VCAM-1 is a TGF-β1 inducible gene upregulated in idiopathic pulmonary fibrosis

Cellular Signalling

Volumn 27, Issue 12, 2015, Pages 2467-2473

  Agassandian, Marianna ^a,b   Tedrow, John R ^a,b   Sembrat, John ^a,b   Kass, Daniel J ^a,b   Zhang, Yingze ^a,b   Goncharova, Elena A ^a,b   Kaminski, Naftali ^d   Mallampalli, Rama K ^b,c   Vuga, Louis J ^a,b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

IPF; Lung fibroblasts; TGF 1; VCAM 1

Indexed keywords

CYCLIN D1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; FIBROSING ALVEOLITIS; FORCED VITAL CAPACITY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG DIFFUSION CAPACITY; LUNG FIBROBLAST; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY DIFFUSION CAPACITY FOR CARBON MONOXIDE; RNA STABILITY; AGED; ANIMAL; C57BL MOUSE; FIBROBLAST; GENETICS; LUNG; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROTEIN TRANSPORT; TRANSCRIPTION INITIATION; UPREGULATION;

AGED; ANIMALS; CELL PROLIFERATION; FEMALE; FIBROBLASTS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; LUNG; MALE; MICE, INBRED C57BL; MIDDLE AGED; PROTEIN TRANSPORT; TRANSCRIPTIONAL ACTIVATION; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84942515446     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2015.09.003     Document Type: Article

References (38)

