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Volumn 156, Issue , 2014, Pages 1-7

Treatment-resistant depression: Definitions, review of the evidence, and algorithmic approach

Author keywords

Atypical antipsychotics; Augmentation; Combination; Lithium; Major depressive disorder; Treatment resistant depression (TRD)

Indexed keywords

ATYPICAL ANTIPSYCHOTICS; AUGMENTATION; COMBINATION; LITHIUM; MAJOR DEPRESSIVE DISORDER; TREATMENT-RESISTANT DEPRESSION (TRD);

EID: 84895065146     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2013.10.043     Document Type: Review
Times cited : (352)

References (44)
  • 1
    • 84867582069 scopus 로고    scopus 로고
    • Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: Randomized double-blind placebo-controlled study
    • S.H. Abbasi, F. Hosseini, A. Modabbernia, M. Ashrafi, and S. Akhondzadeh Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: randomized double-blind placebo-controlled study J. Affect. Disord. 141 2-3 2012 308 314
    • (2012) J. Affect. Disord. , vol.141 , Issue.23 , pp. 308-314
    • Abbasi, S.H.1    Hosseini, F.2    Modabbernia, A.3    Ashrafi, M.4    Akhondzadeh, S.5
  • 2
    • 77649151251 scopus 로고    scopus 로고
    • Combination of antidepressant medications from treatment initiation for major depressive disorder: A double-blind randomized study
    • P. Blier, H.E. Ward, P. Tremblay, L. Laberge, C. Hebert, and R. Bergeron Combination of antidepressant medications from treatment initiation for major depressive disorder: a double-blind randomized study Am. J. Psychiatr. 167 3 2010 281 288
    • (2010) Am. J. Psychiatr. , vol.167 , Issue.3 , pp. 281-288
    • Blier, P.1    Ward, H.E.2    Tremblay, P.3    Laberge, L.4    Hebert, C.5    Bergeron, R.6
  • 3
    • 84878394614 scopus 로고    scopus 로고
    • Neural correlates of rapid antidepressant response to ketamine in treatment-resistant unipolar depression: A preliminary positron emission tomography study
    • P.J. Carlson, N. Diazgranados, A.C. Nugent, L. Ibrahim, D.A. Luckenbaugh, and N. Brutsche et al. Neural correlates of rapid antidepressant response to ketamine in treatment-resistant unipolar depression: a preliminary positron emission tomography study Biol. Psychiatr. 73 12 2013 1213 1221
    • (2013) Biol. Psychiatr. , vol.73 , Issue.12 , pp. 1213-1221
    • Carlson, P.J.1    Diazgranados, N.2    Nugent, A.C.3    Ibrahim, L.4    Luckenbaugh, D.A.5    Brutsche, N.6
  • 4
    • 84863786711 scopus 로고    scopus 로고
    • Treatment-emergent adverse events associated with atypical antipsychotics
    • D.S. Cha, and R.S. McIntyre Treatment-emergent adverse events associated with atypical antipsychotics Expert Opin. Pharmacother. 13 11 2012 1587 1598
    • (2012) Expert Opin. Pharmacother. , vol.13 , Issue.11 , pp. 1587-1598
    • Cha, D.S.1    McIntyre, R.S.2
  • 5
    • 78650371169 scopus 로고    scopus 로고
    • Rapid resolution of suicidal ideation after a single infusion of an N-methyl-d-aspartate antagonist in patients with treatment-resistant major depressive disorder
    • N. Diazgranados, L.A. Ibrahim, N.E. Brutsche, R. Ameli, I.D. Henter, and D.A. Luckenbaugh et al. Rapid resolution of suicidal ideation after a single infusion of an N-methyl-d-aspartate antagonist in patients with treatment-resistant major depressive disorder J. Clin. Psychiatr. 71 12 2010 1605 1611
