Mesenchymal stem cells reverse bone marrow dysfunction following injury and stress

Journal of Trauma and Acute Care Surgery

Volumn 79, Issue 4, 2015, Pages 602-608

  Gore, Amy V ^a   Bible, Letitia E ^a   Livingston, David H ^a   Mohr, Alicia M ^a   Sifri, Ziad C ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

BM dysfunction; Cell based therapy; Chronic stress; MSCs; Rats

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BONE MARROW DEPRESSION; BURST FORMING UNIT E; CELL GROWTH; CHRONIC STRESS; COLONY FORMING UNIT E; COLONY FORMING UNIT GEMM; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; LUNG CONTUSION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL MOBILIZATION; ANIMAL; BLOOD; BONE MARROW; CONTUSION; EXERCISE; LUNG INJURY; MESENCHYMAL STROMA CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; STEM CELL;

ANIMALS; BONE MARROW; CONTUSIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRANULOCYTE COLONY-STIMULATING FACTOR; LUNG INJURY; MALE; MESENCHYMAL STROMAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; STEM CELLS;

EID: 84942586605     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000823     Document Type: Conference Paper

References (32)

1. Corwin HL, Surgenor SD, Gettinger A. Transfusion practice in the critically ill. Crit Care Med. 2003;31:S668-S671.
2. Baranski G, Offin M, Sifri Z, Elhassan IO, Hannoush EJ, Alzate WD, Rameshwar P, Livingston DH, Mohr AM. A-blockade protection of bone marrow following trauma: the role of G-CSF. J Surg Res. 2011;170: 325-331.
3. Elhassan IO, Hannoush EJ, Sifri ZC, Jones E, Alzate WD, Rameshwar P, Livingston DH, Mohr AM. Beta-blockade prevents hematopoietic progenitor cell suppression after hemorrhagic shock. Surg Infect (Larchmt). 2011;12:273-278.
4. Livingston DH, Gentile PS, Malangoni MA. Bone marrow failure after hemorrhagic shock. Circ Shock. 1990;30:255-263.
5. Livingston DH, Anjaria D, Wu J, Hauser CJ, Chang V, Deitch EA, Rameshwar P. Bone marrow failure following severe injury in humans. Ann Surg. 2003;238:748-753.
6. Fonseca RB, Mohr AM, Wang L, Clinton E, Sifri ZC, Rameshwar P, Livingston DH. Adrenergic modulation of erythropoiesis following severe injury is mediated through bone marrow stroma. Surg Infect (Larchmt). 2004 Winter;5(4):385-393.
7. Bible L, Pasupuleti L, Sifri Z, Alzate W, Livingston D, Mohr A. Chronic stress impairs bone marrow function. Shock. 2013;39(S2):176.
8. Ren G, Chen X, Dong F, Li W, Ren X, Zhang Y, Shi Y. Concise review: mesenchymal stem cells and translational medicine: emerging issues. Stem Cells Transl Med. 2012;1(1):51-58.
9. Yi TG, Song SU. Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications. Arch Pharm Res. 2012;35(2): 213-221.
10. Jackson WM, Nesti LJ, Tuan RS. Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem Cells Transl Med. 2012;1(1):44-50.
11. Ghannam S, Bouffi C, Djouad F, Jorgensen C, Noel D. Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications. Stem Cell Res Ther. 2010;1(1):2.
12. Chen AK, Reuveny S, Oh SK. Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: achievements and future direction. Biotechnol Adv. 2013;31(7):1032-1046.
13. Hannoush EJ, Elhassan I, Sifri ZC, Mohr AM, Alzate WD, Livingston DH. Role of bone marrow and mesenchymal stem cells in healing after traumatic injury. Surgery. 2013;153(1):44-51.
14. Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol. 1998; 176:57-66.
15. Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone. 1992;13:69-80.
16. Kawada H, Fujita J, Kinjo K, Matsuzaki Y, Tsuma M, Miyatake H, Mugu ruma Y, Tsuboi K, Itabashi Y, Ikeda Y. Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction. Blood. 2004;104:3581-3587.
17. Jin J,Wang X,Wang Q, Guo X, Cao J, Zhang X, Zhu T, Zhang D,WangW, Wang J, Shen B, Gao X, Shi Y, Zhang J. Chronic psychological stress induces the accumulation of myeloid-derived suppressor cells in mice. PLoS One. 2013;8:e74497.
18. Romana-Souza B, Porto LC, Monte-Alto-Costa A. Cutaneous wound healing of chronically stressed mice is improved through catecholamine blockade. Exp Dermatol. 2010;19:821-829.
19. Wu Y, Cao Y, Li X, Xu L,Wang Z, Liu P, Yan P, Liu Z,Wang J, Jiang S,Wu X, Gao C, DaW, Han Z. Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: successful engraftment and mild GVHD. Stem Cell Res. 2014;12(1): 132-138.
20. Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L, Ponomaryov T, Taichman RS, Arenzana-Seisdedos F, Fugii N, Sandbank J, Zipori D, Lapidot T. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol. 2002;3(7): 687-694.
21. Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA, Frenette PS. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell. 2006;124(2): 407-421.
22. Wu JC, Livingston DH, Hauser CJ, Deitch EA, Rameshwar P. Trauma inhibits erythroid burst-forming unit and granulocyte-monocyte colonyforming unit growth through the production of TGF-beta1 by bone marrow stroma. Ann Surg. 2001;234(2):224-232.
23. Cook K, Sifri Z, Baranski G, Rameshwar P, Mohr A, Livingston D. The role of T regulatory cells in mesenchymal stromal cell (MSC)Ymedicated wound healing. Surg Infect (Larchmt). 2012;13(1):S15.
24. Pedrazza L, Lundardelli A, Luft C, Cruz CU, de Mesquita FC, Bitencourt S, Nunes FB, de Oliveira JR. Mesenchymal stem cells decrease splenocytes apoptosis in a sepsis experimental model. Inflamm Res. 2014;63:719-728.
25. Weil BR, Manukyan MC, Herrmann JL, et al. Mesenchymal stem cells attenuate myocardial functional depression and reduce systemic and myocardial inflammation during endotoxemia. Surgery. 2010;148(2): 444-452.
26. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR, Flake AW. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med. 2000;6:1282-1286.
27. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997;276:71-74.
28. Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O'Brien T, O'Toole D, Laffey JG. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax. 2012;67:496-501.
29. Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, GO K, Phinney DG. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci U S A. 2007;104(26):11002-11007.
30. Mei SH, Haitsma JJ, Dos Santos CC, Deng Y, Lai PF, Slutsky AS, Liles WC, Stewart DJ. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med. 2010;182(8):1047-1057.
31. Spaggiaria GM, Abdelrazik H, Becchetti F, Moretta L. MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood. 2009;113(26):6576-6583.
32. Gore AG, Bible LE, Livingston DH, Mohr AM, Sifri ZC. Can mesenchymal stem cells reverse chronic stress-induced impairment of lung healing following trauma? J Trauma Acute Care Surg. 2015;78(4): 767-772.