levels of inflammatory cytokines. Brain Behav. Immun. 40, e39.
9. Brown, A.S., Hooton, J., Schaefer, C.A., Zhang, H., Petkova, E., Babulas, V., Susser, E.S., 2004. Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am. J. Psychiatry 161 (5), 889-895.
10. Brown, A.S., Sourander, A., Hinkka-Yli-Salomäki, S., McKeague, I., Sundvall, J., Surcel, H., 2013. Elevated maternal C-reactive protein and autism in a national birth cohort. Mol. Psychiatry 19 (2), 259-264.
11. Brüne, M., 2001. Social cognition and psychopathology in an evolutionary perspective. Psychopathology 34 (2), 85-94.
12. Brüne, M., Brüne-Cohrs, U., 2006. Theory of mind-evolution, ontogeny, brain mechanisms and psychopathology. Neurosci. Biobehav. Rev. 30 (4), 437-455.
13. Brydon, L., Harrison, N.A., Walker, C., Steptoe, A., Critchley, H.D., 2008. Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biol. Psychiatry 63 (11), 1022-1029.
14. Buka, S.L., Tsuang, M.T., Torrey, E.F., Klebanoff, M.A., Wagner, R.L., Yolken, R.H., 2001. Maternal cytokine levels during pregnancy and adult psychosis. Brain Behav. Immun. 15 (4), 411-420.
15. Canetta, S., Sourander, A., Surcel, H.-M., Hinkka-Yli-Salomäki, S., Leiviskä, J., Kellendonk, C., Brown, A.S., 2014. Elevated maternal C-reactive protein and increased risk of schizophrenia in a national birth cohort. Am. J. Psychiatry 171(9), 960-968.
16. Couture, S., Penn, D., Losh, M., Adolphs, R., Hurley, R., Piven, J., 2010. Comparison of social cognitive functioning in schizophrenia and high functioning autism: more convergence than divergence. Psychol. Med. 40 (04), 569-579.
17. Eisenberger, N.I., Inagaki, T.K., Mashal, N.M., Irwin, M.R., 2010. Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain Behav. Immun. 24 (4), 558-563.
18. Eisenberger, N.I., Inagaki, T.K., Rameson, L.T., Mashal, N.M., Irwin, M.R., 2009. An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. Neuroimage 47 (3), 881-890.
19. Enstrom, A.M., Onore, C.E., Van de Water, J.A., Ashwood, P., 2010. Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav. Immun. 24 (1), 64-71.
20. Epstein, M.M., Breen, E.C., Magpantay, L., Detels, R., Lepone, L., Penugonda, S., Birmann, B.M., 2013. Temporal stability of serum concentrations of cytokines and soluble receptors measured across two years in low-risk HIV-seronegative men. Cancer Epidemiol. Biomark. Prev. 22 (11), 2009-2015.
21. Fett, A.-K.J., Viechtbauer, W., Dominguez, M.-D.-G., Penn, D.L., van Os, J., Krabbendam, L., 2011. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci. Biobehav. Rev. 35 (3), 573-588.
22. Fineberg, A.M., Ellman, L.M., 2013. Inflammatory cytokines and neurological and neurocognitive alterations in the course of schizophrenia. Biol. Psychiatry 73(10), 951-966.
23. First, M.B., Spitzer, R.L., Gibbon, M., Williams, J.B., 2012. Structured Clinical Interview for DSM-IV® Axis I Disorders (SCID-I), Clinician Version, Administration Booklet. American Psychiatric Pub.
24. Frith, C.D., Corcoran, R., 1996. Exploring 'theory of mind' in people with schizophrenia. Psychol. Med. 26 (03), 521-530.
25. Grigoleit, J.-S., Kullmann, J.S., Wolf, O.T., Hammes, F., Wegner, A., Jablonowski, S., Schedlowski, M., 2011. Dose-dependent effects of endotoxin on neurobehavioral functions in humans. PLoS One 6 (12), e28330.
26. Joiner, T.E., Lewinsohn, P.M., Seeley, J.R., 2002. The core of loneliness: Lack of pleasurable engagement-more so than painful disconnection-predicts social impairment, depression onset, and recovery from depressive disorders among adolescents. J. Pers. Assess. 79 (3), 472-491.
