Pretreatment platelet count early predicts extrahepatic metastasis of human hepatoma

Liver International

Volumn 35, Issue 10, 2015, Pages 2327-2336

  Lee, Chern Horng ^a   Lin, Yu Jr ^a   Lin, Chen Chun ^a   Yen, Cho Li ^a   Shen, Chien Heng ^a   Chang, Chee Jen ^a   Hsieh, Sen Yung ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Cirrhosis; Hepatocellular carcinoma; Metastasis; Platelet

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA FETOPROTEIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; TUMOR MARKER;

ALPHA FETOPROTEIN BLOOD LEVEL; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; COHORT ANALYSIS; EARLY CANCER; EXTRAHEPATIC METASTASIS; FEMALE; FOLLOW UP; HUMAN; LEUKOCYTE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION; LONG TERM SURVIVAL; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; METASTASIS; PREDICTION; RADIOFREQUENCY ABLATION; RETROSPECTIVE STUDY; RISK FACTOR; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TUMOR VOLUME; ADULT; AGED; BLOOD; CLINICAL TRIAL; COMPLICATION; EARLY DIAGNOSIS; KAPLAN MEIER METHOD; LIVER TUMOR; MIDDLE AGED; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; NEOPLASM METASTASIS; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; THROMBOCYTOSIS;

ADULT; AGED; ALPHA-FETOPROTEINS; BIOMARKERS, TUMOR; CARCINOMA, HEPATOCELLULAR; EARLY DIAGNOSIS; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM METASTASIS; PLATELET COUNT; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOCYTOSIS;

EID: 84942363737     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12817     Document Type: Article

References (31)

1. Kanda M, Tateishi R, Yoshida H, et al. Extrahepatic metastasis of hepatocellular carcinoma: incidence and risk factors. Liver Int 2008; 28: 1256-63.
2. Uchino K, Tateishi R, Shiina S, et al. Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors. Cancer 2011; 117: 4475-83.
3. Villanueva A, Hernandez-Gea V, Llovet JM. Medical therapies for hepatocellular carcinoma: a critical view of the evidence. Nat Rev Gastroenterol Hepatol 2013; 10: 34-42.
4. Fan ST, Mau Lo C, Poon RT, et al. Continuous improvement of survival outcomes of resection of hepatocellular carcinoma: a 20-year experience. Ann Surg 2011; 253: 745-58.
5. Reig M, Rimola J, Torres F, et al. Postprogression survival of patients with advanced hepatocellular carcinoma: rationale for second-line trial design. Hepatology (Baltimore, MD) 2013; 58: 2023-31.
6. El-Serag HB, Siegel AB, Davila JA, et al. Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: a population-based study. J Hepatol 2006; 44: 158-66.
7. Jun L, Zhenlin Y, Renyan G, et al. Independent factors and predictive score for extrahepatic metastasis of hepatocellular carcinoma following curative hepatectomy. Oncologist 2012; 17: 963-9.
8. Carr BI, Cavallini A, D'alessandro R, et al. Platelet extracts induce growth, migration and invasion in human hepatocellular carcinoma in vitro. BMC Cancer 2014; 14: 43.
9. Stone RL, Nick AM, Mcneish IA, et al. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med 2012; 366: 610-8.
10. Cho MS, Bottsford-Miller J, Vasquez HG, et al. Platelets increase the proliferation of ovarian cancer cells. Blood 2012; 120: 4869-72.
11. Wang H, Gao J, Bai M, et al. The pretreatment platelet and plasma fibrinogen level correlate with tumor progression and metastasis in patients with pancreatic cancer. Platelets 2014; 25: 382-7.
12. Stanger BZ, Kahn ML. Platelets and tumor cells: a new form of border control. Cancer Cell 2013; 24: 9-11.
13. Borsig L. The role of platelet activation in tumor metastasis. Expert Rev Anticancer Ther 2008; 8: 1247-55.
14. Rothwell PM, Wilson M, Price JF, et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet 2012; 379: 1591-601.
15. Rothwell PM, Wilson M, Elwin CE, et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 2010; 376: 1741-50.
16. Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 2011; 20: 576-90.
17. Coupland LA, Chong BH, Parish CR. Platelets and P-selectin control tumor cell metastasis in an organ-specific manner and independently of NK cells. Cancer Res 2012; 72: 4662-71.
18. Schumacher D, Strilic B, Sivaraj KK, Wettschureck N, Offermanns S. Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 2013; 24: 130-7.
19. Karvellas CJ, Bagshaw SM. Advances in management and prognostication in critically ill cirrhotic patients. Curr Opin Crit Care 2014; 20: 210-7.
20. Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet 2014; 383: 1749-61.
21. Roayaie S, Obeidat K, Sposito C, et al. Resection of hepatocellular cancer
22. Dai CY, Ho CK, Huang JF, et al. Hepatitis C virus viremia and low platelet count: a study in a hepatitis B & C endemic area in Taiwan. J Hepatol 2010; 52: 160-6.
23. Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology (Baltimore, MD) 2011; 53: 1020-2.
24. Lin SM. Local ablation for hepatocellular carcinoma in taiwan. Liver Cancer 2013; 2: 73-83.
25. Hsieh SY, He JR, Hsu CY, et al. Neuregulin/erythroblastic leukemia viral oncogene homolog 3 autocrine loop contributes to invasion and early recurrence of human hepatoma. Hepatology (Baltimore, MD) 2011; 53: 504-16.
26. Hsieh SY, He JR, Yu MC, et al. Secreted ERBB3 isoforms are serum markers for early hepatoma in patients with chronic hepatitis and cirrhosis. J Proteome Res 2011; 10: 4715-24.
27. Fisher ER, Hellstrom HR, Fisher B. Rarity of hepatic metastases in cirrhosis-a misconception. JAMA 1960; 174: 366-9.
28. Goldstein MJ. Metastases in the cirrhotic liver. N Engl J Med 1969; 281: 221.
29. Riediger C, Bachmann J, Hapfelmeier A, et al. Low postoperative platelet count is associated with negative outcome after liver resection for hepatocellular carcinoma. Hepatogastroenterology 2014; 61: 1313-20.
30. Kondo K, Chijiiwa Y, Otani K, et al. Characteristics and surgical outcome of HCC patients with low platelet count. Hepatogastroenterology 2012; 59: 2269-72.
31. Morimoto Y, Nouso K, Wada N, et al. Involvement of platelets in extrahepatic metastasis of hepatocellular carcinoma. Hepatol Res 2014; 44: E353-9.