-
1
-
-
84887613770
-
B-cell receptor signaling as a driver of lymphoma development and evolution
-
Niemann CU, Wiestner A. B-cell receptor signaling as a driver of lymphoma development and evolution. Semin Cancer Biol 2013;23:410-21.
-
(2013)
Semin Cancer Biol
, vol.23
, pp. 410-421
-
-
Niemann, C.U.1
Wiestner, A.2
-
2
-
-
61849183478
-
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain
-
Mohamed AJ, Yu L, Bäckesjö CM, et al. Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev 2009;228:58-73.
-
(2009)
Immunol Rev
, vol.228
, pp. 58-73
-
-
Mohamed, A.J.1
Yu, L.2
Bäckesjö, C.M.3
-
3
-
-
84871806385
-
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
-
Advani RH, Buggy JJ, Sharman JP, et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J Clin Oncol 2013;31:88-94.
-
(2013)
J Clin Oncol
, vol.31
, pp. 88-94
-
-
Advani, R.H.1
Buggy, J.J.2
Sharman, J.P.3
-
4
-
-
84879748062
-
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
-
Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013;369:32-42.
-
(2013)
N Engl J Med
, vol.369
, pp. 32-42
-
-
Byrd, J.C.1
Furman, R.R.2
Coutre, S.E.3
-
5
-
-
84904252369
-
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
-
Byrd JC, Brown JR, O'Brien S, et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med 2014;371:213-23.
-
(2014)
N Engl J Med
, vol.371
, pp. 213-223
-
-
Byrd, J.C.1
Brown, J.R.2
O'Brien, S.3
-
6
-
-
84881225049
-
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma
-
Wang ML, Rule S, Martin P, et al. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N Engl J Med 2013;369:507-16.
-
(2013)
N Engl J Med
, vol.369
, pp. 507-516
-
-
Wang, M.L.1
Rule, S.2
Martin, P.3
-
7
-
-
0034598746
-
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
-
Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000;403:503-11.
-
(2000)
Nature
, vol.403
, pp. 503-511
-
-
Alizadeh, A.A.1
Eisen, M.B.2
Davis, R.E.3
-
8
-
-
73849145729
-
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
-
Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010;463:88-92.
-
(2010)
Nature
, vol.463
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
-
9
-
-
84874585216
-
The Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib (PCI-32765), Has Preferential Activity in the ABC Subtype of Relapsed/Refractory De Novo Diffuse Large B-Cell Lymphoma (DLBCL): Interim Results of a Multicenter, Open-Label, Phase 2 Study
-
Wilson WH, Gerecitano JF, Goy A, et al. The Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib (PCI-32765), Has Preferential Activity in the ABC Subtype of Relapsed/Refractory De Novo Diffuse Large B-Cell Lymphoma (DLBCL): Interim Results of a Multicenter, Open-Label, Phase 2 Study. Blood 2012;120:abstr 623.
-
(2012)
Blood
, vol.120
-
-
Wilson, W.H.1
Gerecitano, J.F.2
Goy, A.3
-
10
-
-
84927674129
-
Ibrutinib Monotherapy in Relapsed/Refractory Follicular Lymphoma (FL): Preliminary Results of a Phase 2 Consortium (P2C) Trial
-
Bartlett NL, LaPlant BR, Qi J, et al. Ibrutinib Monotherapy in Relapsed/Refractory Follicular Lymphoma (FL): Preliminary Results of a Phase 2 Consortium (P2C) Trial. Blood 2014;124:abstr 800.
-
(2014)
Blood
, vol.124
-
-
Bartlett, N.L.1
LaPlant, B.R.2
Qi, J.3
-
11
-
-
84901796219
-
A Prospective Multicenter Study Of The Bruton's Tyrosine Kinase Inhibitor Ibrutinib In Patients With Relapsed Or Refractory Waldenstrom's Macroglobulinemia
-
Treon SP, Tripsas CK, Yang G, et al. A Prospective Multicenter Study Of The Bruton's Tyrosine Kinase Inhibitor Ibrutinib In Patients With Relapsed Or Refractory Waldenstrom's Macroglobulinemia. Blood 2013;122:abstr 251.
