Pragmatic randomized controlled trial of long-term psychoanalytic psychotherapy for treatment-resistant depression: The Tavistock Adult Depression Study (TADS)

World Psychiatry

Volumn 14, Issue 3, 2015, Pages 312-321

  Fonagy, Peter ^a   Rost, Felicitas ^b   Carlyle, Jo Anne ^b   McPherson, Susan ^c   Thomas, Rachel ^b   Pasco Fearon, R M ^a   Goldberg, David ^d   Taylor, David ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TAVISTOCK CLINIC   (United Kingdom)

^c UNIVERSITY OF ESSEX   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

delayed therapeutic effect; long term treatment; psychoanalytic psychotherapy; Treatment resistant depression

Indexed keywords

ANALGESIC AGENT; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; NEUROLEPTIC AGENT;

ADULT; AGED; ARTICLE; BECK DEPRESSION INVENTORY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; FOLLOW UP; GLOBAL ASSESSMENT OF FUNCTIONING; HAMILTON DEPRESSION RATING SCALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PATIENT COUNSELING; PRIORITY JOURNAL; PSYCHOANALYSIS; PSYCHOANALYTIC PSYCHOTHERAPY; PSYCHOTHERAPY; QUALITY OF LIFE ENJOYMENT AND SATISFACTION QUESTIONNAIRE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; SOCIAL INTERACTION; TREATMENT DURATION; TREATMENT RESISTANT DEPRESSION; WELLBEING;

EID: 84942522802     PISSN: 17238617     EISSN: 20515545     Source Type: Journal    
DOI: 10.1002/wps.20267     Document Type: Article

References (50)

