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Volumn 24, Issue 4, 2015, Pages 330-335

Novel iron-based phosphate binders in patients with chronic kidney disease

Author keywords

Chronic kidney disease; Dialysis; Iron; Phosphate; Phosphate binders

Indexed keywords

FERRIC CITRATE; PHOSPHATE; PLACEBO; SEVELAMER CARBONATE; SUCROFERRIC OXYHYDROXIDE; CHELATING AGENT; IRON;

EID: 84942750404     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0000000000000128     Document Type: Review
Times cited : (9)

References (36)
  • 1
    • 20544433192 scopus 로고    scopus 로고
    • Serum phosphate levels and mortality risk among people with chronic kidney disease
    • Kestenbaum B, Sampson JN, Rudser KD, et al. Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 2005;16:520-528.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 520-528
    • Kestenbaum, B.1    Sampson, J.N.2    Rudser, K.D.3
  • 2
    • 36048942723 scopus 로고    scopus 로고
    • High plasma phosphate as a risk factor for decline in renal function and mortality in predialysis patients
    • Voormolen N, Noordzij M, Grootendorst DC, et al. High plasma phosphate as a risk factor for decline in renal function and mortality in predialysis patients. Nephrol Dial Transplant 2007;22:2909-2916.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 2909-2916
    • Voormolen, N.1    Noordzij, M.2    Grootendorst, D.C.3
  • 3
    • 59949084660 scopus 로고    scopus 로고
    • Phosphorus binders and survival on hemodialysis
    • Isakova T, Gutierrez OM, Chang Y, et al. Phosphorus binders and survival on hemodialysis. J Am Soc Nephrol 2009;20:388-396.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 388-396
    • Isakova, T.1    Gutierrez, O.M.2    Chang, Y.3
  • 4
    • 49249104701 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    • Gutiérrez OM, Mannstadt M, Isakova T, et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med 2008;359:584-592.
    • (2008) N Engl J Med , vol.359 , pp. 584-592
    • Gutiérrez, O.M.1    Mannstadt, M.2    Isakova, T.3
  • 5
    • 48049102175 scopus 로고    scopus 로고
    • The mechanism of phosphorus as a cardiovascular risk factor in CKD
    • Mathew S, Tustison KS, Sugatani T, et al. The mechanism of phosphorus as a cardiovascular risk factor in CKD. J Am Soc Nephrol 2008;19:1092-1105.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1092-1105
    • Mathew, S.1    Tustison, K.S.2    Sugatani, T.3
  • 7
    • 0023623472 scopus 로고
    • Clinical disorders of phosphorus metabolism
    • Yu Gc, Lee DBN. clinical disorders of phosphorus metabolism. West J Med 1987;147:569-576.
    • (1987) West J Med , vol.147 , pp. 569-576
    • Yu, G.C.1    Lee, D.B.N.2
  • 8
    • 77950810562 scopus 로고    scopus 로고
    • Oral phosphate binders in patients with kidney failure
    • Tonelli M, Pannu N, Manns B. Oral phosphate binders in patients with kidney failure. N Engl J Med 2010;362:1312-1324.
    • (2010) N Engl J Med , vol.362 , pp. 1312-1324
    • Tonelli, M.1    Pannu, N.2    Manns, B.3
  • 10
    • 0009435787 scopus 로고
    • Absorption of calcium, phosphorus and magnesium
    • Nordin BEC, editor, Edinburg and London: Churchill-Livingstone
    • Wilkinson R. Absorption of calcium, phosphorus and magnesium. In: Nordin BEC, editor. Calcium, phosphate and magnesium metabolism. Edinburg and London: Churchill-Livingstone; 1976. pp. 36-112.
    • (1976) Calcium, Phosphate and Magnesium Metabolism , pp. 36-112
    • Wilkinson, R.1
  • 11
    • 79958725801 scopus 로고    scopus 로고
