Somatic mutation spectrum of non-small-cell lung cancer in African Americans a pooled analysis

Journal of Thoracic Oncology

Volumn 10, Issue 10, 2015, Pages 1430-1436

  Araujo, Luiz H ^a   Lammers, Philip E ^b   Matthews Smith, Velmalia ^c   Eisenberg, Rosana ^d   Gonzalez, Adriana ^e   Schwartz, Ann G ^f   Timmers, Cynthia ^a   Shilo, Konstantin ^a   Zhao, Weiqiang ^a   Natarajan, Thanemozhi G ^g   Zhang, Jianying ^h   Yilmaz, Ayse Selen ^a,h   Liu, Tom ^a   Coombes, Kevin ^a,h   Carbone, David P ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b MEHARRY MEDICAL COLLEGE   (United States)

^c Department of Internal Medicine Baptist Center for Cancer Care   (United States)

^d VANDERBILT INGRAM CANCER CENTER   (United States)

^e Pathology Associates of St Thomas   (United States)

^f WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g GenomOncology   (United States)

^h OHIO STATE UNIVERSITY   (United States)

Author keywords

African Americans; EGFR; Ethnic groups; Lung neoplasms; Mutations

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; EGFR PROTEIN, HUMAN;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; CANCER SURVIVAL; CAUCASIAN; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTYPE; HUMAN; LUNG ADENOCARCINOMA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEXT GENERATION SEQUENCING; NON SMALL CELL LUNG CANCER; ONCOGENE N RAS; OVERALL SURVIVAL; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SOMATIC MUTATION; SQUAMOUS CELL LUNG CARCINOMA; UNITED STATES; VERY ELDERLY; ENZYMOLOGY; ETHNOLOGY; GENETICS; LUNG TUMOR; MUTATION; PATHOLOGY; RETROSPECTIVE STUDY;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; GENOTYPE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RETROSPECTIVE STUDIES;

EID: 84942513614     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0000000000000650     Document Type: Article

References (27)

1. Kris MG, Johnson BE, Berry LD, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA 2014;311:1998-2006.
2. Jänne PA, Engelman JA, Johnson BE. Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology. J Clin Oncol 2005;23:3227-3234.
3. Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013;368:2385-2394.
4. Cappuzzo F, Hirsch FR, Rossi E, et al. Epidermal growth factor receptor gene and protein and geftinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 2005;97:643-655.
5. Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to geftinib. N Engl J Med 2004;350:2129-2139.
6. Rosell R, Moran T, Queralt C, et al.; Spanish Lung Cancer Group. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009;361:958-967.
7. Shi Y, Au JS, Thongprasert S, et al. A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER). J Thorac Oncol 2014;9:154-162.
8. Ward E, Jemal A, Cokkinides V, et al. Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clin 2004;54:78-93.
9. Bauml J, Mick R, Zhang Y, et al. Frequency of EGFR and KRAS mutations in patients with non small cell lung cancer by racial background: do disparities exist? Lung Cancer 2013;81:347-353.
10. Cote ML, Haddad R, Edwards DJ, et al. Frequency and type of epidermal growth factor receptor mutations in African Americans with non-small cell lung cancer. J Thorac Oncol 2011;6:627-630.
11. Krishnaswamy S, Kanteti R, Duke-Cohan JS, et al. Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res 2009;15:5714-5723.
12. Leidner RS, Fu P, Clifford B, et al. Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer. J Clin Oncol 2009;27:5620-5626.
13. Phelps MA, Stinchcombe TE, Blachly JS, et al. Erlotinib in African Americans with advanced non-small cell lung cancer: a prospective randomized study with genetic and pharmacokinetic analyses. Clin Pharmacol Ther 2014;96:182-191.
14. Reinersman JM, Johnson ML, Riely GJ, et al. Frequency of EGFR and KRAS mutations in lung adenocarcinomas in African Americans. J Thorac Oncol 2011;6:28-31.
15. Yang SH, Mechanic LE, Yang P, et al. Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer. Clin Cancer Res 2005;11:2106-2110.
16. Bollig-Fischer A, Chen W, Gadgeel SM, et al. Racial diversity of actionable mutations in non-small cell lung cancer. J Thorac Oncol, 2014;10:250-255.
17. Cancer Genome Atlas Research N. Comprehensive molecular profling of lung adenocarcinoma. Nature 2014;511:543-550.
18. Cancer Genome Atlas Research N. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012;489:519-525.
19. Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2012;2:401-404.
20. Su Z, Dias-Santagata D, Duke M, et al. A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer. J Mol Diagn 2011;13:74-84.
21. Pan Q, Pao W, Ladanyi M. Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adeno-carcinomas. J Mol Diagn 2005;7:396-403.
22. Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 2009;27:4247-4253.
23. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015;65:5-29.
24. Clifford B F, Fu P, Pennell NA, et al. EGFR molecular testing in African-American non-small cell lung cancer patients-a review of discrepant data. Transl Lung Cancer Res 2013;2:251-255.
25. Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-1703.
26. Gadgeel SC, Cote ML, Bepler G, et al. Frequency of anaplastic lymphoma kinase (ALK) positive tumors among African American non-small cell lung cancer (NSCLC) patients. J Clin Oncol 2012;30 (abstr 7593).
27. Zakharia F, Basu A, Absher D, et al. Characterizing the admixed African ancestry of African Americans. Genome Biol 2009;10:R141.