-
1
-
-
0034076189
-
Mechanisms of angiogenesis and arteriogenesis
-
Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6(4):389-395.
-
(2000)
Nat Med
, vol.6
, Issue.4
, pp. 389-395
-
-
Carmeliet, P.1
-
2
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16(9):4604-4613.
-
(1996)
Mol Cell Biol
, vol.16
, Issue.9
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
-
3
-
-
0034648793
-
-
Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature. 2000;407(6801):242-248.
-
(2000)
Nature
, vol.407
, Issue.6801
, pp. 242-248
-
-
-
4
-
-
0038376002
-
Molecular regulation of vessel maturation
-
Jain RK. Molecular regulation of vessel maturation. Nat Med. 2003;9(6):685-693.
-
(2003)
Nat Med
, vol.9
, Issue.6
, pp. 685-693
-
-
Jain, R.K.1
-
5
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005;307(5706):58-62.
-
(2005)
Science
, vol.307
, Issue.5706
, pp. 58-62
-
-
Jain, R.K.1
-
6
-
-
0032585864
-
Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix
-
Knocke TH, Weitmann HD, Feldmann HJ, Selzer E, Potter R. Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix. Radiother Oncol. 1999;53(2):99-104.
-
(1999)
Radiother Oncol
, vol.53
, Issue.2
, pp. 99-104
-
-
Knocke, T.H.1
Weitmann, H.D.2
Feldmann, H.J.3
Selzer, E.4
Potter, R.5
-
7
-
-
0032708195
-
Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
-
Brizel DM, Dodge RK, Clough RW, Dewhirst MW. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol. 1999;53(2):113-117.
-
(1999)
Radiother Oncol
, vol.53
, Issue.2
, pp. 113-117
-
-
Brizel, D.M.1
Dodge, R.K.2
Clough, R.W.3
Dewhirst, M.W.4
-
8
-
-
0033962101
-
Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39
-
Kakolyris S, Fox SB, Koukourakis M, et al. Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39. Br J Cancer. 2000;82(4):844-851.
-
(2000)
Br J Cancer
, vol.82
, Issue.4
, pp. 844-851
-
-
Kakolyris, S.1
Fox, S.B.2
Koukourakis, M.3
-
9
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350(23):2335-2342.
-
(2004)
N Engl J Med
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
10
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007 20;25(12):1539-544.
-
(2000)
J Clin Oncol
, vol.20
, Issue.12
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
-
11
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008;26(12):2013-2019.
-
(2008)
J Clin Oncol
, vol.26
, Issue.12
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
-
12
-
-
33748999448
-
Safety of bevacizumab plus chemotherapy as first-line treatment of patients with metastatic colorectal cancer: Updated results from a large observational registry in the US (BRiTE)
-
Hedrick E, Kozloff M, Hainsworth J, et al. Safety of bevacizumab plus chemotherapy as first-line treatment of patients with metastatic colorectal cancer: Updated results from a large observational registry in the US (BRiTE). J Clin Oncol. (Meeting Abstracts). 2006;24(18 Suppl):3536.
-
(2006)
J Clin Oncol. (Meeting Abstracts)
, vol.24
, Issue.18 SUPPL
, pp. 3536
-
-
Hedrick, E.1
Kozloff, M.2
Hainsworth, J.3
-
13
-
-
33746833739
-
Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: An NCI Treatment Referral Center Trial TRC-0301
-
Chen HX, Mooney M, Boron M, et al. Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: an NCI Treatment Referral Center Trial TRC-0301. J Clin Oncol. 2006;24(21):3354-3360.
-
(2006)
J Clin Oncol
, vol.24
, Issue.21
, pp. 3354-3360
-
-
Chen, H.X.1
Mooney, M.2
Boron, M.3
-
15
-
-
69549147378
-
A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: Results of NSABP Protocol C-08
-
abstr LBA14
-
Wolmark N, Yothers G, O'Connell M, et al. A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: Results of NSABP Protocol C-08. J Clin Oncol. 2009;27:18s(Suppl; abstr LBA14).
