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Volumn 3, Issue 5, 2008, Pages 539-545

Thiazolides: A new class of drugs for the treatment of chronic hepatitis B and C

Author keywords

Chronic hepatitis B; Chronic hepatitis C; Eukaryotic initiation factor 2 phosphorylation; HBV; HCV; Interferon; Nitazoxanide; Peginterferon; Protein kinase RNA activated phosphorylation; Ribavirin; Thiazolides

Indexed keywords

ADEFOVIR; ANTIVIRUS AGENT; LAMIVUDINE; NITAZOXANIDE; PEGINTERFERON ALPHA2A; RIBAVIRIN; RM 4863; THIAZOLIDINE DERIVATIVE; TIZOXANIDE; UNCLASSIFIED DRUG; THIAZOLE DERIVATIVE;

EID: 55449122030     PISSN: 17460913     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460913.3.5.539     Document Type: Review
Times cited : (48)

References (34)
  • 1
    • 34548345811 scopus 로고    scopus 로고
    • Nitazoxanide: A review of its use in the treatment of gastrointestinal infections
    • Anderson VR, Curran MP: Nitazoxanide: a review of its use in the treatment of gastrointestinal infections. Drugs 67, 1947-1967 (2007).
    • (2007) Drugs , vol.67 , pp. 1947-1967
    • Anderson, V.R.1    Curran, M.P.2
  • 2
    • 37549034628 scopus 로고    scopus 로고
    • Nitazoxanide: Clinical studies of a broad-spectrum anti-infective agent
    • Aslam S, Musher DM: Nitazoxanide: clinical studies of a broad-spectrum anti-infective agent. Future Microbiol. 2. 583-590 (2007).
    • (2007) Future Microbiol , vol.2 , pp. 583-590
    • Aslam, S.1    Musher, D.M.2
  • 3
    • 16844372587 scopus 로고    scopus 로고
    • Nitazoxanide: A new thiazolide antiparasitic agent
    • Fox LM, Saravolatz LD: Nitazoxanide: a new thiazolide antiparasitic agent. Clin. Infect. Dis. 40, 1173-1180 (2005).
    • (2005) Clin. Infect. Dis , vol.40 , pp. 1173-1180
    • Fox, L.M.1    Saravolatz, L.D.2
  • 4
    • 2942590820 scopus 로고    scopus 로고
    • Nitazoxanide: A new broad spectrum antiparasitic agent
    • White AC Jr: Nitazoxanide: a new broad spectrum antiparasitic agent. Expert. Rev. Anti-infect. Ther. 2, 43-50 (2004).
    • (2004) Expert. Rev. Anti-infect. Ther , vol.2 , pp. 43-50
    • White Jr, A.C.1
  • 5
    • 0008151853 scopus 로고
    • New derivative of 2-benzamido 5-nitrothiazoles
    • Rossignol JF, Cavier R: New derivative of 2-benzamido 5-nitrothiazoles. Chem. Abstr. 83, 28216n (1975).
    • (1975) Chem. Abstr , vol.83
    • Rossignol, J.F.1    Cavier, R.2
  • 6
    • 0019276704 scopus 로고
    • Expérimentation des propriétés anthelminthiques de la nitazoxanide chez le chien, le chat et les ovins.
    • Euzéby J, Prom Tep S, Rossignol JF: Expérimentation des propriétés anthelminthiques de la nitazoxanide chez le chien, le chat et les ovins. Revue de Médecine Vétérinaire 131, 687-696 (1980).
    • (1980) Revue de Médecine Vétérinaire , vol.131 , pp. 687-696
    • Euzéby, J.1    Prom Tep, S.2    Rossignol, J.F.3
  • 7
    • 0020410323 scopus 로고
    • Etude pharmacologique de diverses associations d'anthelminthiques chez la souris.
    • Cavier R, Rossignol JF: Etude pharmacologique de diverses associations d'anthelminthiques chez la souris. Revue de Médecine Vétérinaire 133, 779-783 (1982).
    • (1982) Revue de Médecine Vétérinaire , vol.133 , pp. 779-783
    • Cavier, R.1    Rossignol, J.F.2
  • 8
    • 0021281840 scopus 로고
    • Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana
    • Rossignol JF, Maisonneuve H: Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana. Am. J. Trop. Med. Hyg. 33, 511-512 (1984).
    • (1984) Am. J. Trop. Med. Hyg , vol.33 , pp. 511-512
    • Rossignol, J.F.1    Maisonneuve, H.2
  • 9
    • 0035399892 scopus 로고    scopus 로고
    • Treatment of diarrhea caused by Cryptosporidium parvum: A propective randomized double-blind placebo-controlled study of nitazoxanide
    • Rossignol JF, Ayoub A, Ayers MS: Treatment of diarrhea caused by Cryptosporidium parvum: a propective randomized double-blind placebo-controlled study of nitazoxanide. J Infect. Dis. 184, 103-106 (2001).
