Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers

Cytogenetic and Genome Research

Volumn 146, Issue 1, 2015, Pages 19-27

  Schneider, Eberhard ^a   El Hajj, Nady ^a   Müller, Fabian ^b   Navarro, Bianca ^c   Haaf, Thomas ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b MAX PLANCK INSTITUTE FOR INFORMATICS   (Germany)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Cortex; DNA methylation; Suicidal behavior; Transcription regulation

Indexed keywords

ARTICLE; BRAIN; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DNA METHYLATION; EPIGENETIC DYSREGULATION; EPIGENETICS; GENE; GENETIC ASSOCIATION; GENETIC DISORDER; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN TISSUE; MALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROMOTER REGION; SUDDEN DEATH; SUICIDE; SUICIDE GENE; CASE CONTROL STUDY; CPG ISLAND; GENETIC EPIGENESIS; MOLECULAR GENETICS; PATHOPHYSIOLOGY;

CASE-CONTROL STUDIES; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; MALE; MOLECULAR SEQUENCE ANNOTATION; PREFRONTAL CORTEX; PROMOTER REGIONS, GENETIC; SUICIDE;

EID: 84941932868     PISSN: 14248581     EISSN: 1424859X     Source Type: Journal    
DOI: 10.1159/000435778     Document Type: Article

References (56)

