Free radical scavenging by lazaroids improves renal blood flow during sepsis

Surgery

Volumn 120, Issue 4, 1996, Pages 657-662

  Krysztopik, R J ^a   Bently, F R ^a   Spain, D A ^a   Wilson, M A ^a   Garrison, R N ^a   Steinberg, S ^a   Lucas, C E ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; ANTIOXIDANT; LAZAROID; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ACUTE KIDNEY FAILURE; ANIMAL MODEL; ARTERY DIAMETER; ARTICLE; BACTEREMIA; CONTROLLED STUDY; ESCHERICHIA COLI; HEART OUTPUT; HEART RATE; HYDRONEPHROSIS; KIDNEY BLOOD FLOW; KIDNEY PERFUSION; LIPID PEROXIDATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; SURGICAL PATIENT; VASOCONSTRICTION;

EID: 0029806882     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-6060(96)80013-4     Document Type: Article

References (25)

1. Groeneveld ABJ Pathogenesis of acute renal failure during sepsis Nephrol Dial Transplant 9 suppl 4 1994 47 51
2. Lucas C The renal response to acute injury and sepsis Surg Clin North Am 56 1976 953 957
3. Lugon JR Boim MA Oswaldo LR Renal function and glomerular hemodynamics in male endotoxemic rats Kidney Int 36 1989 570 575
4. Cryer HM Unger LS Garrison RN Harris PD Prostaglandins maintain renal blood flow during hyperdynamic bacteremia Circ Shock 26 1988 71 88
5. Badr KF Sepsis associated renal vasoconstriction: potential targets for future therapy Am J Kidney Dis 20 1992 207 213
6. Spain DA Wilson MA Garrison RN Nitric oxide synthase inhibition exacerbates sepsis induced renal hypoperfusion Surgery 116 1994 322 331
7. Kehrer J Free radicals as mediators of tissue injury and disease Crit Rev Toxicol 23 1993 21 48
8. Powell RJ Machiedo GW Rush BF Dikdan GS Effect of oxygenfree radical scavengers on survival in sepsis Am Surg 57 1991 86 88
9. Morrow JD Hill KE Burk RF Nammour TM Badr KF Roberts LJI A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism Proc Natl Acad Sci USA 87 1990 9383 9387
10. Galat JA Robinson AV Rhodes RS Oxygen free radical mediated renal dysfunction J Surg Res 46 1989 520 525
11. Buhrle CP Hackenthal E Helmchen U The hydronephrotic kidney in the mouse as a tool for intravital microscopy and in vitro electrophysiological studies of renin containing cells Lab Invest 54 1986 462 472
12. Goode HF Cowley HC Walker BE Howdle PD Webster NR Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction Crit Care Med 23 1995 646 651
13. Andreoli SP McAteer JA Reactive oxygen molecule-mediated injury in endothelial and renal tubular epithelial cells in vitro Kidney Int 38 1990 785 794
14. Maridonneau-Parini I Radin A Touqui L Russo-Marie F Effect of intracellular oxygen-free radicals on the formation of lipid derived mediators in rat renomedullary interstitial cells Biochem Pharmacol 34 1985 4137 4143
15. 2 release by adherent neutrophil leukocytes J Immunol 154 1995 1383 1390
16. 2 receptors J Clin Invest 90 1992 136 141
17. Braughler JM Chase RL Neff GL A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotrophin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells J Pharmacol Exp Ther 244 1988 423 427
18. Ward PA Johnson KJ Till GO Oxygen radicals and microvascular injury of lungs and kidney Acta Physiol Scand 548 1986 79 85
19. McKelvey TG Hollwarth ME Granger DN Engerson TD Landler U Jones HP Mechanisms of conversion of xanthine dehydrogenase to xanthine oxidase in ischemic rat liver and kidney Am J Physiol 254 1988 G753 G760
20. Friedl HP Till GO Ryan US Mediator induced activation of xanthine oxidase in endothelial cells FASEB J 3 1989 2512 2518
21. Beckman JS Beckman TW Chen J Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide Proc Natl Acad Sci USA 87 1990 1620 1624
22. Thomas PD Mao GD Rabinovitch A Poznansky MJ Inhibition of superoxide generating NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 21-aminochromans) Biochem Pharmacol 45 1993 241 251
23. 2 release is restored by treatment with lazaroid Prostaglandins 45 1993 535 546
24. Tolins JP Vercellotti GM Jacob HS Raij L Role of platelet activating factor in endotoxemic acute renal failure in the male rat J Lab Clin Med 113 1989 316 324
25. 2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite Circ Res 77 1995 335 341