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Volumn 2014, Issue 4, 2014, Pages

Nitazoxanide for chronic hepatitis C

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; NITAZOXANIDE; PEGINTERFERON; PEGINTERFERON ALPHA2A; PLACEBO; RIBAVIRIN; TELAPREVIR; ANTIVIRUS AGENT; THIAZOLE DERIVATIVE;

EID: 84942784552     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD009182.pub2     Document Type: Review
Times cited : (12)

References (138)
  • 1
    • 84878782433 scopus 로고    scopus 로고
    • A phase II, randomized, double-blind, placebo-controlled study of nitazoxanide plus peginterferon and ribavirin in naive patients with chronic hepatitis C genotype 1 infection: final report
    • Bacon B, Shiffman M, Lim J, Berman A, Rustgi V, Keeffe E. A phase II, randomized, double-blind, placebo-controlled study of nitazoxanide plus peginterferon and ribavirin in naive patients with chronic hepatitis C genotype 1 infection: final report. Gastroenterology 2010;139(1):e18.
    • (2010) Gastroenterology , vol.139 , Issue.1
    • Bacon, B.1    Shiffman, M.2    Lim, J.3    Berman, A.4    Rustgi, V.5    Keeffe, E.6
  • 2
    • 78650982889 scopus 로고    scopus 로고
    • Phase 2 randomized, double-blind, placebo-controlled study of nitazoxanide plus peginterferon and ribavirin in HCV genotype 1 naive patients: week 12 sustained virological response rate
    • Bacon B, Shiffman M, Lim J, Berman A, Rustgi V, Keeffe E. Phase 2 randomized, double-blind, placebo-controlled study of nitazoxanide plus peginterferon and ribavirin in HCV genotype 1 naive patients: week 12 sustained virological response rate. Journal of Hepatology 2010;52(Suppl 1):S3.
    • (2010) Journal of Hepatology , vol.52
    • Bacon, B.1    Shiffman, M.2    Lim, J.3    Berman, A.4    Rustgi, V.5    Keeffe, E.6
  • 3
    • 67650553098 scopus 로고    scopus 로고
    • Phase 2 randomized, double-blind, placebo-controlled study of nitazoxanide plus peginterferon and ribavirin in HCV genotype 1 patients: interim analysis shows increase in EVR
    • Bacon B, Shiffman M, Lim J, Berman A, Rustgi V, Keeffe E. Phase 2 randomized, double-blind, placebo-controlled study of nitazoxanide plus peginterferon and ribavirin in HCV genotype 1 patients: interim analysis shows increase in EVR. Journal of Hepatology 2009;50(Suppl 1):S381.
    • (2009) Journal of Hepatology , vol.50
    • Bacon, B.1    Shiffman, M.2    Lim, J.3    Berman, A.4    Rustgi, V.5    Keeffe, E.6
  • 4
    • 85041539064 scopus 로고    scopus 로고
    • Combined thiazolide nitazoxanide plus PEG-IFN Alfa-2a/ribavirin improved viral response in HCV genotype 1: presented at EASL 2010
    • (accessed 4.04.2014)
    • Berrie C. Combined thiazolide nitazoxanide plus PEG-IFN Alfa-2a/ribavirin improved viral response in HCV genotype 1: presented at EASL 2010. http://www.firstwordpharma.com/node/604408?tsid=17#axzz2y2MTgiDa (accessed 4.04.2014).
    • Berrie, C.1
  • 5
    • 85041516594 scopus 로고    scopus 로고
    • Study of nitazoxanide, peginterferon alfa-2a and ribavirin in treatment-naive hepatitis C patients (STEALTH-3)
    • (accessed 24 January 2014)
    • NCT00637923. Study of nitazoxanide, peginterferon alfa-2a and ribavirin in treatment-naive hepatitis C patients (STEALTH-3). http://clinicaltrials.gov/show/NCT00637923 (accessed 24 January 2014).
  • 6
    • 85041532570 scopus 로고    scopus 로고
    • Pegylated interferon alfa, nitazoxanide, telapravir, ribavirin, in genotype 1 undergoing prior experienced chronic hepatitis C patients-a randomized placebo control clinical pilot trial (INTRIGUE C) interim
    • 22nd Conference of the Asian Pacific Association for the Study of the Liver, APASL 2012 Taipei Taiwan:. [CRS-ID: 6800100000029745]
    • Basu P, Nair T, Farhat S, Ang L, Jafri M, Mittimani K, et al.Pegylated interferon alfa, nitazoxanide, telapravir, ribavirin, in genotype 1 undergoing prior experienced chronic hepatitis C patients-a randomized placebo control clinical pilot trial (INTRIGUE C) interim. Hepatology International 2012; Vol. 22nd Conference of the Asian Pacific Association for the Study of the Liver, APASL 2012 Taipei Taiwan:64. [CRS-ID: 6800100000029745].
    • (2012) Hepatology International , pp. 64
    • Basu, P.1    Nair, T.2    Farhat, S.3    Ang, L.4    Jafri, M.5    Mittimani, K.6
  • 7
    • 85041511701 scopus 로고    scopus 로고
    • Peg-interferon alfa, nitazoxanide, telapravir, ribaverin, in genotype 1 in treatment experienced chronic hepatitis C patients - a randomized control pilot trial
    • CRS-ID: 6800100000029736]
    • Basu P, Nair T, Farhat S, Ang L, Mittimani K, Shah NJ, et al.Peg-interferon alfa, nitazoxanide, telapravir, ribaverin, in genotype 1 in treatment experienced chronic hepatitis C patients - a randomized control pilot trial. Journal of Gastroenterology and Hepatology 2012; Vol. 27, issue S5:207. [CRS-ID: 6800100000029736].
    • (2012) Journal of Gastroenterology and Hepatology , vol.27 , pp. 207
    • Basu, P.1    Nair, T.2    Farhat, S.3    Ang, L.4    Mittimani, K.5    Shah, N.J.6
  • 8
    • 85041530298 scopus 로고    scopus 로고
    • Pegylated interferon alfa, nitazoxanide, telaprevir, ribavirin, in genotype 1 undergoing prior experienced chronic hepatitis C patients - a randomized placebo control clinical pilot trial (intrigue-C)
    • CRS-ID: 6800100000029740]
    • Basu P, Shah N, Farhat S, Siriki R, Rahman M, Lynn A, et al.Pegylated interferon alfa, nitazoxanide, telaprevir, ribavirin, in genotype 1 undergoing prior experienced chronic hepatitis C patients - a randomized placebo control clinical pilot trial (intrigue-C). American Journal of Gastroenterology 2012; Vol. 107, issue S1:S154. [CRS-ID: 6800100000029740].
    • (2012) American Journal of Gastroenterology , vol.107
    • Basu, P.1    Shah, N.2    Farhat, S.3    Siriki, R.4    Rahman, M.5    Lynn, A.6
  • 9
    • 85041530298 scopus 로고    scopus 로고
    • Pegylated interferon alfa, nitazoxanide, telaprevir, ribavirin, in genotype 1 undergoing prior experienced chronic hepatitis C patients - a randomized placebo control clinical pilot trial (INTRIGUE-C) Interim
    • [CRS-ID: 6800100000029788]
    • Basu P, Shah N, Farhat S, Siriki R, Rahman MD, Lynn A, et al.Pegylated interferon alfa, nitazoxanide, telaprevir, ribavirin, in genotype 1 undergoing prior experienced chronic hepatitis C patients - a randomized placebo control clinical pilot trial (INTRIGUE-C) Interim. American Journal of Gastroenterology 2012; Vol. 142, issue 5:S932. [CRS-ID: 6800100000029788].
