Circulating histones are major mediators of cardiac injury in patients with sepsis

Critical Care Medicine

Volumn 43, Issue 10, 2015, Pages 2094-2103

  Alhamdi, Yasir ^a   Abrams, Simon T ^a   Cheng, Zhenxing ^b   Jing, Shengjie ^b   Su, Dunhao ^a   Liu, Zhiyong ^b   Lane, Steven ^a   Welters, Ingeborg ^a,c   Wang, Guozheng ^a   Toh, Cheng Hock ^a,c  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b SOUTHEAST UNIVERSITY   (China)

^c ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Arrhythmias; Cardiac troponins; Extracellular histones; Left ventricular function; Mortality; Sepsis

Indexed keywords

HISTONE; HISTONE ANTIBODY; NORADRENALIN; TROPONIN T;

ADULT; ADVERSE OUTCOME; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR MORTALITY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; ECHOCARDIOGRAPHY; EX VIVO STUDY; HEART ARRHYTHMIA; HEART CELL CULTURE; HEART HEMODYNAMICS; HEART INJURY; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OBSERVATIONAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SEPSIS; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; TRANSLATIONAL RESEARCH; ANIMAL; BLOOD; COMPLICATION; FEMALE; HEART DISEASE; MICROBIOLOGY; MIDDLE AGED;

AGED; ANIMALS; FEMALE; HEART DISEASES; HISTONES; HUMANS; MALE; MICE; MIDDLE AGED; PROSPECTIVE STUDIES; SEPSIS;

EID: 84941924101     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001162     Document Type: Article

References (50)

