메뉴 건너뛰기




Volumn 22, Issue 4, 2015, Pages 309-316

Small molecule regulation of normal and leukemic stem cells

Author keywords

Hematopoietic stem cell; Leukemic stem cell; Self renewal; Small molecules

Indexed keywords

CD34 ANTIGEN; CD45RA ANTIGEN; CHEMICAL COMPOUND; CYTOKINE; NICOTINAMIDE; PROSTAGLANDIN E2; SHEMREGENIN 1; SITAGLIPTIN; UM 171; UNCLASSIFIED DRUG; VALPROIC ACID; AROMATIC HYDROCARBON RECEPTOR; INDOLE DERIVATIVE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; STEMREGENIN 1; UM171 COMPOUND;

EID: 84942811534     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0000000000000151     Document Type: Review
Times cited : (22)

References (41)
  • 1
    • 58149165364 scopus 로고    scopus 로고
    • Results of the Cord Blood Transplantation Study (COBLT) : Clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies
    • Kurtzberg J, Prasad VK, Carter SL, et al. Results of the Cord Blood Transplantation Study (COBLT) : Clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood 2008; 112: 4318-4327.
    • (2008) Blood , vol.112 , pp. 4318-4327
    • Kurtzberg, J.1    Prasad, V.K.2    Carter, S.L.3
  • 2
    • 78649462137 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for hematologic malignancy: Relative risks and benefits of double umbilical cord blood
    • Brunstein CG, Gutman JA, Weisdorf DJ, et al. Allogeneic hematopoietic cell transplantation for hematologic malignancy: Relative risks and benefits of double umbilical cord blood. Blood 2010; 116: 4693-4699.
    • (2010) Blood , vol.116 , pp. 4693-4699
    • Brunstein, C.G.1    Gutman, J.A.2    Weisdorf, D.J.3
  • 3
    • 79960172161 scopus 로고    scopus 로고
    • Delayed platelet recovery after allogeneic transplantation: A predictor of increased treatment-related mortality and poorer survival
    • Ramirez P, Brunstein CG, Miller B, et al. Delayed platelet recovery after allogeneic transplantation: A predictor of increased treatment-related mortality and poorer survival. Bone Marrow Transplant 2011; 46: 981-986.
    • (2011) Bone Marrow Transplant , vol.46 , pp. 981-986
    • Ramirez, P.1    Brunstein, C.G.2    Miller, B.3
  • 4
    • 9244219607 scopus 로고    scopus 로고
    • Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia
    • Rocha V, Labopin M, Sanz G, et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004; 351: 2276-2285.
    • (2004) N Engl J Med , vol.351 , pp. 2276-2285
    • Rocha, V.1    Labopin, M.2    Sanz, G.3
  • 5
    • 84888212251 scopus 로고    scopus 로고
    • Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice
    • Cheung AM, Nguyen LV, Carles A, et al. Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice. Blood 2013; 122: 3129-3137.
    • (2013) Blood , vol.122 , pp. 3129-3137
    • Cheung, A.M.1    Nguyen, L.V.2    Carles, A.3
  • 7
    • 79960106880 scopus 로고    scopus 로고
    • Isolation of single human hematopoietic stem cells capable of long-Term multilineage engraftment
    • Notta F, Doulatov S, Laurenti E, et al. Isolation of single human hematopoietic stem cells capable of long-Term multilineage engraftment. Science 2011; 333: 218-221.
    • (2011) Science , vol.333 , pp. 218-221
    • Notta, F.1    Doulatov, S.2    Laurenti, E.3
  • 8
    • 3242754448 scopus 로고    scopus 로고
    • Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
    • Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 2004; 5: 738-743.
    • (2004) Nat Immunol , vol.5 , pp. 738-743
    • Hope, K.J.1    Jin, L.2    Dick, J.E.3
  • 10
    • 84863011896 scopus 로고    scopus 로고
    • Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling
    • Csaszar E, Kirouac DC, Yu M, et al. Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell 2012; 10: 218-229.
    • (2012) Cell Stem Cell , vol.10 , pp. 218-229
    • Csaszar, E.1    Kirouac, D.C.2    Yu, M.3
  • 11
    • 84871071832 scopus 로고    scopus 로고
    • Cord-blood engraftment with ex vivo mesenchymal-cell coculture