    • (2001) J Infect. Dis , vol.184 , pp. 103-106
    • Rossignol, J.F.1    Ayoub, A.2    Ayers, M.S.3
  • 10
    • 0037010366 scopus 로고    scopus 로고
    • Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: A randomised controlled trial
    • Amadi B, Mwiya M, Musuku J et al.: Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Lancet 360, 1375-1380 (2002).
    • (2002) Lancet , vol.360 , pp. 1375-1380
    • Amadi, B.1    Mwiya, M.2    Musuku, J.3
  • 11
    • 33644761697 scopus 로고    scopus 로고
    • Double-blind placebo controlled study of nitazoxanide in the treatment of cryptosporidial diarrhea in 90 immunocompetent adults and adolescents from the Nile delta of Egypt
    • Rossignol JF, Kabil SM, Younis A M, El-Gohary Y: Double-blind placebo controlled study of nitazoxanide in the treatment of cryptosporidial diarrhea in 90 immunocompetent adults and adolescents from the Nile delta of Egypt. Clin. Gastroenterol. Hepatol. 4, 320-324 (2006).
    • (2006) Clin. Gastroenterol. Hepatol , vol.4 , pp. 320-324
    • Rossignol, J.F.1    Kabil, S.M.2    Younis, A.M.3    El-Gohary, Y.4
  • 12
    • 0032426949 scopus 로고    scopus 로고
    • A double-blind placebo controlled study of nitazoxanide in the treatment of cryptosporidial diarrhea in AIDS patients
    • Rossignol JF, Hidalgo H, Feregrino M et al.: A double-blind placebo controlled study of nitazoxanide in the treatment of cryptosporidial diarrhea in AIDS patients. Trans. R. Soc. Trop. Med. Hyg. 92, 663-666 (1998).
    • (1998) Trans. R. Soc. Trop. Med. Hyg , vol.92 , pp. 663-666
    • Rossignol, J.F.1    Hidalgo, H.2    Feregrino, M.3
  • 13
    • 0029836681 scopus 로고    scopus 로고
    • In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms
    • Dubreuil L, Houcke I, Mouton Y, Rossignol JF: In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms. Antimicrob. Agents Chemother. 40, 2266-2270 (1996).
    • (1996) Antimicrob. Agents Chemother , vol.40 , pp. 2266-2270
    • Dubreuil, L.1    Houcke, I.2    Mouton, Y.3    Rossignol, J.F.4
  • 14
    • 0033836004 scopus 로고    scopus 로고
    • In vitro and in vivo activities of nitazoxanide against Clostridium difficile
    • McVay CS, Rolfe RD: In vitro and in vivo activities of nitazoxanide against Clostridium difficile. Antimicrob. Agents Chemother. 44. 2254-2258 (2000).
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 2254-2258
    • McVay, C.S.1    Rolfe, R.D.2
  • 15
    • 33644653117 scopus 로고    scopus 로고
    • Activities of tizoxanide and nitazoxanide compared to those of five other thiazolides and three other agents against anaerobic species
    • Pankuch GA, Appelbaum PC: Activities of tizoxanide and nitazoxanide compared to those of five other thiazolides and three other agents against anaerobic species. Antimicrob. Agents Chemother. 50, 1112-1117 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 1112-1117
    • Pankuch, G.A.1    Appelbaum, P.C.2
  • 16
    • 34547640095 scopus 로고    scopus 로고
    • In vitro activities of 15 antimicrobial agents against 110 toxogenic Clostridium difficile clinical isolates collected from 1983 to 2004
    • Hech DW, Galang MA, Sambol SP, Osmolski JR, Johnson S, Gerding DN: In vitro activities of 15 antimicrobial agents against 110 toxogenic Clostridium difficile clinical isolates collected from 1983 to 2004. Antimicrob. Agents Chemother. 51, 2716-1719 (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 2716-1719
    • Hech, D.W.1    Galang, M.A.2    Sambol, S.P.3    Osmolski, J.R.4    Johnson, S.5    Gerding, D.N.6
  • 17
    • 33746626011 scopus 로고    scopus 로고
    • Nitazoxanide in the treatment of Clostridium difficile associated diseases
    • Musher DM, Logan N, Hamill RJ et al.: Nitazoxanide in the treatment of Clostridium difficile associated diseases. Clin. Infect. Dis. 43, 421-427 (2006).
