Autoantibodies from long-lived 'memory' plasma cells of NZB/W mice drive immune complex nephritis

Annals of the Rheumatic Diseases

Volumn 72, Issue 12, 2013, Pages 2011-2017

  Cheng, Qingyu ^a,b   Mumtaz, Imtiaz M ^a,b   Khodadadi, Laleh ^a,b   Radbruch, Andreas ^a   Hoyer, Bimba F ^b   Hiepe, Falk ^a,b  

^a DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; RAG1 PROTEIN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; BAGG ALBINO MOUSE; CELL HOMING; CELL PROLIFERATION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNE COMPLEX NEPHRITIS; IMMUNOGLOBULIN DEPOSITION; IMMUNOHISTOLOGY; MEMORY CELL; MOUSE; NEW ZEALAND BLACK MOUSE; NONHUMAN; PATHOGENESIS; PLASMA CELL; PRIORITY JOURNAL; PROTEINURIA; SYSTEMIC LUPUS ERYTHEMATOSUS;

AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; B CELLS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BONE MARROW CELLS; CELL PROLIFERATION; DNA; FEMALE; HOMEODOMAIN PROTEINS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; KIDNEY; LUPUS NEPHRITIS; MICE; MICE, INBRED BALB C; MICE, INBRED NZB; MICE, KNOCKOUT; PLASMA CELLS; SPLEEN;

EID: 84887488775     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-203455     Document Type: Article

References (32)

1. Martin F, Chan AC. B cell immunobiology in disease: evolving concepts from the clinic. Annu Rev Immunol 2006;24:467-96.
2. Manz RA, Thiel A, Radbruch A. Lifetime of plasma cells in the bone marrow. Nature 1997;388:133-4.
3. Slifka MK, Antia R, Whitmire JK, et al. Humoral immunity due to long-lived plasma cells. Immunity 1998;8:363-72.
4. Manz RA, Hauser AE, Hiepe F, et al. Maintenance of serum antibody levels. Annu Rev Immunol 2005;23:367-86.
5. Hoyer BF, Moser K, Hauser AE, et al. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J Exp Med 2004;199:1577-84.
6. Radbruch A, Muehlinghaus G, Luger EO, et al. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol 2006;6:741-50.
7. Odendahl M, Mei H, Hoyer BF, et al. Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response. Blood 2005;105:1614-21.
8. Hiepe F, Dörner T, Hauser AE, et al. Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat Rev Rheumatol 2011;7:170-8.
9. Jacobi AM, Mei H, Hoyer BF, et al. HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus. Ann Rheum Dis 2010;69:305-8.
10. Odendahl M, Jacobi A, Hansen A, et al. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J Immunol 2000;165:5970-9.
11. Liu Z, Bethunaickan R, Huang W, et al. Interferon-alpha accelerates murine systemic lupus erythematosus in a T cell-dependent manner. Arthritis Rheum 2011;63:219-29.
12. Mathian A, Gallegos M, Pascual V, et al. Interferon-alpha induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZBxNZW) F1 mice but not in BALB/c mice. Eur J Immunol 2011;41:863-72.
13. Stohl W, Hiepe F, Latinis KM, et al. Belimumab reduces autoantibodies, normalizes low complement, and reduces select B-cell populations in patients with systemic lupus erythematosus. Arthritis Rheum 2012;64:2328-37.
14. Manz RA, Löhning M, Cassese G, et al. Survival of long-lived plasma cells is independent of antigen. Int Immunol 1998;10:1703-11.
15. Ahuja A, Anderson SM, Khalil A, et al. Maintenance of the plasma cell pool is independent of memory B cells. Proc Natl Acad Sci USA 2008;105:4802-7.
16. Yoshida T, Mei H, Dorner T, et al. Memory B and memory plasma cells. Immunol Rev 2010;237:117-39.
17. Mumtaz IM, Hoyer BF, Panne D, et al. Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: implications for the treatment of autoimmunity. J Autoimmun 2012;39:180-8.
18. Di Lillo DJ, Hamaguchi Y, Ueda Y, et al. Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. J Immunol 2008;180:361-71.
19. Alexander T, Thiel A, Rosen O, et al. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system. Blood 2009;113:214-23.
20. Neubert K, Meister S, Moser K, et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med 2008;14:748-55.
21. Mombaerts P, Iacomini J, Johnson RS, et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992;68:869-77.
22. Cassese G, Lindenau S, de Boer B, et al. Inflamed kidneys of NZB/W mice are a major site for the homeostasis of plasma cells. Eur J Immunol 2001;31:2726-32.
23. Hauser AE, Debes GF, Arce S, et al. Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response. J Immunol 2002;169:1277-82.
24. Espeli M, Bokers S, Giannico G, et al. Local renal autoantibody production in lupus nephritis. J Am Soc Nephrol 2011;22:296-305.
25. Starke C, Frey S, Wellmann U, et al. High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice. Eur J Immunol 2011;41:2107-12.
26. Reininger L, Radaszkiewicz T, Kosco M, et al. Development of autoimmune disease in SCID mice populated with long-term "in vitro" proliferating (NZB x NZW) F1 pre-B cells. J Exp Med 1992;176:1343-53.
27. Fricker SP, Anastassov V, Cox J, et al. Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4. Biochem Pharmacol 2006;72:588-96.
28. Cocco M, Stephenson S, Care MA, et al. In vitro generation of long-lived human plasma cells. J Immunol 2012;189:5773-85.
29. Hahn BH. Antibodies to DNA. N Engl J Med 1998;338:1359-68.
30. van Bavel CC, Fenton KA, Rekvig OP, et al. Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus. Arthritis Rheum 2008;58:1892-9.
31. Kramers C, Hylkema MN, van Bruggen MC, et al. Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo. J Clin Invest 1994;94:568-77.
32. Okamoto A, Fujio K, van Rooijen N, et al. Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice. J Immunol 2008;181:5264-71.