-
(2009)
J Clin Oncol
, vol.18
, Issue.SUPPL.
, pp. 27
-
-
Wolmark, N.1
Yothers, G.2
O'Connell, M.3
-
19
-
-
84857424492
-
-
National Cancer Institute, Accessed Aug 17, 2009
-
National Cancer Institute. FDA Approval for Bevacizumab. http://www.cancer.gov/cancertopics/druginfo/fda-bevacizumab. Accessed Aug 17, 2009.
-
FDA Approval for Bevacizumab
-
-
-
20
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007;357(26):2666-2676.
-
(2007)
N Engl J Med
, vol.357
, Issue.26
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
-
21
-
-
54249120945
-
Randomized, double-blind, placebo- controlled, phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO
-
Miles D, Chan A, Romieu G, et al. Randomized, double-blind, placebo- controlled, phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO. J Clin Oncol. 2008;26:1008s.
-
(2008)
J Clin Oncol
, vol.26
-
-
Miles, D.1
Chan, A.2
Romieu, G.3
-
22
-
-
70249097518
-
RIBBON-1: Randomized, doubleblind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab (B) for first-line treatment of HER2-negative locally recurrent or metastatic breast cancer (MBC)
-
Robert NJ, Dieras V, Glaspy J, et al. RIBBON-1: Randomized, doubleblind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab (B) for first-line treatment of HER2-negative locally recurrent or metastatic breast cancer (MBC). J Clin Oncol. 2009;27:42s(abstr 1005).
-
(2009)
J Clin Oncol
, vol.42 s
, Issue.abstr 1005
, pp. 27
-
-
Robert, N.J.1
Dieras, V.2
Glaspy, J.3
-
23
-
-
20044364346
-
Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
-
Miller KD, Chap LI, Holmes FA, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol. 2005;23(4):792-799.
-
(2005)
J Clin Oncol
, vol.23
, Issue.4
, pp. 792-799
-
-
Miller, K.D.1
Chap, L.I.2
Holmes, F.A.3
-
24
-
-
77955878497
-
-
United States Food and Drug Administration, December 2007, AVASTIN (Bevacizumab), Accessed Nov 29, 2009
-
United States Food and Drug Administration. Oncology Drugs Advisory Committee Meeting 5 December 2007, AVASTIN (Bevacizumab). 2008; http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4332b1-03-Genentech.pdf. Accessed Nov 29, 2009.
-
(2008)
Oncology Drugs Advisory Committee Meeting 5
-
-
-
26
-
-
51849134272
-
Phase II feasibility trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node-positive breast cancer: A trial of the Eastern Cooperative Oncology Group (E2104)
-
May
-
Miller KD, O'Neill A, Perez EA, Seidman AD, Sledge GW. Phase II feasibility trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node-positive breast cancer: A trial of the Eastern Cooperative Oncology Group (E2104). J Clin Oncol. (Meeting Abstracts). 2008 May 20;26(15 Suppl):520.
-
(2008)
J Clin Oncol. (Meeting Abstracts)
, vol.20
, Issue.SUPPL.
, pp. 520
-
-
Miller, K.D.1
O'Neill, A.2
Perez, E.A.3
Seidman, A.D.4
Sledge, G.W.5
-
29
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006;355(24):2542-2550.
-
(2006)
N Engl J Med
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
30
-
-
62449124416
-
Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
-
Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol. 2009;27(8):1227-1234.
-
(2009)
J Clin Oncol
, vol.27
, Issue.8
, pp. 1227-1234
-
-
Reck, M.1
von Pawel, J.2
Zatloukal, P.3
-
31
-
-
62349107301
-
B017704 (AVAIL): A phase III randomised study of first-line bevacizumab combined with cisplatin/gemcitabine (CG) in patients with advanced or recurrent non-squamous, non-small cell lung cancer
-
Manegold C, von Pawel J, Zatloukal P, et al. B017704 (AVAIL): A phase III randomised study of first-line bevacizumab combined with cisplatin/gemcitabine (CG) in patients with advanced or recurrent non-squamous, non-small cell lung cancer. Ann Oncol. 2008; 19(Suppl 8):viii.
