Impaired motor performance in adolescents at familial high-risk for schizophrenia

Schizophrenia Research

Volumn 168, Issue 1-2, 2015, Pages 44-49

  Manschreck, T C ^a,b   Chun, J ^a,b   Merrill, A M ^a,b   Maher, B A ^b   Boshes, R A ^a,b   Glatt, S J ^c,d   Faraone, S V ^d   Tsuang, M T ^e   Seidman, L J ^a,b,f  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c Medical Genetics Research Center   (United States)

^d SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Familial high risk; Genetics; Lateralization; Motor performance; Schizophrenia

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL DISEASE; FEMALE; FIRST DEGREE RELATIVE; GENETIC LOAD; GENETIC SUSCEPTIBILITY; HEMISPHERIC DOMINANCE; HIGH RISK POPULATION; HUMAN; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; PEDIGREE; PREDICTIVE VALUE; PRIORITY JOURNAL; RISK ASSESSMENT; SCHIZOPHRENIA; COMPLICATION; FAMILY HEALTH; GENETICS; NEUROPSYCHOLOGICAL TEST; PSYCHOMOTOR DISORDERS; RISK; YOUNG ADULT;

ADOLESCENT; ADULT; FAMILY HEALTH; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR DISORDERS; RISK; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84942369775     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2015.06.013     Document Type: Article

References (58)

