Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice

Journal of Hepatology

Volumn 63, Issue 5, 2015, Pages 1147-1155

  Iracheta Vellve, Arvin ^a   Petrasek, Jan ^a   Satishchandran, Abhishek ^a   Gyongyosi, Benedek ^a   Saha, Banishree ^a   Kodys, Karen ^a   Fitzgerald, Katherine A ^a   Kurt Jones, Evelyn A ^a   Szabo, Gyongyi ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Alcoholic steatohepatitis; Damage associated molecular patterns; Determinants of liver inflammation; Inflammasome; Pathogen associated molecular patterns; Sterile inflammatory response

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ALCOHOL; ALLOPURINOL; INFLAMMASOME; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROBENECID; PURINERGIC P2X RECEPTOR; PURINERGIC RECEPTOR P2X LIGAND GATED ION CHANNEL 7; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; URATE OXIDASE; URIC ACID; ANTIMETABOLITE; PHARMACEUTICAL VEHICLES AND ADDITIVES;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOLIC FATTY LIVER; ALCOHOLIC STEATOHEPATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IN VITRO STUDY; LIVER CELL; LIVER INJURY; LIVER PROTECTION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION; URIC ACID BLOOD LEVEL; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CONFOCAL MICROSCOPY; DISEASE MODEL; DRUG EFFECTS; FATTY LIVER, ALCOHOLIC; METABOLISM; PATHOLOGY;

ADENOSINE TRIPHOSPHATE; ADJUVANTS, PHARMACEUTIC; ALLOPURINOL; ANIMALS; ANTIMETABOLITES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FATTY LIVER, ALCOHOLIC; FEMALE; HEPATOCYTES; INFLAMMASOMES; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; PROBENECID; SIGNAL TRANSDUCTION; URIC ACID;

EID: 84942819919     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.06.013     Document Type: Article

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