-
(2008)
Ann Oncol
, vol.19
, Issue.SUPPL. 8
-
-
Manegold, C.1
von Pawel, J.2
Zatloukal, P.3
-
32
-
-
54949106715
-
A phase II, randomized, non-comparative clinical trial of the effect of bevacizumab (BV) alone or in combination with irinotecan (CPT) on 6-month progression free survival (PFS6) in recurrent, treatment-refractory glioblastoma (GBM)
-
May 20, abstr 2010b
-
Cloughesy TF, Prados MD, Wen PY, et al. A phase II, randomized, non-comparative clinical trial of the effect of bevacizumab (BV) alone or in combination with irinotecan (CPT) on 6-month progression free survival (PFS6) in recurrent, treatment-refractory glioblastoma (GBM). J Clin Oncol. 2008;26 May 20 Suppl; abstr 2010b.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Cloughesy, T.F.1
Prados, M.D.2
Wen, P.Y.3
-
33
-
-
59949083263
-
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
-
Kreisl TN, Kim L, Moore K, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol. 2009;27(5): 740-45.
-
(2009)
J Clin Oncol
, vol.27
, Issue.5
, pp. 740-745
-
-
Kreisl, T.N.1
Kim, L.2
Moore, K.3
-
34
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
-
Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet. 2007;370(9605):2103-2111.
-
(2007)
Lancet
, vol.370
, Issue.9605
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
35
-
-
84863799345
-
-
ASCO Genitourinary Cancers Symposium, San Francisco, CA, USA
-
Rini BI, Halabi S, Rosenberg JE, et al. CALGB 90206: A phase III trial of bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in metastatic renal cell carcinoma. Paper presented at: ASCO Genitourinary Cancers Symposium 2008; San Francisco, CA, USA.
-
(2008)
CALGB 90206: A Phase III Trial of Bevacizumab Plus Interferon-alpha Versus Interferon-alpha Monotherapy In Metastatic Renal Cell Carcinoma. Paper Presented At
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
36
-
-
67649921334
-
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: A multidisciplinary phase II study
-
Willett CG, Duda DG, di Tomaso E, et al. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol. 2009;27(18):3020-3026.
-
(2009)
J Clin Oncol
, vol.27
, Issue.18
, pp. 3020-3026
-
-
Willett, C.G.1
Duda, D.G.2
di Tomaso, E.3
-
37
-
-
45249097586
-
Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: Interim analysis of safety and tolerability
-
Lai A, Filka E, McGibbon B, et al. Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int J Radiat Oncol Biol Phys. 2008;71(5):1372-1380.
-
(2008)
Int J Radiat Oncol Biol Phys
, vol.71
, Issue.5
, pp. 1372-1380
-
-
Lai, A.1
Filka, E.2
McGibbon, B.3
-
40
-
-
84863788183
-
-
Roche Products Limited. Summary of product characteristics: Avastin 25 mg/ml concentrate for solution for infusion, Accessed Aug 17, 2009
-
Roche Products Limited. Summary of product characteristics: Avastin 25 mg/ml concentrate for solution for infusion. http://emc.medicines.org.uk/document.aspx?documentId=15748. Accessed Aug 17, 2009.
-
-
-
-
41
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64(19):7099-7109.
-
(2004)
Cancer Res
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
42
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
Ratain MJ, Eisen T, Stadler WM, et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol. 2006;24(16):2505-2512.
-
(2006)
J Clin Oncol
, vol.24
, Issue.16
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
-
43
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356(2):125-134.
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
44
-
-
34548315347
-
Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: Survival and biomarker analysis
-
June 20
-
Bukowski RM, Eisen T, Szczylik C, et al. Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: Survival and biomarker analysis. J Clin Oncol (Meeting Abstracts). 2007 June 20;25(18S):5023.