    • (2012) American Journal of Gastroenterology , vol.142 , Issue.5 , pp. S932
    • Basu, P.1    Shah, N.2    Farhat, S.3    Siriki, R.4    Rahman, M.D.5    Lynn, A.6
  • 10
    • 85041512146 scopus 로고    scopus 로고
    • Controlled release nitazoxanide in combination with peginterferon alfa-2a plus ribavirin results in high early virologic response rates for treatment of chronic hepatitis C genotype 4
    • Keeffe EB, Elfert A, Abousaif S, Rossignol J. Controlled release nitazoxanide in combination with peginterferon alfa-2a plus ribavirin results in high early virologic response rates for treatment of chronic hepatitis C genotype 4. Hepatology 2009; Vol. 50, issue 4 (Suppl):1038A.
    • (2009) Hepatology , vol.50 , Issue.4
    • Keeffe, E.B.1    Elfert, A.2    Abousaif, S.3    Rossignol, J.4
  • 11
    • 84859048423 scopus 로고    scopus 로고
    • Dose-related increase in virologic responses using controlled release nitazoxanide plus peginterferon alfa-2A and ribavirin for treatment of chronic hepatitis C genotype 4: final report
    • Keeffe EB, Elfert AA, Abousaif SA. Dose-related increase in virologic responses using controlled release nitazoxanide plus peginterferon alfa-2A and ribavirin for treatment of chronic hepatitis C genotype 4: final report. Journal of Hepatology 2011;54(Suppl 1):S479-80.
    • (2011) Journal of Hepatology , vol.54 , pp. S479-S480
    • Keeffe, E.B.1    Elfert, A.A.2    Abousaif, S.A.3
  • 13
    • 48449084880 scopus 로고    scopus 로고
    • Clinical trial: randomized, double-blind, placebo-controlled study of nitazoxanide monotherapy for the treatment of patients with chronic hepatitis C genotype 4
    • Rossignol JF, Kabil SM, El-Gohary Y, Keeffe EB. Clinical trial: randomized, double-blind, placebo-controlled study of nitazoxanide monotherapy for the treatment of patients with chronic hepatitis C genotype 4. Alimentary Pharmacology & Therapeutics 2008; Vol. 28:574-80.
    • (2008) Alimentary Pharmacology & Therapeutics , vol.28 , pp. 574-580
    • Rossignol, J.F.1    Kabil, S.M.2    El-Gohary, Y.3    Keeffe, E.B.4
  • 14
    • 48449083564 scopus 로고    scopus 로고
    • Randomized double blind placebo-controlled trial of nitazoxanide in the treatment of patients with chronic hepatitis C genotype 4 [abstract]
    • Rossignol JF, Kabil SM, El-Gohary Y, Keeffe EB. Randomized double blind placebo-controlled trial of nitazoxanide in the treatment of patients with chronic hepatitis C genotype 4 [abstract]. Journal of Hepatology 2008;48(Suppl 2):S311-2.
    • (2008) Journal of Hepatology , vol.48
    • Rossignol, J.F.1    Kabil, S.M.2    El-Gohary, Y.3    Keeffe, E.B.4
  • 15
    • 60449108708 scopus 로고    scopus 로고
    • Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin
    • Rossignol JF, Elfert A, El-Gohary Y, Keeffe EB. Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin. Gastroenterology 2009;136(3):856-62.
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 856-862
    • Rossignol, J.F.1    Elfert, A.2    El-Gohary, Y.3    Keeffe, E.B.4
  • 16
    • 48449096340 scopus 로고    scopus 로고
    • Randomized controlled trial of nitazoxanide-peginterferonribavirin, nitazoxanide-peginterferon and peginterferon-ribavirin in the treatment of patients with chronic hepatitis C genotype 4
    • Rossignol JF, Elfert A, El-Gohary Y, Keeffe EB. Randomized controlled trial of nitazoxanide-peginterferonribavirin, nitazoxanide-peginterferon and peginterferon-ribavirin in the treatment of patients with chronic hepatitis C genotype 4. Journal of Hepatology 2008;48(Suppl 2):S30.
    • (2008) Journal of Hepatology , vol.48
    • Rossignol, J.F.1    Elfert, A.2    El-Gohary, Y.3    Keeffe, E.B.4
  • 17
    • 41749115080 scopus 로고    scopus 로고
    • Interim data from a randomized controlled trial of nitazoxanide-peginterferon-ribavirin, nitazoxanide-peginterferon and peginterferon-ribavirin in the treatment of patients with chronic hepatitis C genotype 4
    • Rossignol JF, Elfert A, El-Gohary Y, Keeffe EB, Glenn J. Interim data from a randomized controlled trial of nitazoxanide-peginterferon-ribavirin, nitazoxanide-peginterferon and peginterferon-ribavirin in the treatment of patients with chronic hepatitis C genotype 4. Hepatology 2007;46(4 Suppl 1):316A-317A.
    • (2007) Hepatology , vol.46 , Issue.4 , pp. 316A-317A
    • Rossignol, J.F.1    Elfert, A.2    El-Gohary, Y.3    Keeffe, E.B.4    Glenn, J.5
  • 18
    • 85041496264 scopus 로고    scopus 로고
    • Efficacy of nitazoxanide in the treatment of chronic hepatitis C virus (HCV)
    • (accessed 24 January 2014). [: NCT01276756]
    • NCT01276756. Efficacy of nitazoxanide in the treatment of chronic hepatitis C virus (HCV). http://clinicaltrials.gov/ct2/show/NCT01276756?term=Efficacy+of+nitazoxanide+in+the+treatment+of+chronic+hepatitis+C+virus+%28HCV%29&rank=1 (accessed 24 January 2014). [: NCT01276756].
  • 19
    • 85041506681 scopus 로고    scopus 로고
    • Efficiacy of nitazoxanide in the treatment of chronic hepatitis C virus (HCV)
    • 28.11.2012
    • Shehab H [pers comm]. Efficiacy of nitazoxanide in the treatment of chronic hepatitis C virus (HCV). By email 28.11.2012.
    • By email
    • Shehab, H.C.1
  • 20
    • 85041518263 scopus 로고    scopus 로고
    • The addition of nitazoxanide to pegylated interferon and ribavirin does not improve SVR rates in chronic HCV genotype 4
    • Shehab H, Elbaz T, Draz D. The addition of nitazoxanide to pegylated interferon and ribavirin does not improve SVR rates in chronic HCV genotype 4. Journal of Hepatology 2013; Vol. 58, issue Suppl 1:495.
    • (2013) Journal of Hepatology , vol.58 , pp. 495
    • Shehab, H.1    Elbaz, T.2    Draz, D.3
  • 21
    • 85041503412 scopus 로고    scopus 로고
    • Study of nitazoxanide, peginterferon alfa-2a and ribavirin for the treatment of hepatitis c (STEALTH-2)
    • (accessed 24 January 2014)
    • NCT00495391. Study of nitazoxanide, peginterferon alfa-2a and ribavirin for the treatment of hepatitis c (STEALTH-2). http://clinicaltrials.gov/ct2/show/NCT00495391?term=NCT00495391&rank=1 (accessed 24 January 2014).
  • 22
    • 67650559106 scopus 로고    scopus 로고
    • Phase 2 randomized, double-blind, placebo-controlled study of nitazoxanide with peginterferon alfa-2A and ribavirin in nonresponders (NR) with chronic HCV genotype 1: week 28 interim analysis
    • Shiffman M, Ahmed A, Jacobson I, Pruitt R, Keeffe E. Phase 2 randomized, double-blind, placebo-controlled study of nitazoxanide with peginterferon alfa-2A and ribavirin in nonresponders (NR) with chronic HCV genotype 1: week 28 interim analysis. Journal of Hepatology 2009; Vol. 50, issue Suppl 1:S385.
