-
1
-
-
79951972586
-
Exposure to environmental microorganisms and childhood asthma
-
Ege M.J., et al. Exposure to environmental microorganisms and childhood asthma. N. Engl. J. Med. 364, 701-709 (2011
-
(2011)
N. Engl. J. Med
, vol.364
, pp. 701-709
-
-
Ege, M.J.1
-
2
-
-
33644785697
-
Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle-the parsifal study
-
Alfven T., et al. Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle-the PARSIFAL study. Allergy 61, 414-421 (2006
-
(2006)
Allergy
, vol.61
, pp. 414-421
-
-
Alfven, T.1
-
3
-
-
77649248142
-
Toward improved prediction of risk for atopy and asthma among preschoolers: A prospective cohort study
-
Holt P.G., et al. Toward improved prediction of risk for atopy and asthma among preschoolers: a prospective cohort study. J. Allergy Clin. Immunol. 125, 653-659 (2010
-
(2010)
J. Allergy Clin. Immunol
, vol.125
, pp. 653-659
-
-
Holt, P.G.1
-
4
-
-
79952466300
-
Indoor allergen exposure, sensitization, and development of asthma in a high-risk birth cohort
-
Carlsten C., et al. Indoor allergen exposure, sensitization, and development of asthma in a high-risk birth cohort. Pediatr. Allergy Immunol. 21, e740-e746 (2010
-
(2010)
Pediatr. Allergy Immunol
, vol.21
, pp. e740-e746
-
-
Carlsten, C.1
-
5
-
-
84887014838
-
Outcomes of the childhood asthma prevention study at 11.5 years
-
Toelle B.G., et al. Outcomes of the Childhood Asthma Prevention Study at 11.5 years. J Allergy Clin. Immunol. 132, 1220-1222 (2013
-
(2013)
J Allergy Clin. Immunol
, vol.132
, pp. 1220-1222
-
-
Toelle, B.G.1
-
6
-
-
84883154738
-
Probiotics in primary prevention of allergic disease -follow-up at 8-9 years of age
-
West C.E., Hammarstrom M.L., & Hernell O. Probiotics in primary prevention of allergic disease -follow-up at 8-9 years of age. Allergy 68, 1015-1020 (2013
-
(2013)
Allergy
, vol.68
, pp. 1015-1020
-
-
West, C.E.1
Hammarstrom, M.L.2
Hernell, O.3
-
7
-
-
70049101346
-
Mono and multifaceted inhalant and/or food allergen reduction interventions for preventing asthma in children at high risk of developing asthma
-
Maas T., et al. Mono and multifaceted inhalant and/or food allergen reduction interventions for preventing asthma in children at high risk of developing asthma. Cochrane Database Syst Rev., CD006480 (2009
-
(2009)
Cochrane Database Syst Rev
, pp. CD006480
-
-
Maas, T.1
-
8
-
-
84860666096
-
Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment
-
Holt P.G., & Sly P.D. Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat. Med. 18, 726-735 (2012
-
(2012)
Nat. Med
, vol.18
, pp. 726-735
-
-
Holt, P.G.1
Sly, P.D.2
-
9
-
-
80053085384
-
Asthma phenotypes and interleukin-13 -moving closer to personalized medicine
-
Kraft M. Asthma phenotypes and interleukin-13 -moving closer to personalized medicine. N. Engl. J. Med. 365, 1141-1144 (2011
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 1141-1144
-
-
Kraft, M.1
-
10
-
-
84891660714
-
Lung dendritic cell developmental programming, environmental stimuli, and asthma in early periods of life
-
Awasthi S., Singh B., Welliver R.C., & Dietert R.R. Lung dendritic cell developmental programming, environmental stimuli, and asthma in early periods of life. J. Allergy (Cairo) 2012, 176468 (2012
-
(2012)
J. Allergy (Cairo
, vol.2012
, pp. 176468
-
-
Awasthi, S.1
Singh, B.2
Welliver, R.C.3
Dietert, R.R.4
-
11
-
-
84859821508
-
Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of risk for persistent airways hyper-responsiveness in experimental asthma
-
Strickland D.H., et al. Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of risk for persistent airways hyper-responsiveness in experimental asthma. Mucosal Immunol 5, 332-341 (2012
-
(2012)
Mucosal Immunol
, vol.5
, pp. 332-341
-
-
Strickland, D.H.1
-
12
-
-
84860655039
-
Innate and adaptive immune responses in asthma
-
Holgate S.T. Innate and adaptive immune responses in asthma. Nat.Med. 18, 673-683 (2012
-
(2012)
Nat.Med
, vol.18
, pp. 673-683
-
-
Holgate, S.T.1
-
13
-
-
79955740934
-
Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice
-
Perkins C., et al. Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice. J. Exp. Med. 208, 853-867 (2011
-
(2011)
J. Exp. Med
, vol.208
, pp. 853-867
-
-
Perkins, C.1
-
14
-
-
0036344597
-
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
-
Kuperman D.A., et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 8, 885-889 (2002
-
(2002)
Nat. Med
, vol.8
, pp. 885-889
-
-
Kuperman, D.A.1
-
15
-
-
38649090061
-
Immunological decision-making: How does the immune system decide to mount a helper T-cell response?
