Antimicrobial functionalization of bacterial nanocellulose by loading with polihexanide and povidone-iodine

Journal of Materials Science: Materials in Medicine

Volumn 26, Issue 10, 2015, Pages

  Wiegand, Cornelia ^a   Moritz, Sebastian ^b   Hessler, Nadine ^b   Kralisch, Dana ^b   Wesarg, Falko ^b   Müller, Frank A ^b   Fischer, Dagmar ^b   Hipler, Uta Christina ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOCOMPATIBILITY; BYPRODUCTS; CELLULOSE; COMPRESSIVE STRENGTH; ENZYME INHIBITION; MICROORGANISMS; TENSILE STRENGTH;

ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL FUNCTIONALIZATION; BACTERICIDAL ACTIVITY; BIOLOGICAL ASSAYS; COMPRESSIVE AND TENSILE STRENGTHS; HUMAN KERATINOCYTES; MECHANICAL CHARACTERISTICS; STAPHYLOCOCCUS AUREUS;

IODINE;

ANTIINFECTIVE AGENT; BACTERIAL NANOCELLULOSE; CELLULOSE; NANOPARTICLE; POLIHEXANIDE; POVIDONE IODINE; UNCLASSIFIED DRUG; BIGUANIDE DERIVATIVE; BIOMATERIAL; POLY(HEXAMETHYLENEBIGUANIDE); TOPICAL ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; BIOCOMPATIBILITY; COMPRESSIVE STRENGTH; CONTROLLED STUDY; DIFFUSION; DRUG EFFICACY; DRUG RELEASE; HUMAN; HUMAN CELL; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STAPHYLOCOCCUS AUREUS; TENSILE STRENGTH; WETTABILITY; WOUND DRESSING; ACETOBACTERACEAE; BANDAGE; BIOMECHANICS; CELL LINE; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; MATERIALS TESTING; METABOLISM; ULTRASTRUCTURE;

ACETOBACTERACEAE; ANTI-INFECTIVE AGENTS, LOCAL; BANDAGES; BIGUANIDES; BIOCOMPATIBLE MATERIALS; BIOMECHANICAL PHENOMENA; CELL LINE; CELLULOSE; HUMANS; MATERIALS TESTING; NANOPARTICLES; POVIDONE-IODINE; STAPHYLOCOCCUS AUREUS;

EID: 84942788408     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-015-5571-7     Document Type: Article

References (55)