    • (2010) J. Clin. Psychiatr. , vol.71 , Issue.12 , pp. 1605-1611
    • Diazgranados, N.1    Ibrahim, L.A.2    Brutsche, N.E.3    Ameli, R.4    Henter, I.D.5    Luckenbaugh, D.A.6
  • 6
    • 0141828593 scopus 로고    scopus 로고
    • Adjunct modafinil for the short-term treatment of fatigue and sleepiness in patients with major depressive disorder: A preliminary double-blind, placebo-controlled study
    • C. DeBattista, K. Doghramji, M.A. Menza, M.H. Rosenthal, and R.R. Fieve Adjunct modafinil for the short-term treatment of fatigue and sleepiness in patients with major depressive disorder: a preliminary double-blind, placebo-controlled study J. Clin. Psychiatr. 64 9 2003 1057 1064 (Pubitemid 37158251)
    • (2003) Journal of Clinical Psychiatry , vol.64 , Issue.9 , pp. 1057-1064
    • DeBattista, C.1    Doghramji, K.2    Menza, M.A.3    Rosenthal, M.H.4    Fieve, R.R.5
  • 7
    • 39649091265 scopus 로고    scopus 로고
    • Coadministration of modafinil and a selective serotonin reuptake inhibitor from the initiation of treatment of major depressive disorder with fatigue and sleepiness: A double-blind, placebo-controlled study
    • DOI 10.1097/jcp.0b013e31815abefb, PII 0000471420071200000010
    • B.W. Dunlop, P. Crits-Christoph, D.L. Evans, J. Hirschowitz, H.B. Solvason, and K. Rickels et al. Coadministration of modafinil and a selective serotonin reuptake inhibitor from the initiation of treatment of major depressive disorder with fatigue and sleepiness: a double-blind, placebo-controlled study J. Clin. Psychopharmacol. 27 6 2007 614 619 (Pubitemid 351339449)
    • (2007) Journal of Clinical Psychopharmacology , vol.27 , Issue.6 , pp. 614-619
    • Dunlop, B.W.1    Crits-Christoph, P.2    Evans, D.L.3    Hirschowitz, J.4    Solvason, H.B.5    Rickels, K.6    Garlow, S.J.7    Gallop, R.J.8    Ninan, P.T.9
  • 8
    • 13844315590 scopus 로고    scopus 로고
    • A multicenter, placebo-controlled study of modafinil augmentation in partial responders to selective serotonin reuptake inhibitors with persistent fatigue and sleepiness
    • M. Fava, M.E. Thase, and C. DeBattista A multicenter, placebo-controlled study of modafinil augmentation in partial responders to selective serotonin reuptake inhibitors with persistent fatigue and sleepiness J. Clin. Psychiatr. 66 1 2005 85 93
    • (2005) J. Clin. Psychiatr. , vol.66 , Issue.1 , pp. 85-93
    • Fava, M.1    Thase, M.E.2    Debattista, C.3
  • 9
    • 84856169699 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of aripiprazole adjunctive to antidepressant therapy among depressed outpatients with inadequate response to prior antidepressant therapy (ADAPT-A Study)
    • M. Fava, D. Mischoulon, D. Iosifescu, J. Witte, M. Pencina, and M. Flynn et al. A double-blind, placebo-controlled study of aripiprazole adjunctive to antidepressant therapy among depressed outpatients with inadequate response to prior antidepressant therapy (ADAPT-A Study) Psychother. Psychosom. 81 2 2012 87 97
    • (2012) Psychother. Psychosom. , vol.81 , Issue.2 , pp. 87-97
    • Fava, M.1    Mischoulon, D.2    Iosifescu, D.3    Witte, J.4    Pencina, M.5    Flynn, M.6
  • 10
    • 84867054707 scopus 로고    scopus 로고
    • Antidepressant response in patients with major depression exposed to NSAIDs: A pharmacovigilance study
