Predicting sudden cardiac death using common genetic risk variants for coronary artery disease

European Heart Journal

Volumn 36, Issue 26, 2015, Pages 1669-1675

  Hernesniemi, Jussi A ^a,b   Lyytikäinen, Leo Pekka ^a   Oksala, Niku ^a,c   Seppälä, Ilkka ^a   Kleber, Marcus E ^d   Mononen, Nina ^a   März, Winfried ^a,d,e   Mikkelsson, Jussi ^a,f   Pessi, Tanja ^a,g   Louhelainen, Anne Mari ^a   Martiskainen, Mika ^a   Nikus, Kjell ^h   Klopp, Norman ^i,j   Waldenberger, Melanie ⁱ   Illig, Thomas ^i,j   Kähönen, Mika ^a   Laaksonen, Reijo ^a   Karhunen, Pekka J ^a   Lehtimäki, Terho ^a  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b NORTH KARELIA CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d SYNLAB ACADEMY   (Germany)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f SATAKUNTA CENTRAL HOSPITAL   (Finland)

^g PIRKANMAA HOSPITAL DISTRICT   (Finland)

^h UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

ⁱ INSTITUTE OF EPIDEMIOLOGY   (Germany)

^j HANNOVER MEDICAL SCHOOL   (Germany)

more..

Author keywords

Coronary artery disease; Death; Genetics; Sudden

Indexed keywords

ALLELE; ARTICLE; AUTOPSY; BODY MASS; CORONARY ARTERY DISEASE; DISEASE CLASSIFICATION; EXERCISE TEST; FOLLOW UP; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HERITABILITY; HUMAN; META ANALYSIS; POPULATION GENETICS; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SUDDEN CARDIAC DEATH; SYSTEMATIC REVIEW; AGED; DEATH, SUDDEN, CARDIAC; EPIDEMIOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; MIDDLE AGED;

AGED; AUTOPSY; CORONARY ARTERY DISEASE; DEATH, SUDDEN, CARDIAC; EPIDEMIOLOGIC METHODS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84942420556     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehv106     Document Type: Article

References (23)

1. CARDIoGRAMplusC4D. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2013;45:25-33.
2. Rubart M, Zipes DP. Mechanisms of sudden cardiac death. J Clin Invest 2005;115: 2305-2315.
3. Newton-Cheh C, Cook NR, VanDenburgh M, Rimm EB, Ridker PM, Albert CM. A common variant at 9p21 is associated with sudden and arrhythmic cardiac death. Circulation 2009;120:2062-2068.
4. Hernesniemi JA, Karhunen PJ, Oksala N, Kähönen M, Levula M, Rontu R, Ilveskoski E, Kajander O, Goebeler S, Viiri LE, Hurme M, Lehtimäki T. Interleukin 18 gene promoter polymorphism: A link between hypertension and pre-hospital sudden cardiac death: The Helsinki Sudden Death Study. Eur Heart J 2009;30:2939-2946.
5. Albert CM, MacRae CA, Chasman DI, VanDenburgh M, Buring JE, Manson JE, CookNR, Newton-Cheh C.Commonvariants in cardiac ion channel genes are associated with sudden cardiac death. Circulation 2010;3:222-229.
6. Noseworthy PA, Havulinna AS, Porthan K, Lahtinen AM, Jula A, Karhunen PJ, Perola M, Oikarinen L, Kontula KK, Salomaa V, Newton-Cheh C. Common genetic variants, QTinterval, and sudden cardiac death in a Finnish population-based study. Circ Cardiovasc Genet 2011;4:305-311.
7. Arking DE, Reinier K, PostW, Jui J, Hilton G, O'Connor A, Prineas RJ, Boerwinkle E, Psaty BM, Tomaselli GF, Rea T, Sotoodehnia N, Siscovick DS, Burke GL, Marban E, Spooner PM, Chakravarti A, Chugh SS. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. PLoS ONE 2010;5:e9879.
8. Mikkelsson J, Perola M, Laippala P, Penttila A, Karhunen PJ. Glycoprotein IIIa Pl (A1/A2) polymorphism and sudden cardiac death. J Am Coll Cardiol 2000;36:1317-1323.
9. Snapir A, Mikkelsson J, Perola M, Penttila A, Scheinin M, Karhunen PJ. Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death. J Am Coll Cardiol 2003;41:190-194.
10. Evans DM, Visscher PM, Wray NR. Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk. Hum Mol Genet 2009;18:3525-3531.
11. Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A, Guiducci C, Perola M, Jula A, Sinisalo J, Lokki ML, Nieminen MS, Melander O, Salomaa V, Peltonen L, Kathiresan S. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet 2010;376: 1393-1400.
12. Wu SC, Li CY, Ke DS. The agreement between self-reporting and clinical diagnosis for selected medical conditions among the elderly in Taiwan. Public Health 2000;114: 137-142.
13. Burgess S, Thompson SG. Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol 2013;42:1134-1144.
14. Pencina MJ, D'Agostino RBS, D'Agostino RBJ, Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Statist Med 2008;27:157-172; discussion 207-12.
15. Zipes DP, Wellens HJ. Sudden cardiac death. Circulation 1998;98:2334-2351.
16. Lunetta P, Lounamaa A, Sihvonen S. Surveillance of injury-related deaths: medicolegal autopsy rates and trends in Finland. Inj Prev 2007;13:282-284.
17. Kaikkonen KS, Kortelainen ML, Linna E, Huikuri HV. Family history and the risk of sudden cardiac death as a manifestation of an acute coronary event. Circulation 2006;114:1462-1467.
18. Jouven X, Desnos M, Guerot C, Ducimetiere P. Predicting sudden death in the population: The Paris Prospective Study I. Circulation 1999;99:1978-1983.
19. Christou DD, Gentile CL, DeSouza CA, Seals DR, Gates PE. Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men. Circulation 2005;111:1904-1914.
20. QT-IGC. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet 2014;46:826-836.
21. Consortium GLG. Discovery and refinement of loci associated with lipid levels. Nat Genet 2013;45:1274-1283.
22. Studies ICFBPG-WA. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011;478:103-109.
23. Ference BA, YooW, Alesh I, Mahajan N, Mirowska KK, Mewada A, Kahn J, Afonso L, Williams KAS, Flack JM. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: A Mendelian randomization analysis. J Am Coll Cardiol 2012;60:2631-2639.