    • (2009) Journal of Hepatology , vol.50 , pp. S385
    • Shiffman, M.1    Ahmed, A.2    Jacobson, I.3    Pruitt, R.4    Keeffe, E.5
  • 23
    • 77958190293 scopus 로고    scopus 로고
    • Phase 2 randomized, double-blind, placebo-controlled study of nitazoxanide with peginterferon alfa-2a and ribavirin in nonresponders (NR) with chronic hepatitis C genotype 1: final report
    • Shiffman ML, Ahmed A, Jacobson IM, Pruitt RE, Keeffe EB. Phase 2 randomized, double-blind, placebo-controlled study of nitazoxanide with peginterferon alfa-2a and ribavirin in nonresponders (NR) with chronic hepatitis C genotype 1: final report. Journal of Hepatology 2010;52(Suppl 1):S459-S71.
    • (2010) Journal of Hepatology , vol.52 , pp. S459-SS71
    • Shiffman, M.L.1    Ahmed, A.2    Jacobson, I.M.3    Pruitt, R.E.4    Keeffe, E.B.5
  • 24
    • 85041550654 scopus 로고    scopus 로고
    • Nitazoxanide for the prevention of recurrent hepatitis C virus infection after liver transplantation: A pilot study
    • Asrani SK, Anderson S, Wilson J, Myhre LJ, Heimbach J, Kremes WK, et al.Nitazoxanide for the prevention of recurrent hepatitis C virus infection after liver transplantation: A pilot study. Hepatology 2010;52(S1):874A.
    • (2010) Hepatology , vol.52 , pp. 874A
    • Asrani, S.K.1    Anderson, S.2    Wilson, J.3    Myhre, L.J.4    Heimbach, J.5    Kremes, W.K.6
  • 25
    • 85041532427 scopus 로고    scopus 로고
    • Effects of high dose ribavirin (RBV), alinia (nitazoxanide) and pegylated Interferon (peg) alfa-2a in attaining sustained viral response (SVR) in treatment of chronic hepatitis C (ERAIS-C Trial) - interim results in naive genotype 1 patients
    • CRS-ID: 6800100000029790]
    • Basu P, Rayapudi K, Shah NJ, Krishnaswamy N, Pacana T, Khemani J, et al.Effects of high dose ribavirin (RBV), alinia (nitazoxanide) and pegylated Interferon (peg) alfa-2a in attaining sustained viral response (SVR) in treatment of chronic hepatitis C (ERAIS-C Trial) - interim results in naive genotype 1 patients. Hepatology 2009; Vol. 50, issue 4:730A-1A. [CRS-ID: 6800100000029790].
    • (2009) Hepatology , vol.50 , Issue.4 , pp. 730A-731A
    • Basu, P.1    Rayapudi, K.2    Shah, N.J.3    Krishnaswamy, N.4    Pacana, T.5    Khemani, J.6
  • 26
    • 85041492519 scopus 로고    scopus 로고
    • Effect of high-dose ribavirin (RBV), alinia (nitazoxanide) and pegylated Interferon (pegifn) alfa-2a in attaining sustained virologic response (SVR) in treatment of chronic hepatitis C
    • [CRS-ID: 6800100000029779]
    • Basu P, Rayapudi K, Shah NJ, Pacana T, Krishnaswamy N, Brown R. Effect of high-dose ribavirin (RBV), alinia (nitazoxanide) and pegylated Interferon (pegifn) alfa-2a in attaining sustained virologic response (SVR) in treatment of chronic hepatitis C. Journal of Hepatology 2010; Vol. 52, issue S1:S102. [CRS-ID: 6800100000029779].
    • (2010) Journal of Hepatology , vol.52 , pp. S102
    • Basu, P.1    Rayapudi, K.2    Shah, N.J.3    Pacana, T.4    Krishnaswamy, N.5    Brown, R.6
  • 27
    • 85041531074 scopus 로고    scopus 로고
    • Effects of high dose ribavirin, alinia (R) (nitazoxanide) and pegylated interferon alfa-2a in attaining sustained viral response in treatment of chronic hepatitis C (ERAIS-C Trial) - interim results in naive genotype 1 patients
    • Basu PP, Rayapudi K, Pacana T, Shah NJ, Brown R. Effects of high dose ribavirin, alinia (R) (nitazoxanide) and pegylated interferon alfa-2a in attaining sustained viral response in treatment of chronic hepatitis C (ERAIS-C Trial) - interim results in naive genotype 1 patients. American Journal of Gastroenterology 2009;104(Suppl 3):S125.
    • (2009) American Journal of Gastroenterology , vol.104 , pp. S125
    • Basu, P.P.1    Rayapudi, K.2    Pacana, T.3    Shah, N.J.4    Brown, R.5
  • 28
    • 85041505760 scopus 로고    scopus 로고
    • Effect of high-dose ribavirin (RBV), alinia (nitazoxanide) and pegylated interferon (pegIFN) alfa-2a in attaining sustained virologic response (SVR) in treatment of chronic hepatitis C (ERAIS-C Trial) in naïve genotype 1 patients
    • Basu PP, Rayapudi K, Pacana T, Shah NJ, Krishnaswamy N, Brown RS. Effect of high-dose ribavirin (RBV), alinia (nitazoxanide) and pegylated interferon (pegIFN) alfa-2a in attaining sustained virologic response (SVR) in treatment of chronic hepatitis C (ERAIS-C Trial) in naïve genotype 1 patients. International Journal of Infectuous Diseases 2010;14(S2):S1-S2.
    • (2010) International Journal of Infectuous Diseases , vol.14 , pp. S1-S2
    • Basu, P.P.1    Rayapudi, K.2    Pacana, T.3    Shah, N.J.4    Krishnaswamy, N.5    Brown, R.S.6
  • 29
    • 85041543089 scopus 로고    scopus 로고
    • Effects of high-dose ribavirin (RBV), alinia (nitazoxanide) and pegylated interferon (pegIFN) alfa-2a in attaining sustained virological response (SVR) in treatment of chronic hepatitis C (ERAIS-C trial) in naive genotype 1 patients
    • Basu PP, Rayapudi K, Pacana T, Shah NJ, Krishnaswamy N, Brown RS. Effects of high-dose ribavirin (RBV), alinia (nitazoxanide) and pegylated interferon (pegIFN) alfa-2a in attaining sustained virological response (SVR) in treatment of chronic hepatitis C (ERAIS-C trial) in naive genotype 1 patients. Gastroenteology 2010;138(5):S-218.
    • (2010) Gastroenteology , vol.138 , Issue.5
    • Basu, P.P.1    Rayapudi, K.2    Pacana, T.3    Shah, N.J.4    Krishnaswamy, N.5    Brown, R.S.6
  • 30
    • 78650852334 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 4 therapy: progress and challenges
    • Kamal SM. Hepatitis C virus genotype 4 therapy: progress and challenges. Liver International 2011; Vol. 31, issue Suppl 1:45-52.
    • (2011) Liver International , vol.31 , pp. 45-52
    • Kamal, S.M.1
  • 31
    • 77958105927 scopus 로고    scopus 로고
    • New antiviral therapies for chronic hepatitis C
    • Kanda T, Imazeki F, Yokosuka O. New antiviral therapies for chronic hepatitis C. Hepatology International 2010; Vol. 4, issue 3:548-61.