    • P.J. Gallagher, V. Castro, M. Fava, J.B. Weilburg, S.N. Murphy, and V.S. Gainer et al. Antidepressant response in patients with major depression exposed to NSAIDs: a pharmacovigilance study Am. J. Psychiatr. 169 10 2012 1065 1072
    • (2012) Am. J. Psychiatr. , vol.169 , Issue.10 , pp. 1065-1072
    • Gallagher, P.J.1    Castro, V.2    Fava, M.3    Weilburg, J.B.4    Murphy, S.N.5    Gainer, V.S.6
  • 12
    • 84859777474 scopus 로고    scopus 로고
    • Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: Results from a 4-week, double-blind, placebo-controlled study
    • L. Ibrahim, N. Diazgranados, J. Franco-Chaves, N. Brutsche, I.D. Henter, and P. Kronstein et al. Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study Neuropsychopharmacology 37 6 2012 1526 1533
    • (2012) Neuropsychopharmacology , vol.37 , Issue.6 , pp. 1526-1533
    • Ibrahim, L.1    Diazgranados, N.2    Franco-Chaves, J.3    Brutsche, N.4    Henter, I.D.5    Kronstein, P.6
  • 13
    • 84868540518 scopus 로고    scopus 로고
    • Synaptic mechanisms underlying rapid antidepressant action of ketamine
    • E.T. Kavalali, and L.M. Monteggia Synaptic mechanisms underlying rapid antidepressant action of ketamine Am. J. Psychiatr. 169 11 2012 1150 1156
    • (2012) Am. J. Psychiatr. , vol.169 , Issue.11 , pp. 1150-1156
    • Kavalali, E.T.1    Monteggia, L.M.2
  • 15
    • 69649083323 scopus 로고    scopus 로고
    • Canadian network for mood and anxiety treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. IV. Neurostimulation therapies
    • S.H. Kennedy, R. Milev, P. Giacobbe, R. Ramasubbu, R.W. Lam, and S.V. Parikh et al. Canadian network for mood and anxiety treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. IV. Neurostimulation therapies J. Affect. Disord. 117 Suppl. 1 2009 S44 S53
    • (2009) J. Affect. Disord. , vol.117 , Issue.SUPPL. 1
    • Kennedy, S.H.1    Milev, R.2    Giacobbe, P.3    Ramasubbu, R.4    Lam, R.W.5    Parikh, S.V.6
  • 17
    • 79952198019 scopus 로고    scopus 로고
    • Aerobic physical exercise as a possible treatment for neurocognitive dysfunction in bipolar disorder
    • A. Kucyi, M.T. Alsuwaidan, S.S. Liauw, and R.S. McIntyre Aerobic physical exercise as a possible treatment for neurocognitive dysfunction in bipolar disorder Postgrad. Med. 122 6 2010 107 116
    • (2010) Postgrad. Med. , vol.122 , Issue.6 , pp. 107-116
    • Kucyi, A.1    Alsuwaidan, M.T.2    Liauw, S.S.3    McIntyre, R.S.4
  • 18
    • 69649098040 scopus 로고    scopus 로고
    • Canadian network for mood and anxiety treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. Introduction
    • S.H. Kennedy, R.W. Lam, S.V. Parikh, S.B. Patten, and A.V. Ravindran Canadian network for mood and anxiety treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. Introduction J. Affect. Disord. 117 Suppl 1 2009 S1 S2
    • (2009) J. Affect. Disord. , vol.117 , Issue.SUPPL. 1
    • Kennedy, S.H.1    Lam, R.W.2    Parikh, S.V.3    Patten, S.B.4    Ravindran, A.V.5
  • 19
    • 84865989655 scopus 로고    scopus 로고
    • Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States
    • R.C. Kessler, M. Petukhova, N.A. Sampson, A.M. Zaslavsky, and H.U. Wittchen Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States Int. J. Methods. Psychiatr. Res. 21 3 2012 169 184
