Optimizing the design of protein nanoparticles as carriers for vaccine applications

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 11, Issue 7, 2015, Pages 1705-1713

  Doll, Tais A P F ^a   Neef, Tobias ^a   Duong, Nha ^a   Lanar, David E ^b   Ringler, Philippe ^c   Müller, Shirley A ^c   Burkhard, Peter ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Malaria; Protein design; Protein nanoparticle; Self assembly; Vaccine carrier

Indexed keywords

DESIGN; NANOPARTICLES; OLIGOMERIZATION; OLIGOMERS; PROTEINS; SELF ASSEMBLY; VACCINES;

BASIC BUILDING BLOCK; BIOPHYSICAL CHARACTERIZATION; CHEMICAL AND BIOLOGICALS; MALARIA; PROTEIN DESIGN; PROTEIN NANOPARTICLES; VACCINE CARRIERS; VACCINE DEVELOPMENT;

DISEASES;

CYSTEINE; DRUG CARRIER; GLYCINE; LEUCINE; NANOPARTICLE; TYROSINE; VACCINE; PROTEIN;

ARTICLE; BIOPHYSICS; COMPUTER; COMPUTER MODEL; DRUG DELIVERY SYSTEM; IN VITRO STUDY; OLIGOMERIZATION; PROTEIN DATABASE; CHEMISTRY; COMPUTER SIMULATION; HIV INFECTIONS; HUMAN; IMMUNOLOGY; INFLUENZA, HUMAN; MALARIA;

COMPUTER SIMULATION; DATABASES, PROTEIN; HIV INFECTIONS; HUMANS; INFLUENZA, HUMAN; MALARIA; NANOPARTICLES; PROTEINS; VACCINES;

EID: 84942119784     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2015.05.003     Document Type: Article

References (41)

