Obesity, intrapancreatic fatty infiltration, and pancreatic cancer

Clinical Cancer Research

Volumn 21, Issue 15, 2015, Pages 3369-3371

  Wang, Hua ^a   Maitra, Anirban ^a   Wang, Huamin ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLOOXYGENASE 2; INSULIN; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; SOMATOMEDIN C;

ARTICLE; BODY MASS; CALORIC INTAKE; CANCER RISK; CANCER SURVIVAL; CARCINOGENESIS; HUMAN; INTRAABDOMINAL FAT; INTRAPANCREATIC FATTY INFILTRATION; LIPID DIET; NONHUMAN; OBESITY; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PANCREAS ADENOMA; PANCREAS CANCER; PANCREAS DISEASE; PANCREAS RESECTION; PANCREATIC NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; FEMALE; MALE; PANCREAS; PANCREAS TUMOR; PATHOLOGY; PRECANCER;

FEMALE; HUMANS; MALE; OBESITY; PANCREAS; PANCREATIC NEOPLASMS; PRECANCEROUS CONDITIONS;

EID: 84942862542     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-0718     Document Type: Article

References (12)

1. Rebours V, Gaujoux S, d'Assignies G, Sauvanet A, Ruszniewski P, Levy P, et al. Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN). Clin Cancer Res 2015; 21: 3522-8.
2. Hori M, Takahashi M, Hiraoka N, Yamaji T, Mutoh M, Ishigamori R, et al. Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma. Clin Transl Gastroenterol 2014; 5: e53.
3. Silverman DT, Swanson CA, Gridley G, Wacholder S, Greenberg RS, Brown LM, et al. Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews. J Natl Cancer Inst 1998; 90: 1710-9.
4. Arslan AA, Helzlsouer KJ, Kooperberg C, Shu XO, Steplowski E, Bueno-de-Mesquita HB, et al. Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Arch Intern Med 2010; 170: 791-802.
5. Li D, Morris JS, Liu J, Hassan MM, Day RS, Bondy ML, et al. Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA 2009; 301: 2553-62.
6. Wang F, Kumagai-Braesch M, Herrington MK, Larsson J, Permert J. Increased lipid metabolism and cell turnover of MiaPaCa2 cells induced by high-fat diet in an orthotopic system. Metabolism 2009; 58: 1131-6.
7. Hori M, Kitahashi T, Imai T, Ishigamori R, Takasu S, Mutoh M, et al. Enhancement of carcinogenesis and fatty infiltration in the pancreas in N-nitrosobis(2-oxopropyl)amine-treated hamsters by high-fat diet. Pancreas 2011; 40: 1234-40.
8. Philip B, Roland CL, Daniluk J, Liu Y, Chatterjee D, Gomez SB, et al. A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice. Gastroenterology 2013; 145: 1449-58.
9. Harvey AE, Lashinger LM, Hays D, Harrison LM, Lewis K, Fischer SM, et al. Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner. PLoS One 2014; 9: e94151.
10. Singhi AD, Pai RK, Kant JA, Bartholow TL, Zeh HJ, Lee KK, et al. The histopathology of PRSS1 hereditary pancreatitis. Am J Surg Pathol 2014; 38: 346-53.
11. Grippo PJ, Fitchev PS, Bentrem DJ, Melstrom LG, Dangi-Garimella S, Krantz SB, et al. Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice. Gut 2012; 61: 1454-64.
12. Li D, Abbruzzese JL. New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts. Clin Cancer Res 2010; 16: 4313-8.