    • (2012) Int. J. Methods. Psychiatr. Res. , vol.21 , Issue.3 , pp. 169-184
    • Kessler, R.C.1    Petukhova, M.2    Sampson, N.A.3    Zaslavsky, A.M.4    Wittchen, H.U.5
  • 21
    • 84869207228 scopus 로고    scopus 로고
    • Oral scopolamine augmentation in moderate to severe major depressive disorder: A randomized, double-blind, placebo-controlled study
    • D. Khajavi, M. Farokhnia, A. Modabbernia, M. Ashrafi, S.H. Abbasi, and M. Tabrizi et al. Oral scopolamine augmentation in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled study J. Clin. Psychiatr. 73 11 2012 1428 1433
    • (2012) J. Clin. Psychiatr. , vol.73 , Issue.11 , pp. 1428-1433
    • Khajavi, D.1    Farokhnia, M.2    Modabbernia, A.3    Ashrafi, M.4    Abbasi, S.H.5    Tabrizi, M.6
  • 22
    • 84873846205 scopus 로고    scopus 로고
    • Predicting treatment response in major depressive disorder: The impact of early symptomatic improvement
    • P.A. Kudlow, D.S. Cha, and R.S. McIntyre Predicting treatment response in major depressive disorder: the impact of early symptomatic improvement Can. J. Psychiatr. 57 12 2012 782 788
    • (2012) Can. J. Psychiatr. , vol.57 , Issue.12 , pp. 782-788
    • Kudlow, P.A.1    Cha, D.S.2    McIntyre, R.S.3
  • 23
    • 69649095792 scopus 로고    scopus 로고
    • Canadian network for mood and anxiety treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy
    • R.W. Lam, S.H. Kennedy, S. Grigoriadis, R.S. McIntyre, R. Milev, and R. Ramasubbu et al. Canadian network for mood and anxiety treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy J. Affect. Disord. 117 Suppl. 1 2009 S26 S43
    • (2009) J. Affect. Disord. , vol.117 , Issue.SUPPL. 1
    • Lam, R.W.1    Kennedy, S.H.2    Grigoriadis, S.3    McIntyre, R.S.4    Milev, R.5    Ramasubbu, R.6
  • 24
    • 84855209507 scopus 로고    scopus 로고
    • A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression
    • A.M. Lozano, P. Giacobbe, C. Hamani, S.J. Rizvi, S.H. Kennedy, and T.T. Kolivakis et al. A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression J. Neurosurg. 116 2 2012 315 322
    • (2012) J. Neurosurg. , vol.116 , Issue.2 , pp. 315-322
    • Lozano, A.M.1    Giacobbe, P.2    Hamani, C.3    Rizvi, S.J.4    Kennedy, S.H.5    Kolivakis, T.T.6
  • 26
    • 1942440965 scopus 로고    scopus 로고
    • The Human Cost of Not Achieving Full Remission in Depression
    • R.S. McIntyre, and C. O'Donovan The human cost of not achieving full remission in depression Can. J. Psychiatr. 49 3 Suppl. 1 2004 10S 16S (Pubitemid 38506487)
    • (2004) Canadian Journal of Psychiatry , vol.49 , Issue.3
    • McIntyre, R.S.1    O'Donovan, C.2
  • 27
    • 69949087539 scopus 로고    scopus 로고
    • Atypical antipsychotic augmentation in major depressive disorder: A meta-analysis of placebo-controlled randomized trials
    • J.C. Nelson, and G.I. Papakostas Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials Am. J. Psychiatr. 166 9 2009 980 991
    • (2009) Am. J. Psychiatr. , vol.166 , Issue.9 , pp. 980-991
    • Nelson, J.C.1    Papakostas, G.I.2
  • 28
    • 77955360283 scopus 로고    scopus 로고
    • S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: A double-blind, randomized clinical trial
    • G.I. Papakostas, D. Mischoulon, I. Shyu, J.E. Alpert, and M. Fava S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial Am. J. Psychiatr. 167 8 2010 942 948