    • de Lima M, McNiece I, Robinson SN, et al. Cord-blood engraftment with ex vivo mesenchymal-cell coculture. N Engl J Med 2012; 367: 2305-2315.
    • (2012) N Engl J Med , vol.367 , pp. 2305-2315
    • De Lima, M.1    McNiece, I.2    Robinson, S.N.3
  • 12
    • 84923351242 scopus 로고    scopus 로고
    • Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitors
    • Chattopadhyay S, Stewart AL, Mukherjee S, et al. Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitors. Cell Rep 2015; 10: 755-770.
    • (2015) Cell Rep , vol.10 , pp. 755-770
    • Chattopadhyay, S.1    Stewart, A.L.2    Mukherjee, S.3
  • 13
    • 84920063456 scopus 로고    scopus 로고
    • Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells
    • Ito S, Barrett AJ, Dutra A, et al. Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells. Stem Cell Res 2015; 14: 95-104.
    • (2015) Stem Cell Res , vol.14 , pp. 95-104
    • Ito, S.1    Barrett, A.J.2    Dutra, A.3
  • 14
    • 76349113345 scopus 로고    scopus 로고
    • Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution
    • Delaney C, Heimfeld S, Brashem-Stein C, et al. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 2010; 16: 232-236.
    • (2010) Nat Med , vol.16 , pp. 232-236
    • Delaney, C.1    Heimfeld, S.2    Brashem-Stein, C.3
  • 15
    • 77956519710 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
    • Boitano AE, Wang J, Romeo R, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010; 329: 1345-1348.
    • (2010) Science , vol.329 , pp. 1345-1348
    • Boitano, A.E.1    Wang, J.2    Romeo, R.3
  • 16
    • 34250883337 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    • North TE, Goessling W, Walkley CR, et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 2007; 447: 1007-1011.
    • (2007) Nature , vol.447 , pp. 1007-1011
    • North, T.E.1    Goessling, W.2    Walkley, C.R.3
  • 17
    • 67049134758 scopus 로고    scopus 로고
    • Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation
    • Hoggatt J, Singh P, Sampath J, Pelus LM. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood 2009; 113: 5444-5455.
    • (2009) Blood , vol.113 , pp. 5444-5455
    • Hoggatt, J.1    Singh, P.2    Sampath, J.3    Pelus, L.M.4
  • 18
    • 79953885122 scopus 로고    scopus 로고
    • Prostaglandin E2 enhances human cord blood stemcell xenotransplants and shows long-Term safety in preclinical nonhuman primate transplant models
    • Goessling W, Allen RS, Guan X, et al. Prostaglandin E2 enhances human cord blood stemcell xenotransplants and shows long-Term safety in preclinical nonhuman primate transplant models. Cell Stem Cell 2011; 8: 445-458.
    • (2011) Cell Stem Cell , vol.8 , pp. 445-458
    • Goessling, W.1    Allen, R.S.2    Guan, X.3
  • 19
    • 34347334543 scopus 로고    scopus 로고
    • + or lineage-human umbilical cord blood donor hematopoietic stem cells/hematopoietic progenitor cells improves long-Term engraftment into NOD/SCID/Beta2null immunodeficient mice
    • + or lineage-human umbilical cord blood donor hematopoietic stem cells/hematopoietic progenitor cells improves long-Term engraftment into NOD/SCID/Beta2null immunodeficient mice. Stem Cells Dev 2007; 16: 355-360.
    • (2007) Stem Cells Dev , vol.16 , pp. 355-360
    • Christopherson, K.W.1    Paganessi, L.A.2    Napier, S.3    Porecha, N.K.4
  • 20
    • 2942622157 scopus 로고    scopus 로고
    • + cells and increases their engraftment potential in NOD/SCID mice
    • + cells and increases their engraftment potential in NOD/SCID mice. Exp Hematol 2004; 32: 547-555.
    • (2004) Exp Hematol , vol.32 , pp. 547-555
    • Peled, T.1    Landau, E.2    Mandel, J.3
  • 21
    • 84858339102 scopus 로고    scopus 로고
    • Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment
    • Peled T, Shoham H, Aschengrau D, et al. Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment. Exp Hematol 2012; 40: 342.e1-355.e1.