    • (2006) Clin. Infect. Dis , vol.43 , pp. 421-427
    • Musher, D.M.1    Logan, N.2    Hamill, R.J.3
  • 19
    • 33847660062 scopus 로고    scopus 로고
    • Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites and Campilobacter jejuni
    • Hoffman PS, Sission G, Croxen MA et al.: Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites and Campilobacter jejuni. Antimicrob. Agents Chemother. 51, 868-876 (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 868-876
    • Hoffman, P.S.1    Sission, G.2    Croxen, M.A.3
  • 20
    • 0036246883 scopus 로고    scopus 로고
    • Nitazoxanide pharmacokinetics and tolerability in man after single ascending oral doses
    • Stockis A, Allemon AM, De Bryn S, Gengler C: Nitazoxanide pharmacokinetics and tolerability in man after single ascending oral doses, Int. J. Clin. Pharmacol. 40, 213-220 (2002).
    • (2002) Int. J. Clin. Pharmacol , vol.40 , pp. 213-220
    • Stockis, A.1    Allemon, A.M.2    De Bryn, S.3    Gengler, C.4
  • 21
    • 0036245589 scopus 로고    scopus 로고
    • Stockis A, Allemon AM, Gengler C, Rosillon D: Nitazoxanide pharmacokinetics and tolerability in man during 7 days of 0.5 g and 1 g b.i.d. dosing. Int. J. Clin. Pharmacol. 40, 221-227 (2002).
    • Stockis A, Allemon AM, Gengler C, Rosillon D: Nitazoxanide pharmacokinetics and tolerability in man during 7 days of 0.5 g and 1 g b.i.d. dosing. Int. J. Clin. Pharmacol. 40, 221-227 (2002).
  • 22
    • 0029745128 scopus 로고    scopus 로고
    • Pharmacokinetics of nitazoxanide after single oral dose administration in 6 health volunteers
    • Stockis A, Deroubaix X, Lins R et al.: Pharmacokinetics of nitazoxanide after single oral dose administration in 6 health volunteers, Int. J. Pharmacol. Ther. 34, 349-351 (1996).
    • (1996) Int. J. Pharmacol. Ther , vol.34 , pp. 349-351
    • Stockis, A.1    Deroubaix, X.2    Lins, R.3
  • 24
    • 0036796184 scopus 로고    scopus 로고
    • In vitro transfer of nitazoxanide across the intestinal barrier
    • Matysiak-Budnik T, Mégraud F, Heyman M: In vitro transfer of nitazoxanide across the intestinal barrier. J. Pharm. Pharmacol. 54, 1413-1417 (2002).
    • (2002) J. Pharm. Pharmacol , vol.54 , pp. 1413-1417
    • Matysiak-Budnik, T.1    Mégraud, F.2    Heyman, M.3
  • 25
    • 55649084523 scopus 로고    scopus 로고
    • Nitazoxanide co-administration with warfarin sodium: A Phase I crossover study
    • In press
    • Vets E, Rossignol JF, Jackson AS: Nitazoxanide co-administration with warfarin sodium: a Phase I crossover study. Am. J. Health Syst. Pharm. (2008) (In press).
    • (2008) Am. J. Health Syst. Pharm
    • Vets, E.1    Rossignol, J.F.2    Jackson, A.S.3
  • 26
    • 37449014458 scopus 로고    scopus 로고
    • Nitazoxanide, tizoxanide, and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
    • Korba BE, Montero AB, Farrar K et al.: Nitazoxanide, tizoxanide, and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antivir. Res. 77, 56-63 (2008).
    • (2008) Antivir. Res , vol.77 , pp. 56-63
    • Korba, B.E.1    Montero, A.B.2    Farrar, K.3
  • 27
    • 55649108136 scopus 로고    scopus 로고
    • Studies of the potential for nitazoxanide or tizoxanide resistance in hepatitis C virus replicon-containing cell lines
    • In press
    • Korba BE, Elazar M, Lui P et al.: Studies of the potential for nitazoxanide or tizoxanide resistance in hepatitis C virus replicon-containing cell lines. Antimicrob. Agents Chemother. (2008) (In press).
    • (2008) Antimicrob. Agents Chemother
    • Korba, B.E.1    Elazar, M.2    Lui, P.3
  • 28
    • 55649122742 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis B (CHB) with nitazoxanide (NTZ) alone or NTZ plus adefovir (ADV) for two years with loss of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg): Report of two cases [abstract]
    • In press