-
(2013)
Blood
, vol.122
-
-
Treon, S.P.1
Tripsas, C.K.2
Yang, G.3
-
13
-
-
84893249799
-
PI3K and cancer: lessons, challenges and opportunities
-
Fruman DA, Rommel C. PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov 2014;13:140-56.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 140-156
-
-
Fruman, D.A.1
Rommel, C.2
-
14
-
-
84901712964
-
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110d, for relapsed/refractory chronic lymphocytic leukemia
-
Brown JR, Byrd JC, Coutre SE, et al. Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110d, for relapsed/refractory chronic lymphocytic leukemia. Blood 2014;123:3390-7.
-
(2014)
Blood
, vol.123
, pp. 3390-3397
-
-
Brown, J.R.1
Byrd, J.C.2
Coutre, S.E.3
-
15
-
-
84896692766
-
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
-
Furman RR, Sharman JP, Coutre SE, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 2014;370:997-1007.
-
(2014)
N Engl J Med
, vol.370
, pp. 997-1007
-
-
Furman, R.R.1
Sharman, J.P.2
Coutre, S.E.3
-
16
-
-
84901703641
-
Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-d, as therapy for previously treated indolent non-Hodgkin lymphoma
-
Flinn IW, Kahl BS, Leonard JP, et al. Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-d, as therapy for previously treated indolent non-Hodgkin lymphoma. Blood 2014;123:3406-13.
-
(2014)
Blood
, vol.123
, pp. 3406-3413
-
-
Flinn, I.W.1
Kahl, B.S.2
Leonard, J.P.3
-
17
-
-
84896693794
-
PI3Kd inhibition by idelalisib in patients with relapsed indolent lymphoma
-
Gopal AK, Kahl BS, de Vos S, et al. PI3Kd inhibition by idelalisib in patients with relapsed indolent lymphoma. N Engl J Med 2014;370:1008-18.
-
(2014)
N Engl J Med
, vol.370
, pp. 1008-1018
-
-
Gopal, A.K.1
Kahl, B.S.2
de Vos, S.3
-
18
-
-
84901724050
-
A phase 1 study of the PI3Kd inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL)
-
Kahl BS, Spurgeon SE, Furman RR, et al. A phase 1 study of the PI3Kd inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL). Blood 2014;123:3398-405.
-
(2014)
Blood
, vol.123
, pp. 3398-3405
-
-
Kahl, B.S.1
Spurgeon, S.E.2
Furman, R.R.3
-
19
-
-
84927776088
-
A Phase 1 evaluation of duvelisib (IPI-145), a PI3K-δ,γ inhibitor, in patients with relapsed/refractory iNHL
-
Flinn I, Oki Y, Patel M, et al. A Phase 1 evaluation of duvelisib (IPI-145), a PI3K-δ,γ inhibitor, in patients with relapsed/refractory iNHL. Blood 2014;124:abstr 802.
-
(2014)
Blood
, vol.124
-
-
Flinn, I.1
Oki, Y.2
Patel, M.3
-
20
-
-
84927728003
-
Duvelisib (IPI-145), a Phosphoinositide-3-Kinase-δ,γ Inhibitor, Shows Activity in Patients with Relapsed/Refractory T-Cell Lymphoma
-
Horwitz SM, Porcu P, Flinn I, et al. Duvelisib (IPI-145), a Phosphoinositide-3-Kinase-δ,γ Inhibitor, Shows Activity in Patients with Relapsed/Refractory T-Cell Lymphoma. Blood 2014;124:abstr 803.
-
(2014)
Blood
, vol.124
-
-
Horwitz, S.M.1
Porcu, P.2
Flinn, I.3
-
21
-
-
84859784778
-
Phase I/II Study of Dasatinib In Relapsed or Refractory Non-Hodgkin's Lymphoma (NHL)
-
William BM, Hohenstein M, Loberiza FR, et al. Phase I/II Study of Dasatinib In Relapsed or Refractory Non-Hodgkin's Lymphoma (NHL). Blood 2010;116:abstr 288.
-
(2010)
Blood
, vol.116
-
-
William, B.M.1
Hohenstein, M.2
Loberiza, F.R.3
-
22
-
-
84888216911
-
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
-
Dubovsky JA, Beckwith KA, Natarajan G, et al. Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood 2013;122:2539-49.