    • (2010) Hepatology International , vol.4 , Issue.3 , pp. 548-561
    • Kanda, T.1    Imazeki, F.2    Yokosuka, O.3
  • 32
    • 36148961976 scopus 로고    scopus 로고
    • Future treatment of chronic hepatitis C
    • Keeffe EB. Future treatment of chronic hepatitis C. Antiviral Therapy 2007; Vol. 12, issue 7:1015-25.
    • (2007) Antiviral Therapy , vol.12 , Issue.7 , pp. 1015-1025
    • Keeffe, E.B.1
  • 33
    • 85041546775 scopus 로고    scopus 로고
    • Controlled release tablet improves pharmacokinetics, viral kinetics and tolerability of nitazoxanide for treatment of chronic hepatitis C. 19th Conference of the Asian Pacific Association for the Study of the Liver, Hong Kong, China
    • Keeffe EB, Rossignol JF, Elfert A, Abdelatif S, Cravens L, Phuong TLT. Controlled release tablet improves pharmacokinetics, viral kinetics and tolerability of nitazoxanide for treatment of chronic hepatitis C. 19th Conference of the Asian Pacific Association for the Study of the Liver, Hong Kong, China. Hepatology International 2009;3:34-69.
    • (2009) Hepatology International , vol.3 , pp. 34-69
    • Keeffe, E.B.1    Rossignol, J.F.2    Elfert, A.3    Abdelatif, S.4    Cravens, L.5    Phuong, T.L.T.6
  • 34
    • 77954579144 scopus 로고    scopus 로고
    • Current research on nitazoxanide in the treatment of chronic hepatitis C
    • Keeffe EB. Current research on nitazoxanide in the treatment of chronic hepatitis C. Gastroenterology and Hepatology 2009; Vol. 5, issue 9:620-2.
    • (2009) Gastroenterology and Hepatology , vol.5 , Issue.9 , pp. 620-622
    • Keeffe, E.B.1
  • 35
    • 67650558979 scopus 로고    scopus 로고
    • Nitazoxanide for the treatment of chronic hepatitis C New opportunities but new challenges?
    • Mederacke I, Wedemeyer H. Nitazoxanide for the treatment of chronic hepatitis C New opportunities but new challenges?. Annals of Hepatology 2009; Vol. 8, issue 2:166-8.
    • (2009) Annals of Hepatology , vol.8 , Issue.2 , pp. 166-168
    • Mederacke, I.1    Wedemeyer, H.2
  • 36
    • 70449567127 scopus 로고    scopus 로고
    • New perspectives in treatment of chronic hepatitis C
    • [Nowe mozliwosci leczenia przewleklych zakazen HCV]
    • Parfieniuk A, Flisiak R. New perspectives in treatment of chronic hepatitis C [Nowe mozliwosci leczenia przewleklych zakazen HCV]. Gastroenterologia Polska 2009; Vol. 16, issue 4:329-32.
    • (2009) Gastroenterologia Polska , vol.16 , Issue.4 , pp. 329-332
    • Parfieniuk, A.1    Flisiak, R.2
  • 37
    • 54149103861 scopus 로고    scopus 로고
    • Emerging therapies for chronic hepatitis C virus
    • Pockros PJ. Emerging therapies for chronic hepatitis C virus. Gastroenterology and Hepatology 2008; Vol. 4, issue 10:729-34.
    • (2008) Gastroenterology and Hepatology , vol.4 , Issue.10 , pp. 729-734
    • Pockros, P.J.1
  • 39
    • 77955678507 scopus 로고    scopus 로고
    • Emerging therapy for chronic hepatitis C: Highlights from the 59th Annual Meeting of the American Association for the Study of Liver Diseases, 31 October-4 November 2008, San Francisco, CA
    • Pockros PJ. Emerging therapy for chronic hepatitis C: Highlights from the 59th Annual Meeting of the American Association for the Study of Liver Diseases, 31 October-4 November 2008, San Francisco, CA. Reviews in Gastroenterological Disorders. 2009; Vol. 9, issue 1:27-34.
    • (2009) Reviews in Gastroenterological Disorders , vol.9 , Issue.1 , pp. 27-34
    • Pockros, P.J.1
  • 40
    • 55449122030 scopus 로고    scopus 로고
    • Thiazolides: a new class of drugs for the treatment of chronic hepatitis B and C
    • CRS-ID: 6800100000028352; JC--NLM: Journal ID:101278120]
    • Rossignol JF, Keeffe EB. Thiazolides: a new class of drugs for the treatment of chronic hepatitis B and C. Future Microbiology 2008; Vol. 3, issue 5:539-45. [CRS-ID: 6800100000028352; JC--NLM: Journal ID:101278120].
    • (2008) Future Microbiology , vol.3 , Issue.5 , pp. 539-545
    • Rossignol, J.F.1    Keeffe, E.B.2
  • 41
    • 55649090726 scopus 로고    scopus 로고
    • Evaluation of a 4 week lead-in phase with nitazoxanide (NTZ) prior to peginterferon (pegifn) plus NTZ for treatment of chronic hepatitis C: final report
    • CRS-ID: 6800100000029791]
    • Rossignol JF, Elfert A, Keeffe EB. Evaluation of a 4 week lead-in phase with nitazoxanide (NTZ) prior to peginterferon (pegifn) plus NTZ for treatment of chronic hepatitis C: final report. Hepatology 2008; Vol. 48, issue 4:1132A-1133A. [CRS-ID: 6800100000029791].
    • (2008) Hepatology , vol.48 , Issue.4 , pp. 1132A-1133A
    • Rossignol, J.F.1    Elfert, A.2    Keeffe, E.B.3
  • 42
    • 77955146829 scopus 로고    scopus 로고
    • Evaluation of a 4-week lead-in with nitazoxanide (NTZ) prior to peginterferon (PegIFN) plus NTZ for treatment of chronic hepatitis C
    • [PUBMED: 20048684]
    • Rossignol JF, Elfert A, Keeffe EB. Evaluation of a 4-week lead-in with nitazoxanide (NTZ) prior to peginterferon (PegIFN) plus NTZ for treatment of chronic hepatitis C. Journal of Clinical Gastroenterology 2010; Vol. 44, issue 7:504-9. [DOI:; PUBMED: 20048684].
    • (2010) Journal of Clinical Gastroenterology , vol.44 , Issue.7 , pp. 504-509
    • Rossignol, J.F.1    Elfert, A.2    Keeffe, E.B.3
  • 43
    • 55649090726 scopus 로고    scopus 로고
    • Evaluation of a 4-week lead-in with nitazoxanide (NTZ) prior to peginterferon (PegIFN) plus NTZ for treatment of chronic hepatitis C: final report
    • Rossignol JF, Elfert A, Keeffe EB. Evaluation of a 4-week lead-in with nitazoxanide (NTZ) prior to peginterferon (PegIFN) plus NTZ for treatment of chronic hepatitis C: final report. Hepatology 2008; Vol. 48, issue Suppl:1132A-3A.
    • (2008) Hepatology , vol.48 , pp. 1132A-1133A
    • Rossignol, J.F.1    Elfert, A.2    Keeffe, E.B.3
  • 44
    • 85041496876 scopus 로고    scopus 로고
    • Interim results: single center pilot efficacy study of nitazoxanide plus pegylated alpha-2a interferon and ribavirin in prior genotype 1 nonresponders with HCV induced cirrhosis
    • Yoffe B, Gasitashvili K, Khaoustov V. Interim results: single center pilot efficacy study of nitazoxanide plus pegylated alpha-2a interferon and ribavirin in prior genotype 1 nonresponders with HCV induced cirrhosis. Journal of Hepatology 2009;50(Suppl 1):S353.