1. Annett M. A classification of hand preference by association analysis. Br. J. Psychiatry 1970, 139:427-430.
2. Armstrong E., Schleicher A., Omran H., Curtis M., Zilles K. The ontogeny of human gyrification. Cereb. Cortex 1995, 5:56-63.
3. Ballard J.E. Biobehavioral Markers of a Liability to Schizotypic Psychopathology: Verbal Memory Deficits, Atypical Patterns of Manual Performance Lateralization, and Schizotypal Symptoms in Relatives of Individuals with Schizophrenia 2000, Harvard University.
4. Blanton R.E., Levitt J.G., Thompson P.M., Narr K.L., Capetillo-Cunliffe L., Nobel A., et al. Mapping cortical asymmetry and complexity patterns in normal children. Psychiatry Res. 2001, 107:29-43.
5. Bleuler E. Dementia Praecox or the group of Schizophrenias. Psychol. 1950, 548.
6. Blyler C.R., Maher B.A., Manschreck T.C., Fenton W.S. Line drawing as a possible measure of lateralized motor performance in schizophrenia. Schizophr. Res. 1997, 26:15-23.
7. Boshes R.A., Manschreck T.C., Konigsberg W. Genetics of the schizophrenias: a model accounting for their persistence and myriad of phenotypes. Harv. Rev. Psychiatry 2012, 20(3):119-129.
8. Chapman J. The early symptoms of schizophrenia. Br. J. Psychiatry 1966, 112:225-251.
9. Cortese L., Caligiuri M.P., Malla A.K., Manchanda R., Takhar J., Haricharan R. Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naïve schizophrenia patients. Schizophr. Res. 2005, 75:65-75.
10. Crow T.J. Is schizophrenia the price that Homo sapiens pay for language?. Schizophr. Res. 1997, 28:127-141.
11. Crow T.J., Cross A.J., Johnstone E.C., Owen F., Owens D.G.C., Waddington J.L. Abnormal involuntary movements in schizophrenia: are they related to the disease process or its treatment? Are they associated with changes in dopamine receptors?. J. Clin. Psychopharmacol. 1982, 2:336-340.
12. Crow T.J., Done D.J., Sacker A. Cerebral lateralization is delayed in children who later develop schizophrenia. Schizophr. Res. 1996, 22:181-185.
13. Dazzan P., Murray R.M. Neurological soft signs in first-episode psychosis: a systematic review. Br. J. Psychiatry 2002, 181(43):s50-s57.
14. Dobzhansky T.G. Genetics and the Origin of Species 1951, Columbia University Press, New York. 3rd ed.
15. Faraone S.V., Tsuang D., Tsuang M.T. Genetics of Mental Disorders: A Guide for Students, Clinicians, and Researchers 1999, Guilford, NewYork.
16. Fenton W.S., Blyler C.R., Wyatt R.J., McGlashan T.H. Prevalence of spontaneous dyskinesia in schizophrenia and nonschizophrenia patients. Br. J. Psychiatry 1997, 171:265-268.
17. Fish B. Biological antecedents of psychosis in children. Biology of the Major Psychoses 1975, Raven, New York, NY. D.X. Freedman (Ed.).
18. Foong J., Symms M.R., Barker G.J., Maier M., Woermann F.G., Miller D.H., Ron M.A. Neuropathological abnormalities in schizophrenia: evidence from magnetization transfer imaging. Brain 2001, 124:882-892.
19. Gamma F., Goldstein J.M., Seidman L.J., Fitzmaurice G., Tsuang M.T., Buka S.L. Early intermodal integration in offspring of parents with psychosis. Schizophr. Bull. 2014, 40:992-1000.
20. Glatt S.J., Stone W.S., Faraone S.V., Seidman L.J., Tsuang M.T. Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia. Br. J. Psychiatry 2006, 189(4):337-345.
21. Goldberg E., Seidman L.J. Higher cortical functions in normals and in schizophrenia: a selective review. Handbook of Schizophrenia, Volume V-Neuropsychology, Psychophysiology and Information Processing 1991, 553-597. Elsevier, Amsterdam. S.R. Steinhauer, J.H. Gruzelier, J. Zubin (Eds.).
22. Gottesman I.I., Laursen T.M., Bertelsen A., Mortensen P.B. Severe mental disorders in offspring with two psychiatrically ill patients. Arch. Gen. Psychiatry 2010, 67(3):252-257.
23. Gupta S., Andreasen N.C., Arndt S., Flaum M., Schultz S.K., Hubbard W.C., Smith M. Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects. Am. J. Psychiatr. 1995, 152(2):191-196.
24. Harris J.M., Whalley H., Yates S., Miller P., Johnstone E.C., Lawrie S.M. Abnormal cortical folding in high-risk individuals: a predictor of the development of schizophrenia?. Biol. Psychiatry 2004, 56(3):182-189.
25. Heston L.L. Psychiatric disorders in foster home reared children of schizophrenic mothers. Br. J. Psychiatry 1966, 112:819-825.
26. Hollingshead A.B. Four Factor Index of Social Status 1975, Department of Sociology, Yale University, New Haven.
27. Koning L.P., Kahn R.S., Tenback D.E., vanSchelven L.J., vanHarten P.N. Movement disorders in nonpsychotic siblings of patients with nonaffective psychosis. Psychiatry Res. 2011, 188:133-137.
28. Kraepelin E. Manic-Depressive Insanity and Paranoia (trans. R. M. Barclay) 1919, Livingstone, Edinburgh.
29. Lenzenweger M.F., Maher B.A. Psychometric schizotypy and motor performance. J. Abnorm. Psychol. 2002, 11(4):546-555.
30. Maher B.A. Manual for the Measurement and Interpretation of Lateralization by Line Drawing 1993, Harvard University, Cambridge, MA.
31. Manoach D.S., Maher B.A., Manschreck T.C. Left handedness and thought disorder in the schizophrenias. J. Abnorm. Psychol. 1988, 97(1):97-99.