-
(2013)
Blood
, vol.122
, pp. 2539-2549
-
-
Dubovsky, J.A.1
Beckwith, K.A.2
Natarajan, G.3
-
23
-
-
38949106198
-
Thalidomide has limited single-agent activity in relapsed or refractory indolent non-Hodgkin lymphomas: a phase II trial of the Cancer and Leukemia Group B
-
Smith SM, Grinblatt D, Johnson JL, et al. Thalidomide has limited single-agent activity in relapsed or refractory indolent non-Hodgkin lymphomas: a phase II trial of the Cancer and Leukemia Group B. Br J Haematol 2008;140:313-9.
-
(2008)
Br J Haematol
, vol.140
, pp. 313-319
-
-
Smith, S.M.1
Grinblatt, D.2
Johnson, J.L.3
-
24
-
-
28844472902
-
Lenalidomide and thalidomide: mechanisms of action--similarities and differences
-
Anderson KC. Lenalidomide and thalidomide: mechanisms of action--similarities and differences. Semin Hematol 2005;42:S3-8.
-
(2005)
Semin Hematol
, vol.42
, pp. S3-S8
-
-
Anderson, K.C.1
-
25
-
-
80855156719
-
Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
-
Zhu YX, Braggio E, Shi CX, et al. Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide. Blood 2011;118:4771-9.
-
(2011)
Blood
, vol.118
, pp. 4771-4779
-
-
Zhu, Y.X.1
Braggio, E.2
Shi, C.X.3
-
26
-
-
84865165316
-
Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer
-
Ramsay AG, Clear AJ, Fatah R, et al. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Blood 2012;120:1412-21.
-
(2012)
Blood
, vol.120
, pp. 1412-1421
-
-
Ramsay, A.G.1
Clear, A.J.2
Fatah, R.3
-
27
-
-
79959722615
-
An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma
-
Witzig TE, Vose JM, Zinzani PL, et al. An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma. Ann Oncol 2011;22:1622-7.
-
(2011)
Ann Oncol
, vol.22
, pp. 1622-1627
-
-
Witzig, T.E.1
Vose, J.M.2
Zinzani, P.L.3
-
28
-
-
84889099537
-
Single-agent lenalidomide in patients with mantle-cell lymphoma who relapsed or progressed after or were refractory to bortezomib: phase II MCL-001 (EMERGE) study
-
Goy A, Sinha R, Williams ME, et al. Single-agent lenalidomide in patients with mantle-cell lymphoma who relapsed or progressed after or were refractory to bortezomib: phase II MCL-001 (EMERGE) study. J Clin Oncol 2013;31:3688-95.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3688-3695
-
-
Goy, A.1
Sinha, R.2
Williams, M.E.3
-
29
-
-
84887030194
-
Long-term follow-up of lenalidomide in relapsed/refractory mantle cell lymphoma: subset analysis of the NHL-003 study
-
Zinzani PL, Vose JM, Czuczman MS, et al. Long-term follow-up of lenalidomide in relapsed/refractory mantle cell lymphoma: subset analysis of the NHL-003 study. Ann Oncol 2013;24:2892-7.
-
(2013)
Ann Oncol
, vol.24
, pp. 2892-2897
-
-
Zinzani, P.L.1
Vose, J.M.2
Czuczman, M.S.3
-
30
-
-
51649111684
-
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
-
Lenz G, Wright GW, Emre NC, et al. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci U S A 2008;105:13520-5.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13520-13525
-
-
Lenz, G.1
Wright, G.W.2
Emre, N.C.3
-
31
-
-
80053502780
-
Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype
-
Hernandez-Ilizaliturri FJ, Deeb G, Zinzani PL, et al. Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype. Cancer 2011;117:5058-66.
