Neuronal and behavioural modulations by pathway-selective optogenetic stimulation of the primate oculomotor system

Nature Communications

Volumn 6, Issue , 2015, Pages

  Inoue, Ken Ichi ^a   Takada, Masahiko ^a   Matsumoto, Masayuki ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIORAL RESPONSE; BRAIN; EYE; GENETIC ANALYSIS; NERVOUS SYSTEM; NEUROLOGY; PRIMATE; RODENT; SPATIOTEMPORAL ANALYSIS;

ADULT; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; FRONTAL EYE FIELD; MALE; NERVE CELL NETWORK; NERVE CELL STIMULATION; NEUROMODULATION; NONHUMAN; OCULOMOTOR SYSTEM; OPTOGENETICS; RHESUS MONKEY; SACCADIC EYE MOVEMENT; SUPERIOR COLLICULUS; ANIMAL; EYE MOVEMENT; GENETICS; NERVE CELL; NERVE TRACT; PHYSIOLOGY; PSYCHOLOGY; VISUAL SYSTEM;

PRIMATES; RODENTIA;

ANIMALS; BEHAVIOR, ANIMAL; EYE MOVEMENTS; MACACA MULATTA; MALE; NEURAL PATHWAYS; NEURONS; OPTOGENETICS; SACCADES; SUPERIOR COLLICULI; VISUAL PATHWAYS;

EID: 84942155858     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9378     Document Type: Article

References (26)

1. Bernstein, J. G. & Boyden, E. S. Optogenetic tools for analyzing the neural circuits of behavior. Trends Cogn. Sci. 15, 592-600 (2011).
2. Tye, K. M. & Deisseroth, K. Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat. Rev. Neurosci. 13, 251-266 (2012).
3. Tye, K. M. et al. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature 471, 358-362 (2011).
4. Stuber, G. D. et al. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature 475, 377-380 (2011).
5. Stamatakis, A. M. & Stuber, G. D. Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance. Nat. Neurosci. 15, 1105-1107 (2012).
6. Warden, M. R. et al. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature 492, 428-432 (2012).
7. Cavanaugh, J. et al. Optogenetic inactivation modifies monkey visuomotor behavior. Neuron 76, 901-907 (2012).
8. Dai, J., Brooks, D. I. & Sheinberg, D. L. Optogenetic and electrical microstimulation systematically bias visuospatial choice in primates. Curr. Biol. 24, 63-69 (2014).
9. Gerits, A. et al. Optogenetically induced behavioral and functional network changes in primates. Curr. Biol. 22, 1722-1726 (2012).
10. Jazayeri, M., Lindbloom-Brown, Z. & Horwitz, G. D. Saccadic eye movements evoked by optogenetic activation of primate V1. Nat. Neurosci. 15, 1368-1370 (2012).
11. Ohayon, S., Grimaldi, P., Schweers, N. & Tsao, D. Y. Saccade modulation by optical and electrical stimulation in the macaque frontal eye field. J. Neurosci. 33, 16684-16697 (2013).
12. Moschovakis, A. K., Scudder, C. A. & Highstein, S. M. The microscopic anatomy and physiology of the mammalian saccadic system. Prog. Neurobiol. 50, 133-254 (1996).
13. Hikosaka, O., Takikawa, Y. & Kawagoe, R. Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol. Rev. 80, 953-978 (2000).
14. Sparks, D. L. The brainstem control of saccadic eye movements. Nat. Rev. Neurosci. 3, 952-964 (2002).
15. Wurtz, R. H. & Goldberg, M. E. The Neurobiology of Saccadic Eye Movements (Elsevier, 1989).
16. Fuchs, A. F., Kaneko, C. R. & Scudder, C. A. Brainstem control of saccadic eye movements. Annu. Rev. Neurosci. 8, 307-337 (1985).
17. Distel, H. & Fries, W. Contralateral cortical projections to the superior colliculus in the macaque monkey. Exp. Brain Res. 48, 157-162 (1982).
18. Fries, W. Cortical projections to the superior colliculus in the macaque monkey: a retrograde study using horseradish peroxidase. J. Comp. Neurol. 230, 55-76 (1984).
19. Schall, J. D. Visuomotor areas of the frontal lobe. in: Cerebral Cortex. (eds Rockland, K. S., Kaas, J. H. & Peters, A.) 527-638 (Plenum Press, 1997).
20. Tehovnik, E. J., Sommer, M. A., Chou, I. H., Slocum, W. M. & Schiller, P. H. Eye fields in the frontal lobes of primates. Brain Res. Brain Res. Rev. 32, 413-448 (2000).
21. Sommer, M. A. & Wurtz, R. H. Frontal eye field sends delay activity related to movement, memory, and vision to the superior colliculus. J. Neurophysiol. 85, 1673-1685 (2001).
22. Sommer, M. A. & Wurtz, R. H. Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus. J. Neurophysiol. 83, 1979-2001 (2000).
23. Segraves, M. A. & Goldberg, M. E. Functional properties of corticotectal neurons in the monkey's frontal eye field. J. Neurophysiol. 58, 1387-1419 (1987).
24. Schiller, P. H. & Stryker, M. Single-unit recording and stimulation in superior colliculus of the alert rhesus monkey. J. Neurophysiol. 35, 915-924 (1972).
25. Bruce, C. J., Goldberg, M. E., Bushnell, M. C. & Stanton, G. B. Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. J. Neurophysiol. 54, 714-734 (1985).
26. Robbins, A. A., Fox, S. E., Holmes, G. L., Scott, R. C. & Barry, J. M. Short duration waveforms recorded extracellularly from freely moving rats are representative of axonal activity. Front. Neural Circ. 7, 181 (2013).