-
(2007)
J Clin Oncol (Meeting Abstracts)
, vol.25
, Issue.18 S
, pp. 5023
-
-
Bukowski, R.M.1
Eisen, T.2
Szczylik, C.3
-
45
-
-
84856983566
-
-
National Cancer Institute, Accessed Sept 16, 2009
-
National Cancer Institute. FDA Approval for Sorafenib Tosylate. http://www.cancer.gov/cancertopics/druginfo/fda-sorafenib-tosylate. Accessed Sept 16, 2009.
-
FDA Approval For Sorafenib Tosylate
-
-
-
46
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359(4):378-390.
-
(2008)
N Engl J Med
, vol.359
, Issue.4
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
48
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003;9(1):327-337.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.1
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
49
-
-
33744954585
-
Sunitinib in patients with metastatic renal cell carcinoma
-
Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA. 2006;295(21):2516-2524.
-
(2006)
JAMA
, vol.295
, Issue.21
, pp. 2516-2524
-
-
Motzer, R.J.1
Rini, B.I.2
Bukowski, R.M.3
-
50
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer RJ, Michaelson MD, Redman BG, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 2006;24(1):16-24.
-
(2006)
J Clin Oncol
, vol.24
, Issue.1
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
-
51
-
-
34447120142
-
CCR drug updates: Sorafenib and sunitinib in renal cell carcinoma
-
Stein MN, Flaherty KT. CCR drug updates: sorafenib and sunitinib in renal cell carcinoma. Clin Cancer Res. 2007;13(13):3765-3770.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.13
, pp. 3765-3770
-
-
Stein, M.N.1
Flaherty, K.T.2
-
52
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356(2):115-124.
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
53
-
-
84863796908
-
-
National Cancer Institute
-
National Cancer Institute. FDA Approval for Sunitinib Malate. http://www.cancer.gov/cancertopics/druginfo/fda-sunitinib-malate.
-
FDA Approval For Sunitinib Malate
-
-
-
56
-
-
45149093253
-
Gastrointestinal stromal tumors: ESMO clinical recommendations for diagnosis, treatment and follow-up
-
Casali PG, Jost L, Reichardt P, Schlemmer M, Blay JY. Gastrointestinal stromal tumors: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2008;19 Suppl 2:ii35-ii38.
-
(2008)
Ann Oncol
, vol.19
, Issue.SUPPL. 2
-
-
Casali, P.G.1
Jost, L.2
Reichardt, P.3
Schlemmer, M.4
Blay, J.Y.5
-
57
-
-
33645092405
-
Gastrointestinal stromal tumours: An update
-
Rubin BP. Gastrointestinal stromal tumours: an update. Histopathology. 2006;48(1):83-96.
-
(2006)
Histopathology
, vol.48
, Issue.1
, pp. 83-96
-
-
Rubin, B.P.1
-
58
-
-
0242670019
-
PDGFRA activating mutations in gastrointestinal stromal tumors
-
Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299(5607): 708-710.
-
(2003)
Science
, vol.299
, Issue.5607
, pp. 708-710
-
-
Heinrich, M.C.1
Corless, C.L.2
Duensing, A.3
-
59
-
-
24944529613
-
Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study
-
Van Glabbeke M, Verweij J, Casali PG, et al. Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: a European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study. J Clin Oncol. 2005;23(24):5795-5804.
-
(2005)
J Clin Oncol
, vol.23
, Issue.24
, pp. 5795-5804
-
-
van Glabbeke, M.1
Verweij, J.2
Casali, P.G.3
-
60
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
-
Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet. 2006;368(9544):1329-1338.