1. ATS/ERS International Multidisciplinary Consensus Classification of the idiopathic interstitial pneumonias. Am. J. Respir. Crit. Care Med. 2002, 165:277-304.
2. C.H, Raghu G., Egan J.J., Martinez F.J., Behr J., Brown K.K., Colby T.V., Cordier J.F., Flaherty K.R., Lasky J.A., Lynch D.A., Ryu J.H., Swigris J.J., Wells A.U., Ancochea J., Bouros D., Carvalho C., Costabel U., Ebina M., Hansell D.M., Johkoh T., Kim D.S., King T.E., Kondoh Y., Myers J., Müller N.L., Nicholson A.G., Richeldi L., Selman M., Dudden R.F., Griss B.S., Protzko S.L., Schünemann H.J. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am. J. Respir. Crit. Care Med. 2011, 183:788-824.
3. Lynch J., Saggar R., Weigt S., Zisman D., White E. Usual interstitial pneumonia. Semin. Respir. Crit. Care Med. 2006, 27:634-651.
4. Flaherty K., Travis W., Colby T., Toews G., Kazerooni E., Gross B., Jain A., Strawderman R., Flint A., Lynch J., MARTINEZ F. Histopathologic variability in usual and nonspecific interstitial pneumonias. Am. J. Respir. Crit. Care Med. 2001, 164:1722-1727.
5. Selman M., King T.E., Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann. Intern. Med. 2001, 134:136-151.
6. M.T., Pottier N., Chevalier B., Puisségur M.P., Lebrigand K., Robbe-Sermesant K., Bertero T., Lino Cardenas C.L., Courcot E., Rios G., Fourre S., Lo-Guidice J.M., Marcet B., Cardinaud B., Barbry P., Mari B. Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions. PLoS ONE 2009, 4. e6718.
7. Brigham Z.B., Willis C. TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease. AJP - Lung Physiol 2007, 293:L525-L534.
8. Y.H. Pandit KV CD, Yarlagadda M, Tzouvelekis A, Gibson KF, Konishi K, Yousem SA, Singh M, Handley D et al, Inhibition and role of let-7d in idiopathic pulmonary fibrosis, Am. J. Respir. Crit. Care Med., 182 (2010) 220-229.
9. Zhang D., Yuan D., Shen J., Yan Y., Gong C., Gu J., Xue H., Qian Y., Zhang W., He X., Yao L., Ji Y., Shen A. Up-regulation of VCAM1 relates to neuronal apoptosis after intracerebral hemorrhage in adult rats. Neurochem. Res. 2015.
10. Navarro-Hernandez R.E., Oregon-Romero E., Vazquez-Del Mercado M., Rangel-Villalobos H., Palafox-Sanchez C.A., Munoz-Valle J.F. Expression of ICAM1 and VCAM1 serum levels in rheumatoid arthritis clinical activity 2009, 26:119-126.
11. Yamada Y., Arao T., Matsumoto K., Gupta V., Tan W., Fedynyshyn J., Nakajima T.E., Shimada Y., Hamaguchi T., Kato K., Taniguchi H., Saito Y., Matsuda T., Moriya Y., Akasu T., Fujita S., Yamamoto S., Nishio K. Plasma concentrations of VCAM-1 and PAI-1: a predictive biomarker for post-operative recurrence in colorectal cancer. Cancer Sci. 2010, 101:1886-1890.
12. Richards T.J., Kaminski N., Baribaud F., Flavin S., Brodmerkel C., Horowitz D., Li K., Choi J., Vuga L.J., Lindell K.O., Klesen M., Zhang Y., Gibson K.F. Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2012, 185:67-76.
13. Nakao A., Hasegawa Y., Tsuchiya Y., Shimokata K. Expression of cell adhesion molecules in the lungs of patients with idiopathic pulmonary fibrosis. Chest 1995, 108:233-239.
14. M.a.U.C. Demedts ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Eur. Respir. J. 2002, 19:794-796.
15. King T.E., et al. Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model. Am. J. Respir. Crit. Care Med. 2001, 164:1171-1181.
16. Vuga L., Ben-Yehudah A., Kovkarova-Naumovski E., Oriss T., Gibson K.F., Feghali-Bostwick C., Kaminski N. WNT5A is a regulator of fibroblasts proliferation and resistance to apoptosis. Am. J. Respir. Cell Mol. Biol. 2009, 10.1165/rcmb.2008-0201OC.
17. Xue J., Kass D.J., Bon J., Vuga L., Tan J., Csizmadia E., Otterbein L., Soejima M., Levesque M.C., Gibson K.F., Kaminski N., Pilewski J.M., Donahoe M., Sciurba F.C., Duncan S.R. Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients. J. Immunol. 2013, 191:2089-2095.
18. Vuga L.J., Milosevic J., Pandit K., Ben-Yehudah A., Chu Y., Richards T., Sciurba J., Myerburg M., Zhang Y., Parwani A.V., Gibson K.F., Kaminski N. Cartilage oligomeric matrix protein in idiopathic pulmonary fibrosis. PLoS One 2013, 8.
19. Chen B.B., Glasser J.R., Coon T.A., Z.C., M.H.L., M, Fenton M., J.F., B.M., R.K, Mallampalli F. box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. Blood 2012, 119:3132-3141.
20. Chen B.B., Glasser J.R., Coon T.A., Mallampalli R.K. FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest. Cell Cycle 2011, 10.
21. Gene Expression Omnibus Available from: http://www.ncbi.nlm.nih.gov/geo/, (accessed 2013 May 16).
22. Lung Tissue Research Consortium, http://www.ltrcpublic.com/, (accessed 2013 Jun 4).
23. Meyer O. Prognostic markers for systemic sclerosis 2006, 73:490-494.
24. Shahin A.A., Anwar S., Elawar A.H., Sharaf A.E., Hamid M.A., Eleinin A.A., Eltablawy M. Circulating soluble adhesion molecules in patients with systemic sclerosis: correlation between circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) and impaired left ventricular diastolic function. Rheumatol. Int. 2000, 20:21-24.
25. Denton C.P., Bickerstaff M.C., Shiwen X., Carulli M.T., Haskard D.O., Dubois R.M., Black C.M. Serial circulating adhesion molecule levels reflect disease severity in systemic sclerosis. Br. J. Rheumatol. 1995, 34:1048-1054.
26. Popper H.H., Pailer S., Wurzinger G., Feldner H., Hesse C., Eber E. Expression of adhesion molecules in allergic lung diseases. Virchows Archiv: an international journal of pathology 2002, 440:172-180.
27. Zonneveld R., Martinelli R., Shapiro N.I., Kuijpers T.W., Plotz F.B., Carman C.V. Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults. Crit. Care 2014, 18:204.
28. Epperly M.W., Sikora C.A., DeFilippi S.J., Gretton J.E., Bar-Sagi D., Archer H., Carlos T., Guo H., Greenberger J.S. Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy, biology of blood and marrow transplantation. J Am.Soc.Blood Marrow Transplant. 2002, 8:175-187.
29. Nathan S.D., King C.S. Treatment of pulmonary hypertension in idiopathic pulmonary fibrosis: shortfall in efficacy or trial design?. Drug Des. Devel. Ther. 2014, 8:875-885.
30. Pitsiou G., Papakosta D., Bouros D. Pulmonary hypertension in idiopathic pulmonary fibrosis: a review 2011, 82:294-304.
31. Lee I.T., Yang C.M. Inflammatory signalings involved in airway and pulmonary diseases. Mediat. Inflamm. 2013, 2013:791231.
32. Cook-Mills J.M., Marchese M.E., Abdala-Valencia H. Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxid. Redox Signal. 2011, 15:1607-1638.
33. Burke D.L., Frid M.G., Kunrath C.L., Karoor V., Anwar A., Wagner B.D., Strassheim D., Stenmark K.R. Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment. Am. J. Physiol. Lung Cell. Mol. Physiol. 2009, 297:L238-L250.
34. Bartolome R.A., Sanz-Rodriguez F., Robledo M.M., Hidalgo A., Teixido J. Rapid up-regulation of alpha4 integrin-mediated leukocyte adhesion by transforming growth factor-beta1. Mol. Biol. Cell 2003, 14:54-66.
35. Croft D., McIntyre P., Wibulswas A., Kramer I. Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability. Am. J. Pathol. 1999, 154:1149-1158.
36. Winkler M.K., Beveniste E.N. Transforming growth factor-beta inhibition of cytokine-induced vascular cell adhesion molecule-1 expression in human astrocytes. Glia 1998, 22:171-179.
37. Lazaar A.L., Krymskaya V.P., Das S.K. VCAM-1 activates phosphatidylinositol 3-kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells. J. Immunol. 2001, 166:155-161.
38. Chen Q., Massague J. Molecular pathways: VCAM-1 as a potential therapeutic target in metastasis. Clin. Cancer Res. 2012, 18:5520-5525.