Single-cell analysis of B cell/antibody cross-reactivity using a novel multicolor fluorospot assay

Journal of Immunology

Volumn 195, Issue 7, 2015, Pages 3490-3496

  Hadjilaou, Alexandros ^a,b   Green, Angela M ^a   Coloma, Josefina ^a   Harris, Eva ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENT DYE; NEUTRALIZING ANTIBODY; DENGUE VACCINE; MONOCLONAL ANTIBODY; VIRUS ANTIBODY; VIRUS ANTIGEN; VIRUS ENVELOPE PROTEIN;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; ASSAY; B LYMPHOCYTE; CELL TRANSFORMATION; CONTROLLED STUDY; CROSS REACTION; DENGUE; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; EX VIVO STUDY; IMMUNE RESPONSE; LYMPHOCYTE SUBPOPULATION; MULTICOLOR FLUOROSPOT ASSAY; NONHUMAN; PRIORITY JOURNAL; PUBLIC HEALTH; QUAD COLOR FLUOROSPOT ASSAY; SEROTYPE; STOICHIOMETRY; VACCINATION; VIRUS TRANSFORMATION; AEDES; ANIMAL; CELL CULTURE; CLASSIFICATION; DENGUE VIRUS; GENETICS; HUMAN; IMMUNOLOGY; PROCEDURES; SINGLE CELL ANALYSIS; VIROLOGY;

AEDES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; B-LYMPHOCYTES; CELLS, CULTURED; CROSS REACTIONS; DENGUE; DENGUE VACCINES; DENGUE VIRUS; ENZYME-LINKED IMMUNOSPOT ASSAY; HUMANS; SINGLE-CELL ANALYSIS; VACCINATION; VIRAL ENVELOPE PROTEINS;

EID: 84942446781     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500918     Document Type: Article

References (28)