-
Kaiko G.E., Horvat J.C., Beagley K.W., & Hansbro P.M. Immunological decision-making: how does the immune system decide to mount a helper T-cell response?. Immunology 123, 326-338 (2008
-
(2008)
Immunology
, vol.123
, pp. 326-338
-
-
Kaiko, G.E.1
Horvat, J.C.2
Beagley, K.W.3
Hansbro, P.M.4
-
16
-
-
40049088465
-
Dendritic cells and epithelial cells: Linking innate and adaptive immunity in asthma
-
Hammad H., & Lambrecht B.N. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat. Rev. Immunol. 8, 193-204 (2008
-
(2008)
Nat. Rev. Immunol
, vol.8
, pp. 193-204
-
-
Hammad, H.1
Lambrecht, B.N.2
-
17
-
-
0038517976
-
Interleukin-4 and interleukin-13 signaling connections maps
-
Kelly-Welch A.E., Hanson E.M., Boothby M.R., & Keegan A.D. Interleukin-4 and interleukin-13 signaling connections maps. Science 300, 1527-1528 (2003
-
(2003)
Science
, vol.300
, pp. 1527-1528
-
-
Kelly-Welch, A.E.1
Hanson, E.M.2
Boothby, M.R.3
Keegan, A.D.4
-
18
-
-
0029057858
-
Cloning of murine stat6 and human stat6 stat proteins that are tyrosine phosphorylated in responses to il-4 and il-3 but are not required for mitogenesis
-
Quelle F.W., et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell Biol. 15, 3336-3343 (1995
-
(1995)
Mol. Cell Biol
, vol.15
, pp. 3336-3343
-
-
Quelle, F.W.1
-
19
-
-
0030810155
-
The transcription factor gata-3 is necessary and sufficient for th2 cytokine gene expression incd4 tcells
-
Zheng W., & Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression inCD4 Tcells. Cell 89, 587-596 (1997
-
(1997)
Cell
, vol.89
, pp. 587-596
-
-
Zheng, W.1
Flavell, R.A.2
-
20
-
-
53849139093
-
Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma
-
Kuperman D.A., & Schleimer R.P. Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr. Mol. Med. 8, 384-392 (2008
-
(2008)
Curr. Mol. Med
, vol.8
, pp. 384-392
-
-
Kuperman, D.A.1
Schleimer, R.P.2
-
21
-
-
78149443789
-
The effects of antisense interleukin-4 gene transferred by recombinant adeno-associated virus vector on the airway remodeling in allergic rats
-
Cao Y., et al. The effects of antisense interleukin-4 gene transferred by recombinant adeno-associated virus vector on the airway remodeling in allergic rats. J. Asthma. 47, 951-958 (2010
-
(2010)
J. Asthma
, vol.47
, pp. 951-958
-
-
Cao, Y.1
-
22
-
-
77649198441
-
Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
-
Oh C.K., Geba G.P., & Molfino N. Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. Eur. Respir. Rev. 19, 46-54 (2010
-
(2010)
Eur. Respir. Rev
, vol.19
, pp. 46-54
-
-
Oh, C.K.1
Geba, G.P.2
Molfino, N.3
-
23
-
-
84879298475
-
Sustained suppression of IL-13 by a vaccine attenuates airway inflammation and remodeling in mice
-
Ma Y., et al. Sustained suppression of IL-13 by a vaccine attenuates airway inflammation and remodeling in mice. Am. J. Respir. Cell Mol. Biol. 48, 540-549 (2013
-
(2013)
Am. J. Respir. Cell Mol. Biol
, vol.48
, pp. 540-549
-
-
Ma, Y.1
-
24
-
-
34848848833
-
Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative stat-6 peptide
-
McCusker C.T., et al. Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT-6 peptide. J. Immunol. 179, 2556-2564 (2007
-
(2007)
J. Immunol
, vol.179
, pp. 2556-2564
-
-
McCusker, C.T.1
-
25
-
-
80054030236
-
Effective treatment of experimental ragweed-induced asthma with stat-6-ip, a topically delivered cell-penetrating peptide
