Bortezomib plus continuous b cell depletion results in sustained plasma cell depletion and amelioration of lupus nephritis in NZB/WF1 Mice

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Khodadadi, Laleh ^a,b   Cheng, Qingyu ^a,b   Alexander, Tobias ^a,b   Sercan Alp, Ozen ^a   Klotsche, Jens ^a   Radbruch, Andreas ^a   Hiepe, Falk ^a,b   Hoyer, Bimba F ^a,b   Taddeo, Adriano ^a,b  

^a DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CD20 ANTIBODY; IMMUNOGLOBULIN G; ANTINEOPLASTIC AGENT; AUTOANTIBODY; CD20 ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; DRUG RESPONSE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HUMORAL IMMUNE DEFICIENCY; IMMUNE RESPONSE; LUPUS ERYTHEMATOSUS NEPHRITIS; MOLECULAR DYNAMICS; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PLASMA CELL; PRE B LYMPHOCYTE; SURVIVAL RATE; TARGET CELL DESTRUCTION; ANIMAL; B LYMPHOCYTE; BLOOD; BONE MARROW; CELL SEPARATION; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; LUPUS NEPHRITIS; METABOLISM; NEW ZEALAND BLACK MOUSE; PATHOLOGY; REGENERATION; SPLEEN;

ANIMALS; ANTIGENS, CD20; ANTINEOPLASTIC AGENTS; AUTOANTIBODIES; B-LYMPHOCYTES; BONE MARROW; BORTEZOMIB; CELL SEPARATION; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; INTEGRIN ALPHA4BETA1; LUPUS NEPHRITIS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, INBRED NZB; PLASMA CELLS; REGENERATION; SPLEEN;

EID: 84942163700     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135081     Document Type: Article

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