27. Kullmann, J.S., Grigoleit, J.-S., Wolf, O.T., Engler, H., Oberbeck, R., Elsenbruch, S., Gizewski, E.R., 2013. Experimental human endotoxemia enhances brain activity during social cognition. Social Cogn. Affect. Neurosci., nst049
28. Masi, A., Quintana, D., Glozier, N., Lloyd, A., Hickie, I., Guastella, A., 2014. Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis. Mol. Psychiatry.
29. McNair, D.M., Lorr, M., Droppleman, L.F., 1971. Manual for the Profile of Mood States. Education and Industrial Testing Service, San Diego, CA.
30. Merz, C.J., Wolf, O.T., Hennig, J., 2010. Stress impairs retrieval of socially relevant information. Behav. Neurosci. 124 (2), 288.
31. Meyer, U., Feldon, J., Dammann, O., 2011. Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation? Pediatr. Res. 69, 26R-33R.
32. Meyer, U., Feldon, J., Yee, B.K., 2009. A review of the fetal brain cytokine imbalance hypothesis of schizophrenia. Schizophr. Bull. 35 (5), 959-972.
33. Michel, M., Schmidt, M.J., Mirnics, K., 2012. Immune system gene dysregulation in autism and schizophrenia. Dev. Neurobiol. 72 (10), 1277-1287.
34. Miller, B.J., Buckley, P., Seabolt, W., Mellor, A., Kirkpatrick, B., 2011. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol. Psychiatry 70 (7), 663-671.
35. Moieni, M., Irwin, M.R., Jevtic, I., Olmstead, R., Breen, E.C., Eisenberger, N.I., in press. Sex differences in depressive and socioemotional responses to an inflammatory challenge: implications for sex differences in depression [published online ahead of print 02/04/2015]. Neuropsychopharmacology. http://dx.doi.org/10.1038/npp.2015.17.
36. Onore, C., Careaga, M., Ashwood, P., 2012. The role of immune dysfunction in the pathophysiology of autism. Brain Behav. Immun. 26 (3), 383-392.
37. Osborne, J.W., Overbay, A., 2004. The power of outliers (and why researchers should always check for them). Pract. Assess Res. Evaluat. 9 (6), 1-12.
38. Patterson, P.H., 2009. Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav. Brain Res. 204 (2), 313-321.
39. Premack, D., Woodruff, G., 1978. Does the chimpanzee have a theory of mind? Behav. Brain Sci. 1 (04), 515-526.
40. Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., Pollmächer, T., 2001. Cytokine-associated emotional and cognitive disturbances in humans. Arch. Gen. Psychiatry 58 (5), 445-452.
41. Ricci, S., Businaro, R., Ippoliti, F., Vasco, V.L., Massoni, F., Onofri, E., Ricciardi, M.R., 2013. Altered cytokine and BDNF levels in Autism spectrum disorder. Neurotox. Res. 24 (4), 491-501.
42. Romero, E., Guaza, C., Castellano, B., Borrell, J., 2008. Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia. Mol. Psychiatry 15 (4), 372-383.
43. Russell, D.W., 1996. UCLA loneliness scale (Version 3): reliability, validity, and factor structure. J. Pers. Assess. 66 (1), 20-40.
44. Sprong, M., Schothorst, P., Vos, E., Hox, J., Van Engeland, H., 2007. Theory of mind in schizophrenia meta-analysis. Br. J. Psychiatry 191 (1), 5-13.
45. Suffredini, A.F., O'Grady, N.P., 1999a. Pathophysiological responses to endotoxin in humans. In: Braude, H., Opal, S.M., Vogel, S.N., Morrison, D.C. (Eds.), Endotoxin in Health and Disease, first ed. Marcel Dekker, New York, pp. 817-830.
46. Suffredini, A.F., Fantuzzi, G., Badolato, R., Oppenheim, J.J., O'Grady, N.P., 1999b. New insights into the biology of the acute phase response. J. Clin. Immunol. 19 (4), 203-214.
47. Suzuki, K., Matsuzaki, H., Iwata, K., Kameno, Y., Shimmura, C., Kawai, S., Takagai, S., 2011. Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. PLoS One 6 (5), e20470.
48. Willette, A.A., Lubach, G.R., Coe, C.L., 2007. Environmental context differentially affects behavioral, leukocyte, cortisol, and interleukin-6 responses to low doses of endotoxin in the rhesus monkey. Brain Behav. Immun. 21 (6), 807-815.