    • (2009) Journal of Hepatology , vol.50 , pp. S353
    • Yoffe, B.1    Gasitashvili, K.2    Khaoustov, V.3
  • 45
    • 77249108100 scopus 로고    scopus 로고
    • Pilot study of lead-in nitazoxanide plus pegylated alpha-2a interferon and ribavirin in HCV-genotype 1 nonresponders with cirrhosis: Interim results
    • Yoffe B, Gasitashvili K, Khaoustov V. Pilot study of lead-in nitazoxanide plus pegylated alpha-2a interferon and ribavirin in HCV-genotype 1 nonresponders with cirrhosis: Interim results. Hepatology 2009;50(S4):1034A.
    • (2009) Hepatology , vol.50
    • Yoffe, B.1    Gasitashvili, K.2    Khaoustov, V.3
  • 46
    • 85041541693 scopus 로고    scopus 로고
    • Impact of nitazoxanide on early virologic response (EVR) in Egyptian patients with chronic hepatitis C genotype 4: a double blind placebo-controlled trial
    • CRS-ID: 6800100000029739]
    • Kohla M, EL-Said H, El-Fert AY, Ehsan N, Ezzat S, Taha HA. Impact of nitazoxanide on early virologic response (EVR) in Egyptian patients with chronic hepatitis C genotype 4: a double blind placebo-controlled trial. Hepatology 2012; Vol. 56, issue S1:583A. [CRS-ID: 6800100000029739].
    • (2012) Hepatology , vol.56
    • Kohla, M.1    EL-Said, H.2    El-Fert, A.Y.3    Ehsan, N.4    Ezzat, S.5    Taha, H.A.6
  • 47
    • 85041510270 scopus 로고    scopus 로고
    • Impact of nitazoxanide on rapid virologic response in patients with chronic hepatitis C genotype 4: a double blind placebo-controlled trial
    • CRS-ID: 6800100000029735]
    • Kohla M, El-Said H, El-Fert A, Ehsan N, Ezzat S, Taha H. Impact of nitazoxanide on rapid virologic response in patients with chronic hepatitis C genotype 4: a double blind placebo-controlled trial. Journal of Gastroenterology and Hepatology 2012; Vol. 27, issue S5:236. [CRS-ID: 6800100000029735].
    • (2012) Journal of Gastroenterology and Hepatology , vol.27 , pp. 236
    • Kohla, M.1    El-Said, H.2    El-Fert, A.3    Ehsan, N.4    Ezzat, S.5    Taha, H.6
  • 48
    • 85041495658 scopus 로고    scopus 로고
    • Study of the impact of nitazoxanide on chronic hepatitis patients
    • (accessed 24 January 2014)
    • NCT01197157. Study of the impact of nitazoxanide on chronic hepatitis patients. http://clinicaltrials.gov/ct2/show/NCT01197157?term=NCT01197157&rank=1 (accessed 24 January 2014).
  • 49
    • 84921702413 scopus 로고    scopus 로고
    • Interaction revisited: the difference between two estimates
    • Altman D, Bland M. Interaction revisited: the difference between two estimates. BMJ (Clinical Research Ed.) 2003;326:219.
    • (2003) BMJ (Clinical Research Ed.) , vol.326 , pp. 219
    • Altman, D.1    Bland, M.2
  • 50
    • 84857683435 scopus 로고    scopus 로고
    • Current status and future directions in the management of chronic hepatitis C
    • Aman W, Mousa S, Shiha G, Mousa SA. Current status and future directions in the management of chronic hepatitis C. Virology Journal 2012;9:57.
    • (2012) Virology Journal , vol.9 , pp. 57
    • Aman, W.1    Mousa, S.2    Shiha, G.3    Mousa, S.A.4
  • 53
    • 45949100256 scopus 로고    scopus 로고
    • Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
    • Brok J, Thorlund K, Gluud C, Wetterslev J. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. Journal of Clinical Epidemiology 2008;61(8):763-9.
    • (2008) Journal of Clinical Epidemiology , vol.61 , Issue.8 , pp. 763-769
    • Brok, J.1    Thorlund, K.2    Gluud, C.3    Wetterslev, J.4
  • 56
    • 0033756370 scopus 로고    scopus 로고
    • Interferon therapy reduces the risk for hepatocellular carcinoma
    • Bown JL. Interferon therapy reduces the risk for hepatocellular carcinoma. Gut 2000;47:610-611. [DOI:].
    • (2000) Gut , vol.47 , pp. 610-611
    • Bown, J.L.1
  • 57
    • 0033919083 scopus 로고    scopus 로고
    • Adverse effects and other safety aspects of the hepatitis C antivirals
    • Chutaputti A. Adverse effects and other safety aspects of the hepatitis C antivirals. Journal of Gastroenterology and Hepatology 2000;15(Suppl E):156-63. [PUBMED: 10921400].
    • (2000) Journal of Gastroenterology and Hepatology , vol.15 , pp. 156-163
    • Chutaputti, A.1
  • 58
    • 85041542514 scopus 로고    scopus 로고
    • TSA - Trial Sequential Analysis
    • 2011 (accessed 4 September 2013)
    • Copenhagen Trial Unit. TSA - Trial Sequential Analysis. ctu.dk/tsa/ 2011 (accessed 4 September 2013).
    • ctu.dk/tsa/
  • 59
    • 0033373404 scopus 로고    scopus 로고
    • Hepatitis C virus genotypes and quasi species
    • Davis GL. Hepatitis C virus genotypes and quasi species. American Journal of Medicine 1999;107(6B):21S-26S.
    • (1999) American Journal of Medicine , vol.107 , Issue.6 , pp. 21S-26S
    • Davis, G.L.1
  • 60
    • 0023280282 scopus 로고
    • Methods of combining randomized clinical trials: strengths and limitations
    • DeMets DL. Methods of combining randomized clinical trials: strengths and limitations. Statistics in Medicine 1987;6(3):341-50.
    • (1987) Statistics in Medicine , vol.6 , Issue.3 , pp. 341-350
    • DeMets, D.L.1
  • 63
    • 84892761609 scopus 로고    scopus 로고
    • Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection
    • Everson GT, Sims KD, Rodriguez-Torres M, Hézode C, Lawitz E, Bourlière M, et al.Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection. Gastroenterology 2014;146(2):420-9. [DOI:].
    • (2014) Gastroenterology , vol.146 , Issue.2 , pp. 420-429
    • Everson, G.T.1    Sims, K.D.2    Rodriguez-Torres, M.3    Hézode, C.4    Lawitz, E.5    Bourlière, M.6
  • 64
    • 85041541761 scopus 로고    scopus 로고
    • Drug development guidelines for Hepatitis C virus
    • (accessed 23 February 2014)
    • US Food, Drugs Administration. Drug development guidelines for Hepatitis C virus. http://www.fda.gov/drugs/newsevents/ucm385395.htm (accessed 23 February 2014).
    • US, F.1    Drugs, A.2
  • 67
    • 79958816097 scopus 로고    scopus 로고
    • Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection
    • Fried MW, Hadziyannis SJ, Shiffman ML, Messinger D, Zeuzem S. Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection. Journal of Hepatology 2011;55:69-75.
    • (2011) Journal of Hepatology , vol.55 , pp. 69-75
    • Fried, M.W.1    Hadziyannis, S.J.2    Shiffman, M.L.3    Messinger, D.4    Zeuzem, S.5
  • 68
    • 65449136656 scopus 로고    scopus 로고
    • Diagnosis, management, and treatment of hepatitis C: an update
    • Ghany MG, Strader DB, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009;49(4):1335-74.
