How can we develop universal H5N1 vaccines

Immunotherapy

Volumn 7, Issue 7, 2015, Pages 713-716

  Tan, Yunrui ^a   He, Fang ^a   Kwang, Jimmy ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

epitope chimeric; H5N1; influenza; stalked based; subunit vaccine; universal vaccine; viral vector based vaccine

Indexed keywords

CHIMERIC PROTEIN; EPITOPE; INACTIVATED VIRUS VACCINE; INFLUENZA VACCINE; SUBUNIT VACCINE; VIRUS VECTOR;

HUMAN; INFLUENZA A (H5N1); INFLUENZA A VIRUS (H5N1); INFLUENZA VACCINATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; VACCINE PRODUCTION; CONTRAINDICATIONS; GENETICS; IMMUNOLOGY; INFLUENZA, HUMAN; TRANSMISSION;

HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN;

EID: 84942107782     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.15.42     Document Type: Review

References (20)

1. Antigenic and genetic characteristics of h5n1 viruses and candidate h5n1 vaccine viruses developed for potential use as pre-pandemic vaccines. Wkly Epidemiol. Rec. 81(34/35), 328-330 (2006).
2. Madhan S, Prabakaran M, Kwang J. Baculovirus as vaccine vectors. Curr. Gene Ther. 10(3), 201-213 (2010).
3. Houser K, Subbarao K. Influenza vaccines: challenges and solutions. Cell host microbe 17(3), 295-300 (2015).
4. Khurana S, Verma S, Verma N et al. Bacterial ha1 vaccine against pandemic h5n1 influenza virus: evidence of oligomerization, hemagglutination, and cross-protective immunity in ferrets. J. Virol. 85(3), 1246-1256 (2011).
5. Lin SC, Huang MH, Tsou PC, Huang LM, Chong P, Wu SC. Recombinant trimeric ha protein immunogenicity of h5n1 avian influenza viruses and their combined use with inactivated or adenovirus vaccines. PLoS One 6(5), e20052 (2011).
6. Ma JH, Yang FR, Yu H et al. An m2e-based synthetic peptide vaccine for influenza a virus confers heterosubtypic protection from lethal virus challenge. Virol. J. 10, 227 (2013).
7. Zhao G, Lin Y, Du L et al. An m2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent h5n1 influenza viruses. Virol. J. 7, 9 (2010).
8. Khow O, Suntrarachun S. Strategies for production of active eukaryotic proteins in bacterial expression system. Asian Pac. J. Trop. Biomed. 2(2), 159-162 (2012).
9. Prabakaran M, Leyrer S, He F et al. Progress toward a universal h5n1 vaccine: A recombinant modified vaccinia virus ankara-expressing trivalent hemagglutinin vaccine. PloS One 9(9), e107316 (2014).
10. Rajesh Kumar S, Syed Khader SM, Kiener TK, Szyporta M, Kwang J. Intranasal immunization of baculovirus displayed hemagglutinin confers complete protection against mouse adapted highly pathogenic h7n7 reassortant influenza virus. PloS One 8(6), e63856 (2013).
11. Prabakaran M, Kolpe AB, He F, Kwang J. Cross-protective efficacy of bivalent recombinant baculoviral vaccine against heterologous influenza h5n1 challenge. Vaccine 31(10), 1385-1392 (2013).
12. Abe T, Matsuura Y. Host innate immune responses induced by baculovirus in mammals. Curr. Gene Ther. 10(3), 226-231 (2010).
13. Airenne KJ, Hu YC, Kost TA et al. Baculovirus: An insect-derived vector for diverse gene transfer applications. Mol. Ther. 21(4), 739-749 (2013).
14. Prabakaran M, Kumar SR, Raj KV et al. Cross-protective efficacy of baculovirus displayed hemagglutinin against highly pathogenic influenza h7 subtypes. Antiviral Res. 109, 149-159 (2014).
15. He F, Prabakaran M, Rajesh Kumar S, Tan Y, Kwang J. Monovalent h5 vaccine based on epitope-chimeric ha provides broad cross-clade protection against variant h5n1 viruses in mice. Antiviral Res. 105, 143-151 (2014).
16. Krammer F, Pica N, Hai R, Margine I, Palese P. Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies. J. Virol. 87(12), 6542-6550 (2013).
17. Uranowska K, Tyborowska J, Jurek A, Szewczyk B, Gromadzka B. Hemagglutinin stalk domain from h5n1 strain as a potentially universal antigen. Acta Biochim. Pol. 61(3), 541-550 (2014).
18. Nachbagauer R, Wohlbold TJ, Hirsh A et al. Induction of broadly reactive anti-hemagglutinin stalk antibodies by an h5n1 vaccine in humans. J. Virol. 88(22), 13260-13268 (2014).
19. Khurana S, Loving CL, Manischewitz J et al. Vaccine-induced anti-ha2 antibodies promote virus fusion and enhance influenza virus respiratory disease. Sci. Transl. Med. 5(200), 200ra114 (2013).
20. Gottlieb T, Ben-Yedidia T. Epitope-based approaches to a universal influenza vaccine. J. Autoimmun. 54, 15-20 (2014).