1. Jonas R, Farah LF. Production and application of microbial cellulose. Poly Deg Stab. 1998;59:101–6.
2. Borzani W, De Souza SJ. Mechanism of the film thickness increasing during bacterial production of cellulose in non-agitated liquid media. Biotechnol Lett. 1995;17:1271–2.
3. El-Saied H, El-Diwany AI, Basta AH, Atwa NA, El-Ghwas DE. Production and characterization of economical bacterial cellulose. Bioresources. 2008;3:1196–217.
4. Czaja W, Krystynowicz A, Bielecki S, Brown RM Jr. Microbial cellulose—the natural power to heal wounds. Biomaterials. 2006;27:145–51.
5. Czaja W, Young DJ, Kawecki M, Brown RM Jr. The future prospects of microbial cellulose in biomedical applications. Biomacromol. 2007;8:1–12.
6. Fontana JD, DeSouza AM, Fontana CK, Torriani IL, Moreschi JC, Gallotti BJ, DeSouza SJ, Narcisco GP, Bichara JA, Farah LFX. Acetobacter cellulose pellicle as a temporary skin substitute. Appl Biochem Biotechnol. 1990;24–25:253–64.
7. Rebello C, Almeida DAD, Lima EM Jr, Dornelas MDP. Biofill a new skin substitute: our experience. Rev Bras Cir. 1987;77:407–14.
8. Warriner R, Burrel RE. Infection and the chronic wound: a focus on silver. Adv Skin Wound Care. 2005;18:2–12.
9. Wright JB, Lam K, Buret AG, Olson ME, Burrell RE. Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound Rep Reg. 2002;10:141–51.
10. Berndt S, Wesarg F, Wiegand C, Kralisch D, Müller F. Antimicrobial porous hybrids consisting of bacterial nanocellulose and silver nanoparticles. Cellulose. 2013;20:771–83.
11. Müller A, Ni Z, Hessler N, Wesarg F, Müller FA, Kralisch D, Fischer D. The biopolymer bacterial nanocellulose as drug delivery system: investigation of drug loading and release using the model protein albumin. J Pharm Sci. 2013;102:579–92.
12. Jipa IM, Stoica A, Stroescu M, Dobre LM, Dobre T, Jinga S, Tardei C. Potassium sorbate release from poly(vinyl alcohol)-bacterial cellulose films. Chem Pap. 2012;66:138–43.
13. Mori R, Nakai T, Enomoto K, Uchio Y, Yoshino K. Increased antibiotic release from a bone cement containing bacterial cellulose. Clin Orthop Relat Res. 2011;469:600–6.
14. Trovatti E, Silva NHCS, Duarte IF, Rosado CF, Almeida IF, Costa P, Freire CSR, Silvestre AJD, Pascoal NC. Biocellulose membranes as supports for dermal release of lidocaine. Biomacromol. 2011;12:4162–8.
15. Bodhibukkana C, Srichana T, Kaewnopparat S, Tangthong N, Bouking P, Martin GP, Suedee R. Composite membrane of bacterially-derived cellulose and molecularly imprinted polymer for use as a transdermal enantioselective controlled-release system of racemic propranolol. J Controlled, Release. 2006;113:43–56.
16. Yang G, Xie J, Hong F, Cao Z, Yang X. Antimicrobial activity of silver nanoparticle impregnated bacterial cellulose membrane: effect of fermentation carbon sources of bacterial cellulose. Carbohydr Polym. 2012;87:839–45.
17. Maneerung T, Tokura S, Rujiravanit R. Impregnation of silver nanoparticles into bacterial cellulose for antimicrobial wound dressing. Carbohydr Polym. 2008;72:43–51.
18. Wiegand C, Heinze T, Hipler UC. Comparative in vitro study on cytotoxicity, antimicrobial activity, and binding capacity for pathophysiological factors in chronic wounds of alginate and silver-containing alginate. Wound Rep Reg. 2009;17:511–21.
19. Ip M, Lui SL, Poon VKM, Lung I, Burd A. Antimicrobial activities of silver dressings: an in vitro comparison. J Med Microbiol. 2006;55:59–63.
20. Hidalgo E, Bartolome R, Barroso C, Moreno A, Dominguez C. Silver nitrate: antimicrobial activity related to cytotoxicity in cultured human fibroblasts. Skin Pharmacol Appl Skin Physiol. 1998;11:140–51.
21. Moritz S, Wiegand C, Wesarg F, Hessler N, Müller FA, Kralisch D, Hipler UC, Fischer D. Active wound dressings based on bacterial nanocellulose as drug delivery system for octenidine. Int J Pharm. 2014;471:45–55.
22. Wei B, Yang G, Hong F. Preparation and evaluation of a kind of bacterial cellulose dry films with antibacterial properties. Carbohydr Polym. 2011;84:533–8.
23. Zheng Y, Wu J, Peng S, Guo J, Yang H, Xi T, Fei H, He X, Liu X. Preparation of silver sulfadiazine/bacterial cellulose composite membranes as antibacterial wound dressing for controlling burn or scald wound infections. Beijing: University of Science and Technology Beijing; 2010. p. 12.
24. Kralisch D, Hessler N, Klemm D, Erdmann R, Schmidt W. White biotechnology for cellulose manufacturing-The HoLiR concept. Biotechnol Bioeng. 2009;105:740–7.
25. Niazi SN. Handbook of pharmaceutical manufacturing formulations liquid products. 2nd ed. Boca Raton: CRC Press; 2009.
26. Küsters M, Beyer S, Kutscher S, Schlesinger H, Gerhartz M. Rapid, simple and stability-indicating determination of polyhexamethylene biguanide in liquid and gel-like dosage forms by liquid chromatography with diode-array detection. J Pharmaceut Anal. 2013;3:408–14.
27. Ritger PL, Peppas NA. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Controlled Release. 1987;5:37–42.
28. Wiegand C, Hipler UC. Evaluation of biocompatibility and cytotoxicity using keratinocyte and fibroblast cultures. Skin Pharmacol Physiol. 2009;22:74–82.
