Intranasal Immunization of Baculovirus Displayed Hemagglutinin Confers Complete Protection against Mouse Adapted Highly Pathogenic H7N7 Reassortant Influenza Virus

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Rajesh Kumar, Subaschandrabose ^a   Syed Khader, Syed Musthaq ^a   Kiener, Tanja K ^a   Szyporta, Milene ^a   Kwang, Jimmy ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; LIVE RECOMBINANT BACULOVIRUS H7N7 HEMAGGLUTININ SUBUNIT VACCINE; UNCLASSIFIED DRUG; VIRUS HEMAGGLUTININ; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BACULOVIRUS; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RESPONSE; DRUG EFFICACY; FEMALE; IMMUNE RESPONSE; INFECTION PREVENTION; INFLUENZA A; INFLUENZA A (H7N7); MASS IMMUNIZATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPLEEN CELL; TH1 TH2 BALANCE;

ADAPTATION, PHYSIOLOGICAL; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, NEUTRALIZING; BACULOVIRIDAE; ENZYME-LINKED IMMUNOSPOT ASSAY; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, MUCOSAL; IMMUNIZATION; INFLUENZA A VIRUS, H7N7 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; LUNG; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; REASSORTANT VIRUSES; REPRODUCIBILITY OF RESULTS; SUBCUTANEOUS TISSUE;

AVES; MUS; ORTHOMYXOVIRIDAE;

EID: 84878746469     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063856     Document Type: Article

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