Genome-wide siRNA screen identifies the radiosensitizing effect of downregulation of MASTL and FOXM1 in NSCLC

Molecular Cancer Therapeutics

Volumn 14, Issue 6, 2015, Pages 1434-1444

  Nagel, Remco ^a   Stigter Van Walsum, Marijke ^a   Buijze, Marijke ^a   Van Den Berg, Jaap ^b   Van Der Meulen, Ida H ^b   Hodzic, Jasmina ^b   Piersma, Sander R ^b   Pham, Thang V ^b   Jiménez, Connie R ^b   Van Beusechem, Victor W ^b   Brakenhoff, Ruud H ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICROTUBULE ASSOCIATED SERINE THREONINE KINASE LIKE PROTEIN; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; RAD51 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXM1; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXM1 PROTEIN, HUMAN; MASTL PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE REGULATION; CELL DEATH; CELL SURVIVAL; CLONOGENESIS; CONTROLLED STUDY; CYTOKINESIS; DNA DAMAGE; DOWN REGULATION; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC SCREENING; HUMAN; HUMAN CELL; IONIZING RADIATION; LOSS OF FUNCTION MUTATION; LUNG CANCER CELL LINE; LUNG FIBROBLAST; M PHASE CELL CYCLE CHECKPOINT; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS; RADIATION RESPONSE; RADIOSENSITIVITY; RADIOSENSITIZATION; ANIMAL; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CONFOCAL MICROSCOPY; DRUG SCREENING; GAMMA RADIATION; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN GENOME; LUNG NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SURVIVAL ANALYSIS; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL LINE, TUMOR; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GAMMA RAYS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; MICE, NUDE; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SURVIVAL ANALYSIS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84942114039     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-14-0846     Document Type: Article

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