    • (2010) Am. J. Psychiatr. , vol.167 , Issue.8 , pp. 942-948
    • Papakostas, G.I.1    Mischoulon, D.2    Shyu, I.3    Alpert, J.E.4    Fava, M.5
  • 29
    • 84871824309 scopus 로고    scopus 로고
    • L-methylfolate as adjunctive therapy for SSRI-resistant major depression: Results of two randomized, double-blind, parallel-sequential trials
    • G.I. Papakostas, R.C. Shelton, J.M. Zajecka, B. Etemad, K. Rickels, and A. Clain et al. l-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials Am. J. Psychiatr. 169 12 2012 1267 1274
    • (2012) Am. J. Psychiatr. , vol.169 , Issue.12 , pp. 1267-1274
    • Papakostas, G.I.1    Shelton, R.C.2    Zajecka, J.M.3    Etemad, B.4    Rickels, K.5    Clain, A.6
  • 30
    • 33751112745 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression
    • DOI 10.1097/01.jcp.0000246212.03530.fd, PII 0000471420061200000017
    • A.A. Patkar, P.S. Masand, C.U. Pae, K. Peindl, C. Hooper-Wood, and P. Mannelli et al. A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression J. Clin. Psychopharmacol. 26 6 2006 653 656 (Pubitemid 44772745)
    • (2006) Journal of Clinical Psychopharmacology , vol.26 , Issue.6 , pp. 653-656
    • Patkar, A.A.1    Masand, P.S.2    Pae, C.-U.3    Peindl, K.4    Hooper-Wood, C.5    Mannelli, P.6    Ciccone, P.7
  • 31
    • 84871986003 scopus 로고    scopus 로고
    • A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: The role of baseline inflammatory biomarkers
    • C.L. Raison, R.E. Rutherford, B.J. Woolwine, C. Shuo, P. Schettler, and D.F. Drake et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers JAMA Psychiatr. 70 1 2013 31 41
    • (2013) JAMA Psychiatr. , vol.70 , Issue.1 , pp. 31-41
    • Raison, C.L.1    Rutherford, R.E.2    Woolwine, B.J.3    Shuo, C.4    Schettler, P.5    Drake, D.F.6
  • 32
    • 39549119969 scopus 로고    scopus 로고
    • Osmotic-release oral system methylphenidate augmentation of antidepressant monotherapy in major depressive disorder: Results of a double-blind, randomized, placebo-controlled trial
    • A.V. Ravindran, S.H. Kennedy, M.C. O'donovan, A. Fallu, F. Camacho, and C.E. Binder Osmotic-release oral system methylphenidate augmentation of antidepressant monotherapy in major depressive disorder: results of a double-blind, randomized, placebo-controlled trial J. Clin. Psychiatr. 69 1 2008 87 94 (Pubitemid 351282001)
    • (2008) Journal of Clinical Psychiatry , vol.69 , Issue.1 , pp. 87-94
    • Ravindran, A.V.1    Kennedy, S.H.2    O'Donovan, M.C.3    Fallu, A.4    Camacho, F.5    Binder, C.E.6
  • 33
    • 84855246307 scopus 로고    scopus 로고
    • Neurostimulation therapies for treatment resistant depression: A focus on vagus nerve stimulation and deep brain stimulation
    • S.J. Rizvi, M. Donovan, P. Giacobbe, F. Placenza, S. Rotzinger, and S.H. Kennedy Neurostimulation therapies for treatment resistant depression: a focus on vagus nerve stimulation and deep brain stimulation Int. Rev. Psychiatr. 23 5 2011 424 436
    • (2011) Int. Rev. Psychiatr. , vol.23 , Issue.5 , pp. 424-436
    • Rizvi, S.J.1    Donovan, M.2    Giacobbe, P.3    Placenza, F.4    Rotzinger, S.5    Kennedy, S.H.6
  • 35
    • 79960533628 scopus 로고    scopus 로고