-
Wang Y., Li Y., Shan J., Fixman E., & McCusker C. Effective treatment of experimental ragweed-induced asthma with STAT-6-IP, a topically delivered cell-penetrating peptide. Clin. Exp. Allergy. 41, 1622-1630 (2011
-
(2011)
Clin. Exp. Allergy
, vol.41
, pp. 1622-1630
-
-
Wang, Y.1
Li, Y.2
Shan, J.3
Fixman, E.4
McCusker, C.5
-
26
-
-
0242353358
-
Age-related changes in intracellular th1/th2 cytokine production, immunoproliferative t lymphocyte response and natural killer cell activity in newborns, children and adults
-
Gasparoni A., et al. Age-related changes in intracellular TH1/TH2 cytokine production, immunoproliferative T lymphocyte response and natural killer cell activity in newborns, children and adults. Biol. Neonate. 84, 297-303 (2003
-
(2003)
Biol. Neonate
, vol.84
, pp. 297-303
-
-
Gasparoni, A.1
-
27
-
-
70349777300
-
Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: Low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life
-
Belderbos M.E., et al. Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life. Clin. Immunol. 133, 228-237 (2009
-
(2009)
Clin. Immunol
, vol.133
, pp. 228-237
-
-
Belderbos, M.E.1
-
28
-
-
59849099959
-
Airway epithelial cells regulate the functional phenotype of locally differentiating dendritic cells: Implications for the pathogenesis of infectious and allergic airway disease
-
Rate A., Upham J.W., Bosco A., McKenna K.L., & Holt P.G. Airway epithelial cells regulate the functional phenotype of locally differentiating dendritic cells: implications for the pathogenesis of infectious and allergic airway disease. J. Immunol. 182, 72-83 (2009
-
(2009)
J. Immunol
, vol.182
, pp. 72-83
-
-
Rate, A.1
Upham, J.W.2
Bosco, A.3
McKenna, K.L.4
Holt, P.G.5
-
29
-
-
78149277909
-
How tolerogenic dendritic cells induce regulatory T cells
-
Maldonado R.A., & von Andrian U.H. How tolerogenic dendritic cells induce regulatory T cells. Adv. Immunol. 108, 111-165 (2010
-
(2010)
Adv. Immunol
, vol.108
, pp. 111-165
-
-
Maldonado, R.A.1
Von Andrian, U.H.2
-
30
-
-
33745369494
-
Neonatal exposure with LPS and/or allergen prevents experimental allergic airways disease: Development of tolerance using environmental antigens
-
Wang Y., & McCusker C. Neonatal exposure with LPS and/or allergen prevents experimental allergic airways disease: development of tolerance using environmental antigens. J. Allergy Clin. Immunol. 118, 143-151 (2006
-
(2006)
J. Allergy Clin. Immunol
, vol.118
, pp. 143-151
-
-
Wang, Y.1
McCusker, C.2
-
31
-
-
38949191258
-
Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma
-
Verhasselt V., et al. Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat. Med. 14, 170-175 (2008
-
(2008)
Nat. Med
, vol.14
, pp. 170-175
-
-
Verhasselt, V.1
-
32
-
-
78049289417
-
Neonatal tolerance under breastfeeding influence
-
Verhasselt V. Neonatal tolerance under breastfeeding influence. Curr. Opin. Immunol. 22, 623-630 (2010
-
(2010)
Curr. Opin. Immunol
, vol.22
, pp. 623-630
-
-
Verhasselt, V.1
-
33
-
-
0036907606
-
Site-specific sensitization in a murine model of allergic rhinitis: Role of the upper airway in lower airways disease
-
McCusker C., Chicoine M., Hamid Q., & Mazer B. Site-specific sensitization in a murine model of allergic rhinitis: role of the upper airway in lower airways disease. J. Allergy Clin. Immunol. 110, 891-898 (2002