-
(2011)
Cancer
, vol.117
, pp. 5058-5066
-
-
Hernandez-Ilizaliturri, F.J.1
Deeb, G.2
Zinzani, P.L.3
-
32
-
-
84921764017
-
Lenalidomide Combined With R-CHOP Overcomes Negative Prognostic Impact of Non-Germinal Center B-Cell Phenotype in Newly Diagnosed Diffuse Large B-Cell Lymphoma: A Phase II Study
-
Nowakowski GS, LaPlant B, Macon WR, et al. Lenalidomide Combined With R-CHOP Overcomes Negative Prognostic Impact of Non-Germinal Center B-Cell Phenotype in Newly Diagnosed Diffuse Large B-Cell Lymphoma: A Phase II Study. J Clin Oncol 2015;33:251-7.
-
(2015)
J Clin Oncol
, vol.33
, pp. 251-257
-
-
Nowakowski, G.S.1
LaPlant, B.2
Macon, W.R.3
-
33
-
-
84901391325
-
Lenalidomide plus R-CHOP21 in elderly patients with untreated diffuse large B-cell lymphoma: results of the REAL07 open-label, multicentre, phase 2 trial
-
Vitolo U, Chiappella A, Franceschetti S, et al. Lenalidomide plus R-CHOP21 in elderly patients with untreated diffuse large B-cell lymphoma: results of the REAL07 open-label, multicentre, phase 2 trial. Lancet Oncol 2014;15:730-7.
-
(2014)
Lancet Oncol
, vol.15
, pp. 730-737
-
-
Vitolo, U.1
Chiappella, A.2
Franceschetti, S.3
-
34
-
-
73949145763
-
Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma
-
Witzig TE, Wiernik PH, Moore T, et al. Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma. J Clin Oncol 2009;27:5404-9.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5404-5409
-
-
Witzig, T.E.1
Wiernik, P.H.2
Moore, T.3
-
35
-
-
84868193664
-
CALGB 50401: A randomized trial of lenalidomide alone versus lenalidomide plus rituximab in patients with recurrent follicular lymphoma
-
Leonard J, Jung SH, Johnson JL, et al. CALGB 50401: A randomized trial of lenalidomide alone versus lenalidomide plus rituximab in patients with recurrent follicular lymphoma. J Clin Oncol 2012;30:abstr 8000.
-
(2012)
J Clin Oncol
, vol.30
-
-
Leonard, J.1
Jung, S.H.2
Johnson, J.L.3
-
36
-
-
84908600494
-
CALGB 50803 (Alliance): A phase II trial of lenalidomide plus rituximab in patients with previously untreated follicular lymphoma
-
Martin P, Jung SH, Johnson JL, et al. CALGB 50803 (Alliance): A phase II trial of lenalidomide plus rituximab in patients with previously untreated follicular lymphoma. J Clin Oncol 2014;32:abstr 8521.
-
(2014)
J Clin Oncol
, vol.32
-
-
Martin, P.1
Jung, S.H.2
Johnson, J.L.3
-
37
-
-
84875922053
-
Lenalidomide and Rituximab for Untreated Indolent Lymphoma: Final Results of a Phase II Study
-
Fowler NH, Neelapu SS, Hagemeister FB, et al. Lenalidomide and Rituximab for Untreated Indolent Lymphoma: Final Results of a Phase II Study. Blood 2012;120:abstr 901.
-
(2012)
Blood
, vol.120
-
-
Fowler, N.H.1
Neelapu, S.S.2
Hagemeister, F.B.3
-
38
-
-
33750625445
-
Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma
-
Fisher RI, Bernstein SH, Kahl BS, et al. Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol 2006;24:4867-74.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4867-4874
-
-
Fisher, R.I.1
Bernstein, S.H.2
Kahl, B.S.3
-
39
-
-
84910073165
-
Randomized phase 3 study of rituximab, cyclophosphamide, doxorubicin, and prednisone plus vincristine (R-CHOP) or bortezomib (VR-CAP) in newly diagnosed mantle cell lymphoma (MCL) patients (pts) ineligible for bone marrow transplantation (BMT)
-
Cavalli F, Rooney B, Pei L, et al. Randomized phase 3 study of rituximab, cyclophosphamide, doxorubicin, and prednisone plus vincristine (R-CHOP) or bortezomib (VR-CAP) in newly diagnosed mantle cell lymphoma (MCL) patients (pts) ineligible for bone marrow transplantation (BMT). J Clin Oncol 2014;32:abstr 8500.