    • The intact nephron hypothesis: The concept and its implications for phosphate management in CKD-related mineral and bonedisorder
    • Slatopolsky E. The intact nephron hypothesis: the concept and its implications for phosphate management in CKD-related mineral and bonedisorder. Kidney Int 2011;79(Suppl 121):S3-S8.
    • (2011) Kidney Int , vol.79 , pp. S3-S8
    • Slatopolsky, E.1
  • 12
    • 17944400289 scopus 로고
    • Phosphate transport along the nephron
    • Knox FG, Oswald H, Marchand GR, et al. Phosphate transport along the nephron. Am J Physiol 1977;233:F261-F268.
    • (1977) Am J Physiol , vol.233 , pp. F261-F268
    • Knox, F.G.1    Oswald, H.2    Marchand, G.R.3
  • 13
    • 0015514781 scopus 로고
    • On the pathogenesis of the uremic state. An exposition of the 'trade of hypothesis'
    • Bricker NS. On the pathogenesis of the uremic state. An exposition of the 'trade of hypothesis'. N Engl J Med 1972;286:1093-1099.
    • (1972) N Engl J Med , vol.286 , pp. 1093-1099
    • Bricker, N.S.1
  • 14
    • 0026040622 scopus 로고
    • Calcium and phosphorus fluxes during hemodialysis with low calcium dialysate
    • Hou SH, Zhao J, Ellman CF. Calcium and phosphorus fluxes during hemodialysis with low calcium dialysate. Am J Kidney Dis 1991;18:217-224.
    • (1991) Am J Kidney Dis , vol.18 , pp. 217-224
    • Hou, S.H.1    Zhao, J.2    Ellman, C.F.3
  • 15
    • 0025781465 scopus 로고
    • Phosphate removal rate: A comparative study of five high flux dialysers
    • Chauveau P, Poigent JL, Kuno T. Phosphate removal rate: a comparative study of five high flux dialysers. Nephrol Dial Transplant 1991;6(Suppl 2):114-115.
    • (1991) Nephrol Dial Transplant , vol.6 , pp. 114-115
    • Chauveau, P.1    Poigent, J.L.2    Kuno, T.3
  • 16
    • 0027690435 scopus 로고
    • Phosphate kinetics during high flux hemodialysis
    • Desoi A, Umans J. Phosphate kinetics during high flux hemodialysis. J Am Soc Nephrol 1993;4:1214-1218.
    • (1993) J Am Soc Nephrol , vol.4 , pp. 1214-1218
    • Desoi, A.1    Umans, J.2
  • 18
    • 0032919282 scopus 로고    scopus 로고
    • Stabilized polynuclear iron hydroxide is an efficient oral phosphate binder in uraemic patients
    • Hergesell O, Ritz E. Stabilized polynuclear iron hydroxide is an efficient oral phosphate binder in uraemic patients. Nephrol Dial Transplant 1999;14:863-867.
    • (1999) Nephrol Dial Transplant , vol.14 , pp. 863-867
    • Hergesell, O.1    Ritz, E.2
  • 19
    • 77954738634 scopus 로고    scopus 로고
    • PA21: A novel phosphate binder for the treatment of hyperphosphatemia in chronic kidney disease
    • Geisser P, Philipp E. PA21: a novel phosphate binder for the treatment of hyperphosphatemia in chronic kidney disease. Clin Nephrol 2010;74:4-11.
    • (2010) Clin Nephrol , vol.74 , pp. 4-11
    • Geisser, P.1    Philipp, E.2
  • 20
    • 84896536028 scopus 로고    scopus 로고
    • The iron-based phosphate binder PA21 has potent phosphate binding capacity and minimal iron release across a physiological pH range in vitro
    • Wilhelm M, Gaillard S, Rakov V, Funk F. The iron-based phosphate binder PA21 has potent phosphate binding capacity and minimal iron release across a physiological pH range in vitro. Clin Nephrol 2014;81:251-258.
    • (2014) Clin Nephrol , vol.81 , pp. 251-258
    • Wilhelm, M.1    Gaillard, S.2    Rakov, V.3    Funk, F.4
  • 21
    • 84875035936 scopus 로고    scopus 로고
    • Randomized clinical trial of the ironbased phosphate binder PA21 in hemodialysis patients
    • Wüthrich RP, Chonchol M, Covic A, et al. Randomized clinical trial of the ironbased phosphate binder PA21 in hemodialysis patients. Clin J Am Soc Nephrol 2013;8:280-289.