-
(2006)
Lancet
, vol.368
, Issue.9544
, pp. 1329-1338
-
-
Demetri, G.D.1
van Oosterom, A.T.2
Garrett, C.R.3
-
61
-
-
68949188438
-
Novel statistical analysis of long-term survival to account for crossover in a phase III trial of sunitinib (SU) vs placebo (PL) in advanced GIST after imatinib (IM) failure
-
Meeting Abstracts, May 20 Suppl, abstr 10524
-
Demetri GD, Huang X, Garrett CR, et al. Novel statistical analysis of long-term survival to account for crossover in a phase III trial of sunitinib (SU) vs placebo (PL) in advanced GIST after imatinib (IM) failure. J Clin Oncol. (Meeting Abstracts). 2008;26(May 20 Suppl): abstr 10524.
-
(2008)
J Clin Oncol
, vol.26
-
-
Demetri, G.D.1
Huang, X.2
Garrett, C.R.3
-
62
-
-
70349782389
-
An overview of small-molecule inhibitors of VEGFR signaling
-
Ivy SP, Wick JY, Kaufman BM. An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol. 2009;6(10):569-579.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, Issue.10
, pp. 569-579
-
-
Ivy, S.P.1
Wick, J.Y.2
Kaufman, B.M.3
-
63
-
-
0035874067
-
An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release
-
Aigner A, Butscheid M, Kunkel P, et al. An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release. Int J Cancer. 2001;92(4):510-517.
-
(2001)
Int J Cancer
, vol.92
, Issue.4
, pp. 510-517
-
-
Aigner, A.1
Butscheid, M.2
Kunkel, P.3
-
64
-
-
18144364350
-
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
-
Presta M, Dell'Era P, Mitola S, Moroni E, Ronca R, Rusnati M. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev. 2005;16(2):159-178.
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, Issue.2
, pp. 159-178
-
-
Presta, M.1
Dell'era, P.2
Mitola, S.3
Moroni, E.4
Ronca, R.5
Rusnati, M.6
-
65
-
-
0028216334
-
Thalidomide is an inhibitor of angiogenesis
-
D'Amato RJ, Loughnan MS, Flynn E, Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A. 1994;91(9): 4082-4085.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, Issue.9
, pp. 4082-4085
-
-
D'amato, R.J.1
Loughnan, M.S.2
Flynn, E.3
Folkman, J.4
-
66
-
-
0029925419
-
Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade
-
Geitz H, Handt S, Zwingenberger K. Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade. Immunopharmacology. 1996;31(2-3):213-221.
-
(1996)
Immunopharmacology
, vol.31
, Issue.2-3
, pp. 213-221
-
-
Geitz, H.1
Handt, S.2
Zwingenberger, K.3
-
67
-
-
0029664920
-
Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production
-
Turk BE, Jiang H, Liu JO. Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci U S A. 1996;93(15):7552-7556.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.15
, pp. 7552-7556
-
-
Turk, B.E.1
Jiang, H.2
Liu, J.O.3
-
68
-
-
0037739753
-
High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma
-
Child JA, Morgan GJ, Davies FE, et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med. 2003;348(19):1875-1883.
-
(2003)
N Engl J Med
, vol.348
, Issue.19
, pp. 1875-1883
-
-
Child, J.A.1
Morgan, G.J.2
Davies, F.E.3
-
69
-
-
8944220233
-
A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma
-
Attal M, Harousseau JL, Stoppa AM, et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. N Engl J Med. 1996;335(2):91-97.
-
(1996)
N Engl J Med
, vol.335
, Issue.2
, pp. 91-97
-
-
Attal, M.1
Harousseau, J.L.2
Stoppa, A.M.3
-
70
-
-
33644831033
-
Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the Eastern Cooperative Oncology Group
-
Rajkumar SV, Blood E, Vesole D, Fonseca R, Greipp PR. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol. 2006;24(3):431-436.
-
(2006)
J Clin Oncol
, vol.24
, Issue.3
, pp. 431-436
-
-
Rajkumar, S.V.1
Blood, E.2
Vesole, D.3
Fonseca, R.4
Greipp, P.R.5
-
71
-
-
43749117945
-
Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma
-
Rajkumar SV, Rosinol L, Hussein M, et al. Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma. J Clin Oncol. 2008;26(13):2171-2177.