    • Kolozsi WZ, El-Gohary Y, Keeffe EB, Rossignol JF: Treatment of chronic hepatitis B (CHB) with nitazoxanide (NTZ) alone or NTZ plus adefovir (ADV) for two years with loss of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg): report of two cases [abstract]. Am. J. Gastroenterol. (2008) (In press).
    • (2008) Am. J. Gastroenterol
    • Kolozsi, W.Z.1    El-Gohary, Y.2    Keeffe, E.B.3    Rossignol, J.F.4
  • 29
    • 48449084880 scopus 로고    scopus 로고
    • Clinical trial: Randomized, double-blind, placebo-controlled study of nitazoxanide monotherapy for the treatment of patients with chronic hepatitis C genotype 4
    • Rossignol JF, Kabil SM, El-Gohary Y, Elfert A, Keeffe EB: Clinical trial: randomized, double-blind, placebo-controlled study of nitazoxanide monotherapy for the treatment of patients with chronic hepatitis C genotype 4. Aliment. Pharmacol. Ther. 28, 574-580 (2008).
    • (2008) Aliment. Pharmacol. Ther , vol.28 , pp. 574-580
    • Rossignol, J.F.1    Kabil, S.M.2    El-Gohary, Y.3    Elfert, A.4    Keeffe, E.B.5
  • 30
    • 41749115080 scopus 로고    scopus 로고
    • Interim data from a randomized controlled trial of nitazoxanide-peginterferon-ribavirin, nitazoxanide-peginterferon and peginterferon-ribavirin in the treatment of patients with chronic hepatitis C genotype 4 [abstract]
    • Rossignol JF, Elfert A, El-Gohary Y, Keeffe EB, Glenn JS: Interim data from a randomized controlled trial of nitazoxanide-peginterferon-ribavirin, nitazoxanide-peginterferon and peginterferon-ribavirin in the treatment of patients with chronic hepatitis C genotype 4 [abstract]. Hepatology 46(Suppl. 1), 316A-317A (2007).
    • (2007) Hepatology , vol.46 , Issue.SUPPL. 1
    • Rossignol, J.F.1    Elfert, A.2    El-Gohary, Y.3    Keeffe, E.B.4    Glenn, J.S.5
  • 31
    • 55649107215 scopus 로고    scopus 로고
    • Rossignol JF, Elfert A, El-Gohary Y. Keeffe EB: Randomized controlled trial of nitazoxanide-peginterferon-ribavirin, nitazoxanide-peginterferon and peginterferon-ribavirin in the treatment of patients with chronic hepatitis C genotype 4 [abstract]. J. Hepatol. 48(Suppl. 2), S30 (2008).
    • Rossignol JF, Elfert A, El-Gohary Y. Keeffe EB: Randomized controlled trial of nitazoxanide-peginterferon-ribavirin, nitazoxanide-peginterferon and peginterferon-ribavirin in the treatment of patients with chronic hepatitis C genotype 4 [abstract]. J. Hepatol. 48(Suppl. 2), S30 (2008).
  • 32
    • 55649105806 scopus 로고    scopus 로고
    • Rossignol JF, Elfert A, Keeffe EB: Evaluation of a 4 week lead-in phase with nitazoxanide prior to nitazoxanide + peginterferon in treating chronic hepatitis C [abstractl. J. Hepatol. 48(Suppl. 2), S312 (2008).
    • Rossignol JF, Elfert A, Keeffe EB: Evaluation of a 4 week lead-in phase with nitazoxanide prior to nitazoxanide + peginterferon in treating chronic hepatitis C [abstractl. J. Hepatol. 48(Suppl. 2), S312 (2008).
  • 33
    • 55649090726 scopus 로고    scopus 로고
    • Evaluation of a 4 week lead-in phase with nitazoxanide (NTZ) prior to peginterferon (PegIFN) plus NTZ for treatment of chronic hepatitis C: Final report
    • In press
    • Rossignol JF, Elfert A, Keeffe EB: Evaluation of a 4 week lead-in phase with nitazoxanide (NTZ) prior to peginterferon (PegIFN) plus NTZ for treatment of chronic hepatitis C: final report. Hepatology (2008) (In press).
    • (2008) Hepatology
    • Rossignol, J.F.1    Elfert, A.2    Keeffe, E.B.3
  • 34
    • 60449090699 scopus 로고    scopus 로고
    • Nitazoxanide (NTZ) is an induced of eIF2α and PKR phosphorylation [abstractl
    • In Press
    • Elazar M, Liu M, McKenna S et al.: Nitazoxanide (NTZ) is an induced of eIF2α and PKR phosphorylation [abstractl. Hepatology (2008) (In Press).
    • (2008) Hepatology
    • Elazar, M.1    Liu, M.2    McKenna, S.3


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