1. Gustot T: Multiple organ failure in sepsis: Prognosis and role of systemic inflammatory response. Curr Opin Crit Care 2011;17:153-159
2. Cann M, Stevenson T, Fiallos E, et al: Depressed cardiac performance in sepsis. Surg Gynecol Obstet 1972;134:759-763
3. Kirkpatrick JR, Heilbrunn A, Sankaran S: Cardiac arrhythmias: An early sign of sepsis. Am Surg 1973;39:380-382
4. Merx MW, Weber C: Sepsis and the heart. Circulation 2007;116:793-802
5. Mahajan VS, Jarolim P: How to interpret elevated cardiac troponin levels. Circulation 2011;124:2350-2354
6. Bessière F, Khenifer S, Dubourg J, et al: Prognostic value of troponins in sepsis: A meta-analysis. Intensive Care Med 2013;39:1181-1189
7. Hussain N: Elevated cardiac troponins in setting of systemic inflammatory response syndrome, sepsis, and septic shock. ISRN Cardiol 2013;2013:723435
8. Xu RY, Zhu XF, Yang Y, et al: High-sensitive cardiac troponin T. J Geriatr Cardiol 2013;10:102-109
9. John J, Woodward DB, Wang Y, et al: Troponin-I as a prognosticator of mortality in severe sepsis patients. J Crit Care 2010;25:270-275
10. Mehta NJ, Khan IA, Gupta V, et al: Cardiac troponin I predicts myocardial dysfunction and adverse outcome in septic shock. Int J Cardiol 2004;95:13-17
11. Ver Elst KM, Spapen HD, Nguyen DN, et al: Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock. Clin Chem 2000;46:650-657
12. Tiruvoipati R, Sultana N, Lewis D: Cardiac troponin I does not independently predict mortality in critically ill patients with severe sepsis. Emerg Med Australas 2012;24:151-158
13. Vasile VC, Chai HS, Abdeldayem D, et al: Elevated cardiac troponin T levels in critically ill patients with sepsis. Am J Med 2013;126:1114-1121
14. Landesberg G, Jaffe AS, Gilon D, et al: Troponin elevation in severe sepsis and septic shock: The role of left ventricular diastolic dysfunction and right ventricular dilatation. Crit Care Med 2014;42:790-800
15. Annane D, Sébille V, Duboc D, et al: Incidence and prognosis of sustained arrhythmias in critically ill patients. Am J Respir Crit Care Med 2008;178:20-25
16. Walkey AJ, Wiener RS, Ghobrial JM, et al: Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis. JAMA 2011;306:2248-2254
17. Ferdman B, Jureidini SB, Gale G, et al: Severe left ventricular dysfunction and arrhythmias as complications of gram-positive sepsis: Rapid recovery in children. Pediatr Cardiol 1998;19:482-486
18. Parker MM, Shelhamer JH, Bacharach SL, et al: Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984;100:483-490
19. Charpentier J, Luyt CE, Fulla Y, et al: Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis. Crit Care Med 2004;32:660-665
20. Vieillard-Baron A, Caille V, Charron C, et al: Actual incidence of global left ventricular hypokinesia in adult septic shock. Crit Care Med 2008;36:1701-1706
21. Jardin F, Fourme T, Page B, et al: Persistent preload defect in severe sepsis despite fluid loading: A longitudinal echocardiographic study in patients with septic shock. Chest 1999;116:1354-1359
22. Vincent JL, Gris P, Coffernils M, et al: Myocardial depression characterizes the fatal course of septic shock. Surgery 1992;111:660-667
23. Wilhelm J, Hettwer S, Schuermann M, et al: Severity of cardiac impairment in the early stage of community-acquired sepsis determines worse prognosis. Clin Res Cardiol 2013;102:735-744
24. Parrillo JE, Parker MM, Natanson C, et al: Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 1990;113:227-242
25. Zanotti-Cavazzoni SL, Hollenberg SM: Cardiac dysfunction in severe sepsis and septic shock. Curr Opin Crit Care 2009;15:392-397
26. Phillips DP, Kaynar AM: Septic cardiomyopathy. Int Anesthesiol Clin 2012;50:187-201
27. Cunnion RE, Schaer GL, Parker MM, et al: The coronary circulation in human septic shock. Circulation 1986;73:637-644
28. Suffredini AF, Fromm RE, Parker MM, et al: The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 1989;321:280-287
29. Natanson C, Eichenholz PW, Danner RL, et al: Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med 1989;169:823-832
30. Levy RJ, Deutschman CS: Evaluating myocardial depression in sepsis. Shock 2004;22:1-10
31. Xu J, Zhang X, Pelayo R, et al: Extracellular histones are major mediators of death in sepsis. Nat Med 2009;15:1318-1321
32. Abrams ST, Zhang N, Manson J, et al: Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med 2013;187:160-169
33. Semeraro F, Ammollo CT, Morrissey JH, et al: Extracellular histones promote thrombin generation through platelet-dependent mechanisms: Involvement of platelet TLR2 and TLR4. Blood 2011;118:1952-1961
34. Fuchs TA, Bhandari AA, Wagner DD: Histones induce rapid and profound thrombocytopenia in mice. Blood 2011;118:3708-3714
35. Kalbitz M, Grailer JJ, Fattahi F, et al: Role of extracellular histones in the cardiomyopathy of sepsis. FASEB J 2015;29:2185-2193
36. Ekaney ML, Otto GP, Sossdorf M, et al: Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation. Crit Care 2014;18:543
37. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644-1655
38. Levy MM, Fink MP, Marshall JC, et al; SCCM/ESICM/ACCP/ATS/SIS: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003;31:1250-1256
39. Takasu O, Gaut JP, Swanson PE, et al: Reply: The role of arrhythmias in defining cardiac dysfunction during sepsis. Am J Respir Crit Care Med 2013;188:751
40. Meierhenrich R, Steinhilber E, Eggermann C, et al: Incidence and prognostic impact of new-onset atrial fibrillation in patients with septic shock: A prospective observational study. Crit Care 2010;14:R108
41. Frimodt-Moller N, Knudsen JD, Espersen F: The mouse peritonitis/sepsis model. In: Handbook of Animal Models of Infection. Sande OZaMA (Ed). London, United Kingdom, Academic Press, 1999, pp 127-136
42. Zeerleder S, Stephan F, Emonts M, et al: Circulating nucleosomes and severity of illness in children suffering from meningococcal sepsis treated with protein C. Crit Care Med 2012;40:3224-3229
43. Little WC: The left ventricular dP/dtmax-end-diastolic volume relation in closed-chest dogs. Circ Res 1985;56:808-815
44. Weiss JL, Frederiksen JW, Weisfeldt ML: Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest 1976;58:751-760
45. Hirota Y: A clinical study of left ventricular relaxation. Circulation 1980;62:756-763
46. Wang Y, Goldhaber JI: Return of calcium: Manipulating intracellular calcium to prevent cardiac pathologies. Proc Natl Acad Sci U S A 2004;101:5697-5698
47. Vassalle M, Lin CI: Calcium overload and cardiac function. J Biomed Sci 2004;11:542-565
48. Romero-Bermejo FJ, Ruiz-Bailen M, Gil-Cebrian J, et al: Sepsisinduced cardiomyopathy. Curr Cardiol Rev 2011;7:163-183
49. Gandhi S, Litt D, Narula N: New-onset atrial fibrillation in sepsis is associated with increased morbidity and mortality. Neth Heart J 2015;23:82-88
50. Nishida K, Michael G, Dobrev D, et al: Animal models for atrial fibrillation: Clinical insights and scientific opportunities. Europace 2010;12:160-172