-
(2008)
J Clin Oncol
, vol.26
, Issue.13
, pp. 2171-2177
-
-
Rajkumar, S.V.1
Rosinol, L.2
Hussein, M.3
-
72
-
-
22044452126
-
Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma
-
Cavo M, Zamagni E, Tosi P, et al. Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma. Blood. 2005;106(1):35-39.
-
(2005)
Blood
, vol.106
, Issue.1
, pp. 35-39
-
-
Cavo, M.1
Zamagni, E.2
Tosi, P.3
-
73
-
-
33644843725
-
Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: Randomised controlled trial
-
Palumbo A, Bringhen S, Caravita T, et al. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial. Lancet. 2006;367(9513):825-831.
-
(2006)
Lancet
, vol.367
, Issue.9513
, pp. 825-831
-
-
Palumbo, A.1
Bringhen, S.2
Caravita, T.3
-
74
-
-
34848833957
-
Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reducedintensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): A randomised trial
-
Facon T, Mary JY, Hulin C, et al. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reducedintensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial. Lancet. 2007;370(9594):1209-1218.
-
(2007)
Lancet
, vol.370
, Issue.9594
, pp. 1209-1218
-
-
Facon, T.1
Mary, J.Y.2
Hulin, C.3
-
75
-
-
68949137225
-
Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial
-
Hulin C, Facon T, Rodon P, et al. Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial. J Clin Oncol. 2009;27(22): 3664-3670.
-
(2009)
J Clin Oncol
, vol.27
, Issue.22
, pp. 3664-3670
-
-
Hulin, C.1
Facon, T.2
Rodon, P.3
-
78
-
-
39149109289
-
Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma
-
Palumbo A, Rajkumar SV, Dimopoulos MA, et al. Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma. Leukemia. 2008;22(2):414-423.
-
(2008)
Leukemia
, vol.22
, Issue.2
, pp. 414-423
-
-
Palumbo, A.1
Rajkumar, S.V.2
Dimopoulos, M.A.3
-
79
-
-
0036843032
-
Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma
-
Rajkumar SV, Hayman S, Gertz MA, et al. Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma. J Clin Oncol. 2002;20(21):4319-4323.
-
(2002)
J Clin Oncol
, vol.20
, Issue.21
, pp. 4319-4323
-
-
Rajkumar, S.V.1
Hayman, S.2
Gertz, M.A.3
-
80
-
-
0035469858
-
Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy
-
Zangari M, Anaissie E, Barlogie B, et al. Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy. Blood. 2001;98(5):1614-1615.
-
(2001)
Blood
, vol.98
, Issue.5
, pp. 1614-1615
-
-
Zangari, M.1
Anaissie, E.2
Barlogie, B.3
-
81
-
-
0037370067
-
Increased frequency of venous thromboembolism with the combination of docetaxel and thalidomide in patients with metastatic androgen-independent prostate cancer
-
Horne MK, 3rd, Figg WD, Arlen P, et al. Increased frequency of venous thromboembolism with the combination of docetaxel and thalidomide in patients with metastatic androgen-independent prostate cancer. Pharmacotherapy. 2003;23(3):315-318.
-
(2003)
Pharmacotherapy
, vol.23
, Issue.3
, pp. 315-318
-
-
Horne III, M.K.1
Figg, W.D.2
Arlen, P.3
-
82
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A. 2002;99(17):11393-11398.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.17
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
-
87
-
-
65349186800
-
Aflibercept (AVE0005): An alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors
-
Chu QS. Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors. Expert Opin Biol Ther. 2009;9(2):263-271.
-
(2009)
Expert Opin Biol Ther
, vol.9
, Issue.2
, pp. 263-271
-
-
Chu, Q.S.1
-
88
-
-
0035417875
-
Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability
-
Tozer GM, Prise VE, Wilson J, et al. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Res. 2001;61(17):6413-6422.
