Phenotypic switching in Candida tropicalis: Association with modification of putative virulence attributes and antifungal drug sensitivity

Medical Mycology

Volumn 52, Issue 1, 2014, Pages 106-114

  Moralez, Alane T P ^a   França, Emanuele J G ^a   Furlaneto Maia, Luciana ^b   Quesada, Regina M B ^a   Furlaneto, Marcia C ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

biofilm; Candida tropicalis; filamentation; hemolytic factor; phenotypic switching

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; FLUCONAZOLE; ITRACONAZOLE; VIRULENCE FACTOR; CULTURE MEDIUM;

ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BIOFILM; CANDIDA TROPICALIS; FUNGUS GROWTH; FUNGUS ISOLATION; MINIMUM INHIBITORY CONCENTRATION; MYCELIAL GROWTH; NONHUMAN; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; ANTIFUNGAL RESISTANCE; CANDIDIASIS; CHEMISTRY; CULTURE MEDIUM; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY; VIRULENCE;

ANTIFUNGAL AGENTS; BIOFILMS; CANDIDA TROPICALIS; CANDIDIASIS; CULTURE MEDIA; DRUG RESISTANCE, FUNGAL; HUMANS; ITRACONAZOLE; MICROBIAL SENSITIVITY TESTS; PHENOTYPE; VIRULENCE; VIRULENCE FACTORS;

EID: 84942092772     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693786.2013.825822     Document Type: Article

References (44)