-
(2014)
J Clin Oncol
, vol.32
-
-
Cavalli, F.1
Rooney, B.2
Pei, L.3
-
40
-
-
80053567237
-
VcR-CVAD induction chemotherapy followed by maintenance rituximab in mantle cell lymphoma: a Wisconsin Oncology Network study
-
Chang JE, Peterson C, Choi S, et al. VcR-CVAD induction chemotherapy followed by maintenance rituximab in mantle cell lymphoma: a Wisconsin Oncology Network study. Br J Haematol 2011;155:190-7.
-
(2011)
Br J Haematol
, vol.155
, pp. 190-197
-
-
Chang, J.E.1
Peterson, C.2
Choi, S.3
-
41
-
-
74549164108
-
Time to treatment response in patients with follicular lymphoma treated with bortezomib is longer compared with other histologic subtypes
-
O'Connor OA, Portlock C, Moskowitz C, et al. Time to treatment response in patients with follicular lymphoma treated with bortezomib is longer compared with other histologic subtypes. Clin Cancer Res 2010;16:719-26.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 719-726
-
-
O'Connor, O.A.1
Portlock, C.2
Moskowitz, C.3
-
42
-
-
79960892918
-
Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: a randomised phase 3 trial
-
Coiffier B, Osmanov EA, Hong X, et al. Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: a randomised phase 3 trial. Lancet Oncol 2011;12:773-84.
-
(2011)
Lancet Oncol
, vol.12
, pp. 773-784
-
-
Coiffier, B.1
Osmanov, E.A.2
Hong, X.3
-
43
-
-
80052746696
-
Bortezomib, bendamustine, and rituximab in patients with relapsed or refractory follicular lymphoma: the phase II VERTICAL study
-
Fowler N, Kahl BS, Lee P, et al. Bortezomib, bendamustine, and rituximab in patients with relapsed or refractory follicular lymphoma: the phase II VERTICAL study. J Clin Oncol 2011;29:3389-95.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3389-3395
-
-
Fowler, N.1
Kahl, B.S.2
Lee, P.3
-
44
-
-
79952154013
-
Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma
-
Ruan J, Martin P, Furman RR, et al. Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma. J Clin Oncol 2011;29:690-7.
-
(2011)
J Clin Oncol
, vol.29
, pp. 690-697
-
-
Ruan, J.1
Martin, P.2
Furman, R.R.3
-
45
-
-
84870502798
-
Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia
-
Lapalombella R, Sun Q, Williams K, et al. Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood 2012;120:4621-34.
-
(2012)
Blood
, vol.120
, pp. 4621-4634
-
-
Lapalombella, R.1
Sun, Q.2
Williams, K.3
-
46
-
-
84879566083
-
Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas
-
Azmi AS, Al-Katib A, Aboukameel A, et al. Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas. Haematologica 2013;98:1098-106.
-
(2013)
Haematologica
, vol.98
, pp. 1098-1106
-
-
Azmi, A.S.1
Al-Katib, A.2
Aboukameel, A.3
-
47
-
-
84924145196
-
A phase 1 dose-escalation study of the oral selective inhibitor of nuclear export (SINE) KPT-330 (selinexor) in patients (pts) with heavily pretreated non-Hodgkin lymphoma (NHL)
-
Gutierrez M, Goy A, Byrd JC, et al. A phase 1 dose-escalation study of the oral selective inhibitor of nuclear export (SINE) KPT-330 (selinexor) in patients (pts) with heavily pretreated non-Hodgkin lymphoma (NHL). J Clin Oncol 2014;32:abstr 8518.
-
(2014)
J Clin Oncol
, vol.32
-
-
Gutierrez, M.1
Goy, A.2
Byrd, J.C.3
-
48
-
-
84905055451
-
The tumour microenvironment in B cell lymphomas
-
Scott DW, Gascoyne RD. The tumour microenvironment in B cell lymphomas. Nat Rev Cancer 2014;14:517-34.