1. Antypa N, Serretti A, Rujescu D: Serotonergic genes and suicide: A systematic review. Eur Neuropsychopharmacol 23: 1125-1142 (2013).
2. Coon H, Darlington T, Pimentel R, Smith KR, Huff CD, et al: Genetic risk factors in two Utah pedigrees at high risk for suicide. Transl Psychiatry 3: e325 (2013).
3. Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, et al: Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol 13: R43 (2012).
4. Deaton AM, Bird A: CpG islands and the regulation of transcription. Genes Dev 25: 1010-1022 (2011).
5. Du P, Kibbe WA, Lin SM: lumi : A pipeline for processing Illumina microarray. Bioinformatics 24: 1547-1548 (2008).
6. Du P, Zhang X, Huang CC, Jafari N, Kibbe WA, et al: Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics 11: 587 (2010).
7. Dwivedi Y: Brain-derived neurotrophic factor and suicide pathogenesis. Ann Med 42: 87-96 (2010).
8. El Hajj N, Pliushch G, Schneider E, Dittrich M, Müller T, et al: Metabolic programming of MEST DNA methylation by intrauterine exposure to gestational diabetes mellitus. Diabetes 62: 1320-1328 (2013).
9. Ernst C, Deleva V, Deng X, Sequeira A, Pomarenski A, et al: Alternative splicing, methylation state, and expression profile of tropomyosinrelated kinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry 66: 22-32 (2009).
10. Farcas R, Schneider E, Frauenknecht K, Kondova I, Bontrop R, et al: Differences in DNA methylation patterns and expression of the CCRK gene in human and nonhuman primate cortices. Mol Biol Evol 26: 1379-1389 (2009).
11. Feil R, Fraga MF: Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet 13: 97-109 (2012).
12. Fiori LM, Turecki G: Epigenetic regulation of spermidine/spermine N1-acetyltransferase (SAT1) in suicide. J Psychiatr Res 45: 1229-1235 (2011).
13. Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, et al: STRING v9. 1: Proteinprotein interaction networks, with increased coverage and integration. Nucleic Acids Res 41: D808-D815 (2013).
14. Gladkevich A, Kauffman HF, Korf J: Lymphocytes as a neural probe: Potential for studying psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 28: 559-576 (2004).
15. Gross JA, Fiori LM, Labonté B, Lopez JP, Turecki G: Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide. J Psychiatr Res 47: 513-519 (2013).
16. Grundberg E, Meduri E, Sandling JK, Hedman AK, Keildson S, et al: Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements. Am J Hum Genet 93: 876-890 (2013).
17. Guintivano J, Brown T, Newcomer A, Jones M, Cox O, et al: Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors. Am J Psychiatry 171: 1287-1296 (2014).
18. Guipponi M, Deutsch S, Kohler K, Perroud N, Le Gal F, et al: Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 150B: 799-807 (2009).
19. Hatchwell E, Greally JM: The potential role of epigenomic dysregulation in complex human disease. Trends Genet 23: 588-595 (2007).
20. Hawton K, van Heeringen K: Suicide. Lancet 373: 1372-1381 (2009).
21. Hoffmann A, Spengler D: The lasting legacy of social stress on the epigenome of the hypothalamic-pituitary-adrenal axis. Epigenomics 4: 431-444 (2012).
22. Jaenisch R, Bird A: Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 Suppl: 245-254 (2003).
23. Kang HJ, Kim JM, Lee JY, Kim SY, Bae KY, et al: BDNF promoter methylation and suicidal behavior in depressive patients. J Affect Disord 151: 679-685 (2013).
24. Keller S, Sarchiapone M, Zarrilli F, Videtic A, Ferraro A, et al: Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 67: 258-267 (2010).
25. Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, et al: Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet 40: 904-908 (2008).
26. Klempan TA, Ernst C, Deleva V, Labonte B, Turecki G: Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder. Biol Psychiatry 66: 824-831 (2009).
27. Labonte B, Suderman M, Maussion G, Navaro L, Yerko V, et al: Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry 69: 722-731 (2012).
28. Labonte B, Suderman M, Maussion G, Lopez JP, Navarro-Sanchez L, et al: Genome-wide methylation changes in the brains of suicide completers. Am J Psychiatry 170: 511-520 (2013).
29. Lutz PE, Turecki G: DNA methylation and childhood maltreatment: from animal models to human studies. Neuroscience 264: 142-156 (2014).
30. Mandelli L, Serretti A: Gene environment interaction studies in depression and suicidal behavior: An update. Neurosci Biobehav Rev 37: 2375-2397 (2013).
31. Mann JJ, Brent DA, Arango V: The neurobiology and genetics of suicide and attempted suicide: A focus on the serotonergic system. Neuropsychopharmacology 24: 467-447 (2001).
32. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, et al: Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12: 342-348 (2009).
33. Monsalve EM, Garcia-Gutierrez MS, Navarrete F, Giner S, Laborda J, Manzanares J: Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims. Mol Neurobiol 49: 957-965 (2014).
34. Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmuhl Y, et al: Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 12: 1559-1566 (2009).
35. OECD: Health at a glance 2011: OECD indicators. OECD publishing. http: //www. oecd. org/els/ health-systems/49105858. pdf (2011).
36. Partonen T: Clock gene variants in mood and anxiety disorders. J Neural Transm 119: 1133-1145 (2012).
37. Paykel ES: Life stress, depression and attempted suicide. J Human Stress 2: 3-12 (1976).
38. Perez-Ortiz JM, Garcia-Gutierrez MS, Navarrete F, Giner S, Manzanares J: Gene and protein alterations of FKBP5 and glucocorticoid receptor in the amygdala of suicide victims. Psychoneuroendocrinology 38: 1251-1258 (2013).
39. Perlis RH, Huang J, Purcell S, Fava M, Rush AJ, et al: Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry 167: 1499-1507 (2010).
40. Poulter MO, Du L, Weaver IC, Palkovits M, Faludi G, et al: GABA A receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes. Biol Psychiatry 64: 645-652 (2008).
41. Pregelj P, Nedic G, Paska AV, Zupanc T, Nikolac M, et al: The association between brainderived neurotrophic factor polymorphism (BDNF Val66Met) and suicide. J Affect Disord 128: 287-290 (2011).
42. Punzi G, Ursini G, Shin JH, Kleinman JE, Hyde TM, Weinberger DR: Increased expression of MARCKS in post-mortem brain of violent suicide completers is related to transcription of a long, noncoding, antisense RNA. Mol Psychiatry 19: 1057-1059 (2014).
43. Raust A, Slama F, Mathieu F, Roy I, Chenu A, et al: Prefrontal cortex dysfunction in patients with suicidal behavior. Psychol Med 37: 411-419 (2007).
44. Robillard R, Naismith SL, Hickie IB: Recent advances in sleep-wake cycle and biological rhythms in bipolar disorder. Curr Psychiatry Rep 15: 402 (2013).
45. Sadkowski M, Dennis B, Clayden RC, Elsheikh W, Rangarajan S, et al: The role of the serotonergic system in suicidal behavior. Neuropsychiatr Dis Treat 9: 1699-1716 (2013).
46. Schild AH, Pietschnig J, Tran US, Voracek M: Genetic association studies between SNPs and suicidal behavior: A meta-analytical field synopsis. Prog Neuropsychopharmacol Biol Psychiatry 46: 36-42 (2013).
47. Sequeira A, Morgan L, Walsh DM, Cartagena PM, Choudary P, et al: Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide. PloS One 7: e35367 (2012).
48. Sher L: The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior. Int J Adolesc Med Health 23: 181-185 (2011).
49. Szyf M: The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life. Epigenetics 6: 971-978 (2011).
50. Triche TJ Jr, Weisenberger DJ, van den Berg D, Laird PW, Siegmund KD: Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Res 41: e90 (2013).
51. Turecki G, Ernst C, Jollant F, Labonte B, Mechawar N: The neurodevelopmental origins of suicidal behavior. Trends Neurosci 35: 14-23 (2012).
52. van Heeringen C: Suicide, serotonin, and the brain. Crisis 22: 66-70 (2001).
53. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, et al: Epigenetic programming by maternal behavior. Nat Neurosci 7: 847-854 (2004).
54. Yen S, Shea MT, Sanislow CA, Skodol AE, Grilo CM, et al: Personality traits as prospective predictors of suicide attempts. Acta Psychiatr Scand 120: 222-229 (2009).
55. Zannas AS, West AE: Epigenetics and the regulation of stress vulnerability and resilience. Neuroscience 264: 157-170 (2014).
56. Zhurov V, Stead JD, Merali Z, Palkovits M, Faludi G, et al: Molecular pathway reconstruction and analysis of disturbed gene expression in depressed individuals who died by suicide. PLoS One 7: e47581 (2012).