Pharmacokinetics of cefazolin prophylaxis in obese gravidae at time of cesarean delivery

American Journal of Obstetrics and Gynecology

Volumn 213, Issue 4, 2015, Pages 541.e1-541.e7

  Young, Omar M ^a   Shaik, Imam H ^d   Twedt, Roxanna ^c   Binstock, Anna ^c   Althouse, Andrew D ^c,e   Venkataramanan, Raman ^c,d,e   Simhan, Hyagriv N ^b,e   Wiesenfeld, Harold C ^c,e   Caritis, Steve N ^b,e  

^a WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

cefazolin; cesarean delivery; obesity; pharmacokinetics; surgical prophylaxis

Indexed keywords

CEFAZOLIN; ANTIINFECTIVE AGENT;

ADULT; AREA UNDER THE CURVE; BODY MASS; CESAREAN SECTION; CLINICAL ARTICLE; CONFERENCE PAPER; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG HALF LIFE; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; MATERNAL PLASMA; MINIMUM INHIBITORY CONCENTRATION; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; PLASMA VOLUME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN INCISION; UMBILICAL CORD BLOOD; ANTIBIOTIC PROPHYLAXIS; BLOOD; CHEMISTRY; CONTROLLED STUDY; FETUS BLOOD; INTRAVENOUS DRUG ADMINISTRATION; MICROBIAL SENSITIVITY TEST; OBESITY; PREGNANCY; PREGNANCY COMPLICATION; PROCEDURES; STATISTICAL MODEL; SUBCUTANEOUS FAT; SURGICAL WOUND INFECTION; YOUNG ADULT;

ADMINISTRATION, INTRAVENOUS; ADULT; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; AREA UNDER CURVE; BODY MASS INDEX; CEFAZOLIN; CESAREAN SECTION; DOUBLE-BLIND METHOD; FEMALE; FETAL BLOOD; HUMANS; LINEAR MODELS; MICROBIAL SENSITIVITY TESTS; OBESITY; PREGNANCY; PREGNANCY COMPLICATIONS; SUBCUTANEOUS FAT; SURGICAL WOUND INFECTION; YOUNG ADULT;

EID: 84942295372     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2015.06.034     Document Type: Conference Paper

References (15)

1. C.L. Ogden, M.D. Carroll, B.K. Kit, and K.M. Flegal Prevalence of childhood and adult obesity in the United States, 2011-2012 JAMA 311 2014 806 814
2. American College of Obstetricians and Gynecologists Obesity in pregnancy. ACOG Committee opinion no. 549 Obstet Gynecol 121 2013 213 217
3. American College of Obstetricians and Gynecologists Use of prophylactic antibiotics in labor and delivery. ACOG Practice bulletin no 120 Obstet Gynecol 117 2011 1472 1483
4. M.J. Dinsmoor, S. Gilbert, M.B. Landon, and et al. Perioperative antibiotic prophylaxis for nonlaboring cesarean delivery. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit Network Obstet Gynecol 114 2009 752 756
5. M.P. Pai, and D.T. Bearden Antimicrobial dosing considerations in obese adult patients Pharmacology 27 2007 1081 1091
6. W.A. Craig Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins Diagn Microbiol Infect Dis 22 1995 89 96
7. L. Pevzner, M. Swank, C. Krepel, D.A. Wing, K. Chan, and C.E. Edmiston Effects of maternal obesity on tissue concentrations of prophylactic cefazolin during cesarean delivery Obstet Gynecol 117 2011 877 882
8. A. Douglas, A.A. Udy, S.C. Wallis, and et al. Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm Antimicrob Agents Chemother 55 2011 5238 5242
9. S. von Kralingen, M. Taks, J. Diepstraten, E.M. van de Grade, E.P. van Dongen, and et al. Pharmacokinetics and protein binding of cefazolin in morbidly obese patients Eur J Clin Pharmacol 67 2011 985 992
10. M.N. Dudley, C.H. Nightingale, A.D. Drezner, H.B. Low, and R. Quintiliani Comparative penetration of cefonicid and cefazolin into the atrial appendage and pericardial fluid of patients undergoing open-heart surgery Antimicrob Agents Chemother 26 1984 347 350
11. F.M. Small, and R.M. Grivell Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean delivery Cochrane Database Syst Rev 10 2014 CD007482
12. Clinical and Laboratory Standards Institute Performance standards for antimicrobial susceptibility testing: twenty-second informational supplement, M100-S22 2012 Clinical Laboratory Standards Institute Wayne, PA
13. R.A. Forse, B. Karam, L.D. MacLean, and N.V. Christou Antibiotic prophylaxis for surgery in morbidly obese patients Surgery 106 1989 750 756
14. V.P. Ho, D.P. Nicolau, G.F. Dakin, and et al. Cefazolin dosing for surgical prophylaxis in morbidly obese patients Surg Infect 13 2012 33 37
15. O. Toma, P. Suntrup, A. Stefanescu, A. London, M. Mutch, and E. Kharasch Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection Anesth Analg 113 2011 730 737