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 517-534
-
-
Scott, D.W.1
Gascoyne, R.D.2
-
49
-
-
84879866976
-
PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies
-
Chen BJ, Chapuy B, Ouyang J, et al. PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies. Clin Cancer Res 2013;19:3462-73.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3462-3473
-
-
Chen, B.J.1
Chapuy, B.2
Ouyang, J.3
-
50
-
-
84921793999
-
Blocking tumor escape in hematologic malignancies: The anti-PD-1 strategy
-
Bryan LJ, Gordon LI. Blocking tumor escape in hematologic malignancies: The anti-PD-1 strategy. Blood Rev 2015;29:25-32.
-
(2015)
Blood Rev
, vol.29
, pp. 25-32
-
-
Bryan, L.J.1
Gordon, L.I.2
-
51
-
-
84925717350
-
PD-1 Blockade with the Monoclonal Antibody Pembrolizumab (MK-3475) in Patients with Classical Hodgkin Lymphoma after Brentuximab Vedotin Failure: Preliminary Results from a Phase 1b Study (KEYNOTE-013)
-
Moskowitz CH, Ribrag V, Michot JM, et al. PD-1 Blockade with the Monoclonal Antibody Pembrolizumab (MK-3475) in Patients with Classical Hodgkin Lymphoma after Brentuximab Vedotin Failure: Preliminary Results from a Phase 1b Study (KEYNOTE-013). Blood 2014;124:abstr 290.
-
(2014)
Blood
, vol.124
-
-
Moskowitz, C.H.1
Ribrag, V.2
Michot, J.M.3
-
52
-
-
84929410618
-
Nivolumab in Patients with Relapsed or Refractory Hodgkin Lymphoma - Preliminary Safety, Efficacy and Biomarker Results of a Phase I Study
-
Armand P, Ansell SM, Lesokhin AM, et al. Nivolumab in Patients with Relapsed or Refractory Hodgkin Lymphoma - Preliminary Safety, Efficacy and Biomarker Results of a Phase I Study. Blood 2014;124:abstr 289.
-
(2014)
Blood
, vol.124
-
-
Armand, P.1
Ansell, S.M.2
Lesokhin, A.M.3
-
53
-
-
84925587926
-
Preliminary Results of a Phase I Study of Nivolumab (BMS-936558) in Patients with Relapsed or Refractory Lymphoid Malignancies
-
Lesokhin AM, Ansell SM, Armand P, et al. Preliminary Results of a Phase I Study of Nivolumab (BMS-936558) in Patients with Relapsed or Refractory Lymphoid Malignancies. Blood 2014;124:abstr 291.
-
(2014)
Blood
, vol.124
-
-
Lesokhin, A.M.1
Ansell, S.M.2
Armand, P.3
-
54
-
-
84890096527
-
Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial
-
Armand P, Nagler A, Weller EA, et al. Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial. J Clin Oncol 2013;31:4199-206.
-
(2013)
J Clin Oncol
, vol.31
, pp. 4199-4206
-
-
Armand, P.1
Nagler, A.2
Weller, E.A.3
-
55
-
-
84904439445
-
Targeting BCL2 for the treatment of lymphoid malignancies
-
Anderson MA, Huang D, Roberts A. Targeting BCL2 for the treatment of lymphoid malignancies. Semin Hematol 2014;51:219-27.
-
(2014)
Semin Hematol
, vol.51
, pp. 219-227
-
-
Anderson, M.A.1
Huang, D.2
Roberts, A.3
-
56
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T, Elmore SW, Shoemaker AR, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005;435:677-81.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
-
57
-
-
84863116430
-
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease
-
Roberts AW, Seymour JF, Brown JR, et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol 2012;30:488-96.
-
(2012)
J Clin Oncol
, vol.30
, pp. 488-496
-
-
Roberts, A.W.1
Seymour, J.F.2
Brown, J.R.3
-
58
-
-
78649630259
-
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
-
Wilson WH, O'Connor OA, Czuczman MS, et al. Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol 2010;11:1149-59.
