Bee venom enhances the differentiation of human regulatory T cells

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 70, Issue 10, 2015, Pages 1340-1345

  Caramalho, I ^a   Melo, A ^a   Pedro, E ^b   Barbosa, M M P ^b   Victorino, R M M ^a,b   Pereira Santos, M C ^a   Sousa, A E ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b HOSPITAL DE SANTA MARIA   (Portugal)

Author keywords

bee venom; regulatory T cells; venom specific immunotherapy

Indexed keywords

BEE VENOM; CD39 ANTIGEN; IMMUNOMODULATING AGENT; INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE ANTIGEN; T LYMPHOCYTE RECEPTOR;

ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MALE; MOLECULAR STABILITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; THYMOCYTE; CELL DIFFERENTIATION; CYTOLOGY; DESENSITIZATION; IMMUNOLOGY; IMMUNOPHENOTYPING; INFANT; METABOLISM; NEWBORN; PRESCHOOL CHILD; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, SURFACE; BEE VENOMS; CELL DIFFERENTIATION; CHILD, PRESCHOOL; DESENSITIZATION, IMMUNOLOGIC; FEMALE; HUMANS; IMMUNOMODULATION; IMMUNOPHENOTYPING; INFANT; INFANT, NEWBORN; MALE; RECEPTORS, ANTIGEN, T-CELL; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84942368921     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12691     Document Type: Article

References (16)

1. Bilo BM, Rueff F, Mosbech H, Bonifazi F, Oude-Elberink JN,. Diagnosis of Hymenoptera venom allergy. Allergy 2005; 60: 1339-1349.
2. Ozdemir C, Kucuksezer UC, Akdis M, Akdis CA,. Mechanisms of immunotherapy to wasp and bee venom. Clin Exp Allergy 2011; 41: 1226-1234.
3. Soyer OU, Akdis M, Ring J, Behrendt H, Crameri R, Lauener R, et al., Mechanisms of peripheral tolerance to allergens. Allergy 2013; 68: 161-170.
4. Pereira-Santos MC, Baptista AP, Melo A, Alves RR, Soares RS, Pedro E, et al., Expansion of circulating Foxp3+CD25bright CD4+ T cells during specific venom immunotherapy. Clin Exp Allergy 2008; 38: 291-297.
5. Meiler F, Zumkehr J, Klunker S, Ruckert B, Akdis CA, Akdis M,. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 2008; 205: 2887-2898.
6. Kerstan A, Beyersdorf N, Stoevesandt J, Trautmann A,. Wasp venom immunotherapy expands a subpopulation of CD4(+)CD25+ forkhead box protein 3-positive regulatory T cells expressing the T-cell receptor Vbeta2 and Vbeta5.1 chains. J Allergy Clin Immunol 2012; 130: 994-996.
7. Kerstan A, Albert C, Klein D, Brocker EB, Trautmann A,. Wasp venom immunotherapy induces activation and homing of CD4(+)CD25(+) forkhead box protein 3-positive regulatory T cells controlling T(H)1 responses. J Allergy Clin Immunol 2011; 127: 495-501.
8. Lee H, Lee EJ, Kim H, Lee G, Um EJ, Kim Y, et al., Bee venom-associated Th1/Th2 immunoglobulin class switching results in immune tolerance of NZB/W F1 murine lupus nephritis. Am J Nephrol 2011; 34: 163-172.
9. Choi MS, Park S, Choi T, Lee G, Haam KK, Hong MC, et al., Bee venom ameliorates ovalbumin induced allergic asthma via modulating CD4+CD25+ regulatory T cells in mice. Cytokine 2013; 61: 256-265.
10. Lee MJ, Jang M, Choi J, Lee G, Min HJ, Chung WS, et al., Bee venom acupuncture alleviates experimental autoimmune encephalomyelitis by upregulating regulatory T cells and suppressing Th1 and Th17 responses. Mol Neurobiol 2015;Advance online publication. doi: 10.1007/s12035-014-9012-2.
11. Son DJ, Lee JW, Lee YH, Song HS, Lee CK, Hong JT,. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacol Ther 2007; 115: 246-270.
12. Mirshafiey A,. Venom therapy in multiple sclerosis. Neuropharmacology 2007; 53: 353-361.
13. Mota C, Nunes-Silva V, Pires AR, Matoso P, Victorino RM, Sousa AE, et al., Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells. J Immunol 2014; 193: 5854-5862.
14. Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A, et al., Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009; 30: 899-911.
15. Bourgeois EA, Subramaniam S, Cheng TY, De Jong A, Layre E, Ly D, et al., Bee venom processes human skin lipids for presentation by CD1a. J Exp Med 2015; 212: 149-163.
16. Caramalho I, Nunes-Silva V, Pires AR, Mota C, Pinto AI, Nunes-Cabaco H, et al., Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus. J Autoimmun 2015; 56: 98-110.