    • (2009) Hepatology , vol.49 , Issue.4 , pp. 1335-1374
    • Ghany, M.G.1    Strader, D.B.2    Thomas, D.L.3    Seeff, L.B.4
  • 69
    • 0032146967 scopus 로고    scopus 로고
    • Quality assessment of reports on clinical trials in the Journal of Hepatology
    • Gluud C, Nikolova D. Quality assessment of reports on clinical trials in the Journal of Hepatology. Journal of Hepatology 1998;29(2):321-7.
    • (1998) Journal of Hepatology , vol.29 , Issue.2 , pp. 321-327
    • Gluud, C.1    Nikolova, D.2
  • 70
    • 0032590185 scopus 로고    scopus 로고
    • Evidence based medicine in LIVER
    • Gluud C. Evidence based medicine in LIVER. Liver 1999;19(1):1-2.
    • (1999) Liver , vol.19 , Issue.1 , pp. 1-2
    • Gluud, C.1
  • 71
    • 0036207503 scopus 로고    scopus 로고
    • Validity of randomized clinical trials in Gastroenterology from 1964 to 2000
    • Kjaergard LL, Frederiksen SL, Gluud C. Validity of randomized clinical trials in Gastroenterology from 1964 to 2000. Gastroenterology 2002;122(4):1157-60.
    • (2002) Gastroenterology , vol.122 , Issue.4 , pp. 1157-1160
    • Kjaergard, L.L.1    Frederiksen, S.L.2    Gluud, C.3
  • 72
    • 32444441010 scopus 로고    scopus 로고
    • The culture of designing hepato-biliary randomised trials
    • Gluud C. The culture of designing hepato-biliary randomised trials. Journal of Hepatology 2006;44(1):607-15.
    • (2006) Journal of Hepatology , vol.44 , Issue.1 , pp. 607-615
    • Gluud, C.1
  • 73
    • 33947203978 scopus 로고    scopus 로고
    • Hepatology may have problems with putative surrogate outcome measures
    • Gluud C, Brok J, Gong Y, Koretz RL. Hepatology may have problems with putative surrogate outcome measures. Journal of Hepatology 2007;46(4):734-42.
    • (2007) Journal of Hepatology , vol.46 , Issue.4 , pp. 734-742
    • Gluud, C.1    Brok, J.2    Gong, Y.3    Koretz, R.L.4
  • 75
    • 84892571704 scopus 로고    scopus 로고
    • Is sustained virological response a marker of treatment efficacy in patients with chronic hepatitis C viral infection with no response or relapse to previous antiviral intervention?
    • Gurusamy KS, Wilson E, Koretz RL, Allen VB, Davidson BR, Burroughs AK, et al.Is sustained virological response a marker of treatment efficacy in patients with chronic hepatitis C viral infection with no response or relapse to previous antiviral intervention?. PLoS One 2013;8(12):e83313. [DOI:].
    • (2013) PLoS One , vol.8 , Issue.12
    • Gurusamy, K.S.1    Wilson, E.2    Koretz, R.L.3    Allen, V.B.4    Davidson, B.R.5    Burroughs, A.K.6
  • 76
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon alfa-2a (40 kilodaltons) and ribavirin combination therapy in chronic hepatitis C: randomized study of the effect of treatment duration and ribavirin dose
    • Hadziyannis SJ, Sette H, Morgan TR, Balan V, Diago M, Marcellin P, et al.Peginterferon alfa-2a (40 kilodaltons) and ribavirin combination therapy in chronic hepatitis C: randomized study of the effect of treatment duration and ribavirin dose. Annals of Internal Medicine 2004;140:346-55.
    • (2004) Annals of Internal Medicine , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Sette, H.2    Morgan, T.R.3    Balan, V.4    Diago, M.5    Marcellin, P.6
  • 79
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 2002;21(11):1539-58.
    • (2002) Statistics in Medicine , vol.21 , Issue.11 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 80
    • 84872417999 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011
    • Available from
    • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
    • Higgins, J.P.T.1    Green, S.2
  • 81
    • 70249142565 scopus 로고    scopus 로고
    • Viral hepatitis - clinical aspects
    • Warrell DA, Cox TM, Firth JD, Benz EJ Jr editor(s).. 5th Edition. Oxford/ New York: Oxford University Press
    • Hodgson HJF. Viral hepatitis - clinical aspects. In: Warrell DA, Cox TM, Firth JD, Benz EJ Jr editor(s). Oxford Textbook of Medicine. 5th Edition. Oxford/ New York: Oxford University Press, 2003:http://otm.oxfordmedicine.com/cgi/content/essentials/5/1/med-9780199204854-chapter-152101.
    • (2003) Oxford Textbook of Medicine
    • Hodgson, H.J.F.1
  • 82
    • 0033546995 scopus 로고    scopus 로고
    • What is meant by intention to treat analysis? Survey of published randomised controlled trials
    • Hollis S, Campbell F. What is meant by intention to treat analysis? Survey of published randomised controlled trials. BMJ (Clinical Research Edition) 1999;319:670-4.
    • (1999) BMJ (Clinical Research Edition) , vol.319 , pp. 670-674
    • Hollis, S.1    Campbell, F.2
  • 84
    • 79959438789 scopus 로고    scopus 로고
    • Original article telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson IM, McHutchison JG, Dusheiko G. Original article telaprevir for previously untreated chronic hepatitis C virus infection. New England Journal of Medicine 2011;364:2405-16. [DOI:].
    • (2011) New England Journal of Medicine , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 87
    • 0035808035 scopus 로고    scopus 로고
    • Reported methodological quality and discrepancies between small and large randomized trials in meta-analyses
    • Kjaergard LL, Villumsen J, Gluud C. Reported methodological quality and discrepancies between small and large randomized trials in meta-analyses. Annals of Internal Medicine 2001;135(11):982-9.
    • (2001) Annals of Internal Medicine , vol.135 , Issue.11 , pp. 982-989
    • Kjaergard, L.L.1    Villumsen, J.2    Gluud, C.3
  • 88
    • 84871462769 scopus 로고    scopus 로고
    • Efficacy and tolerability of telaprevir for chronic hepatitis virus C genotype 1 infection: a meta-analysis
    • Kong Y, Wang X, Shang Y, Schroder PM, Liang W, Ling X, et al.Efficacy and tolerability of telaprevir for chronic hepatitis virus C genotype 1 infection: a meta-analysis. PLoS ONE 2012;7(12):e52158.
    • (2012) PLoS ONE , vol.7 , Issue.12
    • Kong, Y.1    Wang, X.2    Shang, Y.3    Schroder, P.M.4    Liang, W.5    Ling, X.6
  • 89
    • 37449014458 scopus 로고    scopus 로고
    • Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
    • Korba B, Montero A, Farrar K, Gaye K, Mukerjee S, Ayers M, et al.Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Research 2008;77(1):56-63.
    • (2008) Antiviral Research , vol.77 , Issue.1 , pp. 56-63
    • Korba, B.1    Montero, A.2    Farrar, K.3    Gaye, K.4    Mukerjee, S.5    Ayers, M.6
  • 90
    • 60449096365 scopus 로고    scopus 로고
    • Potential role for nitazoxanide in combination with STAT-C agents for the inhibition of HCV replication without the development of resistance
    • Korba BE, Elazar M, Lui P, et al.Potential role for nitazoxanide in combination with STAT-C agents for the inhibition of HCV replication without the development of resistance. Hepatology 2008;48(Suppl):356A.
