Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis

Evidence-based Complementary and Alternative Medicine

Volumn 2015, Issue , 2015, Pages

  Xi, Song Yang ^a,b   Teng, Yu Hao ^a,b   Chen, Yan ^a,b   Li, Jie Ping ^a,b   Zhang, Ying Ying ^a,b   Liu, Shen Lin ^a   Zou, Xi ^a   Zhou, Jin Yong ^a   Wu, Jian ^a   Wang, Rui Ping ^a  

^a AFFILIATED HOSPITAL OF NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ATRACTYLODES MACROCEPHALA EXTRACT; CASPASE 3; CHINESE DRUG; COMPLEMENTARY DNA; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; CYCLIN E1; EUPHORBIA EXTRACT; JIANPI HUAYU DECOCTION; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; RNA; SALVIA MILTIORRHIZA EXTRACT; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; ATRACTYLODES; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION ASSAY; CELL VIABILITY; CHINESE MEDICINE; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; CURCUMA; EUPHORBIA; HUMAN; HUMAN CELL; IN VITRO STUDY; MEDICINAL PLANT; MTT ASSAY; NONHUMAN; PARIS POLYPHYLLA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALVIA MILTIORRHIZA; SCUTELLARIA BARBATA; WESTERN BLOTTING;

EID: 84942758478     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2015/236506     Document Type: Article

References (31)