-
(2002)
J. Allergy Clin. Immunol
, vol.110
, pp. 891-898
-
-
McCusker, C.1
Chicoine, M.2
Hamid, Q.3
Mazer, B.4
-
35
-
-
33645336289
-
Indoleamine-2, 3-dioxygenase modulation of allergic immune responses
-
Le A.V., & Broide D.H. Indoleamine-2, 3-dioxygenase modulation of allergic immune responses. Curr. Allergy Asthma Rep. 6, 27-31 (2006
-
(2006)
Curr. Allergy Asthma Rep
, vol.6
, pp. 27-31
-
-
Le, A.V.1
Broide, D.H.2
-
36
-
-
22544462499
-
+, but not CD8 alpha-, dendritic cells tolerize Th2 responses via contact-dependent and -independentmechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma
-
+, but not CD8 alpha-, dendritic cells tolerize Th2 responses via contact-dependent and -independentmechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma. J. Immunol. 175, 1516-1522 (2005
-
(2005)
J. Immunol
, vol.175
, pp. 1516-1522
-
-
Gordon, J.R.1
Li, F.2
Nayyar, A.3
Xiang, J.4
Zhang, X.5
-
37
-
-
0031913911
-
Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6
-
Patel B.K., Pierce J.H., & LaRochelle W.J. Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6. Proc. Natl. Acad. Sci. USA 95, 172-177 (1998
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 172-177
-
-
Patel, B.K.1
Pierce, J.H.2
Larochelle, W.J.3
-
38
-
-
84875261622
-
Indoleamine 2, 3 dioxygenase and metabolic control of immune responses
-
Munn D.H., & Mellor A.L. Indoleamine 2, 3 dioxygenase and metabolic control of immune responses. Trends Immunol. 34, 137-143 (2013
-
(2013)
Trends Immunol
, vol.34
, pp. 137-143
-
-
Munn, D.H.1
Mellor, A.L.2
-
39
-
-
36248972568
-
+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells
-
+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur. J. Immunol. 37, 3054-3062 (2007
-
(2007)
Eur. J. Immunol
, vol.37
, pp. 3054-3062
-
-
Hill, M.1
-
40
-
-
74549138161
-
Induction of type 2 T helper cell allergen tolerance by IL-10-differentiated regulatory dendritic cells
-
Li X., et al. Induction of type 2 T helper cell allergen tolerance by IL-10-differentiated regulatory dendritic cells. Am. J. Respir. Cell Mol. Biol. 42, 190-199 (2010
-
(2010)
Am. J. Respir. Cell Mol. Biol
, vol.42
, pp. 190-199
-
-
Li, X.1
-
41
-
-
68249162073
-
Balance between early life tolerance and sensitization in allergy: Dependence on the timing and intensity of prenatal and postnatal allergen exposure of the mother
-
Fusaro A.E., et al. Balance between early life tolerance and sensitization in allergy: dependence on the timing and intensity of prenatal and postnatal allergen exposure of the mother. Immunology 128, e541-e550 (2009
-
(2009)
Immunology
, vol.128
, pp. e541-e550
-
-
Fusaro, A.E.1
-
42
-
-
84869136615
-
Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions
-
e10
-
Lisciandro J.G., et al. Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions. J. Allergy Clin. Immunol. 130, 1167-74 e10 (2012
-
(2012)
J. Allergy Clin. Immunol
, vol.130
, pp. 1167-1174
-
-
Lisciandro, J.G.1
-
43
-
-
77953753712
-
Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development
-
Mosconi E., et al. Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development. Mucosal Immunol 3, 461-474 (2010
-
(2010)
Mucosal Immunol
, vol.3
, pp. 461-474
-
-
Mosconi, E.1
-
44
-
-
74549214342
-
