Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 19, 2015, Pages 6497-6509

  Machado, Vera A ^a,b,c   Peixoto, Daniela ^a   Costa, Raquel ^b,c   Froufe, Hugo J C ^d   Calhelha, Ricardo C ^a,d   Abreu, Rui M V ^d   Ferreira, Isabel C F R ^d   Soares, Raquel ^b,c   Queiroz, Maria João R P ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b University of Porto   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d INSTITUTO POLITÉCNICO DE BRAGANÇA   (Portugal)

Author keywords

Antiangiogenesis assays; Enzymatic assays; HUVECs; Molecular docking; Thienopyridinethioether 1,3 diarylureas; VEGFR 2 tyrosine kinase inhibitors; Western blotting

Indexed keywords

1 (3 FLUOROPHENYL) 3 [3 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 (4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL) 3 [4 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 (4 CYANOPHENYL) 3 [2 (THIENO[3,2 B]PIRIDIN 7 YLTHIO)PHENYL]UREA; 1 (4 CYANOPHENYL) 3 [3 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 (4 CYANOPHENYL) 3 [4 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 (4 FLUOROPHENYL) 3 [3 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 (4 METHOXYPHENYL) 3 [2 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 (4 METHOXYPHENYL) 3 [3 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 (4 METHOXYPHENYL) 3 [4 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 ARYL 3 [(THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA DERIVATIVE; 1 PHENYL 3 [2 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 PHENYL 3 [4 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 [3 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL] 3 M TOLYLUREA; 1 [3 (TRIFLUOROMETHYL)PHENYL] 3 [3 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 [3 (TRIFLUOROMETHYL)PHENYL] 3 [4 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; 1 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 3 [3 (THIENO[3,2 B]PYRIDIN 7 YLTHIO)PHENYL]UREA; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; UNCLASSIFIED DRUG; ANGIOGENESIS INHIBITOR; UREA; VASCULOTROPIN RECEPTOR 2;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BRDU ASSAY; CELL MIGRATION; CELL MIGRATION ASSAY; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC50; IMMUNOHISTOCHEMISTRY; MOLECULAR DOCKING; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TUNEL ASSAY; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; WOUND HEALING ASSAY; ANALOGS AND DERIVATIVES; ANGIOGENESIS; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL MOTION; DRUG EFFECTS; METABOLISM; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

ANGIOGENESIS INHIBITORS; APOPTOSIS; BINDING SITES; CELL MOVEMENT; CELL PROLIFERATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84942191894     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.08.010     Document Type: Article

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