Effects of acute and antecedent hypoglycemia on endothelial function and markers of atherothrombotic balance in healthy humans

Diabetes

Volumn 64, Issue 7, 2015, Pages 2571-2580

  Joy, Nino G ^a   Tate, Donna B ^a   Younk, Lisa M ^a   Davis, Stephen N ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOSE; HEMOGLOBIN A1C; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; NITRIC OXIDE; PADGEM PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBIN ANTITHROMBIN COMPLEX; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; GLUCOSE BLOOD LEVEL;

ACUTE HYPOGLYCEMIA; ADULT; ANTECEDENT HYPOGLYCEMIA; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD CLOTTING; BLOOD VESSEL FUNCTION; BRACHIAL ARTERY; COMPARATIVE STUDY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOPPLER FLOWMETRY; FATTY ACID METABOLISM; FEMALE; FIBRINOLYSIS; GLUCOSE BLOOD LEVEL; HEART RATE; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; HYPERINSULINEMIC-EUGLYCEMIC CLAMP TECHNIQUE; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; MALE; MEAN ARTERIAL PRESSURE; NEUROENDOCRINE SYSTEM; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE ACTIVATION; VASODILATATION; ANALYSIS; COMPLICATION; INFLAMMATION; PATHOPHYSIOLOGY; THROMBOSIS; VASCULAR ENDOTHELIUM;

ADULT; BIOMARKERS; BLOOD GLUCOSE; ENDOTHELIUM, VASCULAR; FEMALE; FIBRINOLYSIS; HUMANS; HYPOGLYCEMIA; INFLAMMATION; MALE; PLATELET ACTIVATION; THROMBOSIS;

EID: 84942756638     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-1729     Document Type: Article

References (38)

