Synthesis and Evaluation of Cleistanthin A Derivatives as Potent Vacuolar H+-ATPase Inhibitors

Chemical Biology and Drug Design

Volumn 86, Issue 4, 2015, Pages 691-696

  Zhao, Yu ^a   Lu, Yapeng ^a   Ma, Jinlong ^a   Zhu, Li ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Cleistanthin A; inhibitor; synthesis; vacuolar H+ ATPase

Indexed keywords

4 O [2"',3"',4'",6"' O TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL (1-2) 3",4' DI O METHYL BETA DEXTRO XYLOPYRANOSYL]DIPHYLLIN; 4 O [2"O ETHYL 3",4" DI O METHYL BETA DEXTRO XYLOPYRANOSYL]DIPHYLLIN; 4 O [BETA DEXTRO GALACTOPYRANOSYL (1-2) 3",4" DI O METHYL BETA DEXTRO XYLOPYRANOSYL]DIPHYLLIN; ADENOSINE TRIPHOSPHATASE INHIBITOR; ANTINEOPLASTIC AGENT; CLEISTANTHIN A DERIVATIVE; GLYCOSIDE; PACLITAXEL; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; CLEISTANTHIN; ENZYME INHIBITOR; LIGNAN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

A549 CELL LINE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PH; CHEMICAL ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HCT116 CELL LINE; HEK293 CELL LINE; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYSOSOME; MTT ASSAY; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; METABOLISM; PH; PROCEDURES; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GLYCOSIDES; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIGNANS; LYSOSOMES; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84942505443     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12538     Document Type: Article

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