    • (2013) Clin J Am Soc Nephrol , vol.8 , pp. 280-289
    • Wüthrich, R.P.1    Chonchol, M.2    Covic, A.3
  • 22
    • 84907597180 scopus 로고    scopus 로고
    • A phase III study of & the efficacy and safety of a novel iron-based phosphate binder in dialysis patients
    • Floege J, Covic AC, Ketteler M, et al., PA21 Study Group. A phase III study of & the efficacy and safety of a novel iron-based phosphate binder in dialysis patients. Kidney Int 2014;86:638-6347. This phase III study compares the efficacy and safety of sucroferric oxyhydroxide with that of sevelamer carbonate in both HD and peritoneal dialysis patients.
    • (2014) Kidney Int , vol.86 , pp. 638-6347
    • Floege, J.1    Covic, A.C.2    Ketteler, M.3
  • 23
    • 84942763430 scopus 로고    scopus 로고
    • Accessed 29 December 2014
    • http://auryxia.com/wp-content/uploads/Auryxia-PI-Keryx-112014.pdf. [Accessed 29 December 2014]
  • 24
    • 84933471941 scopus 로고
    • Studies of calcium and phosphorus metabolism with special reference to pathogenesis and effects of dihydrotachysterol (A. T.10) and iron
    • Liu SH, Chu HI. Studies of calcium and phosphorus metabolism with special reference to pathogenesis and effects of dihydrotachysterol (A. T.10) and iron. Medicine (Baltimore) 1943;22:103-161.
    • (1943) Medicine (Baltimore) , vol.22 , pp. 103-161
    • Liu, S.H.1    Chu, H.I.2
  • 25
    • 0033041055 scopus 로고    scopus 로고
    • New phosphate binding agents: Ferric compounds
    • Hsu CH, Patel SR, Young EW. New phosphate binding agents: ferric compounds. J Am Soc Nephrol 1999;10:1274-1280.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1274-1280
    • Hsu, C.H.1    Patel, S.R.2    Young, E.W.3
  • 26
    • 0036177310 scopus 로고    scopus 로고
    • An open-label, crossover study of a new phosphate-binding agent in haemodialysis patients: Ferric citrate
    • Yang WC, Yang CS, Hou CC, et al. An open-label, crossover study of a new phosphate-binding agent in haemodialysis patients: ferric citrate. Nephrol Dial Transplant 2002;17:265-270.
    • (2002) Nephrol Dial Transplant , vol.17 , pp. 265-270
    • Yang, W.C.1    Yang, C.S.2    Hou, C.C.3
  • 27
    • 84876295026 scopus 로고    scopus 로고
    • Doseresponse and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: A short-term randomized trial
    • Dwyer JP, Sika M, Schulman G, et al., Collaborative Study Group. Doseresponse and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial. Am J Kidney Dis 2013;61:759-766.
    • (2013) Am J Kidney Dis , vol.61 , pp. 759-766
    • Dwyer, J.P.1    Sika, M.2    Schulman, G.3
  • 28
    • 84924004431 scopus 로고    scopus 로고
    • Ferric & citrate controls phosphorus and delivers iron in patients on dialysis
    • Lewis JB, Sika M, Koury MJ, et al., for the Collaborative Study Group. Ferric & citrate controls phosphorus and delivers iron in patients on dialysis. J Am Soc Nephrol 2015;26:493-503; doi: 10.1681/ASN.2014020212. [Epub ahead of print] The pivotal phase 3 study of ferric citrate was highly illuminating in terms of characterizing the drug's utility as a phosphate binder and erythropoietic agent.
    • (2015) J Am Soc Nephrol , vol.26 , pp. 493-503
    • Lewis, J.B.1    Sika, M.2    Koury, M.J.3
  • 29
    • 84901316389 scopus 로고    scopus 로고
    • Reduction of costs for anemia-management drugs associated with the use of ferric citrate
    • Thomas A, Peterson LE. Reduction of costs for anemia-management drugs associated with the use of ferric citrate. Int J Nephrol Renovasc Dis 2014;7:191-201.
