Isoforms of Melanopsin Mediate Different Behavioral Responses to Light

Current Biology

Volumn 25, Issue 18, 2015, Pages 2430-2434

  Jagannath, Aarti ^a,b   Hughes, Steven ^a,b   Abdelgany, Amr ^a   Pothecary, Carina A ^a   Di Pretoro, Simona ^a   Pires, Susana S ^a   Vachtsevanos, Athanasios ^a   Pilorz, Violetta ^a   Brown, Laurence A ^a   Hossbach, Markus ^c   MacLaren, Robert E ^a   Halford, Stephanie ^a   Gatti, Silvia ^b   Hankins, Mark W ^a   Wood, Matthew J A ^a   Foster, Russell G ^a   Peirson, Stuart N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c AXOLABS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; MELANOPSIN; SCOTOPSIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CIRCADIAN RHYTHM; GENETICS; HUMAN; LIGHT; METABOLISM; MOLECULAR GENETICS; MOTOR ACTIVITY; MOUSE; NUCLEOTIDE SEQUENCE; PERCEPTION; PHYSIOLOGY; PUPIL; RADIATION RESPONSE; SLEEP;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CIRCADIAN RHYTHM; HUMANS; LIGHT; MICE; MOLECULAR SEQUENCE DATA; MOTOR ACTIVITY; PERCEPTUAL MASKING; PROTEIN ISOFORMS; PUPIL; ROD OPSINS; SLEEP;

EID: 84942295647     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2015.07.071     Document Type: Article

References (33)