29. Wiegand C, Abel M, Ruth P, Hipler UC. HaCaT keratinocytes in co-culture with Staphylococcus aureus can be protected from bacterial damage by polihexanide. Wound Rep Reg. 2009;17:730–8.
30. Amari H, Lari L, Zhang HY, Geelhaar L, Chèze C, Kappers MJ, McAleese C, Humphreys CJ, Walther T. Accurate calibration for the quantification of the Al content in AlGaN epitaxial layers by energy-dispersive X-ray spectroscopy in a transmission electron microscope. J Phys: Conf Ser. 2011;326:012028.
31. Chiaoprakobkij N, Sanchavanakit N, Subbalekha K, Pavasant P, Phisalaphong M. Characterization and biocompatibility of bacterial cellulose/alginate composite sponges with human keratinocytes and gingival fibroblasts. Carbohydr Polym. 2011;85:548–53.
32. Sanchavanakit N, Sangrungraungroj W, Kaomongkolgit R, Banaprasert T, Pavasant P, Phisalaphong M. Growth of human keratinocytes and fibroblasts on bacterial cellulose film. Biotechnol Prog. 2006;22:1194–9.
33. Reimer K, Wichelhaus TA, Schäfer V, Rudolph P, Kramer A, Wutzler P, Ganzer D, Fleischer W. Antimicrobial effectiveness of povidone-iodine and consequences for new applications. Dermatology. 2002;204(Suppl1):114–20.
34. Wiegand C, Abel M, Ruth P, Hipler UC. Analysis of the adaptation capacity of Staphylococcus aureus to commonly used antiseptics by microplate laser nephelometry. Skin Pharmacol Physiol. 2012;25:288–97.
35. Kunisada T, Yamada K, Oda S, Hara O. Investigation on the efficacy of povidone-iodine against antiseptic-resistant species. Dermatol. 1997;195(Suppl2):14–8.
36. Hirsch T, Jacobsen F, Rittig A, Goertz O, Niederbichler A, Steinau HG, Seipp HM, Steintraesser L. Vergleichende In-vitro-Studie zur Zytotoxizität klinisch eingesetzter Antiseptika. Hautarzt. 2009;60:984–91.
37. Daeschlein G, Assadian O, Bruck JC, Meinl C, Kramer A, Koch S. Feasibility and clinical applicability of polihexanide for treatment of second-degree burn wounds. Skin Pharmacol Physiol. 2007;20:292–6.
38. Wilhelms T, Schulze D, Alupeil C, Rohrer C, Abel M, Wiegand C, Hipler UC. Release of polyhexamethylene biguanide hydrochloride (PHMB) from a hydrobalanced cellulose wound dressing with PHMB. In: 17th Conference of the European Wound Management Association, Glasgow/UK; 2007.
39. Calabrese VT, Khan A. Polyiodine and polyiodide species in an aqueous solution of iodine + KI. Theoretical and experimental studies. J Phys Chem A. 2000;104:1287–92.
40. Gazda DB, Lipert RJ, Fritz JS, Porter MD. Investigation of the iodine-poly(vinylpyrrolidone) interaction employed in the determination of biocidal iodine by colorimetric solid-phase extraction. Anal Chim Acta. 2004;510:241–7.
41. Garg S, Jambu L, Vermani K. Development of novel sustained release bioadhesive vaginal tablets of povidone iodine. Drug Dev Ind Pharm. 2007;33:1340–9.
42. Silva NHCS, Rodrigues AF, Almeida IF, Costa PC, Rosado C, Neto CP, Silvestre AJD, Freire CSR. Bacterial cellulose membranes as transdermal delivery systems for diclofenac: in vitro dissolution and permeation studies. Carbohydr Polym. 2014;106:264–9.
43. Huang L, Chen X, Nguyen TX, Tang H, Zhang L, Yang G. Nano-cellulose 3D-networks as controlled-release drug carriers. J Mater Chem B. 2013;1:2976–84.
44. McDonnel G, Russel AD. Antiseptics and disinfectants: activity, action and resistance. Clin Microbiol Rev. 1999;12(1):147–79.
45. Müller G, Koburger T, Jethon FUW, Kramer A. Vergleich der bakterioziden Wirksamkeit und In-vitro-Zytotoxizität von Lavasept und Prontosan. GMS Krankenhaushyg Interdiszip. 2007;2(2):doc42.
46. Müller G, Kramer A. Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. J Antimic Chemther. 2008;61:1281–7.
47. Kramer A, Roth B, Müller G, Rudolph P, Klöcker N. Influence of the antiseptic agents polyhexanide and octenidine on FL Cells and on healing of experimental superficial aseptic wounds in piglets. Skin Pharmacol Physiol. 2004;17:141–6.
48. Wiegand C, Abel M, Kramer A, Müller G, Ruth P, Hipler UC. Proliferationsförderung und Biokompatibilität von Polihexanid. GMS Krankenhaushyg Interdiszip. 2007;2(2):doc43.
49. VantocilTM IB Antimicrobial. Technical information bulletin. Cheschire: Arch Chemicals Inc; 2005.
50. Bunting TG, Sackler RS, Centrone DA, Halpern A. Irradiation of poly(vinylpyrrolidone) and its iodine complex. DE3319019A1; 1983.
51. Barabas ES, Brittain HG. Povidone-Iodine. In: Harry GB, editor. Analytical profiles of drug substances and excipients. San Diego: Academic Press; 1998. p. 341–462.
52. Bühler V. Generic drug formulations. Ludwigshafen: BASF Fine Chemicals Generic Drug Formulations; 1998.
53. Wesarg F, Schlott F, Grabow J, Kurland HD, Hessler N, Kralisch D, Müller FA. In situ synthesis of photocatalytically active hybrids consisting of bacterial nanocellulose and anatase nanoparticles. Langmuir. 2012;28:13518–25.
54. Bäckdahl H, Helenius G, Bodin A, Nannmark U, Johansson BR, Risberg B, Gatenholm P. Mechanical properties of bacterial cellulose and interactions with smooth muscle cells. Biomaterials. 2006;27:2141–9.
55. de Paula GF, Netto GI, Mattoso LHC. Physical and chemical characterization of poly(hexamethylene biguanide) hydrochloride. Polymers. 2011;3:928–41.