    • (2008) Hepatology , vol.48
    • Korba, B.E.1    Elazar, M.2    Lui, P.3
  • 92
    • 84878976866 scopus 로고    scopus 로고
    • Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial
    • Kowdley KV, Lawitz E, Crespo I, Hassanein T, Davis MN, DeMicco M, et al.Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet 2013;381(9883):2100-7. [DOI:].
    • (2013) Lancet , vol.381 , Issue.9883 , pp. 2100-2107
    • Kowdley, K.V.1    Lawitz, E.2    Crespo, I.3    Hassanein, T.4    Davis, M.N.5    DeMicco, M.6
  • 96
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial
    • Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, et al.Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358(9286):958-65.
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6
  • 97
    • 78650741799 scopus 로고    scopus 로고
    • Current therapies for chronic hepatitis C
    • McKenzie CF. Current therapies for chronic hepatitis C. Pharmacotherapy 2011;31(1):92-111.
    • (2011) Pharmacotherapy , vol.31 , Issue.1 , pp. 92-111
    • McKenzie, C.F.1
  • 98
    • 0032558314 scopus 로고    scopus 로고
    • Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?
    • Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M, et al.Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?. Lancet 1998;352:609-13.
    • (1998) Lancet , vol.352 , pp. 609-613
    • Moher, D.1    Pham, B.2    Jones, A.3    Cook, D.J.4    Jadad, A.R.5    Moher, M.6
  • 100
    • 85041513185 scopus 로고    scopus 로고
    • Chronic hepatitis C: current disease management
    • 2010 (accessed December 2010)
    • National Institutes of Health. Chronic hepatitis C: current disease management. http://digestive.niddk.nih.gov/ddiseases/pubs/chronichepc/ 2010 (accessed December 2010).
    • http://digestive.niddk.nih.gov/ddiseases/pubs/chronichepc/
  • 101
    • 85041539676 scopus 로고    scopus 로고
    • 2005 OPTN/SRTR Annual Report (Chapter VI; Liver and Intestine Transplantation in the United States, 1995-2004)
    • 2005 (accessed January 2011)
    • United Network for Organ Sharing. 2005 OPTN/SRTR Annual Report (Chapter VI; Liver and Intestine Transplantation in the United States, 1995-2004). http://optn.transplant.hrsa.gov/ar2009/ar_archives.htm 2005 (accessed January 2011).
    • http://optn.transplant.hrsa.gov/ar2009/ar_archives.htm
  • 102
    • 0034840448 scopus 로고    scopus 로고
    • Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis in children from Northern Peru
    • Ortiz JJ, Ayoub A, Gargala G, Chegne NL, Favennec L. Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis in children from Northern Peru. Alimentary Pharmacology & Therapeutics 2001;15(9):1409-15. [DOI:].
    • (2001) Alimentary Pharmacology & Therapeutics , vol.15 , Issue.9 , pp. 1409-1415
    • Ortiz, J.J.1    Ayoub, A.2    Gargala, G.3    Chegne, N.L.4    Favennec, L.5
  • 103
    • 33644653117 scopus 로고    scopus 로고
    • Activities of tizoxanide and nitazoxanide compared to those of five other thiazolides and three other agents against anaerobic species
    • Pankuch GA, Appelbaum PC. Activities of tizoxanide and nitazoxanide compared to those of five other thiazolides and three other agents against anaerobic species. Antimicrobial Agents and Chemotherapy 2006;50(3):1112-7.
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , Issue.3 , pp. 1112-1117
    • Pankuch, G.A.1    Appelbaum, P.C.2
  • 106
    • 84867586574 scopus 로고    scopus 로고
    • Study and improvement of spectrophotometric and HPLC methods for the determination of nitazoxanide in pharmaceutical preparations
    • Reddy CRMB, Subbareddy GV. Study and improvement of spectrophotometric and HPLC methods for the determination of nitazoxanide in pharmaceutical preparations. Journal of Chemical and Pharmaceutical Research 2012;4(7):3708-14. [: ISSN: 0975-7384].
    • (2012) Journal of Chemical and Pharmaceutical Research , vol.4 , Issue.7 , pp. 3708-3714
    • Reddy, C.R.M.B.1    Subbareddy, G.V.2
  • 107
    • 79960705415 scopus 로고    scopus 로고
    • Review Manager (RevMan)
    • 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration
    • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
    • (2012)
  • 108
    • 0035955558 scopus 로고    scopus 로고
    • Recent advances in the molecular biology of hepatitis C virus
    • Rosenberg S. Recent advances in the molecular biology of hepatitis C virus. Journal of Molecular Biology 2001;313:451-64.
    • (2001) Journal of Molecular Biology , vol.313 , pp. 451-464
    • Rosenberg, S.1
  • 110
    • 0035399892 scopus 로고    scopus 로고
    • Treatment of diarrhea caused by Cryptosporidium parvum: a prospective randomized, double-blind, placebo-controlled study of nitazoxanide
    • Rossignol JF, Ayoub A, Ayers MS. Treatment of diarrhea caused by Cryptosporidium parvum: a prospective randomized, double-blind, placebo-controlled study of nitazoxanide. Journal of Infectious Diseases 2001;184(1):103-6.
    • (2001) Journal of Infectious Diseases , vol.184 , Issue.1 , pp. 103-106
    • Rossignol, J.F.1    Ayoub, A.2    Ayers, M.S.3
  • 112
    • 0344596063 scopus 로고    scopus 로고
    • Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches
    • Royle P, Milne R. Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches. International Journal of Technology Assessment in Health Care 2003;19(4):591-603.
    • (2003) International Journal of Technology Assessment in Health Care , vol.19 , Issue.4 , pp. 591-603
    • Royle, P.1    Milne, R.2
  • 113
    • 84868308325 scopus 로고    scopus 로고
    • Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials
    • Savović J, Jones HE, Altman DG, Harris RJ, Jüni P, Pildal J, et al.Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Annals of Internal Medicine 2012;157:429-38.
    • (2012) Annals of Internal Medicine , vol.157 , pp. 429-438
    • Savović, J.1    Jones, H.E.2    Altman, D.G.3    Harris, R.J.4    Jüni, P.5    Pildal, J.6
  • 114
    • 84866641767 scopus 로고    scopus 로고
    • Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials
    • Savović J, Jones HE, Altman DG, Harris RJ, Jüni P, Pildal J, et al.Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Health Technology Assessment 2012;16(35):1-82.
    • (2012) Health Technology Assessment , vol.16 , Issue.35 , pp. 1-82
    • Savović, J.1    Jones, H.E.2    Altman, D.G.3    Harris, R.J.4    Jüni, P.5    Pildal, J.6
  • 115
    • 85047692188 scopus 로고
    • Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials
    • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408-12.
    • (1995) JAMA , vol.273 , Issue.5 , pp. 408-412
    • Schulz, K.F.1    Chalmers, I.2    Hayes, R.J.3    Altman, D.G.4
  • 116
    • 83155184631 scopus 로고    scopus 로고
    • CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
    • for the CONSORT Group
    • Schulz KF, Altman DG, Moher D, for the CONSORT Group. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. Internal Journal of Surgery 2011;9(8):672-7.
    • (2011) Internal Journal of Surgery , vol.9 , Issue.8 , pp. 672-677
    • Schulz, K.F.1    Altman, D.G.2    Moher, D.3
  • 117
    • 0036828840 scopus 로고    scopus 로고
    • National Institutes of Health consensus development conference: Management of hepatitis C: 2002
    • Seeff LB, Hoofnagle JH. National Institutes of Health consensus development conference: Management of hepatitis C: 2002. Hepatology 2002; Vol. 36:S1-S2. [DOI:].