1. Yang YL, Cheng HH, Lo HJ. Distribution and antifungal susceptibility of Candida species isolated from different age populations in Taiwan. Med Mycol 2006; 44: 237-242.
2. Comert F, Kulah C, Aktas E, Eroglu O, Ozlu N. Identification of Candida species isolated from patients in intensive care unit and in vitro susceptibility to fluconazole for a 3-year period. Mycoses 2007; 50: 52-57.
3. Marol S, Yücesoy M. Molecular epidemiology of Candida species isolated from clinical specimens of intensive care unit patients. Mycoses 2008; 51: 40-49.
4. Kliemann DA, Pasqualotto AC, Falavigna M, Giaretta T, Severo LC. Candida esophagitis: species distribution and risk factors for infection. Rev Inst Med Trop São Paulo 2008; 5: 261-263.
5. Kothari A, Sagar V. Epidemiology of Candida bloodstream infections in a tertiary care institute in India. Indian J Med Micro-biol 2009; 27: 171-172.
6. Colombo AL, Guimarães T, Silva LRBF et al. Prospective observational study of candidemia in São Paulo, Brazil: incidence rate, epidemiology, and predictors of mortality. Infect Cont Hosp Ep 2007; 28: 570-576.
7. Miranda LN, van der Heijden IM, Costa SF et al. Candida colonisation as a source for candidaemia. J Hosp Infect 2009; 72: 9-16.
8. Furlaneto MC, Rota JF, Quesada RMB et al. Species distribution and in vitro fluconazole susceptibility of clinical Candida isolates in a Brazilian tertiary-care hospital over a 3-year period. Rev Soc Bras Med Trop 2011; 44: 595-599.
9. Hoyer LL, Fundyga R, Hecht JE et al. Characterization of agglutinin-like sequence genes from non-albicans Candida and phylogenetic analysis of the ALS family. Genetics 2001; 157: 1555-1567.
10. Zaugg C, Borg-Von Zepelin M, Reichard U, Sanglard D, Monod M. Secreted aspartic proteinase family of Candida tropicalis. Infect Immun 2001; 69: 405-412.
11. Jayatilake JAMS, Samaranayake YH, Cheung LK, Sama-ranayake LP. Quantitative evaluation of tissue invasion by wild type, hyphal and SAP mutants of Candida albicans, and non-albicans Candida species in reconstituted human oral ephitelium. J Oral Pathol Med 2006; 35: 481-491.
12. Tumbarello M, Posteraro B, Trecarichi EM et al. Biofilm production by Candida species and inadequate antifungal therapy as predictors of mortality for patients with candidemia. J Clin Microbiol 2007; 45: 1843-1850.
13. Silva S, Hooper SJ, Henriques M et al. The role of secreted aspartyl proteinases in Candida tropicalis invasion and damage of oral mucosa. Clin Microbiol Infect 2011; 17: 264-272.
14. Favero D, França EJG, Furlaneto-Maia L, Quesada RMB, Furlaneto MC. Prodution of haemolytic factor by clinical isolates of Candida tropicalis. Mycoses 2011; 54: e816-820.
15. Soll DR. Why does Candida albicans switch?FEMS Yeast Res 2009; 9: 973-989.
16. Soll DR. High-frequency switching in Candida albicans. Clin Microbiol Rev 1992; 5: 183-203.
17. Joshi KR, Gavin JB. The morphology of colony variants of three species of Candida. Sabouradia 1975; 13: 274-279.
18. Soll DR, Staebell M, Langtimm C, Pfaller M, Hicks J, Rao TV. Multiple Candida strains in the course of a single systemic infection. J Clin Microbiol 1988; 26: 1448-1459.
19. Odds FC, Merson-Davies LA. Colony variations in Candida species. Mycoses 1989; 32: 275-282.
20. Porman AM, Alby K, Hirakawa MP, Bennett RJ. Discovery of a phenotypic switch regulating sexual mating in the opportunistic fungal pathogen Candida tropicalis. PNAS 2011; 108: 21158-21163.
21. França EJG, Andrade CGTJ, Furlaneto-Maia L et al. Ultrastructural architecture of colonies of different morphologies and biofilm produced by phenotypic switching of Candida tropicalis. Micron 2011; 42: 726-732.
22. Joly S, Pujol C, Schröppel K, Soll DR. Development of two species-specific fingerprinting probes for broad computerassisted epidemiological studies of Candida tropicalis. J Clin Microbiol 1996; 34: 3063-3071.
23. Vargas K, Messer S, Pfaller M et al. Elevated phenotypic switching and drug resistance of Candida albicans from human immunodeficiency virus-positive individuals prior to first thrush episode. J Clin Microbiol 2000; 38: 3595-3607.
24. Antony G, Saralaya V, Bhat KG, Shenoy MS, Shivananda PG. Effect of phenotypic switching on expression of virulence factors by Candida albicans causing candidiasis in diabetic patients. Rev Iberoam Micol 2009; 26: 202-205.
25. Lohse MB, Johnson AD. White-opaque switching in Candida albicans. Curr Op Microbiol 2009; 12: 650-654.
26. França EJG, Furlaneto-Maia L, Quesada RMB et al. Haemolytic and proteinase activities in clinical isolates of Candida para-psilosis and Candida tropicalis with reference to the isolation anatomic site. Mycoses 2010; 54: e41-51.
27. Silva S, Henriques M, Martins A et al. Biofilms of non-Candida albicans species: quantification, structure and matrix composition. Med Mycol 2009; 47: 681-689.
28. Stovicek V, Vachova L, Kuthan M, Palkova Z. General factors important for the formation of structured biofilm-like yeast colonies. Fungal Genet Biol 2010; 47: 1012-1022.
29. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; 4th Informational Supplement, M27-S4. Wayne, PA: Clinical and Laboratory Standards Institute, 2012.
30. Bonfietti LX, Szeszs MW, Chang MR et al. Ten-year study of species distribution and antifungal susceptibilities of Candida bloodstream isolates at a Brazilian tertiary hospital. Myco-pathologia 2012; 174: 389-396.
31. Soll DR, Morrow B, Srikantha T. High frequency phenotypic switching in Candida albicans. Trends Genet 1993; 9: 61-65.
32. Radford DR, Challacombe SJ, Walter JD. A scanning electron microscopy investigation of the structure of colonies of different morphologies produced by phenotypic switching of Candida albicans. J Med Microbiol 1994; 40: 416-423.
33. Lachke SA, Joly S, Daniels K, Soll DR. Phenotypic switching and filamentation in Candida glabrata. Microbiolology 2002; 148: 2661-2674.
34. Miller NS, Dick JD, Merz WG. Phenotypic switching in Candida lusitaniae on copper sulfate indicator agar: association with am-photericin B resistance and filamentation. J Clin Microbiol 2006; 44: 1536-1539.
35. Lachke SA, Srikantha T, Tsai LK, Daniels K, Soll DR. Phe-notypic switching in Candida glabrata involves phase-specific regulation of the metallothionein gene MT-11 and the newly discovered hemolysin gene HLP. Infect Immun 2000; 68: 884-895.
36. Watanabe T, Takano M, Murakami M et al. Characterization of a hemolytic factor from Candida albicans. Microbiology 1999; 145: 689-694.
37. Odds FC. Candida and candidosis: a review and bibliography. 2nd ed., Bailliere Tindall, London, England, 1988.
38. Manns JM, Mosser DM, Buckley HR. Production of a hemolytic factor by Candida albicans. Infect Immun 1994; 62: 5154-5156.
39. Watanabe T, Tanaka H, Nakao N, Mikami T, Matsumoto T. Hemoglobin is utilized by Candida albicans in the hyphal form but not yeast form. Biochem Biophys Res Commun 1997; 232: 350-353.
40. Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Az-eredo J. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev 2012; 36: 288-305.
41. Chai LYA, Denning DW, Warn P. Candida tropicalis in human disease. Crit Rev Microbiol 2010; 36: 282-298.
42. Al-Fattani MA, Douglas LJ. Biofilm matriz of Candida al-bicans and Candida tropicalis: chemical composition and role in drug resistance. J Med Microbiol 2006; 55: 999-1008.
43. Laffey SF, Butler G. Phenotype switching affects biofilm formation by Candida parapsilosis. Microbiology 2005; 151: 1073-1081.
44. Favel A, Michel-Nguyen A, Peyron F et al. Colony morphology switching of Candida lusitaniae and acquisition of multidrug resistance during treatment of a renal infection in a newborn: case report and review of the literature. Diagn Microbiol Infect Dis 2003; 47: 331-339. Nível Superior