    • (2012) Exp Hematol , vol.40 , pp. 342e1-355e1
    • Peled, T.1    Shoham, H.2    Aschengrau, D.3
  • 22
    • 84902206817 scopus 로고    scopus 로고
    • Epigenetic reprogramming induces the expansion of cord blood stem cells
    • Chaurasia P, Gajzer DC, Schaniel C, et al. Epigenetic reprogramming induces the expansion of cord blood stem cells. J Clin Invest 2014; 124: 2378-2395.
    • (2014) J Clin Invest , vol.124 , pp. 2378-2395
    • Chaurasia, P.1    Gajzer, D.C.2    Schaniel, C.3
  • 23
    • 84907221142 scopus 로고    scopus 로고
    • Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
    • Fares I, Chagraoui J, Gareau Y, et al. Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science 2014; 345: 1509-1512.
    • (2014) Science , vol.345 , pp. 1509-1512
    • Fares, I.1    Chagraoui, J.2    Gareau, Y.3
  • 24
    • 77949354161 scopus 로고    scopus 로고
    • In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands shortterm hematopoietic stem cells
    • Frisch BJ, Porter RL, Gigliotti BJ, et al. In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands shortterm hematopoietic stem cells. Blood 2009; 114: 4054-4063.
    • (2009) Blood , vol.114 , pp. 4054-4063
    • Frisch, B.J.1    Porter, R.L.2    Gigliotti, B.J.3
  • 25
    • 62149148156 scopus 로고    scopus 로고
    • Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    • Goessling W, North TE, Loewer S, et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 2009; 136: 1136-1147.
    • (2009) Cell , vol.136 , pp. 1136-1147
    • Goessling, W.1    North, T.E.2    Loewer, S.3
  • 26
    • 84888273208 scopus 로고    scopus 로고
    • Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation
    • Cutler C, Multani P, Robbins D, et al. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood 2013; 122: 3074-3081.
    • (2013) Blood , vol.122 , pp. 3074-3081
    • Cutler, C.1    Multani, P.2    Robbins, D.3
  • 27
    • 84875956072 scopus 로고    scopus 로고
    • In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies
    • Farag SS, Srivastava S, Messina-Graham S, et al. In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies. Stem Cells Dev 2013; 22: 1007-1015.
    • (2013) Stem Cells Dev , vol.22 , pp. 1007-1015
    • Farag, S.S.1    Srivastava, S.2    Messina-Graham, S.3
  • 28
    • 43849087808 scopus 로고    scopus 로고
    • Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: A phase I/II clinical trial
    • de Lima M, McMannis J, Gee A, et al. Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: A phase I/II clinical trial. Bone Marrow Transplant 2008; 41: 771-778.
    • (2008) Bone Marrow Transplant , vol.41 , pp. 771-778
    • De Lima, M.1    McMannis, J.2    Gee, A.3
  • 29
    • 84903794165 scopus 로고    scopus 로고
    • Umbilical cord blood expansion with nicotinamide provides long-Term multilineage engraftment
    • Horwitz ME, Chao NJ, Rizzieri DA, et al. Umbilical cord blood expansion with nicotinamide provides long-Term multilineage engraftment. J Clin Invest 2014; 124: 3121-3128.
    • (2014) J Clin Invest , vol.124 , pp. 3121-3128
    • Horwitz, M.E.1    Chao, N.J.2    Rizzieri, D.A.3
  • 30
    • 47149088471 scopus 로고    scopus 로고
    • Cytokines regulating hematopoietic stem cell function
    • Zhang CC, Lodish HF. Cytokines regulating hematopoietic stem cell function. Curr Opin Hematol 2008; 15: 307-311.
    • (2008) Curr Opin Hematol , vol.15 , pp. 307-311
    • Zhang, C.C.1    Lodish, H.F.2
  • 31
    • 84874299202 scopus 로고    scopus 로고
    • Rapid and sustained engraftment of a single allogeneic ex-vivo expanded cord blood unit (CBU) after reduced intensity conditioning (RIC) in adults. Preliminary Results of a Prospective Trial
    • Abstract 486
    • Milpied N, Dazey B, Ivanovic Z, et al. Rapid and sustained engraftment of a single allogeneic ex-vivo expanded cord blood unit (CBU) after reduced intensity conditioning (RIC) in adults. Preliminary Results of a Prospective Trial. Blood (ASH Annual Meeting Abstracts) 2011, 118 (Abstract 486).