-
(2010)
Lancet Oncol
, vol.11
, pp. 1149-1159
-
-
Wilson, W.H.1
O'Connor, O.A.2
Czuczman, M.S.3
-
59
-
-
84902254046
-
The Single-Agent Bcl-2 Inhibitor ABT-199 (GDC-0199) In Patients With Relapsed/Refractory (R/R) Non-Hodgkin Lymphoma (NHL): Responses Observed In All Mantle Cell Lymphoma (MCL) Patients
-
Davids MS, Seymour JF, Gerecitano JF, et al. The Single-Agent Bcl-2 Inhibitor ABT-199 (GDC-0199) In Patients With Relapsed/Refractory (R/R) Non-Hodgkin Lymphoma (NHL): Responses Observed In All Mantle Cell Lymphoma (MCL) Patients. Blood 2013;122:abstr 1789.
-
(2013)
Blood
, vol.122
-
-
Davids, M.S.1
Seymour, J.F.2
Gerecitano, J.F.3
-
60
-
-
84896479968
-
Bcl-2 Inhibitor ABT-199 (GDC-0199) Monotherapy Shows Anti-Tumor Activity Including Complete Remissions In High-Risk Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)
-
Seymour JF, Davids MS, Pagel JM, et al. Bcl-2 Inhibitor ABT-199 (GDC-0199) Monotherapy Shows Anti-Tumor Activity Including Complete Remissions In High-Risk Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL). Blood 2013;122:abstr 872.
-
(2013)
Blood
, vol.122
-
-
Seymour, J.F.1
Davids, M.S.2
Pagel, J.M.3
-
61
-
-
84881090160
-
Combating the epigenome: epigenetic drugs against non-Hodgkin's lymphoma
-
Hassler MR, Schiefer AI, Egger G. Combating the epigenome: epigenetic drugs against non-Hodgkin's lymphoma. Epigenomics 2013;5:397-415.
-
(2013)
Epigenomics
, vol.5
, pp. 397-415
-
-
Hassler, M.R.1
Schiefer, A.I.2
Egger, G.3
-
62
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic M, Talpur R, Ni X, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 2007;109:31-9.
-
(2007)
Blood
, vol.109
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
-
63
-
-
34547683194
-
Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
-
Olsen EA, Kim YH, Kuzel TM, et al. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 2007;25:3109-15.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3109-3115
-
-
Olsen, E.A.1
Kim, Y.H.2
Kuzel, T.M.3
-
64
-
-
79952977561
-
Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma
-
Piekarz RL, Frye R, Prince HM, et al. Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma. Blood 2011;117:5827-34.
-
(2011)
Blood
, vol.117
, pp. 5827-5834
-
-
Piekarz, R.L.1
Frye, R.2
Prince, H.M.3
-
65
-
-
84857522968
-
Results from a pivotal, open-label, phase II study of romidepsin in relapsed or refractory peripheral T-cell lymphoma after prior systemic therapy
-
Coiffier B, Pro B, Prince HM, et al. Results from a pivotal, open-label, phase II study of romidepsin in relapsed or refractory peripheral T-cell lymphoma after prior systemic therapy. J Clin Oncol 2012;30:631-6.
-
(2012)
J Clin Oncol
, vol.30
, pp. 631-636
-
-
Coiffier, B.1
Pro, B.2
Prince, H.M.3
-
66
-
-
73949149251
-
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
-
Piekarz RL, Frye R, Turner M, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol 2009;27:5410-7.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5410-5417
-
-
Piekarz, R.L.1
Frye, R.2
Turner, M.3
-
67
-
-
77954879663
-
Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma
-
Whittaker SJ, Demierre MF, Kim EJ, et al. Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma. J Clin Oncol 2010;28:4485-91.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4485-4491
-
-
Whittaker, S.J.1
Demierre, M.F.2
Kim, E.J.3
-
68
-
-
84884558230
-
Belinostat, a novel pan-histone deacetylase inhibitor (HDACi), in relapsed or refractory peripheral T-cell lymphoma (R/R PTCL): Results from the BELIEF trial
-
O'Connor OA, Masszi T, Savage KJ, et al. Belinostat, a novel pan-histone deacetylase inhibitor (HDACi), in relapsed or refractory peripheral T-cell lymphoma (R/R PTCL): Results from the BELIEF trial. J Clin Oncol 2013;31:abstr 8507.
-
(2013)
J Clin Oncol
, vol.31
-
-
O'Connor, O.A.1
Masszi, T.2
Savage, K.J.3
|