1. Desouza C, Salazar H, Cheong B, Murgo J, Fonseca V. Association of hypoglycemia and cardiac ischemia: A study based on continuous monitoring. Diabetes Care 2003;26:1485-1489
2. Wright RJ, Frier BM. Vascular disease and diabetes: Is hypoglycaemia an aggravating factor? Diabetes Metab Res Rev 2008;24:353-363
3. Finfer S, Chittock DR, Su SY, et al.; NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009;360:1283-1297
4. Egi M, Bellomo R, Stachowski E, et al. Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc 2010;85:217-224
5. Gerstein HC, Miller ME, Byington RP, et al.; Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008;358:2545-2559
6. Duckworth W, Abraira C, Moritz T, et al.; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009;360:129-139
7. Patel A, MacMahon S, Chalmers J, et al.; ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;358:2560-2572
8. Wei M, Gibbons LW, Mitchell TL, Kampert JB, Stern MP, Blair SN. Low fasting plasma glucose level as a predictor of cardiovascular disease and allcause mortality. Circulation 2000;101:2047-2052
9. Dandona P, Chaudhuri A, Dhindsa S. Proinflammatory and prothrombotic effects of hypoglycemia. Diabetes Care 2010;33:1686-1687
10. Dandona P, Chaudhuri A, Ghanim H, Mohanty P. Effect of hyperglycemia and insulin in acute coronary syndromes. Am J Cardiol 2007;99:12H-18H
11. Wright RJ, Newby DE, Stirling D, Ludlam CA, Macdonald IA, Frier BM. Effects of acute insulin-induced hypoglycemia on indices of inflammation: Putative mechanism for aggravating vascular disease in diabetes. Diabetes Care 2010;33:1591-1597
12. Gogitidze Joy N, Hedrington MS, Briscoe VJ, Tate DB, Ertl AC, Davis SN. Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals. Diabetes Care 2010;33:1529-1535
13. Razavi Nematollahi L, Kitabchi AE, Stentz FB, et al. Proinflammatory cytokines in response to insulin-induced hypoglycemic stress in healthy subjects. Metabolism 2009;58:443-448
14. Abumrad NN, Rabin D, Diamond MP, Lacy WW. Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism 1981;30:936-940
15. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223
16. Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS. Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. N Engl J Med 1987;316:1376-1383
17. Briscoe VJ, Ertl AC, Tate DB, Dawling S, Davis SN. Effects of a selective serotonin reuptake inhibitor, fluoxetine, on counterregulatory responses to hypoglycemia in healthy individuals. Diabetes 2008;57:2453-2460
18. Wide L, Porath J. Radioimmunoassay of proteins with the uses of sephadexcoupled antibodies. Biochim Biophys Acta 1966;130:257-260
19. Causon RC, Carruthers ME, Rodnight R. Assay of plasma catecholamines by liquid chromatography with electrochemical detection. Anal Biochem 1981;116:223-226
20. Ho RJ. Radiochemical assay of long-chain fatty acids using 63Ni as tracer. Anal Biochem 1970;36:105-113
21. Sigurdardottir G, Ekman AK, Ståhle M, Bivik C, Enerbäck C. Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis. J Am Acad Dermatol 2014;70:1067-1075
22. Faulx MD, Wright AT, Hoit BD. Detection of endothelial dysfunction with brachial artery ultrasound scanning. Am Heart J 2003;145:943-951
23. Chaudhuri A, Dandona P, Fonseca V. Cardiovascular benefits of exogenous insulin. J Clin Endocrinol Metab 2012;97:3079-3091
24. Dandona P, Chaudhuri A, Ghanim H. Acute myocardial infarction, hyperglycemia, and insulin. J Am Coll Cardiol 2009;53:1437-1439
25. Ceriello A, Novials A, Ortega E, et al. Evidence that hyperglycemia after recovery from hypoglycemia worsens endothelial function and increases oxidative stress and inflammation in healthy control subjects and subjects with type 1 diabetes. Diabetes 2012;61:2993-2997
26. Poredos P, Jezovnik MK. Testing endothelial function and its clinical relevance. J Atheroscler Thromb 2013;20:1-8
27. Giménez M, Gilabert R, Monteagudo J, et al. Repeated episodes of hypoglycemia as a potential aggravating factor for preclinical atherosclerosis in subjects with type 1 diabetes. Diabetes Care 2011;34:198-203
28. Babar GS, Zidan H, Widlansky ME, et al. Impaired endothelial function in preadolescent children with type 1 diabetes. Diabetes Care 2011;34: 681-685
29. Wang J, Alexanian A, Ying R, et al. Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: Role for AMP kinase. Arterioscler Thromb Vasc Biol 2012;32:712-720
30. Sandu OA, Ragolia L, Begum N. Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation. Diabetes 2000;49: 2178-2189
31. Cryer PE. Hypoglycemia-associated autonomic failure in diabetes. Handb Clin Neurol 2013;117:295-307
32. Rana O, Byrne CD, Kerr D, et al. Acute hypoglycemia decreases myocardial blood flow reserve in patients with type 1 diabetes mellitus and in healthy humans. Circulation 2011;124:1548-1556
33. Mathew M, Tay E, Cusi K. Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects. Cardiovasc Diabetol 2010;9:9
34. Frost RA, Nystrom GJ, Lang CH. Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: Role of c-Jun NH2-terminal kinase and histone deacetylase activity. Am J Physiol Endocrinol Metab 2004;286:E809-E817
35. Halleux CM, Declerck PJ, Tran SL, Detry R, Brichard SM. Hormonal control of plasminogen activator inhibitor-1 gene expression and production in human adipose tissue: Stimulation by glucocorticoids and inhibition by catecholamines. J Clin Endocrinol Metab 1999;84:4097-4105
36. Van Der Poll T, Levi M, Dentener M, et al. Epinephrine exerts anticoagulant effects during human endotoxemia. J Exp Med 1997;185:1143-1148
37. Farmer P, Pugin J. beta-adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the IkappaB/NF-kappaB pathway. Am J Physiol Lung Cell Mol Physiol 2000;279:L675-L682
38. Hafezi-Moghadam A, Simoncini T, Yang Z, et al. Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med 2002;8:473-479