1. Kushnir N., Streatfield S.J., Yusibov V. Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development. Vaccine 2012, 31(1):58-83.
2. Smith D.M., Simon J.K., Baker J.R. Applications of nanotechnology for immunology. Nat Rev Immunol 2013, 13(8):592-605.
3. Doll T.A., Raman S., Dey R., Burkhard P. Nanoscale assemblies and their biomedical applications. J R Soc Interface 2013, 10(80):20120740.
4. Bozic S., Doles T., Gradisar H., Jerala R. New designed protein assemblies. Curr Opin Chem Biol 2013, 17(6):940-945.
5. Fletcher J.M., Harniman R.L., Barnes F.R., Boyle A.L., Collins A., Mantell J., et al. Self-assembling cages from coiled-coil peptide modules. Science 2013, 340(6132):595-599.
6. Der B.S., Kuhlman B. Cages from coils. Nat Biotechnol 2013, 31(9):809-810.
7. Twarock R. A tiling approach to virus capsid assembly explaining a structural puzzle in virology. J Theor Biol 2004, 226(4):477-482.
8. Raman S., Machaidze G., Lustig A., Aebi U., Burkhard P. Structure-based design of peptides that self-assemble into regular polyhedral nanoparticles. Nanomedicine 2006, 2(2):95-102.
9. Pimentel T.A., Yan Z., Jeffers S.A., Holmes K.V., Hodges R.S., Burkhard P. Peptide nanoparticles as novel immunogens: Design and analysis of a prototypic severe acute respiratory syndrome vaccine. Chem Biol Drug Des 2009, 73(1):53-61.
10. Kaba S.A., Brando C., Guo Q., Mittelholzer C., Raman S., Tropel D., et al. A nonadjuvanted polypeptide nanoparticle vaccine confers long-lasting protection against rodent malaria. J Immunol 2009, 183(11):7268-7277.
11. Kaba S.A., McCoy M.E., Doll T.A., Brando C., Guo Q., Dasgupta D., et al. Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccine. PLoS One 2012, 7(10):1-11. e48304.
12. Guo Q., Dasgupta D., Doll T.A., Burkhard P., Lanar D.E. Expression, purification and refolding of a self-assembling protein nanoparticle (SAPN) malaria vaccine. Methods 2013, 60(3):242-247.
13. McCoy M.E., Golden H.E., Doll T.A., Yang Y., Kaba S.A., Zou X., et al. Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine. Malar J 2013, 12(1):1-12. 136.
14. Wahome N., Pfeiffer T., Ambiel I., Yang Y., Keppler O.T., Bosch V., et al. Conformation-specific display of 4E10 and 2F5 epitopes on self-assembling protein nanoparticles as a potential HIV vaccine. Chem Biol Drug Des 2012, 80(3):349-357.
15. El Bissati K., Zhou Y., Dasgupta D., Cobb D., Dubey J.P., Burkhard P., et al. Effectiveness of a novel immunogenic nanoparticle platform for toxoplasma peptide vaccine in HLA transgenic mice. Vaccine 2014, 32(26):3243-3248.
16. Babapoor S., Neef T., Mittelholzer C., Girshick T., Garmendia A., Shang H., et al. A novel vaccine using nanoparticle platform to present immunogenic M2e against avian influenza infection. Influenza Res Treat 2011, 2011:1-12.
17. Yang Y., Ringler P., Muller S.A., Burkhard P. Optimizing the refolding conditions of self-assembling polypeptide nanoparticles that serve as repetitive antigen display systems. J Struct Biol 2012, 177(1):168-176.
18. Yang Y., Burkhard P. Encapsulation of gold nanoparticles into self-assembling protein nanoparticles. J Nanobiotechnol 2012, 10:1-11. 42.
19. Yang Y., Neef T., Mittelholzer C., Garcia Garayoa E., Blauenstein P., Schibli R., et al. The biodistribution of self-assembling protein nanoparticles shows they are promising vaccine platforms. J Nanobiotechnol 2013, 11:1-12. 36.
20. George R.A., Heringa J. An analysis of protein domain linkers: Their classification and role in protein folding. Protein Eng 2002, 15(11):871-879.
21. Linhult M., Gulich S., Graslund T., Nygren P.A., Hober S. Evaluation of different linker regions for multimerization and coupling chemistry for immobilization of a proteinaceous affinity ligand. Protein Eng 2003, 16(12):1147-1152.
22. Wriggers W., Chakravarty S., Jennings P.A. Control of protein functional dynamics by peptide linkers. Biopolymers 2005, 80(6):736-746.
23. Missirlis D., Farine M., Kastantin M., Ananthanarayanan B., Neumann T., Tirrell M. Linker chemistry determines secondary structure of p5314-29 in peptide amphiphile micelles. Bioconjug Chem 2010, 21(3):465-475.
24. Arai R., Ueda H., Kitayama A., Kamiya N., Nagamune T. Design of the linkers which effectively separate domains of a bifunctional fusion protein. Protein Eng 2001, 14(8):529-532.
25. King N.P., Lai Y.T. Practical approaches to designing novel protein assemblies. Curr Opin Struct Biol 2013, 23(4):632-638.
26. Lai Y.T., King N.P., Yeates T.O. Principles for designing ordered protein assemblies. Trends Cell Biol 2012, 22(12):653-661.
27. Jones T.A., Zou J.Y., Cowan S.W., Kjeldgaard M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A 1991, 47(Pt 2):110-119.
28. Laue T.M. Analytical ultracentrifugation in biochemistry and polymer science. R Soc Chem 1992, 90-125.
29. Schuck P. Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. Biophys J 2000, 78(3):1606-1619.
30. Philo J.S. A method for directly fitting the time derivative of sedimentation velocity data and an alternative algorithm for calculating sedimentation coefficient distribution functions. Anal Biochem 2000, 279(2):151-163.
31. Philo J.S. Improved methods for fitting sedimentation coefficient distributions derived by time-derivative techniques. Anal Biochem 2006, 354(2):238-246.
32. Stafford W.F. Boundary analysis in sedimentation transport experiments: A procedure for obtaining sedimentation coefficient distributions using the time derivative of the concentration profile. Anal Biochem 1992, 203(2):295-301.
33. Krzyzanek V., Müller S.A., Engel A., Reichelt R. MASDET - A fast and user-friendly multiplatform software for mass determination by dark-field electron microscopy. J Struct Biol 2009, 165(2):78-87.
34. Müller S.A., Goldie K.N., Burki R., Haring R., Engel A. Factors influencing the precision of quantitative scanning transmission electron microscopy. Ultramicroscopy 1992, 46:317-334.
35. Müller S.A., Engel A. Structure and mass analysis by scanning transmission electron microscopy. Micron 2001, 32:21-31.
36. Papapostolou D., Howorka S. Engineering and exploiting protein assemblies in synthetic biology. Mol BioSyst 2009, 5(7):723-732.
37. Janssens M.E., Geysen D., Broos K., De Goeyse I., Robbens J., Van Petegem F., et al. Folding properties of the hepatitis B core as a carrier protein for vaccination research. Amino Acids 2010, 38(5):1617-1626.
38. Aili D., Tai F.I., Enander K., Baltzer L., Liedberg B. Self-assembly of fibers and nanorings from disulfide-linked helix-loop-helix polypeptides. Angew Chem 2008, 47(30):5554-5556.
39. Chen J., Pompano R.R., Santiago F.W., Maillat L., Sciammas R., Sun T., et al. The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation. Biomaterials 2013, 34(34):8776-8785.
40. Hudalla G.A., Modica J.A., Tian Y.F., Rudra J.S., Chong A.S., Sun T., et al. A self-adjuvanting supramolecular vaccine carrying a folded protein antigen. Adv Healthc Mater 2013, 2(8):1114-1119.
41. Shahbazi Z., Pimentel T.A.P.F., Ilies H., Kazerounian K., Burkhard P. A kinematic observation and conjecture for creating stable constructs of a peptide nanoparticle. Advances in Robot Kinematics: Motion in Man and Machine 2010, Part 3:203-210.