    • Combining medications to enhance depression outcomes (CO-MED): Acute and long-term outcomes of a single-blind randomized study
    • A.J. Rush, M.H. Trivedi, J.W. Stewart, A.A. Nierenberg, M. Fava, and B.T. Kurian et al. Combining medications to enhance depression outcomes (CO-MED): acute and long-term outcomes of a single-blind randomized study Am. J. Psychiatr. 168 7 2011 689 701
    • (2011) Am. J. Psychiatr. , vol.168 , Issue.7 , pp. 689-701
    • Rush, A.J.1    Trivedi, M.H.2    Stewart, J.W.3    Nierenberg, A.A.4    Fava, M.5    Kurian, B.T.6
  • 36
    • 84878122276 scopus 로고    scopus 로고
    • Ketamine as a fast acting antidepressant: Current knowledge and open questions
    • G. Salvadore, and J.B. Singh Ketamine as a fast acting antidepressant: current knowledge and open questions CNS. Neurosci. Ther. 6 2013 428 436
    • (2013) CNS. Neurosci. Ther. , vol.6 , pp. 428-436
    • Salvadore, G.1    Singh, J.B.2
  • 40
    • 84875422087 scopus 로고    scopus 로고
    • Adjunctive atypical antipsychotic treatment for major depressive disorder: A meta-analysis of depression, quality of life, and safety outcomes
    • G.I. Spielmans, M.I. Berman, E. Linardatos, N.Z. Rosenlicht, A. Perry, and A.C. Tsai Adjunctive atypical antipsychotic treatment for major depressive disorder: a meta-analysis of depression, quality of life, and safety outcomes PLoS Med. 10 3 2013 e1001403
    • (2013) PLoS Med. , vol.10 , Issue.3 , pp. 1001403
    • Spielmans, G.I.1    Berman, M.I.2    Linardatos, E.3    Rosenlicht, N.Z.4    Perry, A.5    Tsai, A.C.6
  • 42
    • 79959196520 scopus 로고    scopus 로고
    • Exercise as an augmentation treatment for nonremitted major depressive disorder: A randomized, parallel dose comparison
    • M.H. Trivedi, T.L. Greer, T.S. Church, T.J. Carmody, B.D. Grannemann, and D.I. Galper et al. Exercise as an augmentation treatment for nonremitted major depressive disorder: a randomized, parallel dose comparison J. Clin. Psychiatr. 72 5 2011 677 684
    • (2011) J. Clin. Psychiatr. , vol.72 , Issue.5 , pp. 677-684
    • Trivedi, M.H.1    Greer, T.L.2    Church, T.S.3    Carmody, T.J.4    Grannemann, B.D.5    Galper, D.I.6
  • 43
    • 84867581890 scopus 로고    scopus 로고
    • Contrasting chronic with episodic depression: An analysis of distorted socio-emotional information processing in chronic depression
    • A. van Randenborgh, J. Huffmeier, D. Victor, K. Klocke, J. Borlinghaus, and M. Pawelzik Contrasting chronic with episodic depression: an analysis of distorted socio-emotional information processing in chronic depression J. Affect. Disord. 141 2-3 2012 177 184
    • (2012) J. Affect. Disord. , vol.141 , Issue.23 , pp. 177-184
    • Van Randenborgh, A.1    Huffmeier, J.2    Victor, D.3    Klocke, K.4    Borlinghaus, J.5    Pawelzik, M.6
  • 44
    • 84873162194 scopus 로고    scopus 로고
    • Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: Results of the CoBalT randomised controlled trial
    • N. Wiles, L. Thomas, A. Abel, N. Ridgway, N. Turner, and J. Campbell et al. Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: results of the CoBalT randomised controlled trial Lancet 381 9864 2013 375 384
    • (2013) Lancet , vol.381 , Issue.9864 , pp. 375-384
    • Wiles, N.1    Thomas, L.2    Abel, A.3    Ridgway, N.4    Turner, N.5    Campbell, J.6


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