-
(2001)
Cancer Res
, vol.61
, Issue.17
, pp. 6413-6422
-
-
Tozer, G.M.1
Prise, V.E.2
Wilson, J.3
-
89
-
-
0037373826
-
The first international conference on vascular targeting: Meeting overview
-
Thorpe PE, Chaplin DJ, Blakey DC. The first international conference on vascular targeting: meeting overview. Cancer Res. 2003;63(5): 1144-1147.
-
(2003)
Cancer Res
, vol.63
, Issue.5
, pp. 1144-1147
-
-
Thorpe, P.E.1
Chaplin, D.J.2
Blakey, D.C.3
-
90
-
-
19344378137
-
Vascular disrupting agents: A new class of drug in cancer therapy
-
Gaya AM, Rustin GJ. Vascular disrupting agents: a new class of drug in cancer therapy. Clin Oncol (R Coll Radiol). 2005;17(4): 277-290.
-
(2005)
Clin Oncol (R Coll Radiol)
, vol.17
, Issue.4
, pp. 277-290
-
-
Gaya, A.M.1
Rustin, G.J.2
-
91
-
-
33845286942
-
Vascular disrupting agents
-
Lippert JW 3rd. Vascular disrupting agents. Bioorg Med Chem. 2007;15(2):605-615.
-
(2007)
Bioorg Med Chem
, vol.15
, Issue.2
, pp. 605-615
-
-
Lippert III, J.W.1
-
92
-
-
0033119771
-
Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
-
Tozer GM, Prise VE, Wilson J, et al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Res. 1999;59(7):1626-1634.
-
(1999)
Cancer Res
, vol.59
, Issue.7
, pp. 1626-1634
-
-
Tozer, G.M.1
Prise, V.E.2
Wilson, J.3
-
93
-
-
65549090459
-
A review and update of the current status of the vasculature-disabling agent combretastatin- A4 phosphate (CA4P)
-
Siemann DW, Chaplin DJ, Walicke PA. A review and update of the current status of the vasculature-disabling agent combretastatin- A4 phosphate (CA4P). Expert Opin Investig Drugs. 2009;18(2): 189-197.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, Issue.2
, pp. 189-197
-
-
-
94
-
-
33745175081
-
A Phase Ib trial of combretastatin A-4 phosphate (CA4P) in combination with carboplatin or paclitaxel chemotherapy in patients with advanced cancer. [abstract]
-
Rustin G, Nathan P, Boxhall J, et al. A Phase Ib trial of combretastatin A-4 phosphate (CA4P) in combination with carboplatin or paclitaxel chemotherapy in patients with advanced cancer. [abstract]. J Clin Oncol. 2005;23:3013.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3013
-
-
Rustin, G.1
Nathan, P.2
Boxhall, J.3
-
96
-
-
84863788187
-
A randomized phase 2 trial of combretatstatin A4 phosphate (CA4P) in combination with paclitaxel and carboplatin to evaluate safety and efficacy in subjects with advanced imageable malignancies [abstract 14060]
-
Chicago, IL, USA
-
Akerley W, Schabel M, Morrell G, et al. A randomized phase 2 trial of combretatstatin A4 phosphate (CA4P) in combination with paclitaxel and carboplatin to evaluate safety and efficacy in subjects with advanced imageable malignancies [abstract 14060]. American Society of Clinical Oncology Annual Meeting. Chicago, IL, USA 2007.
-
(2007)
American Society of Clinical Oncology Annual Meeting
-
-
Akerley, W.1
Schabel, M.2
Morrell, G.3
-
97
-
-
84863799352
-
Fosbretabulin (combretastatin A-4 phosphate [CA4P]) carboplatin and paclitaxel is active in patients with platinum resistant ovarian cancer [abstract 315]
-
Rustin G, Jayson G, Reed N, et al. Fosbretabulin (combretastatin A-4 phosphate [CA4P]) carboplatin and paclitaxel is active in patients with platinum resistant ovarian cancer [abstract 315]. International Gynecologic Cancer Society Meeting; 2008.