    • (2011) Blood (ASH Annual Meeting Abstracts) , pp. 118
    • Milpied, N.1    Dazey, B.2    Ivanovic, Z.3
  • 32
    • 80855164547 scopus 로고    scopus 로고
    • Clinical-scale cultures of cord blood CD34 (+) cells to amplify committed progenitors and maintain stem cell activity
    • Ivanovic Z, Duchez P, Chevaleyre J, et al. Clinical-scale cultures of cord blood CD34 (+) cells to amplify committed progenitors and maintain stem cell activity. Cell Transplant 2011; 20: 1453-1463.
    • (2011) Cell Transplant , vol.20 , pp. 1453-1463
    • Ivanovic, Z.1    Duchez, P.2    Chevaleyre, J.3
  • 33
    • 79953681887 scopus 로고    scopus 로고
    • Small-molecule regulators of human stem cell self-renewal
    • Bouchez LC, Boitano AE, de Lichtervelde L, et al. Small-molecule regulators of human stem cell self-renewal. Chembiochem 2011; 12: 854-857.
    • (2011) Chembiochem , vol.12 , pp. 854-857
    • Bouchez, L.C.1    Boitano, A.E.2    De Lichtervelde, L.3
  • 34
    • 84869162797 scopus 로고    scopus 로고
    • G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment
    • Chen X, Skutt-Kakaria K, Davison J, et al. G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment. Genes Dev 2012; 26: 2499-2511.
    • (2012) Genes Dev , vol.26 , pp. 2499-2511
    • Chen, X.1    Skutt-Kakaria, K.2    Davison, J.3
  • 35
    • 84904304099 scopus 로고    scopus 로고
    • Small molecule inhibitors in acute myeloid leukemia: From the bench to the clinic
    • Al-Hussaini M, DiPersio JF. Small molecule inhibitors in acute myeloid leukemia: From the bench to the clinic. Expert Rev Hematol 2014; 7: 439-464.
    • (2014) Expert Rev Hematol , vol.7 , pp. 439-464
    • Al-Hussaini, M.1    DiPersio, J.F.2
  • 36
    • 33746498580 scopus 로고    scopus 로고
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
    • Krivtsov AV, Twomey D, Feng Z, et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 2006; 442: 818-822.
    • (2006) Nature , vol.442 , pp. 818-822
    • Krivtsov, A.V.1    Twomey, D.2    Feng, Z.3
  • 37
    • 78751661556 scopus 로고    scopus 로고
    • Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
    • Notta F, Mullighan CG, Wang JC, et al. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature 2011; 469: 362-367.
    • (2011) Nature , vol.469 , pp. 362-367
    • Notta, F.1    Mullighan, C.G.2    Wang, J.C.3
  • 38
    • 78751644099 scopus 로고    scopus 로고
    • Genetic variegation of clonal architecture and propagating cells in leukaemia
    • Anderson K, Lutz C, van Delft FW, et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 2011; 469: 356-361.
    • (2011) Nature , vol.469 , pp. 356-361
    • Anderson, K.1    Lutz, C.2    Van Delft, F.W.3
  • 39
    • 84897954369 scopus 로고    scopus 로고
    • Identification of small molecules that support human leukemia stem cell activity ex vivo
    • Pabst C, Krosl J, Fares I, et al. Identification of small molecules that support human leukemia stem cell activity ex vivo. Nat Methods 2014; 11: 436-442.
    • (2014) Nat Methods , vol.11 , pp. 436-442
    • Pabst, C.1    Krosl, J.2    Fares, I.3
  • 40
    • 34250789303 scopus 로고    scopus 로고
    • Therapeutic implications of leukemia stem cell development
    • Stubbs MC, Armstrong SA. Therapeutic implications of leukemia stem cell development. Clin Cancer Res 2007; 13: 3439-3442.
    • (2007) Clin Cancer Res , vol.13 , pp. 3439-3442
    • Stubbs, M.C.1    Armstrong, S.A.2
  • 41
    • 84927583177 scopus 로고    scopus 로고
    • Stemistry: The control of stem cells in situ using chemistry
    • Davies SG, Kennewell PD, Russell AJ, et al. Stemistry: The control of stem cells in situ using chemistry. J Med Chem 2015; 28: 2863-2894.
    • (2015) J Med Chem , vol.28 , pp. 2863-2894
    • Davies, S.G.1    Kennewell, P.D.2    Russell, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.