32. Manschreck T.C. Motor abnormalities in schizophrenic disorders. Handbook of Schizophrenia, Vol. 1: The Neurology of Schizophrenia 1986, Elsevier-North Holland, Amsterdam, The Netherlands. H. Nasrallah, D. Weinberger (Eds.).
33. Manschreck T.C. The role of motor behavior in the pathogenesis of schizophrenia. Principles of Experimental Psychopathology: Essays in Honor of Brendan A. Maher 2003, 45-66. American Psychological Association, Washington, DC. M.F. Lenzenweger, J.M. Hooley (Eds.).
34. Manschreck T.C., Maher B.A., Rucklos M.E., Vereen D.R. Disturbed voluntary motor activity in schizophrenic disorder. Psychol. Med. 1982, 12:73-84.
35. Manschreck T.C., Maher B.A., Candela S.F. Earlier age of first diagnosis in schizophrenia is related to impaired motor control. Schizophr. Bull. 2004, 30:351-360.
36. Marcus J., Hans S.L., Lewow E., Wilkinson L., Burack C.M. Neurological findings in high risk children: childhood assessment and 5-year follow-up. Schizophr. Bull. 1985, 11:85-100.
37. Maxwell M.E. Family Interview for Genetic Studies 1996, Clinical Neurogenetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD.
38. Mellor C.S. First rank symptoms of schizophrenia. Br. J. Psychiatry 1970, 117:15-23.
39. Niznikiewicz M., Donnino R., McCarley R.W., Nestor P.G., Iosifescu D.V., O'Donnell B., Levitt J., Shenton M.E. Abnormal angular gyrus asymmetry in schizophrenia. Am. J. Psychiatry 2000, 157:428-437.
40. Nurnberger J., Blehar M.C., Kaufmann C.A., York-Cooler C., Simpson S.G., Harkavy-Friedman J., et al. Diagnostic interview for genetic studies: rationale, unique features and training. Arch. Gen. Psychiatry 1994, 51:849-862.
41. Rogers D.M. Motor Disorder in Psychiatry: Towards a Neurological Psychiatry 1992, J. Wiley & Sons, Chichester, New York.
42. Rossi I.M., Bearden C.E., Hollister J.M., Gasperoni T.L., Sanchez L.E., Hadley T., Cannon T.D. Childhood neuromotor dysfunction in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophr. Bull. 2000, 26(2):367-378.
43. Scala S., Pousada A., Stone W.S., Thermenos H.W., Manschreck T.C., Tsuang M.T., Faraone S.V., Seidman L.J. Verbal and visual-spatial memory impairment in youth at familial high risk for schizophrenia or affective psychosis: a pilot study. Schizophr. Res. 2013, 144:122-128.
44. Schizophrenia Working Group of the Psychiatric Genomics Consortium Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014, 511:421-427.
45. Schneider K. Clinical Psychopathology 1959, New York, NY, Grune and Stratton.
46. Seidman L.J. Schizophrenia and brain dysfunction: an integration of recent neurodiagnostic findings. Psychol. Bull. 1983, 94:195-238.
47. Seidman L.J., Giuliano A.J., Smith C.W., Stone W.S., Glatt S.J., Meyer E., Faraone S.V., Tsuang M.T., Cornblatt B. Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses. Results from the Harvard and Hillside Adolescent High Risk Studies. Schizophr. Bull. 2006, 32(3):507-524.
48. Seidman L.J., Thermenos H.W., Poldrack R.A., Peace N.K., Koch J.K., Faraone S.V., Tsuang M.T. Altered brain activation in dorsolateral prefrontal cortex in adolescents and young adults at genetic risk for schizophrenia: an fMRI study of working memory. Schizophr. Bull. 2006, 85:58-72.
49. Seidman L.J., Meyer E.C., Giuliano A.J., Breiter H.C., Goldstein J.M., Kremen W.S., Thermenos H.W., Toomey R., Stone W.S., Tsuang M.T., Faraone S.V. Auditory working memory impairments in individuals at familial high risk for schizophrenia. Neuropsychology 2012, 26:288-303.
50. Sitskoorn M.M., Aleman A., Ebisch S.J., Appels M., Kahn R.S. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr. Res. 2004, 71(2):285-295.
51. Stone W.S., Faraone S.V., Seidman L.J., Olsen E.A., Tsuang M.T. Searching for the liability to schizophrenia: concepts and methods underlying genetic high-risk studies of adolescents. J. Child Adolesc. Psychopharmacol. 2005, 15:403-417.
52. Sullivan E.V., Shear P.K., Lim K.O., Zipursky R.B., Pfefferbaum A. Cognitive and motor impairments are related to gray matter volume deficits in schizophrenia. Biol. Psychiatry 1996, 39(4):234-240.
53. Sullivan P.F., Kendler K.S., Neale M.C. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry 2003, 60:1187-1192.
54. Sur M., Rubenstein J.L. Patterning and plasticity of the cerebral cortex. Science 2005, 310:805-810.
55. Thompson P.M., Vidal C., Giedd J.N., Gochman P., Blumenthal J., Nicolson R., . . ., Rapoport J.L. Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia. Proc. Natl. Acad. Sci. 2001, 98(20):11650-11655.
56. Walder D.J., Faraone S.V., Glatt S.J., Tsuang M.T., Seidman L.J. Genetic liability, prenatal, stress and family environmental risk factors in the Harvard Adolescent Family High Risk for Schizophrenia study. Schizophr. Res. 2014, 157:142-148.
57. Walker E.F., Savole T., Davis D. Neuromotor precursors of schizophrenia. Schizophr. Bull. 1994, 20(3):441-451.
58. Watt N. Childhood and adolescent routes to schizophrenia. Life History Research in Psychopathology 1974, vol. 3. University of Minnesota Press, Minneapolis, MN.