-
(2008)
International Gynecologic Cancer Society Meeting
-
-
Rustin, G.1
Jayson, G.2
Reed, N.3
-
98
-
-
49049086508
-
Dual targeting of tumor vasculature: Combining Avastin and vascular disrupting agents (CA4P or OXi4503
-
Siemann DW, Shi W. Dual targeting of tumor vasculature: combining Avastin and vascular disrupting agents (CA4P or OXi4503). Anticancer Res. 2008;28(4B):2027-2031.
-
(2008)
Anticancer Re
, vol.2
, Issue.4-8 B
, pp. 2027-2203
-
-
Sieman, D.W.1
Shi, W.2
-
101
-
-
0035254653
-
In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment
-
Landuyt W, Ahmed B, Nuyts S, et al. In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment. Int J Radiat Oncol Biol Phys. 2001;49(2):443-450.
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.49
, Issue.2
, pp. 443-450
-
-
Landuyt, W.1
Ahmed, B.2
Nuyts, S.3
-
102
-
-
0035889331
-
Combretastatin A-4 disodium phosphate: A vascular targeting agent that improves that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy
-
Murata R, Overgaard J, Horsman MR. Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy. Int J Radiat Oncol Biol Phys. 2001;51(4):1018-1024.
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.51
, Issue.4
, pp. 1018-1024
-
-
Murata, R.1
Overgaard, J.2
Horsman, M.R.3
-
103
-
-
0034962379
-
Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumor
-
Murata R, Siemann DW, Overgaard J, Horsman MR. Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors. Radiother Oncol. 2001;60(2):155-161.
-
(2001)
Radiother Onco
, vol.60
, Issue.2
, pp. 155-161
-
-
Murata, R.1
Sieman, D.W.2
Overgaard, J.3
Chorsman, M.R.4
-
104
-
-
0031742231
-
Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: Effects on radiation therapy
-
Li L, Rojiani A, Siemann DW. Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy. Int J Radiat Oncol Biol Phys. 1998;42(4):899-903.
-
(1998)
Int J Radiat Oncol Biol Phys
, vol.42
, Issue.4
, pp. 899-903
-
-
Li, L.1
Rojiani, A.2
Siemann, D.W.3
-
105
-
-
0032950870
-
Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin A4 phosphate
-
Chaplin DJ, Pettit GR, Hill SA. Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate. Anticancer Res. 1999;19(1A):189-195.
-
(1999)
Anticancer Res
, vol.19
, Issue.1 A
, pp. 189-195
-
-
Chaplin, D.J.1
Pettit, G.R.2
Hill, S.A.3
-
106
-
-
33947504434
-
Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer
-
Ng QS, Goh V, Carnell D, et al. Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2007;67(5):1375-1380.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.67
, Issue.5
, pp. 1375-1380
-
-
Ng, Q.S.1
Goh, V.2
Carnell, D.3
-
107
-
-
0642307227
-
Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow
-
Stevenson JP, Rosen M, Sun W, et al. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow. J Clin Oncol. 2003;21(23):4428-4438.
-
(2003)
J Clin Oncol
, vol.21
, Issue.23
, pp. 4428-4438
-
-
Stevenson, J.P.1
Rosen, M.2
Sun, W.3
-
108
-
-
0037096814
-
A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
-
Dowlati A, Robertson K, Cooney M, et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res. 2002;62(12):3408-3416.
-
(2002)
Cancer Res
, vol.62
, Issue.12
, pp. 3408-3416
-
-
Dowlati, A.1
Robertson, K.2
Cooney, M.3
-
109
-
-
0042386700
-
Phase I clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results
-
Rustin GJ, Galbraith SM, Anderson H, et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol. 2003;21(15):2815-2822
-
(2003)
J Clin Oncol
, vol.21
, Issue.15
, pp. 2815-2822
-
-
Rustin, G.J.1
Galbraith, S.M.2
Anderson, H.3
|