1. Moussavi S, Chatterji S, Verdes E, et al., Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet 2007; 370: 851-8.
2. Greden JF., The burden of disease for treatment-resistant depression. J Clin Psychiatry 2001; 62 (Suppl. 16): 26-31.
3. Huhn M, Tardy M, Spineli LM, et al., Efficacy of pharmacotherapy and psychotherapy for adult psychiatric disorders: a systematic overview of meta-analyses. JAMA Psychiatry 2014; 71: 706-15.
4. Stimpson N, Agrawal N, Lewis G., Randomised controlled trials investigating pharmacological and psychological interventions for treatment-refractory depression. Systematic review. Br J Psychiatry 2002; 181: 284-94.
5. Thomas L, Kessler D, Campbell J, et al., Prevalence of treatment-resistant depression in primary care: cross-sectional data. Br J Gen Pract 2013; 63: e852-8.
6. Kubitz N, Mehra M, Potluri RC, et al., Characterization of treatment resistant depression episodes in a cohort of patients from a US commercial claims database. PLoS One 2013; 8: e76882.
7. McIntyre RS, Filteau MJ, Martin L, et al., Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach. J Affect Disord 2014; 156: 1-7.
8. Spijker J, van Straten A, Bockting CL, et al., Psychotherapy, antidepressants, and their combination for chronic major depressive disorder: a systematic review. Can J Psychiatry 2013; 58: 386-92.
9. Carvalho AF, Berk M, Hyphantis TN, et al., The integrative management of treatment-resistant depression: a comprehensive review and perspectives. Psychother Psychosom 2014; 83: 70-88.
10. Lam RW, Chan P, Wilkins-Ho M, et al., Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and metaanalysis. Can J Psychiatry 2008; 53: 621-31.
11. Daban C, Martinez-Aran A, Cruz N, et al., Safety and efficacy of Vagus Nerve Stimulation in treatment-resistant depression. A systematic review. J Affect Disord 2008; 110: 1-15.
12. Morishita T, Fayad SM, Higuchi MA, et al., Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes. Neurotherapeutics 2014; 11: 475-84.
13. Trivedi RB, Nieuwsma JA, Williams JW Jr., Examination of the utility of psychotherapy for patients with treatment resistant depression: a systematic review. J Gen Intern Med 2011; 26: 643-50.
14. Hollon SD, DeRubeis RJ, Fawcett J, et al., Effect of cognitive therapy with antidepressant medications vs antidepressants alone on the rate of recovery in major depressive disorder: a randomized clinical trial. JAMA Psychiatry 2014; 71: 1157-64.
15. Hollon SD, Ponniah K., A review of empirically supported psychological therapies for mood disorders in adults. Depress Anxiety 2010; 27: 891-932.
16. Rawlins M., De Testimonio: on the evidence for decisions about the use of therapeutic interventions. Clin Med 2008; 8: 579-88.
17. Driessen E, Van HL, Don FJ, et al., The efficacy of cognitive-behavioral therapy and psychodynamic therapy in the outpatient treatment of major depression: a randomized clinical trial. Am J Psychiatry 2013; 170: 1041-50.
18. Fonagy P., The effectiveness of psychodynamic psychotherapies: an update. World Psychiatry 2015; 14: 137-50.
19. Leichsenring F, Klein S., Evidence for psychodynamic psychotherapy in specific mental disorders: a systematic review. Psychoanal Psychother 2014; 28: 4-32.
20. de Maat S, de Jonghe F, de Kraker R, et al., The current state of the empirical evidence for psychoanalysis: a meta-analytic approach. Harv Rev Psychiatry 2013; 21: 107-37.
21. Knekt P, Lindfors O, Laaksonen MA, et al., Quasi-experimental study on the effectiveness of psychoanalysis, long-term and short-term psychotherapy on psychiatric symptoms, work ability and functional capacity during a 5-year follow-up. Helsinki Psychotherapy Study Group. J Affect Disord 2011; 132: 37-47.
22. Leichsenring F, Rabung S., Long-term psychodynamic psychotherapy in complex mental disorders: update of a meta-analysis. Br J Psychiatry 2011; 199: 15-22.
23. Shedler J., The efficacy of psychodynamic psychotherapy. Am Psychol 2010; 65: 98-109.
24. Beck AT, Steer R, Brown G., Manual for Beck Depression Inventory-II (BDI-II). San Antonio: Psychological Corporation, 1996.
25. Taylor D, Carlyle JA, McPherson S, et al., Tavistock Adult Depression Study (TADS): a randomised controlled trial of psychoanalytic psychotherapy for treatment-resistant/treatment-refractory forms of depression. BMC Psychiatry 2012; 12: 60.
26. First MB, Spitzer RL, Gibbon M, et al., User's Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders-Research Version. New York: Biometrics Research, New York State Psychiatric Institute, 2001.
27. Hamilton M., A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
28. Taylor D., Treatment manuals and the advancement of psychoanalytic knowledge: the treatment manual of the Tavistock Adult Depression Study. Int J Psychoanalysis 2015; 96: 845-75.
29. McPherson S, Armstrong D., Negotiating 'depression' in primary care: a qualitative study. Soc Sci Med 2009; 69: 1137-43.
30. Andrews G., Reducing the burden of depression. Can J Psychiatry 2008; 53: 420-7.
31. Milton J., Psychoanalysis and cognitive behaviour therapy-rival paradigms or common ground? Int J Psychoanal 2001; 82: 431-47.
32. Jones EE., Therapeutic action: a guide to psychoanalytic therapy. Northvale: Jason Aronson, 2000.
33. National Institute for Health and Clinical Excellence. Depression in adults: the treatment and management of depression in adults. Clinical Guideline 90. London: National Institute for Health and Clinical Excellence, 2009.
34. Beecham JK, Knapp MRJ., Costing psychiatric interventions. In:, Thornicroft G, Brewin C, Wing JK, (eds). Measuring mental health needs. London: Gaskell/Royal College of Psychiatrists, 1992: 163-83.
35. Reimherr FW, Amsterdam JD, Quitkin FM, et al., Optimal length of continuation therapy in depression: a prospective assessment during long-term fluoxetine treatment. Am J Psychiatry 1998; 155: 1247-53.
36. Frank E, Prien RF, Jarrett RB, et al., Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry 1991; 48: 851-5.
37. Hilsenroth MJ, Ackerman SJ, Blagys MD, et al., Reliability and validity of DSM-IV axis V. Am J Psychiatry 2000; 157: 1858-63.
38. Evans C, Mellor-Clark J, Margison F, et al., CORE: Clinical Outcomes in Routine Evaluation. J Ment Health 2000; 9: 247-55.
39. Endicott J, Nee J, Harrison W, et al., Quality of Life Enjoyment and Satisfaction Questionnaire: a new measure. Psychopharmacol Bull 1993; 29: 321-6.
40. Statacorp. Stata statistical software: Release 14. College Station: StataCorp LP, 2015.
41. Bateman A, Fonagy P., Randomized controlled trial of outpatient mentalization-based treatment versus structured clinical management for borderline personality disorder. Am J Psychiatry 2009; 166: 1355-64.
42. Rabe-Hesketh S, Skrondal A., Multilevel and longitudinal modeling using STATA, 3rd ed. College Station: Stata Press, 2012.
43. Keller MB, McCullough JP, Klein DN, et al., A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression. N Engl J Med 2000; 342: 1462-70.
44. Knekt P, Lindfors O, Harkanen T, et al., Randomized trial on the effectiveness of long-and short-term psychodynamic psychotherapy and solution-focused therapy on psychiatric symptoms during a 3-year follow-up. Helsinki Psychotherapy Study Group. Psychol Med 2008; 38: 689-703.
45. Muratori F, Picchi L, Bruni G, et al., A two-year follow-up of psychodynamic psychotherapy for internalizing disorders in children. J Am Acad Child Adolesc Psychiatry 2003; 42: 331-9.
46. Verbeke G, Molenberghs G., Linear mixed models for longitudinal data. New York: Springer, 2000.
47. Rossouw TI, Fonagy P., Mentalization-based treatment for self-harm in adolescents: a randomized controlled trial. J Am Acad Child Adolesc Psychiatry 2012; 51: 1304-13.
48. Keller MB, Lavori PW, Friedman B, et al., The Longitudinal Interval Follow-up Evaluation. A comprehensive method for assessing outcome in prospective longitudinal studies. Arch Gen Psychiatry 1987; 44: 540-8.
49. Luborsky L, Diguer L, Seligman DA, et al., The researcher's own therapy allegiances: a "wild card" in comparisons of treatment efficacy. Clin Psychol Sci Pract 1999; 6: 95-106.
50. Beutel ME, Leuzinger-Bohleber M, Ruger B, et al., Psychoanalytic and cognitive-behavior therapy of chronic depression: study protocol for a randomized controlled trial. Trials 2012; 13: 117.