Role of epigenetic reprogramming in hematopoietic stem cell function

Current Opinion in Hematology

Volumn 22, Issue 4, 2015, Pages 279-285

  Iancu Rubin, Camelia ^a   Hoffman, Ronald ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Epigenetic reprogramming; Hematopoietic stem cell expansion; Hematopoietic stem cell transplantation

Indexed keywords

CD34 ANTIGEN; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; THY 1 ANTIGEN; ANTINEOPLASTIC ANTIMETABOLITE; AZACITIDINE; CHROMATIN; DECITABINE; DNA (CYTOSINE 5) METHYLTRANSFERASE; HYDROXAMIC ACID; LITHIUM CHLORIDE; TRICHOSTATIN A; VALPROIC ACID;

CELL DIFFERENTIATION; CELL RENEWAL; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MALIGNANT TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; CHEMISTRY; CHROMATIN; CYTOLOGY; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; METABOLISM; NUCLEAR REPROGRAMMING;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CELL PROLIFERATION; CELLULAR REPROGRAMMING; CHROMATIN; CYTOKINES; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; HYDROXAMIC ACIDS; LITHIUM CHLORIDE; VALPROIC ACID;

EID: 84942769377     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0000000000000143     Document Type: Review

References (38)

1. Dahlberg A, Delaney C, Bernstein ID. Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood 2011; 117: 6083-6090.
2. Wagner JE Jr, Eapen M, Carter S, et al. One-unit versus two-unit cord-blood transplantation for hematologic cancers. N Engl J Med 2014; 371: 1685-1694.
3. Boitano AE, Wang J, Romeo R, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010; 329: 1345-1348.
4. De Lima M, McNiece I, Robinson SN, et al. Cord-blood engraftment with ex vivo mesenchymal-cell coculture. N Engl J Med 2012; 367: 2305-2315.
5. Delaney C, Ratajczak MZ, Laughlin MJ. Strategies to enhance umbilical cord blood stem cell engraftment in adult patients. Expert Rev Hematol 2010; 3: 273-283.
6. Himburg HA, Muramoto GG, Daher P, et al. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med 2010; 16: 475-482.
7. Nishino T, Miyaji K, Ishiwata N, et al. Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL. Exp Hematol 2009; 37: 1364.e4-1377.e4.
8. North TE, Goessling W, Walkley CR, et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 2007; 447: 1007-1011.
9. Walasek MA, van Os R, de Haan G. Hematopoietic stem cell expansion: Challenges and opportunities. Ann N Y Acad Sci 2012; 1266: 138-150.
10. Fares I, Chagraoui J, Gareau Y, et al. Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science 2014; 345: 1509-1512.
11. Apostolou E, Hochedlinger K. Chromatin dynamics during cellular reprogramming. Nature 2013; 502: 462-471.
12. Cabezas-Wallscheid N, Klimmeck D, Hansson J, et al. Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Cell Stem Cell 2014; 15: 507-522.
13. DeVilbiss AW, Sanalkumar R, Johnson KD, et al. Hematopoietic transcriptional mechanisms: From locus-specific to genome-wide vantage points. Exp Hematol 2014; 42: 618-629.
14. Hochedlinger K, Plath K. Epigenetic reprogramming and induced pluripotency. Development 2009; 136: 509-523.
15. Huang HT, Kathrein KL, Barton A, et al. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nat Cell Biol 2013; 15: 1516-1525.
16. Schonheit J, Leutz A, Rosenbauer F. Chromatin dynamics during differentiation of myeloid cells. J Mol Biol 2015; 427: 670-687.
17. Watanabe A, Yamada Y, Yamanaka S. Epigenetic regulation in pluripotent stem cells: A key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci 2013; 368: 20120292.
18. Bug G, Gul H, Schwarz K, et al. Valproic acid stimulates proliferation and selfrenewal of hematopoietic stem cells. Cancer Res 2005; 65: 2537-2541.
19. Chaurasia P, Berenzon D, Hoffman R. Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells. Blood 2011; 117: 4632-4641.
20. Chaurasia P, Gajzer DC, Schaniel C, et al. Epigenetic reprogramming induces the expansion of cord blood stem cells. J Clin Invest 2014; 124: 2378-2395.
21. De Felice L, Tatarelli C, Mascolo MG, et al. Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells. Cancer Res 2005; 65: 1505-1513.
22. Kaur K, Mirlashari MR, Kvalheim G, Kjeldsen-Kragh J. 30,40-Dimethoxyflavone and valproic acid promotes the proliferation of human hematopoietic stem cells. Stem Cell Res Ther 2013; 4: 60-68.
23. + cell fate decisions. Vox Sang 2014; 107: 83-89.
24. Mahmud N, Petro B, Baluchamy S, et al. Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells. Biol Blood Marrow Transplant 2014; 20: 480-489.
25. Milhem M, Mahmud N, Lavelle D, et al. Modification of hematopoietic stem cell fate by 5aza 20deoxycytidine and trichostatin A. Blood 2004; 103: 4102-4110.
26. Saraf S, Araki H, Petro B, et al. Ex vivo expansion of human mobilized peripheral blood stem cells using epigenetic modifiers. Transfusion 2014; doi: 10.1111/trf.12904. [Epub ahead of print]
27. Seet LF, Teng E, Lai YS, et al. Valproic acid enhances the engraftability of human umbilical cord blood hematopoietic stem cells expanded under serumfree conditions. Eur J Haematol 2009; 82: 124-132.
28. Teng HF, Li PN, Hou DR, et al. Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors. Mol Cell Endocrinol 2014; 383: 147-158.
29. Trecul A, Morceau F, Gaigneaux A, et al. Valproic acid regulates erythromegakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks. Biochem Pharmacol 2014; 92: 299-311.
30. Vulcano F, Milazzo L, Ciccarelli C, et al. Valproic acid affects the engraftment of TPO-expanded cord blood cells in NOD/SCID mice. Exp Cell Res 2012; 318: 400-407.
31. Walasek MA, Bystrykh L, van den Boom V, et al. The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation. Blood 2012; 119: 3050-3059.
32. Walasek MA, Bystrykh LV, Olthof S, et al. Sca-1 is an early-response target of histone deacetylase inhibitors and marks hematopoietic cells with enhanced function. Exp Hematol 2013; 41: 113.e2-123.e2.
33. Zini R, Norfo R, Ferrari F, et al. Valproic acid triggers erythro/megakaryocyte lineage decision through induction of GFI1B and MLLT3 expression. Exp Hematol 2012; 40: 1043.e6-1054.e6.
34. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
35. Santini V. Life after hypomethylating agents in myelodysplastic syndrome: New strategies. Curr Opin Hematol 2015; 22: 155-162.
36. Broxmeyer HE. Inhibiting HDAC for human hematopoietic stem cell expansion. J Clin Invest 2014; 124: 2365-2368.
37. Kang SJ, Park YI, So B, Kang HG. Sodium butyrate efficiently converts fully reprogrammed induced pluripotent stem cells from mouse partially reprogrammed cells. Cell Reprogram 2014; 16: 345-354.
38. Notta F, Doulatov S, Laurenti E, et al. Isolation of single human hematopoietic stem cells capable of long-Term multilineage engraftment. Science 2011; 333: 218-221.