1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, "Global cancer statistics," CA: A Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69-90, 2011.
2. Q. Li, S. Y. Zhou, J. Jing et al., "Oligosaccharide from apple induces apoptosis and cell cycle arrest in HT29 human colon cancer cells," International Journal of BiologicalMacromolecules, vol. 57, pp. 245-254, 2013.
3. M. Gordaliza, "Natural products as leads to anticancer drugs," Clinical and Translational Oncology, vol. 9, no. 12, pp. 767-776, 2007.
4. A. L. Harvey, "Natural products in drug discovery," Drug Discovery Today, vol. 13, no. 19-20, pp. 894-901, 2008.
5. D. J. Newman, G. M. Cragg, and K. M. Snader, "The influence of natural products upon drug discovery," Natural Product Reports, vol. 17, no. 3, pp. 215-234, 2000.
6. X.-Y. Tian and L. Liu, "Drug discovery enters a new era with multi-target intervention strategy," Chinese Journal of Integrative Medicine, vol. 18, no. 7, pp. 539-542, 2012.
7. X. Zou, R. P. Wang, D. Li et al., "Effects serum with Jianpi Huayu prescription on apoptosis of human colon cancer cell lovo," Liaoning Journal of Traditional Chinese Medicine, vol. 38, no. 12, pp. 2355-2356, 2011.
8. B. F. Ling, R. P. Wang, X. Zou et al., "Experimental study of Jianpi Huayu decoction on the effect of subcutaneous transplanted tumor and correlative MicroRNAs expression of nude mice," Journal of Sichuan Traditional Chinese Medicine, vol. 30, no. 8, pp. 49-52, 2012.
9. G. Nguyen-Ba and P. Vasseur, "Epigenetic events during the process of cell transformation induced by carcinogens (review)," Oncology Reports, vol. 6, no. 4, pp. 925-932, 1999.
10. K. Vermeulen, D. R. Van Bockstaele, and Z. N. Berneman, "The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer," Cell Proliferation, vol. 36, no. 3, pp. 131-149, 2003.
11. G. Brooks and N. B. La Thangue, "The cell cycle and drug discovery: the promise and the hope," Drug Discovery Today, vol. 4, no. 10, pp. 455-464, 1999.
12. R. Suryadinata, M. Sadowski, and B. Sarcevic, "Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates," Bioscience Reports, vol. 30, no. 4, pp. 243-255, 2010.
13. J. P. Li, Y. X. Yang, Q. L. Liu et al., "The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38MAPK and Akt/mTOR signaling pathways in human breast cancer cells," Drug Design, Development andTherapy, vol. 9, pp. 1627-1652, 2015.
14. M.Malumbres and M. Barbacid, "Cell cycle, CDKs and cancer: a changing paradigm," Nature Reviews Cancer, vol. 9, no. 3, pp. 153-166, 2009.
15. D. E. Lee, K. Lee, S. K. Jung et al., "6,7,4-Trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2," Carcinogenesis, vol. 32, no. 4, pp. 629-635, 2011.
16. S. H. Lim and P. Kaldis, "Cdks, cyclins and CKIs: roles beyond cell cycle regulation," Development, vol. 140, no. 15, pp. 3079-3093, 2013.
17. L. Zhang, Y. Zheng,H.Deng, L. Liang, and J. Peng, "Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells," International Journal of Molecular Medicine, vol. 33, no. 6, pp. 1613-1620, 2014.
18. P. M. Flatt and J. A. Pietenpol, "Mechanisms of cell-cycle checkpoints: at the crossroads of carcinogenesis and drug discovery," Drug Metabolism Reviews, vol. 32, no. 3-4, pp. 283-305, 2000.
19. J.Massagué, "G1 cell-cycle control and cancer," Nature, vol. 432, no. 7015, pp. 298-306, 2004.
20. J. Cicenas,K.Kalyan, A. Sorokinas et al., "Highlights of the latest advances in research on CDK inhibitors," Cancers, vol. 6, no. 4, pp. 2224-2242, 2014.
21. L.Wei, J. Lin, G.Wu et al., "Scutellaria barbata D. Don induces G1/S arrest via modulation of p53 and Akt pathways in human colon carcinoma cells," Oncology Reports, vol. 29, no. 4, pp. 1623-1628, 2013.
22. D. A. Orlando, C. Y. Lin, A. Bernard et al., "Global control of cell-cycle transcription by coupled CDK and network oscillators," Nature, vol. 453, no. 7197, pp. 944-947, 2008.
23. N. A. Thornberry and Y. Lazebnik, "Caspases: enemies within," Science, vol. 281, no. 5381, pp. 1312-1316, 1998.
24. A. Degterev and J. Yuan, "Expansion and evolution of cell death programmes," Nature ReviewsMolecular Cell Biology, vol. 9, no. 5, pp. 378-390, 2008.
25. J. B. Denault and K. Boatright, "Apoptosis in biochemistry and structural biology," IDrugs, vol. 7, no. 4, pp. 315-317, 2004.
26. T.-J. Fan, L.-H. Han, R.-S. Cong, and J. Liang, "Caspase family proteases and apoptosis," Acta Biochimica et Biophysica Sinica, vol. 37, no. 11, pp. 719-727, 2005.
27. S. Ghavami, M. Hashemi, S. R. Ande et al., "Apoptosis and cancer: mutations within caspase genes," Journal of Medical Genetics, vol. 46, no. 8, pp. 497-510, 2009.
28. R. Matuo, F. G. Sousa, A. E. Escargueil et al., "5-Fluorouracil and its activemetabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line," Journal of Applied Toxicology, vol. 29, no. 4, pp. 308-316, 2009.
29. C. Yu, S.-L. Liu, M.-H. Qi, X. Zou, J.Wu, and J. Zhang, "Herbal medicine Guan Chang Fu Fang enhances 5-fluorouracil cytotoxicity and affects drug-associated genes in human colorectal carcinoma cells," Oncology Letters, vol. 9, no. 2, pp. 701-708, 2015.
30. J. K. Brunelle and A. Letai, "Control ofmitochondrial apoptosis by the Bcl-2 family," Journal of Cell Science, vol. 122, no. 4, pp. 437-441, 2009.
31. S. Salakou, D. Kardamakis, A. C. Tsamandas et al., "Increased bax/bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis," In Vivo, vol. 21, no. 1, pp. 123-132, 2007.