1. Bhatt, S., P. W. Gething, O. J. Brady, J. P. Messina, A. W. Farlow, C. L. Moyes, J. M. Drake, J. S. Brownstein, A. G. Hoen, O. Sankoh, et al. 2013. The global distribution and burden of dengue. Nature 496: 504-507.
2. Halstead, S. B. 2003. Neutralization and antibody-dependent enhancement of dengue viruses. Adv. Virus Res. 60: 421-467.
3. de Alwis, R., M. Beltramello, W. B. Messer, S. Sukupolvi-Petty, W. M. Wahala, A. Kraus, N. P. Olivarez, Q. Pham, J. D. Brien, W. Y. Tsai, et al. 2011. In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection. [Published erratum appears in 2011 PLoS Negl. Trop. Dis. 5: 8.] PLoS Negl. Trop. Dis. 5: e1188.
4. Smith, S. A., Y. Zhou, N. P. Olivarez, A. H. Broadwater, A. M. de Silva, and J. E. Crowe, Jr. 2012. Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infection. J. Virol. 86: 2665-2675.
5. Beltramello, M., K. L. Williams, C. P. Simmons, A. Macagno, L. Simonelli, N. T. Quyen, S. Sukupolvi-Petty, E. Navarro-Sanchez, P. R. Young, A. M. de Silva, et al. 2010. The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity. Cell Host Microbe 8: 271-283.
6. Smith, S. A., R. de Alwis, N. Kose, A. P. Durbin, S. S. Whitehead, A. M. de Silva, and J. E. Crowe, Jr. 2013. Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristics. J. Infect. Dis. 207: 1898-1908.
7. Dejnirattisai, W., W. Wongwiwat, S. Supasa, X. Zhang, X. Dai, A. Rouvinsky, A. Jumnainsong, C. Edwards, N. Than Ha Quyen, T. Duangchinda, et al. 2015. A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus. Nat. Immunol. 16: 170-177.
8. Wrammert, J., N. Onlamoon, R. S. Akondy, G. C. Perng, K. Polsrila, A. Chandele, M. Kwissa, B. Pulendran, P. C. Wilson, O. Wittawatmongkol, et al. 2012. Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans. J. Virol. 86: 2911-2918.
9. Garcia-Bates, T. M., M. T. Cordeiro, E. J. Nascimento, A. P. Smith, K. M. Soares de Melo, S. P. McBurney, J. D. Evans, E. T. Marques, Jr., and S. M. Barratt-Boyes. 2013. Association between magnitude of the virus-specific plasmablast response and disease severity in dengue patients. J. Immunol. 190: 80-87.
10. Mathew, A., K. West, S. Kalayanarooj, R. V. Gibbons, A. Srikiatkhachorn, S. Green, D. Libraty, S. Jaiswal, and A. L. Rothman. 2011. B-cell responses during primary and secondary dengue virus infections in humans. J. Infect. Dis. 204: 1514-1522.
11. Zompi, S., M. Montoya, M. O. Pohl, A. Balmaseda, and E. Harris. 2012. Dominant cross-reactive B cell response during secondary acute dengue virus infection in humans. PLoS Negl. Trop. Dis. 6: e1568.
12. Dejnirattisai, W., A. Jumnainsong, N. Onsirisakul, P. Fitton, S. Vasanawathana, W. Limpitikul, C. Puttikhunt, C. Edwards, T. Duangchinda, S. Supasa, et al. 2010. Cross-reacting antibodies enhance dengue virus infection in humans. Science 328: 745-748.
13. Teoh, E. P., P. Kukkaro, E. W. Teo, A. P. Lim, T. T. Tan, A. Yip, W. Schul, M. Aung, V. A. Kostyuchenko, Y. S. Leo, et al. 2012. The structural basis for serotype-specific neutralization of dengue virus by a human antibody. Sci. Transl. Med. 4: 139ra83.
14. de Alwis, R., S. A. Smith, N. P. Olivarez, W. B. Messer, J. P. Huynh, W. M. Wahala, L. J. White, M. S. Diamond, R. S. Baric, J. E. Crowe, Jr., and A. M. de Silva. 2012. Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions. Proc. Natl. Acad. Sci. USA 109: 7439-7444.
15. Diamond, M. S., T. C. Pierson, and D. H. Fremont. 2008. The structural immunology of antibody protection against West Nile virus. Immunol. Rev. 225: 212-225.
16. Zybert, I. A., H. van der Ende-Metselaar, J. Wilschut, and J. M. Smit. 2008. Functional importance of dengue virus maturation: infectious properties of immature virions. J. Gen. Virol. 89: 3047-3051.
17. Sukupolvi-Petty, S., S. K. Austin, M. Engle, J. D. Brien, K. A. Dowd, K. L. Williams, S. Johnson, R. Rico-Hesse, E. Harris, T. C. Pierson, et al. 2010. Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2. J. Virol. 84: 9227-9239.
18. Sukupolvi-Petty, S., J. D. Brien, S. K. Austin, B. Shrestha, S. Swayne, K. Kahle, B. J. Doranz, S. Johnson, T. C. Pierson, D. H. Fremont, and M. S. Diamond. 2013. Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protection. J. Virol. 87: 8826-8842.
19. Shrestha, B., J. D. Brien, S. Sukupolvi-Petty, S. K. Austin, M. A. Edeling, T. Kim, K. M. O'Brien, C. A. Nelson, S. Johnson, D. H. Fremont, and M. S. Diamond. 2010. The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1. PLoS Pathog. 6: e1000823.
20. Fibriansah, G., J. L. Tan, S. A. Smith, R. de Alwis, T. S. Ng, V. A. Kostyuchenko, R. S. Jadi, P. Kukkaro, A. M. de Silva, J. E. Crowe, and S. M. Lok. 2015. A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins. Nat. Commun. 6: 6341.
21. Pierson, T. C., and M. S. Diamond. 2012. Degrees of maturity: the complex structure and biology of flaviviruses. Curr. Opin. Virol. 2: 168-175.
22. Bera, D., L. Qian, T.-K. Tseng, and P. H. Holloway. 2010. Quantum dots and their multimodal applications: A review. Materials (Basel) 3: 2260-2345.
23. Narvaez, F., G. Gutierrez, M. A. Pérez, D. Elizondo, A. Nuñez, A. Balmaseda, and E. Harris. 2011. Evaluation of the traditional and revised WHO classifications of Dengue disease severity. PLoS Negl. Trop. Dis. 5: e1397.
24. Guzman, M. G., M. Alvarez, and S. B. Halstead. 2013. Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch. Virol. 158: 1445-1459.
25. Tamura, M., R. G. Webster, and F. A. Ennis. 1994. Subtype cross-reactive, infection-enhancing antibody responses to influenza A viruses. J. Virol. 68: 3499-3504.
26. Burke, D. S. 1992. Human HIV vaccine trials: does antibody-dependent enhancement pose a genuine risk? Perspect. Biol. Med. 35: 511-530.
27. Robinson, W. E., Jr., D. C. Montefiori, W. M. Mitchell, A. M. Prince, H. J. Alter, G. R. Dreesman, and J. W. Eichberg. 1989. Antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection in vitro by serum from HIV-1-infected and passively immunized chimpanzees. Proc. Natl. Acad. Sci. USA 86: 4710-4714.
28. Yip,M. S., N.H. Leung,C. Y. Cheung, P. H. Li, H.H. Lee, M.Daëron, J. S. Peiris, R. Bruzzone, and M. Jaume. 2014. Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus. Virol. J. 11: 82.