Racial diversity of actionable mutations in non-small cell lung cancer

Journal of Thoracic Oncology

Volumn 10, Issue 2, 2015, Pages 250-255

  Bollig Fischer, Aliccia ^a   Chen, Wei ^a   Gadgeel, Shirish M ^a   Wenzlaff, Angela S ^a   Cote, Michele L ^a   Schwartz, Ann G ^a   Bepler, Gerold ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

African American; mutations; Non small cell lung cancer; Oncogenes; Tumor suppressors.

Indexed keywords

DISCOIDIN DOMAIN RECEPTOR 2; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; ONCOPROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLACK PERSON; CANCER GENETICS; CANCER PATIENT; CANCER TISSUE; CONTROLLED STUDY; EXON; FEMALE; GENE DELETION; GENETIC ANALYSIS; GENETIC CODE; GENETIC VARIABILITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MIDDLE AGED; MUTATION RATE; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; RACE DIFFERENCE; RISK FACTOR; SOMATIC MUTATION; SQUAMOUS CELL LUNG CARCINOMA; TISSUE SECTION; TUMOR GENE; AFRICAN AMERICAN; CAUCASIAN; DNA MUTATIONAL ANALYSIS; ETHNOLOGY; GENETICS; LUNG TUMOR; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; MUTATION; PATHOLOGY; PROCEDURES; VERY ELDERLY;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; LUNG NEOPLASMS; MIDDLE AGED; MUTATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84922331530     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0000000000000420     Document Type: Article

References (29)

1. Howlander NA, Krapcho M, Neyman N, Aminou R, Waldron W, Altekruse SF, Kosary CL, Rulhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA, Edwards BK. SEER Cancer Statistics Review, 1975-2008. Available at: http://seer.cancer. gov/archive/csr/1975-2008/results-merged/sect-15-lung-bronchus. pdf. Accessed December 2014
2. A genomics-based classification of human lung tumors. Sci Transl Med 2013;5:209ra153
3. Anderson C, Burns DM. Patterns of adolescent smoking initiation rates by ethnicity and sex. Tob Control 2000;9:II4-II8
4. Hardy D, Liu CC, Xia R, et al. Racial disparities and treatment trends in a large cohort of elderly black and white patients with nonsmall cell lung cancer. Cancer 2009;115:2199-2211
5. Gadgeel SM, Severson RK, Kau Y, Graff J, Weiss LK, Kalemkerian GP. Impact of race in lung cancer: Analysis of temporal trends from a surveillance, epidemiology, and end results database. Chest 2001;120:55-63
6. Schwartz AG, Swanson GM. Lung carcinoma in African Americans and whites. A population-based study in metropolitan Detroit, Michigan. Cancer 1997;79:45-52
7. DeSantis C, Naishadham D, Jemal A. Cancer statistics for African Americans, 2013. CA Cancer J Clin 2013;63:151-166
8. Alexandrov LB, Nik-Zainal S, Wedge DC, et al.; Australian Pancreatic Cancer Genome Initiative; ICGC Breast Cancer Consortium; ICGC MMML-Seq Consortium; ICGC PedBrain. Signatures of mutational processes in human cancer. Nature 2013;500:415-421
9. Leidner RS, Fu P, Clifford B, et al. Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer. J Clin Oncol 2009;27:5620-5626
10. Cote ML, Haddad R, Edwards DJ, et al. Frequency and type of epidermal growth factor receptor mutations in African Americans with non-small cell lung cancer. J Thorac Oncol 2011;6:627-630
11. Reinersman JM, Johnson ML, Riely GJ, et al. Frequency of EGFR and KRAS mutations in lung adenocarcinomas in African Americans. J Thorac Oncol 2011;6:28-31
12. El-Telbany A, Ma PC. Cancer genes in lung cancer: racial disparities: Are there any?. Genes Cancer 2012;3:467-480
13. Bauml J, Mick R, Zhang Y, et al. Frequency of EGFR and KRAS mutations in patients with non small cell lung cancer by racial background: Do disparities exist?. Lung Cancer 2013;81:347-353
14. Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008;455:1069-1075
15. Hammerman PS, Sos ML, Ramos AH, et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov 2011;1:78-89
16. Beadling C, Heinrich MC, Warrick A, et al. Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry. J Mol Diagn 2011;13:504-513
17. Exome Variant Server, NHLBI GO Exome Sequencing Project (ESP). Seattle, WA. http://evs.gs.washington.edu/EVS/. Accessed 8 October 2013
18. Tomasetti C, Vogelstein B, Parmigiani G. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci USA 2013;110:1999-2004
19. Krishnaswamy S, Kanteti R, Duke-Cohan JS, et al. Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res 2009;15:5714-5723
20. van Noesel J, van Der Ven WH, van Os TA, et al. Activating germline R776H mutation in the epidermal growth factor receptor associated with lung cancer with squamous differentiation. J Clin Oncol 2013;31:e161-e164
21. Launonen V, Avizienyte E, Loukola A, et al. No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas. Cancer Res 2000;60:546-548
22. Forbes SA, Bindal N, Bamford S, et al. COSMIC: Mining complete cancer genomes in the catalogue of somatic mutations in cancer. Nucleic Acids Res 2011;39:D945-D950
23. Lee VH, Tin VP, Choy TS, et al. Association of exon 19 and 21 EGFR mutation patterns with treatment outcome after first-line tyrosine kinase inhibitor in metastatic non-small-cell lung cancer. J Thorac Oncol 2013;8:1148-1155
24. Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology 2010;138:2073-2087.e3
25. Gazdar A, Robinson L, Oliver D, et al. Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations. J Thorac Oncol 2014;9:456-463
26. Vikis H, Sato M, James M, et al. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Res 2007;67:4665-4670
27. Oxnard G, Heng J, Rainville I, et al. Investigating hereditary risk from T790M (inherit): A prospective multicentered study of risk associated with germ-line EGFR T790M. J Clin Oncol. 2013;31(abstr TPS1606
28. An SJ, Chen ZH, Su J, et al. Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status. PLoS One 2012;7:e40109
29. Gao WM, Mady HH, Yu GY, et al. Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: Unique spectra involving G to A transitions and G to T transversions in both histologic types. Lung Cancer 2003;40:141-150