1. M.S. Freedman, R.J. Lucas, B. Soni, M. von Schantz, M. Muñoz, Z. David-Gray, and R. Foster Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors Science 284 1999 502 504
2. S. Hattar, R.J. Lucas, N. Mrosovsky, S. Thompson, R.H. Douglas, M.W. Hankins, J. Lem, M. Biel, F. Hofmann, R.G. Foster, and K.W. Yau Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice Nature 424 2003 76 81
3. S. Panda, T.K. Sato, A.M. Castrucci, M.D. Rollag, W.J. DeGrip, J.B. Hogenesch, I. Provencio, and S.A. Kay Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting Science 298 2002 2213 2216
4. D. Lupi, H. Oster, S. Thompson, and R.G. Foster The acute light-induction of sleep is mediated by OPN4-based photoreception Nat. Neurosci. 11 2008 1068 1073
5. R.J. Lucas, S. Hattar, M. Takao, D.M. Berson, R.G. Foster, and K.W. Yau Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice Science 299 2003 245 247
6. N. Mrosovsky, and S. Hattar Impaired masking responses to light in melanopsin-knockout mice Chronobiol. Int. 20 2003 989 999
7. S.S. Pires, S. Hughes, M. Turton, Z. Melyan, S.N. Peirson, L. Zheng, M. Kosmaoglou, J. Bellingham, M.E. Cheetham, R.J. Lucas, and et al. Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina J. Neurosci. 29 2009 12332 12342
8. M. Torii, D. Kojima, T. Okano, A. Nakamura, A. Terakita, Y. Shichida, A. Wada, and Y. Fukada Two isoforms of chicken melanopsins show blue light sensitivity FEBS Lett. 581 2007 5327 5331
9. W.I. Davies, B.H. Tay, L. Zheng, J.A. Danks, S. Brenner, R.G. Foster, S.P. Collin, M.W. Hankins, B. Venkatesh, and D.M. Hunt Evolution and functional characterisation of melanopsins in a deep-sea chimaera (elephant shark, Callorhinchus milii) PLoS ONE 7 2012 e51276
10. S. Hughes, A. Jagannath, D. Hickey, S. Gatti, M. Wood, S.N. Peirson, R.G. Foster, and M.W. Hankins Using siRNA to define functional interactions between melanopsin and multiple G Protein partners Cell. Mol. Life Sci. 72 2015 165 179
11. A. Jagannath, R. Butler, S.I. Godinho, Y. Couch, L.A. Brown, S.R. Vasudevan, K.C. Flanagan, D. Anthony, G.C. Churchill, M.J. Wood, and et al. The CRTC1-SIK1 pathway regulates entrainment of the circadian clock Cell 154 2013 1100 1111
12. S.S. Kim, H. Wang, X.Y. Li, T. Chen, V. Mercaldo, G. Descalzi, L.J. Wu, and M. Zhuo Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice Mol. Brain 4 2011 6
13. C.E. Meacham, E.E. Ho, E. Dubrovsky, F.B. Gertler, and M.T. Hemann In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression Nat. Genet. 41 2009 1133 1137
14. H.L. June, J. Liu, K.T. Warnock, K.A. Bell, I. Balan, D. Bollino, A. Puche, and L. Aurelian CRF-amplified neuronal TLR4/MCP-1 signaling regulates alcohol self-administration Neuropsychopharmacology 40 2015 1549 1559
15. J. Hubbard, E. Ruppert, C.M. Gropp, and P. Bourgin Non-circadian direct effects of light on sleep and alertness: lessons from transgenic mouse models Sleep Med. Rev. 17 2013 445 452
16. C.M. Altimus, A.D. Güler, K.L. Villa, D.S. McNeill, T.A. Legates, and S. Hattar Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation Proc. Natl. Acad. Sci. USA 105 2008 19998 20003
17. J.W. Tsai, J. Hannibal, G. Hagiwara, D. Colas, E. Ruppert, N.F. Ruby, H.C. Heller, P. Franken, and P. Bourgin Melanopsin as a sleep modulator: circadian gating of the direct effects of light on sleep and altered sleep homeostasis in Opn4(-/-) mice PLoS Biol. 7 2009 e1000125
18. J.J. Gooley, J. Lu, D. Fischer, and C.B. Saper A broad role for melanopsin in nonvisual photoreception J. Neurosci. 23 2003 7093 7106
19. S. Hattar, M. Kumar, A. Park, P. Tong, J. Tung, K.W. Yau, and D.M. Berson Central projections of melanopsin-expressing retinal ganglion cells in the mouse J. Comp. Neurol. 497 2006 326 349
20. T.C. Chou, T.E. Scammell, J.J. Gooley, S.E. Gaus, C.B. Saper, and J. Lu Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms J. Neurosci. 23 2003 10691 10702
21. S.P. Fisher, S.I. Godinho, C.A. Pothecary, M.W. Hankins, R.G. Foster, and S.N. Peirson Rapid assessment of sleep-wake behavior in mice J. Biol. Rhythms 27 2012 48 58
22. M. Semo, C. Gias, A. Ahmado, E. Sugano, A.E. Allen, J.M. Lawrence, H. Tomita, P.J. Coffey, and A.A. Vugler Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception PLoS ONE 5 2010 e15009
23. T. Xue, M.T. Do, A. Riccio, Z. Jiang, J. Hsieh, H.C. Wang, S.L. Merbs, D.S. Welsbie, T. Yoshioka, P. Weissgerber, and et al. Melanopsin signalling in mammalian iris and retina Nature 479 2011 67 73
24. M.W. Hankins, S.N. Peirson, and R.G. Foster Melanopsin: an exciting photopigment Trends Neurosci. 31 2008 27 36
25. J.G. Krupnick, and J.L. Benovic The role of receptor kinases and arrestins in G protein-coupled receptor regulation Annu. Rev. Pharmacol. Toxicol. 38 1998 289 319
26. S.L. Ritter, and R.A. Hall Fine-tuning of GPCR activity by receptor-interacting proteins Nat. Rev. Mol. Cell Biol. 10 2009 819 830
27. T.M. Schmidt, S.K. Chen, and S. Hattar Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions Trends Neurosci. 34 2011 572 580
28. J.L. Ecker, O.N. Dumitrescu, K.Y. Wong, N.M. Alam, S.K. Chen, T. LeGates, J.M. Renna, G.T. Prusky, D.M. Berson, and S. Hattar Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision Neuron 67 2010 49 60
29. T.M. Schmidt, and P. Kofuji Functional and morphological differences among intrinsically photosensitive retinal ganglion cells J. Neurosci. 29 2009 476 482
30. S.K. Chen, T.C. Badea, and S. Hattar Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs Nature 476 2011 92 95
31. K. Palczewski Oligomeric forms of G protein-coupled receptors (GPCRs) Trends Biochem. Sci. 35 2010 595 600
32. B.A. Jordan, and L.A. Devi G-protein-coupled receptor heterodimerization modulates receptor function Nature 399 1999 697 700
33. T. Galvez, B. Duthey, J. Kniazeff, J. Blahos, G. Rovelli, B. Bettler, L. Prézeau, and J.P. Pin Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function EMBO J. 20 2001 2152 2159