Neonatal tolerance under breastfeeding influence: The presence of allergen and transforming growth factor-beta in breast milk protects the progeny from allergic asthma
-
Verhasselt V. Neonatal tolerance under breastfeeding influence: the presence of allergen and transforming growth factor-beta in breast milk protects the progeny from allergic asthma. J. Pediatr. 156, S16-S20 (2010
-
(2010)
J. Pediatr
, vol.156
, pp. S16-S20
-
-
Verhasselt, V.1
-
45
-
-
60749105008
-
Neonatal exposure to staphylococcal superantigen improves induction of oral tolerance in a mouse model of airway allergy
-
Lonnqvist A., et al. Neonatal exposure to staphylococcal superantigen improves induction of oral tolerance in a mouse model of airway allergy. Eur. J. Immunol. 39, 447-456 (2009
-
(2009)
Eur. J. Immunol
, vol.39
, pp. 447-456
-
-
Lonnqvist, A.1
-
46
-
-
0141991117
-
TGF-beta in human milk is associated with wheeze in infancy
-
Oddy W.H., et al. TGF-beta in human milk is associated with wheeze in infancy. J. Allergy Clin. Immunol. 112, 723-728 (2003
-
(2003)
J. Allergy Clin. Immunol
, vol.112
, pp. 723-728
-
-
Oddy, W.H.1
-
47
-
-
79955779667
-
Milk-derived or recombinant transforming growth factor-beta has effects on immunological outcomes: A review of evidence from animal experimental studies
-
Oddy W.H., & McMahon R.J. Milk-derived or recombinant transforming growth factor-beta has effects on immunological outcomes: a review of evidence from animal experimental studies. Clin. Exp. Allergy 41, 783-793 (2011
-
(2011)
Clin. Exp. Allergy
, vol.41
, pp. 783-793
-
-
Oddy, W.H.1
McMahon, R.J.2
-
48
-
-
84883028120
-
Tgfbeta receptor mutations impose a strong predisposition for human allergic disease
-
195ra94
-
Frischmeyer-Guerrerio P.A., et al. TGFbeta Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease. Sci. Transl. Med. 5, 195ra94 (2013
-
(2013)
Sci. Transl. Med
, vol.5
-
-
Frischmeyer-Guerrerio, P.A.1
-
49
-
-
80052890031
-
Role of dendritic cells in the induction of regulatory T cells
-
Kushwah R., & Hu J. Role of dendritic cells in the induction of regulatory T cells. Cell Biosci. 1, 20 (2011
-
(2011)
Cell Biosci
, vol.1
, pp. 20
-
-
Kushwah, R.1
Hu, J.2
-
50
-
-
70049094943
-
Regulatory T cells in asthma
-
Lloyd C.M., & Hawrylowicz C.M. Regulatory T cells in asthma. Immunity 31, 438-449 (2009
-
(2009)
Immunity
, vol.31
, pp. 438-449
-
-
Lloyd, C.M.1
Hawrylowicz, C.M.2
-
51
-
-
77950377767
-
Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma
-
Nemeth K., et al. Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc. Natl. Acad. Sci. USA 107, 5652-5657 (2010
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 5652-5657
-
-
Nemeth, K.1
-
52
-
-
77956200555
-
Default generation of neonatal regulatory Tcells
-
Wang G., Miyahara Y., Guo Z., Khattar M., Stepkowski S.M., & Chen W. Default generation of neonatal regulatory Tcells. J. Immunol. 185, 71-78 (2010
-
(2010)
J. Immunol
, vol.185
, pp. 71-78
-
-
Wang, G.1
Miyahara, Y.2
Guo, Z.3
Khattar, M.4
Stepkowski, S.M.5
Chen, W.6
-
53
-
-
0035863391
-
Synthetic protein transduction domains: Enhanced transduction potential in vitro and in vivo
-
Ho A., Schwarze S.R., Mermelstein S.J., Waksman G., & Dowdy S.F. Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo. Cancer Res. 61, 474-477 (2001
-
(2001)
Cancer Res
, vol.61
, pp. 474-477
-
-
Ho, A.1
Schwarze, S.R.2
Mermelstein, S.J.3
Waksman, G.4
Dowdy, S.F.5
|