    • (2002) Hepatology , vol.36 , pp. S1-S2
    • Seeff, L.B.1    Hoofnagle, J.H.2
  • 118
    • 80052826527 scopus 로고    scopus 로고
    • Response-guided telaprevir combination treatment for hepatitis C virus infection
    • Sherman KE, Flamm SL, Afdhal NH. Response-guided telaprevir combination treatment for hepatitis C virus infection. New England Journal of Medicine 2011;365:1014-24. [DOI:].
    • (2011) New England Journal of Medicine , vol.365 , pp. 1014-1024
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 119
    • 84873580144 scopus 로고    scopus 로고
    • Telaprevir versus boceprevir in chronic hepatitis C: a meta-analysis of data from phase II and III trials
    • February 2013
    • Sitole M, Silva M, Spooner L, Comee MK, Malloy M. Telaprevir versus boceprevir in chronic hepatitis C: a meta-analysis of data from phase II and III trials. Clinical Therapeutics February 2013;35(2):190-7. [DOI:].
    • Clinical Therapeutics , vol.35 , Issue.2 , pp. 190-197
    • Sitole, M.1    Silva, M.2    Spooner, L.3    Comee, M.K.4    Malloy, M.5
  • 121
    • 0036830507 scopus 로고    scopus 로고
    • Neutropenia during combination therapy of interferon alfa and ribavirin for chronic hepatitis C
    • PUBMED: 12395340]
    • Soza A, Everhart JE, Ghany MG, Doo E, Heller T, Promrat K, et al.Neutropenia during combination therapy of interferon alfa and ribavirin for chronic hepatitis C. Hepatology 2002;36(5):1273-9. [PUBMED: 12395340].
    • (2002) Hepatology , vol.36 , Issue.5 , pp. 1273-1279
    • Soza, A.1    Everhart, J.E.2    Ghany, M.G.3    Doo, E.4    Heller, T.5    Promrat, K.6
  • 123
    • 84872080748 scopus 로고    scopus 로고
    • SPIRIT 2013 Explanation and elaboration: guidance for protocols of clinical trials
    • Chan A-W, Tetzlaff JM, Gøtzsche PC, Altman DG, Mann H, Berlin J, et al.SPIRIT 2013 Explanation and elaboration: guidance for protocols of clinical trials. BMJ 2013;346:e7586.
    • (2013) BMJ , vol.346
    • Chan, A.-W.1    Tetzlaff, J.M.2    Gøtzsche, P.C.3    Altman, D.G.4    Mann, H.5    Berlin, J.6
  • 125
    • 1842479859 scopus 로고    scopus 로고
    • AASLD practice guideline: diagnosis, management, and treatment of hepatitis C
    • Strader DB, Wright T, Thomas LD, Seeff LB. AASLD practice guideline: diagnosis, management, and treatment of hepatitis C. Hepatology 2004;39(4):1147-71.
    • (2004) Hepatology , vol.39 , Issue.4 , pp. 1147-1171
    • Strader, D.B.1    Wright, T.2    Thomas, L.D.3    Seeff, L.B.4
  • 126
    • 1842463813 scopus 로고    scopus 로고
    • Changes in haemoglobin during interferon alpha-2b plus ribavirin combination therapy for chronic hepatitis C virus infection
    • PUBMED: 15117326]
    • Sulkowski MS, Wasserman R, Brooks L, Ball L, Gish R. Changes in haemoglobin during interferon alpha-2b plus ribavirin combination therapy for chronic hepatitis C virus infection. Journal of Viral Hepatitis 2004;11(3):243-50. [PUBMED: 15117326].
    • (2004) Journal of Viral Hepatitis , vol.11 , Issue.3 , pp. 243-250
    • Sulkowski, M.S.1    Wasserman, R.2    Brooks, L.3    Ball, L.4    Gish, R.5
  • 128
    • 77953438405 scopus 로고    scopus 로고
    • Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals
    • Thorlund K, Anema A, Mills E. Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals. Clinical Epidemiology 2010;2:57-66.
    • (2010) Clinical Epidemiology , vol.2 , pp. 57-66
    • Thorlund, K.1    Anema, A.2    Mills, E.3
  • 131
    • 37049035730 scopus 로고    scopus 로고
    • Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
    • Wetterslev J, Thorlund K, Brok J, Gluud C. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. Journal of Clinical Epidemiology 2008;61(1):64-75.
    • (2008) Journal of Clinical Epidemiology , vol.61 , Issue.1 , pp. 64-75
    • Wetterslev, J.1    Thorlund, K.2    Brok, J.3    Gluud, C.4
  • 132
    • 75649084582 scopus 로고    scopus 로고
    • Estimating required information size by quantifying diversity in random-effects model meta-analyses
    • Wetterslev J, Thorlund K, Brok J, Gluud C. Estimating required information size by quantifying diversity in random-effects model meta-analyses. BMC Medical Research Methodology 2009;9:86.
    • (2009) BMC Medical Research Methodology , vol.9 , pp. 86
    • Wetterslev, J.1    Thorlund, K.2    Brok, J.3    Gluud, C.4
  • 133
    • 37049035730 scopus 로고    scopus 로고
    • Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
    • Wetterslev J, Thorlund K, Brok J, Gluud C. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. Journal of Clinical Epidemiology 2008;61:64-75.
    • (2008) Journal of Clinical Epidemiology , vol.61 , pp. 64-75
    • Wetterslev, J.1    Thorlund, K.2    Brok, J.3    Gluud, C.4
  • 134
    • 85041554406 scopus 로고    scopus 로고
    • Viral hepatitis. Report by the secretariat
    • accessed January 2011)
    • World Health Organization. Viral hepatitis. Report by the secretariat. apps.who.int/gb/ebwha/pdf_files/WHA63/A63_15-en.pdf 2010 (accessed January 2011).
    • (2010) apps.who.int/gb/ebwha/pdf_files/WHA63/A63_15-en.pdf
  • 135
    • 1642288430 scopus 로고    scopus 로고
    • Hepatitis C. Fact sheet No. 164
    • accessed 24 January 2014)
    • World Health Organiziation. Hepatitis C. Fact sheet No. 164. http://www.who.int/mediacentre/factsheets/fs164/en/index.html 2011; Vol. (accessed 24 January 2014).
    • (2011)
  • 136
    • 40949113623 scopus 로고    scopus 로고
    • Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study
    • Wood L, Egger M, Gluud LL, Schulz KF, Jüni P, Altman GD, et al.Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ (Clinical Research Ed.) 2008;336:601-5.
    • (2008) BMJ (Clinical Research Ed.) , vol.336 , pp. 601-605
    • Wood, L.1    Egger, M.2    Gluud, L.L.3    Schulz, K.F.4    Jüni, P.5    Altman, G.D.6
  • 137
    • 84875204608 scopus 로고    scopus 로고
    • The efficacy and safety of telaprevir-based regimens for treating chronic hepatitis C virus genotype 1 infection: a meta-analysis of randomized trials
    • Yang D, Liang HJ, Li D, Wei X, Ma L, Jia Z. The efficacy and safety of telaprevir-based regimens for treating chronic hepatitis C virus genotype 1 infection: a meta-analysis of randomized trials. Internal Medicine 2013;52(6):653-60.
    • (2013) Internal Medicine , vol.52 , Issue.6 , pp. 653-660
    • Yang, D.1    Liang, H.J.2    Li, D.3    Wei, X.4    Ma, L.5    Jia, Z.6


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