    • (2014) Int J Nephrol Renovasc Dis , vol.7 , pp. 191-201
    • Thomas, A.1    Peterson, L.E.2
  • 30
    • 0030859097 scopus 로고    scopus 로고
    • An evaluation of the effectiveness of oral iron therapy in hemodialysis patients receiving recombinant human erythropoietin
    • Markowitz GS, Kahn GA, Feingold RE, et al. An evaluation of the effectiveness of oral iron therapy in hemodialysis patients receiving recombinant human erythropoietin. Clin Nephrol 1997;48:34-40.
    • (1997) Clin Nephrol , vol.48 , pp. 34-40
    • Markowitz, G.S.1    Kahn, G.A.2    Feingold, R.E.3
  • 31
    • 0029952883 scopus 로고    scopus 로고
    • A randomized controlled study of iron supplementation in patients treated with erythropoietin
    • Macdougall IC, Tucker B, Thompson J, et al. A randomized controlled study of iron supplementation in patients treated with erythropoietin. Kidney Int 1996;50:1694-1699.
    • (1996) Kidney Int , vol.50 , pp. 1694-1699
    • Macdougall, I.C.1    Tucker, B.2    Thompson, J.3
  • 32
    • 0031805697 scopus 로고    scopus 로고
    • Correction of uremic iron deficiency anemia in hemodialyzed patients: A prospective study
    • Fudin R, Jaichenko J, Shostak A, et al. Correction of uremic iron deficiency anemia in hemodialyzed patients: a prospective study. Nephron 1998;79:299-305.
    • (1998) Nephron , vol.79 , pp. 299-305
    • Fudin, R.1    Jaichenko, J.2    Shostak, A.3
  • 33
    • 84883243996 scopus 로고    scopus 로고
    • Phosphate homeostasis in CKD: Report of a scientific symposium sponsored by the National Kidney Foundation
    • Block GA, Ix JH, Ketteler M, et al. Phosphate homeostasis in CKD: report of a scientific symposium sponsored by the National Kidney Foundation. Am J Kidney Dis 2013;62:457-473.
    • (2013) Am J Kidney Dis , vol.62 , pp. 457-473
    • Block, G.A.1    Ix, J.H.2    Ketteler, M.3
  • 34
    • 84896853425 scopus 로고    scopus 로고
    • Ferric citrate hydrate for the treatment & of hyperphosphatemia in nondialysis-dependent CKD
    • Yokoyama K, Hirakata H, Akiba T, et al. Ferric citrate hydrate for the treatment & of hyperphosphatemia in nondialysis-dependent CKD. Clin J Am Soc Nephrol 2014;9:543-552. Interesting finding of a substantial reduction in FGF-23 levels during ferric citrate treatment.
    • (2014) Clin J Am Soc Nephrol , vol.9 , pp. 543-552
    • Yokoyama, K.1    Hirakata, H.2    Akiba, T.3
  • 35
    • 84926493841 scopus 로고    scopus 로고
    • A 12-week, double-blind, placebo-controlled trial of ferric citrate for the treatment of iron deficiency anemia and reduction of serum phosphate in patients with CKD stages 3-5
    • Block GA, Fishbane S, Rodriguez M, et al. A 12-week, double-blind, placebo-controlled trial of ferric citrate for the treatment of iron deficiency anemia and reduction of serum phosphate in patients with CKD stages 3-5. Am J Kidney Dis 2015;65:728-736; doi: 10.1053/j.ajkd.2014.10.014. [Epub ahead of print] As in the above reference [34&], a clear demonstration of ferric citrate's ability to lower FGF-23 levels.
    • (2015) Am J Kidney Dis , vol.65 , pp. 728-736
    • Block, G.A.1    Fishbane, S.2    Rodriguez, M.3
  • 36
    • 84864859705 scopus 로고    scopus 로고
    • Effects of phosphate binders in moderate CKD
    • Block GA, Wheeler DC, Persky MS, et al. Effects of phosphate binders in moderate CKD. J Am Soc Nephrol 2012;23:1407-1415.
    • (2012) J Am Soc Nephrol , vol.23 , pp. 1407-1415
    • Block, G.A.1    Wheeler, D.C.2    Persky, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.