Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 18, 2009, Pages 6613-6619

  Paula, Stefan ^a   Abell, Josh ^a   Deye, Joel ^a   Elam, Christopher ^a   Lape, Michael ^a   Purnell, Justin ^a   Ratliff, Robert ^a   Sebastian, Kelly ^a   Zultowsky, Jodie ^a   Kempton, Robert J ^a  

^a NORTHERN KENTUCKY UNIVERSITY   (United States)

Author keywords

Calcium pump; Enzyme inhibition; gold; Ligand docking; Medicinal chemistry; Organic synthesis; Prostate cancer; SERCA; Structure activity relationship

Indexed keywords

2 (2 FURANYLMETHYL)HYDROQUINONE; 2 (4 METHOXYBENZYL)HYDROQUINONE; 2 (4 NITROBENZYL) 5 (3 METHYL 3 PENTYL)HYDROQUINONE; 2 (4 NITROBENZYL) 5 TERT AMYLHYDROQUINONE; 2 (4 NITROBENZYL)HYDROQUINONE; 2 BENZYLHYDROQUINONE; 2,5 DI (3 ETHYL 3 PENTYL)HYDROQUINONE; 2,5 DI (3 METHYL 3 PENTYL)HYDROQUINONE; 2,5 DI TERT BUTYLHYDROQUINONE; 2,5 DI TERT PENTYLHYDROQUINONE; 2,5 DIALLYLHYDROQUINONE; ADENOSINE TRIPHOSPHATASE (CALCIUM); HYDROQUINONE DERIVATIVE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; DEPROTECTION REACTION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ESTERIFICATION; IC 50; MOLECULAR DOCKING; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

CALCIUM-TRANSPORTING ATPASES; COMPUTER SIMULATION; ENDOPLASMIC RETICULUM; HYDROQUINONES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69249098322     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.075     Document Type: Article

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